CN104220072B - 利用氨基吡啶治疗中风相关的感觉运动损伤的方法 - Google Patents

利用氨基吡啶治疗中风相关的感觉运动损伤的方法 Download PDF

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Publication number
CN104220072B
CN104220072B CN201280059695.XA CN201280059695A CN104220072B CN 104220072 B CN104220072 B CN 104220072B CN 201280059695 A CN201280059695 A CN 201280059695A CN 104220072 B CN104220072 B CN 104220072B
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CN
China
Prior art keywords
stroke
aminopyridine
impairment
use according
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201280059695.XA
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English (en)
Chinese (zh)
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CN104220072A (zh
Inventor
A·R·布莱特
A·O·卡贾诺
汤姆·J·帕里
J·F·亚奇
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Acorda Therapeutics Inc
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Acorda Therapeutics Inc
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Priority to CN201810257441.8A priority Critical patent/CN108451953A/zh
Publication of CN104220072A publication Critical patent/CN104220072A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
CN201280059695.XA 2011-10-04 2012-10-04 利用氨基吡啶治疗中风相关的感觉运动损伤的方法 Expired - Fee Related CN104220072B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810257441.8A CN108451953A (zh) 2011-10-04 2012-10-04 利用氨基吡啶治疗中风相关的感觉运动损伤的方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161543150P 2011-10-04 2011-10-04
US61/543,150 2011-10-04
US201261591833P 2012-01-27 2012-01-27
US61/591,833 2012-01-27
US201261648695P 2012-05-18 2012-05-18
US61/648,695 2012-05-18
PCT/US2012/058607 WO2013052575A1 (en) 2011-10-04 2012-10-04 Methods for treating a stroke-related sensorimotor impairment using aminopyridines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810257441.8A Division CN108451953A (zh) 2011-10-04 2012-10-04 利用氨基吡啶治疗中风相关的感觉运动损伤的方法

Publications (2)

Publication Number Publication Date
CN104220072A CN104220072A (zh) 2014-12-17
CN104220072B true CN104220072B (zh) 2018-04-17

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201810257441.8A Pending CN108451953A (zh) 2011-10-04 2012-10-04 利用氨基吡啶治疗中风相关的感觉运动损伤的方法
CN201280059695.XA Expired - Fee Related CN104220072B (zh) 2011-10-04 2012-10-04 利用氨基吡啶治疗中风相关的感觉运动损伤的方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201810257441.8A Pending CN108451953A (zh) 2011-10-04 2012-10-04 利用氨基吡啶治疗中风相关的感觉运动损伤的方法

Country Status (22)

Country Link
US (2) US20130085167A1 (enExample)
EP (1) EP2766017B1 (enExample)
JP (1) JP6134722B2 (enExample)
KR (1) KR20140084120A (enExample)
CN (2) CN108451953A (enExample)
AR (1) AR088764A1 (enExample)
AU (2) AU2012318719B2 (enExample)
BR (1) BR112014008082A8 (enExample)
CA (1) CA2850635A1 (enExample)
CL (1) CL2014000799A1 (enExample)
CO (1) CO7061067A2 (enExample)
CR (1) CR20140153A (enExample)
EA (1) EA029558B1 (enExample)
HK (1) HK1201204A1 (enExample)
IL (1) IL231809B (enExample)
MX (1) MX354667B (enExample)
PH (1) PH12014500739B1 (enExample)
SG (2) SG10201600410SA (enExample)
TW (1) TWI592156B (enExample)
UA (1) UA114486C2 (enExample)
WO (1) WO2013052575A1 (enExample)
ZA (1) ZA201402432B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014172266A1 (en) * 2013-04-15 2014-10-23 Acorda Therapeutics, Inc. Methods for treating sensorimotor impairments associated with certain types of stroke using aminopyridines
US10172842B2 (en) 2015-09-11 2019-01-08 PharmaDax Inc. Sustained release oral dosage form containing dalfampridine
DE102017115701B4 (de) * 2017-07-12 2022-03-03 Lts Lohmann Therapie-Systeme Ag Fampridin-TTS
CN109172573B (zh) * 2018-09-12 2021-01-26 黑龙江中桂制药有限公司 一种口服抗血栓药物及其用途
CN115018836A (zh) * 2022-08-08 2022-09-06 四川大学 一种癫痫病灶自动分割与预测方法、系统及设备

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1529598A (zh) * 2001-02-15 2004-09-15 ����˹��ҩ�﹫˾ 治疗脱髓鞘疾病或情况的方法
US20050276851A1 (en) * 2003-12-11 2005-12-15 Sean Cunningham Sustained release aminopyridine composition

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0696575B2 (ja) * 1987-09-17 1994-11-30 三菱化成株式会社 ４−アミノピリジン誘導体及びその酸付加塩
WO1989009600A1 (en) 1988-04-08 1989-10-19 Massachusetts Institute Of Technology Method and composition for treating neurological disorders
IE82916B1 (en) 1990-11-02 2003-06-11 Elan Corp Plc Formulations and their use in the treatment of neurological diseases
CA2085785C (en) * 1992-12-18 2005-03-15 Robert R. Hansebout The use of 4-aminopyridine in the treatment of a neurological condition
US5952357A (en) 1993-12-23 1999-09-14 Cornell Research Foundation, Inc. Treating diseases of the anterior horn cells
DE60034110T2 (de) * 1999-02-09 2007-12-06 The Uab Research Foundation, Birmingham Verwendung von 4-aminopyridin zur behandlung von peripheren neuropathien
FR2791571B1 (fr) * 1999-04-02 2002-10-04 Sod Conseils Rech Applic Association inhibiteur(s) de no synthase et antioxydant(s) metabolique(s)
CA2403555A1 (en) * 2000-03-28 2001-10-04 Queen's University At Kingston Methods for effecting neuroprotection
US8354437B2 (en) 2004-04-09 2013-01-15 Acorda Therapeutics, Inc. Method of using sustained release aminopyridine compositions
EP2667869A1 (en) * 2011-01-28 2013-12-04 Acorda Therapeutics, Inc. Use of potassium channel blockers to treat cerebral palsy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1529598A (zh) * 2001-02-15 2004-09-15 ����˹��ҩ�﹫˾ 治疗脱髓鞘疾病或情况的方法
US20050276851A1 (en) * 2003-12-11 2005-12-15 Sean Cunningham Sustained release aminopyridine composition

Also Published As

Publication number Publication date
CR20140153A (es) 2014-07-04
EA029558B1 (ru) 2018-04-30
TW201321000A (zh) 2013-06-01
NZ623255A (en) 2016-08-26
AU2018200114A1 (en) 2018-01-25
PH12014500739B1 (en) 2019-05-10
EA201490562A1 (ru) 2014-08-29
EP2766017B1 (en) 2020-07-01
TWI592156B (zh) 2017-07-21
JP6134722B2 (ja) 2017-05-24
ZA201402432B (en) 2020-08-26
CL2014000799A1 (es) 2014-11-03
HK1201204A1 (en) 2015-08-28
SG11201401248YA (en) 2014-05-29
CN104220072A (zh) 2014-12-17
WO2013052575A1 (en) 2013-04-11
MX354667B (es) 2018-03-15
BR112014008082A2 (pt) 2017-07-18
IL231809B (en) 2019-06-30
AU2012318719A1 (en) 2014-04-17
BR112014008082A8 (pt) 2018-01-16
CN108451953A (zh) 2018-08-28
US20130085167A1 (en) 2013-04-04
AU2012318719B2 (en) 2017-10-19
CA2850635A1 (en) 2013-04-11
UA114486C2 (uk) 2017-06-26
US20160067232A1 (en) 2016-03-10
HK1204965A1 (en) 2015-12-11
EP2766017A1 (en) 2014-08-20
CO7061067A2 (es) 2014-09-19
SG10201600410SA (en) 2016-02-26
JP2014531470A (ja) 2014-11-27
PH12014500739A1 (en) 2014-05-26
AR088764A1 (es) 2014-07-02
KR20140084120A (ko) 2014-07-04
MX2014003997A (es) 2014-07-22
IL231809A0 (en) 2014-05-28

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