CN105265985B - A kind of corn stigma solid beverage and preparation method thereof - Google Patents
A kind of corn stigma solid beverage and preparation method thereof Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of corn stigma solid beverage and preparation method thereof.The corn stigma solid beverage includes the raw material of following weight parts：10~60 parts of 10~60 parts of Corn silk P.E, 10~60 parts of xylitol and steviol glycoside.The invention also discloses the preparation method of the corn stigma solid beverage.Corn stigma solid beverage of the present invention has the effect such as hypoglycemic, lipid-loweringing and diuresis, and original corn distinctive delicate fragrance taste is retained during dissolving.
Description
Technical field
The present invention relates to solid beverage manufacture field.More particularly, to a kind of corn stigma solid beverage and its preparation side
Method.
Background technology
Corn stigma (stigma maydis) is the style and column cap of the beautiful another name for Sichuan Province platymiscium corn of grass family.In China, corn stigma
As the existing long clinical application history of Chinese medicine, research shows, multiple biological activities composition is contained in corn stigma, such as yellow
Ketone and its glycoside, sterol, alkaloid, carbohydrate, organic acid, volatile oil, trace element and multivitamin etc., its extract have
The effects such as anti-oxidant, diuresis, hypoglycemic, antibacterial, decompression and immune enhancing.Food and Drug Administration confirms corn stigma conduct
Safe and nontoxic material.
In recent years, because of it safely, the characteristics of be easy to get, the research for being related to corn stigma is increasing year by year, various corn stigma systems
Product also accordingly occur.Because corn silk water extract has good health-care efficacy, people start exploitation using corn stigma as primary raw material
Health beverages, such as China Patent Publication No. CN101940349A discloses " a kind of corn stigma mineral water and preparation method thereof "
" a kind of plant health-care beverage and its manufacture craft " is disclosed with China Patent Publication No. CN1159301A, but these patents all belong to
In liquid beverage, increase cost in transportation, carry inconvenient.Corn disclosed in China Patent Publication No. CN1382484A
Palpus parenteral solution and preparation method thereof, but then there are security risks in corn tassel injection, and its production cost is also high compared with other formulations.
Therefore, in the case where corn stigma market is more and more hotter, it is necessary to which to create a kind of safe and convenient product imperative.
The content of the invention
It is an object of the invention to provide a kind of corn stigma solid beverage, the corn stigma solid beverage have hypoglycemic, lipid-loweringing and
Diuresis etc. is acted on, and without any other preservative, retains original with easy to carry, it is easy to the advantages of dissolving, during dissolving
The distinctive delicate fragrance taste of corn.
To reach above-mentioned purpose, the present invention uses following technical proposals：
The present invention provides a kind of corn stigma solid beverage, and the corn stigma solid beverage includes the raw material of following weight parts：It is beautiful
Rice must 10~60 parts of 10~60 parts of extract (solid type or liquid-type), 10~60 parts of xylitol and steviol glycoside.
Preferably, corn stigma solid beverage of the invention also includes luxuriant 10~60 parts of the Cillium of circle.Specifically, circle bud
Isapgol husk is a kind of new raw-food material of No. 10 bulletin approvals of national health and Family Planning Committee 2014 year, and the raw material comes
Come from the luxuriant Chinese herbaceous peony (Classification system of Plantaginaceae Plantago circle of India's artificial growth：Plantago ovata) seed hull.Tool
Relax bowel, reducing blood lipid, reduction type II diabetes risk and supplement soluble dietary fiber the effects such as, it is adaptable to nutrition
Replenishers, solid beverage and bakery etc..Circle bud isapgol husk is common with Corn silk P.E in corn stigma solid beverage
As raw material, with reduction blood glucose, while prevention and the effect of improvement diabetic complication, diuresis is remarkably reinforced.
In above-mentioned formula of the invention, it can be extracted by the biomimetic method of ultrasonic assistant half or heat reflow method in corn stigma
Effective active composition prepares Corn silk P.E.
Specifically, the biomimetic method of ultrasonic assistant half：Weigh corn stigma, add the pH 7.0 of 5~20 times of corn stigma weight~
7.5 aqueous solution carries out ultrasonic extraction, and the power of ultrasonic extraction is 50~100w, and the time is 0.5~3 hour, and filter is collected in filtering
Liquid, gained filter residue is again with the pH 8.1~8.5 of 5~20 times of corn stigma weight aqueous solution ultrasonic extraction 0.5~3 hour, filtering,
Merge and extract gained filtrate, through the liquid-type Corn silk P.E that is concentrated under reduced pressure to obtain；Or, further by the liquid-type corn stigma
Extract freezes 24~36h under the conditions of -100~-50 DEG C, then lyophilized 36 under the conditions of -60~-48 DEG C, air pressure 0.05mbar
~72h, crushed 60 mesh sieves, and obtained freeze-dried powder, obtained solid type Corn silk P.E.
Heat reflow method：Corn stigma is weighed, plus 5~the water heating reflux methods of 20 times of corn stigma weight extracts 2 times, each 1h,
Merge extract solution, through the liquid-type corn stigma extract solution that is concentrated under reduced pressure to obtain；Or, further by the liquid-type corn stigma extract solution
24~36h, then lyophilized 36~72h under the conditions of -60~-48 DEG C, air pressure 0.05mbar are freezed under the conditions of -100~-50 DEG C,
60 mesh sieves were crushed, freeze-dried powder is obtained, solid type Corn silk P.E is obtained.
Further, corn stigma described in the above method is after fresh corn stigma cleaning is dried, to produce.
Present invention also offers the preparation method of above-mentioned corn stigma solid beverage, i.e., including above-mentioned all raw materials are mixed into equal
Particle is made after even.
Beneficial effects of the present invention are as follows：
Corn stigma solid beverage of the present invention keeps enjoying the corn flavor that people like, delicate fragrance is tasty.In addition corn
Must solid beverage can also add the luxuriant isapgol husk of appropriate circle, with relaxing bowel, reducing blood lipid, reduction type II diabetes suffer from
The effects such as risk and supplement soluble dietary fiber, it is adaptable to nutritious supplementary pharmaceutical, solid beverage and bakery etc..Circle bud Chinese herbaceous peony
Sub- shell in corn stigma solid beverage with Corn silk P.E collectively as raw material, with reduction blood glucose, prevention and improve glycosuria
While sick complication effect, diuresis is significantly increased.
To each extract of corn stigma, (corn silk water extract, alcohol extract and the biomimetic method of ultrasonic assistant half are extracted our early stages
Thing) hypoglycemic screening process in, it is found that water extract and the biomimetic method extract hypoglycemic effect of ultrasonic assistant half are better than it
Its extracting method, can improve the mouse hyperglycemic state of alloxan induction, and can repair mice pancreatic, and increase hepatic glycogen contains
Amount；And the hypoglycemic effect of the biomimetic method extract of ultrasonic assistant half is more notable.The present invention is bionical by ultrasonic assistant half
Method extracts the effective active composition in corn stigma, and this method prepares freeze-dried powder recovery rate and prepares freeze-dried powder compared with heating and refluxing extraction method
Improve a lot.
The simple production process of corn stigma solid beverage of the present invention, product is stable.The corn stigma solid drink of the present invention
Material maintains the delicate fragrance taste of original corn stigma.The corn stigma solid beverage has reduction blood glucose, and prevention and improvement diabetes are simultaneously
While sending out disease effect, also with obvious diuresis.
Embodiment
In order to illustrate more clearly of the present invention, with reference to preferred embodiment, the present invention is described further.Ability
Field technique personnel should be appreciated that following specifically described content is illustrative and be not restrictive, and this should not be limited with this
The protection domain of invention.
The biomimetic method of 1 ultrasonic assistant of embodiment half prepares Corn silk P.E
After the cleaning of A corn stigmas is dried, the aqueous solution for adding the pH 7.5 of 10 times of corn stigma weight carries out ultrasonic extraction, ultrasound
The power of extraction is 70w, and the time is 1 hour, filtering, collects filtrate, gained filter residue is again with the pH8.3's of 10 times of corn stigma weight
Aqueous solution ultrasound 1 hour, filtering merges and extracts gained filtrate, through the liquid-type Corn silk P.E that is concentrated under reduced pressure to obtain；This liquid-type
Corn silk P.E can be used as the raw material for preparing its solid beverage.
B is：Gained concentrate freezes 24h at -80 DEG C in step A, in -48 DEG C, air pressure 0.05mbar conditions after freezing
48h is freezed down, crushed 60 mesh sieves, freeze-dried powder is made；This freeze-dried powder can also be as to prepare the raw material of its solid beverage.
The biomimetic method of 2 ultrasonic assistant of embodiment half prepares Corn silk P.E
After the cleaning of A corn stigmas is dried, the aqueous solution for adding the pH 7.0 of 20 times of corn stigma weight carries out ultrasonic extraction, ultrasound
The power of extraction is 100w, and the time is 0.5 hour, filtering, collects filtrate, gained filter residue is again with 20 times of corn stigma weight
The pH8.1 aqueous solution is ultrasonic 0.5 hour, filtering, merges and extracts gained filtrate, through the liquid-type corn stigma extraction that is concentrated under reduced pressure to obtain
Thing；This liquid-type Corn silk P.E can be used as the raw material for preparing its solid beverage.
B is：Gained concentrate freezes 36h at -60 DEG C in step A, in -60 DEG C, air pressure 0.05mbar conditions after freezing
72h is freezed down, crushed 60 mesh sieves, freeze-dried powder is made；This freeze-dried powder can also be as to prepare the raw material of its solid beverage.
The heating reflux method of embodiment 3 prepares Corn silk P.E
After the cleaning of A corn stigmas is dried, corn stigma is extracted 2 times with the water heating reflux method of 10 times of weight, and each 1h, merging is carried
Liquid is taken, through the corn stigma extract solution that is concentrated under reduced pressure to obtain；This extract solution can be used as the raw material for preparing its solid beverage.
B is：Gained concentrate freezes 24h at -80 DEG C in step A, in -48 DEG C, air pressure 0.05mbar conditions after freezing
48h is freezed down, crushed 60 mesh sieves, freeze-dried powder is made；This freeze-dried powder can also be as to prepare the raw material of its solid beverage.
It is prepared by the corn stigma solid beverage of embodiment 4
(1) parts by weight of 1 gained corn stigma freeze-dried powder of Example 40, standby；
(2) 40 parts by weight Corn palpus freeze-dried powder, 40 parts by weight xylitols, the mixing of 20 parts by weight steviol glycosides are taken, dry powder is used
Granulator is directly pelletized, and obtains corn stigma solid beverage.
It is prepared by the corn stigma solid beverage of embodiment 5
(1) step of be the same as Example 4 (1)；
(2) take 40 parts by weight Corn must freeze-dried powder, the luxuriant Plantago Seed of circle of 20 parts by weight, the xylitol of 20 parts by weight,
20 parts by weight steviol glycosides are mixed, and are directly pelletized with dry powder particle machine, are obtained corn stigma solid beverage.
It is prepared by the corn stigma solid beverage of embodiment 6
(1) parts by weight of corn stigma extract solution 10 in the step A of Example 3, standby；
(2) 10 parts by weight Corn palpus extract solution, 30 parts by weight xylitols, 10 parts by weight steviol glycosides are taken to mix, softwood processed,
Pelletized with oscillating granulator, dry, obtain corn stigma solid beverage.
It is prepared by the corn stigma solid beverage of embodiment 7
(1) parts by weight of corn stigma extract solution 60 in the step A of Example 1, standby；
(2) take 60 parts by weight Corn must extract solution, 10 parts by weight xylitols, luxuriant 40 parts of the Cillium of circle, 40 parts by weight
Steviol glycoside is mixed, and softwood processed is pelletized with oscillating granulator, is dried, is obtained corn stigma solid beverage.
Embodiment 8 describes the effect of the present invention in detail below by test example
First, hypoglycemic, lipid-lowering test
1 principle
On the basis of the feeding of high thermal energy fodder, it is aided with low dose of alloxan, causes sugar/disorders of lipid metabolism, insulin resistance,
Induce artificial diabetes.
2 modeling methods
Healthy male rat (150 ± 20g) is bought, common to maintain material to adapt to raise 3 days, fasting 4 hours takes tail blood, surveys
Determine to (i.e. 0 hour) blood glucose value before glucose, to 0.5,2 hours blood glucose values after 2.5g/kgBW glucose, be used as the batch animal
Basic value.With 0,0.5 hours blood glucose 6 groups of level point, i.e., 1 blank control group, 1 model control group, 1 positive drug control
Group and 3 administration groups.
Every group 10.Blank control group is not dealt with, and 3 administration group gavages give different given the test agent, model control group
Different volumes solvent is given, continuous 33 days, wherein each group was given after maintenance material is raised 1 week and height is changed in addition to blank group at blank group
Fat feed, continues after being fed with 3 weeks, alloxan 105mg/kg BW abdominal cavities are given in the fasting 24 hours (can't help water) in addition to blank group
Injection, injection volume 1ml/100g body weight.Continue to give high thermal energy fodder feeding 5 days after injection.Off-test, each group animal fasting
4 hours, detection fasting blood-glucose, sugar tolerance, serum insulin and cholesterol, triglyceride levels.(this method is according to health food
The revised edition of assessment technique specification 2012 carries out modeling)
1 model control group (high lipid food is fed, and gives same volume solvent gastric infusion, once a day)；
1 blank control group (giving same volume solvent gastric infusion, once a day)；
(melbine, dosage 0.375g/kg, the dose,equivalent of rat is pushed away 1 positive drug control group equivalent to human body
5 times of the amount of recommending, same volume gastric infusion daily equivalent to adult human dose 4.5g/, once a day)；
1 administration control group, component is (circle bud Cillium), (dosage 0.5g/kg, same volume gastric infusion,
Once a day)；
1 composition of embodiment 4 (dosage 0.5g/kg, same volume gastric infusion, once a day).
1 composition of embodiment 5 (dosage 0.5g/kg, same volume gastric infusion, once a day).
3 observation index
3.1 fasting blood-glucoses, sugar tolerance
Each group animal fasting 4 hours (early 8 points to 12 noon), determines fasting blood sugar i.e. to (0 hour) before glucose
Blood glucose value, dosage group gives various concentrations given the test agent, and model control group gives same volume solvent, and blank control group, which is not done, to be located
Reason, each group oral administration of glucose 2.5g/kgBW after 15~20 minutes is determined to each group after glucose 0.5, the blood glucose of 2 hours
Value, if the hours blood glucose value of model control group 0.5 >=10mmol/L, or model control group 0.5 hour, 2 hours any time blood
Sugar rise or Area under the curve of blood glucose rise, are compared, difference has a conspicuousness with blank control group, decision model carbohydrate metabolism disturbance into
It is vertical, on this basis, observing and nursing control group in test sample group fasting blood-glucose, to (0.5,2 hour) blood glucose after glucose and
0th, the change of 0.5,2 hours blood glucose TG-AUCs.
Measurement result is shown in Table 1, table 2.
3.2 cholesterol, triglycerides
This day after drug withdrawal, each group animal fasting 3~4 hours, detection serum cholesterol, triglycerides, if model comparison
The group cholesterol or obvious height of triglycerides, is compared with blank control group, and difference has a conspicuousness, decision model disorders of lipid metabolism into
It is vertical, on this basis, observing and nursing control group and given the test agent Blood Lipid.Measurement result is shown in Table 3.
3.3 data processings and result judgement
It is general to use variance analysis, but homogeneity test of variance need to be first carried out by the program of variance analysis, variance is neat, calculates F
Value, F values ＜ 0.05, conclusion：No significant difference between each group mean：F value >=0.05, P≤0.05, with multiple experimental groups and one
The comparative approach two-by-two of mean is counted between control group.
4 experimental results
4.1 experimental animal fasting blood sugars, as shown in table 1.
The experimental animal fasting blood sugar statistical form of table 1
| Group | Fasting blood-glucose |
| Blank | 4.90 |
| Positive drug control group | 5.37 |
| Model group | 6.78 |
| Circle bud Cillium group | 6.12 |
| The composition group of embodiment 4 | 5.49# |
| The composition group of embodiment 5 | 5.21# |
Note：*：With blank group than P ＜ 0.05, #：With model group than P ＜ 0.05
4.2 carbohydrate tolerance test results, as shown in table 2.
The carbohydrate tolerance test result statistical form of table 2
| Sugar tolerance | 0 | 0.5 | 2 |
| Blank | 3.97 | 5.30 | 4.64 |
| Positive drug control group | 5.34 | 6.43 | 5.98 |
| Model group | 5.12 | 7.68* | 6.45* |
| Circle bud Cillium group | 5.26 | 7.59 | 6.03 |
| The composition group of embodiment 4 | 4.68 | 7.01 | 5.96 |
| The composition group of embodiment 5 | 5.05 | 7.10 | 5.83# |
Note：*：With blank group than P ＜ 0.05, #：With model group than P ＜ 0.05
4.3 T-CHOL triglyceride determination results, as shown in table 3.
The T-CHOL triglyceride determination result statistical form of table 3
| Group | T-CHOL | Triglycerides |
| Blank | 2.35 | 0.49 |
| Positive drug control group | 2.96 | 0.98 |
| Model group | 3.57 | 1.49* |
| Circle bud Cillium group | 3.24 | 0.87# |
| The composition group of embodiment 4 | 2.84# | 0.75# |
| The composition group of embodiment 5 | 2.73# | 0.71# |
Note：*：With blank group than P ＜ 0.05, #：With model group than P ＜ 0.05
By fasting blood sugar, sugar tolerance, the measurement result such as cholesterol triglycerides can be seen that in fasting blood sugar, real
The composition group of example 4 is applied in model group than there is significant difference, the composition group of embodiment 5 is in significant difference in model group ratio；
In carbohydrate tolerance test result, model group and blank group are contrasted, 0.5h and 2h blood glucose values are significantly raised, the composition group of embodiment 5 with
Model group is contrasted, and is remarkably decreased in 2h blood glucose values, points out the solid beverage to be had certain effect in delay postprandial hyperglycemia tool.
In the measurement result of cholesterol triglycerides, model group significantly rises with blank group contrast T-CHOL, content of triglyceride, real
The composition group of example 5 is applied to be remarkably decreased with model group contrast T-CHOL, content of triglyceride, it is statistically significant, in summary
Experimental result, the composition group of embodiment 5 is in fasting blood-glucose, sugar tolerance, AUC, is positive in the result of cholesterol, there is obvious effect
Really.
The solid beverage that the present invention is prepared into Corn silk P.E, can effectively reach reduction blood glucose, prevention and improvement sugar
The effect of the sick complication of urine, and convenient to take, safely and effectively, can long-term use and have small side effects, be that diabetic preferably protects
Strong product.
2nd, diuresis is tested
Wister rats (SPF, 160 ± 10g, ♂ ♀ half and half) 60, are randomly divided into 5 groups (♂ ♀ half and half), experiment before with
40mL/kg administration capacity difference gavage physiological saline, then blank control is not dealt with, and positive control, formulation components are not administered；
Frusemide dosage is 2.0mg/kg, the luxuriant isapgol husk of circle, the composition of embodiment 4, the composition dosage of embodiment 5 are
0.5g/kg.Rat is placed in metabolic cage, and urine in 0~1,1~2,2~3,3~4,4~5h each periods, record urine are collected respectively
Liquid is accumulated, as shown in table 4.
The rat urine volume statistical form of table 4
The solid beverage that the present invention is prepared into Corn silk P.E, after composition adds the luxuriant Cillium of circle,
The urine volume of rat, the composition group of embodiment 5 has significant difference in normal group, and diuresis is significantly increased.
Toxicological experiment：
Acute toxicity test：Mouse, rat limosis gavage product of the present invention, are observed 7 days, male and female mouse and rat are showed no
Poisoning symptom, no death, the true nontoxic level in border.
Product Salmonella reversion test of the present invention, mouse marrow cell micro nuclear test and mouse mirror aberration test result are the moon
Property, point out product safety of the present invention.
During 30 days feeding trials of product of the present invention, the activity of animal, ingest, the ordinary circumstance such as defecation has no substantially different
Often, and the body weight to animal, food-intake, routine blood indexes, organ weights have no significant effect, it is phase in male and female rat high dose group
Indices Testing index does not observe anomalous variation when in 20 times of human body recommended amounts.
Human feeding trial is summarized
Function of blood sugar reduction human feeding trial is carried out according to the revised edition of health food assessment technique specification 2012, selection is through drink
Food control or OHA treatment after the state of an illness relatively stablize, it is not necessary to change types of drugs and dosage, only take maintenance dose into
Year H patients with type Ⅰ DM patients include experiment, using itself between group two kinds of control designs, select 100 examinations for meeting inclusive criteria
Trencherman, by blood sugar level, sex, at the age, the course of disease, takes species and is substantially balancedly divided into two groups, every group 50, be randomly divided into examination
Food group and control group, take product of the present invention 30 days, physical examination.
Result of the test shows, after subject takes given the test agent one month, can be obviously improved type-II diabetes patient clinical
Symptom, reduction fasting blood-glucose and 2h-plasma glucose (P ＜ 0.05)；Blood, urine, stool and hepatic and renal function items detection refer to before and after test-meal
Mark points out given the test agent to subject's health without substantially infringement, with auxiliary hyperglycemic effect in normal range (NR).
Obviously, the above embodiment of the present invention is only intended to clearly illustrate example of the present invention, and is not pair
The restriction of embodiments of the present invention, for those of ordinary skill in the field, may be used also on the basis of the above description
To make other changes in different forms, all embodiments can not be exhaustive here, it is every to belong to this hair
Row of the obvious changes or variations that bright technical scheme is extended out still in protection scope of the present invention.
Claims (2)
1. a kind of corn stigma solid beverage, it is characterised in that the corn stigma solid beverage includes the raw material of following weight parts：Corn
10 ~ 60 parts of 10 ~ 60 parts of the luxuriant Cillium of 10 ~ 60 parts of extract of palpus, 10 ~ 60 parts of xylitol, circle and steviol glycoside, wherein：
The Corn silk P.E is prepared by following methods：Corn stigma is weighed, the pH of 5 ~ 20 times of corn stigma weight is added
7.0 ~ 7.5 aqueous solution carries out ultrasonic extraction, and the power of ultrasonic extraction is 50 ~ 100w, and the time is 0.5 ~ 3 hour, filters, collects
Filtrate, gained filter residue is again with the pH 8.1 ~ 8.5 of 5 ~ 20 times of corn stigma weight aqueous solution ultrasonic extraction 0.5 ~ 3 hour, filtering,
Merge and extract gained filtrate, through the liquid-type Corn silk P.E that is concentrated under reduced pressure to obtain；Or, further by the liquid-type corn stigma
Extract freezes 24 ~ 36h under the conditions of -100 ~ -50 DEG C, then freeze under the conditions of -60 ~ -48 DEG C, air pressure 0.05mbar 36 ~
72h, crushed 60 mesh sieves, and obtained freeze-dried powder, obtained solid type Corn silk P.E.
2. a kind of preparation method of corn stigma solid beverage as claimed in claim 1, it is characterised in that this method is included institute
State the luxuriant Cillium of Corn silk P.E, circle, xylitol and particle is made after being mixed with steviol glycoside.
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