CN104211802B - 人凝血因子轻链蛋白及其应用 - Google Patents

人凝血因子轻链蛋白及其应用 Download PDF

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Publication number
CN104211802B
CN104211802B CN201310206823.5A CN201310206823A CN104211802B CN 104211802 B CN104211802 B CN 104211802B CN 201310206823 A CN201310206823 A CN 201310206823A CN 104211802 B CN104211802 B CN 104211802B
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Prior art keywords
protein
recombinant
light chain
blood coagulation
human blood
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CN201310206823.5A
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Chinese (zh)
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CN104211802A (zh
Inventor
宋旭
陈金武
廖东升
马登佼
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Chengdu Origen Biotechnology Co Ltd
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Chengdu Origen Biotechnology Co Ltd
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Priority to CN201310206823.5A priority Critical patent/CN104211802B/zh
Priority to US14/894,415 priority patent/US9782461B2/en
Priority to CN201480042517.5A priority patent/CN105473611B/zh
Priority to PCT/CN2014/078108 priority patent/WO2014190871A1/zh
Priority to JP2016515629A priority patent/JP6441906B2/ja
Priority to EP14804149.4A priority patent/EP3006461A4/en
Publication of CN104211802A publication Critical patent/CN104211802A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201310206823.5A 2013-05-29 2013-05-29 人凝血因子轻链蛋白及其应用 Active CN104211802B (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201310206823.5A CN104211802B (zh) 2013-05-29 2013-05-29 人凝血因子轻链蛋白及其应用
US14/894,415 US9782461B2 (en) 2013-05-29 2014-05-22 Human coagulation factor light chain protein and use of the same
CN201480042517.5A CN105473611B (zh) 2013-05-29 2014-05-22 人凝血因子轻链蛋白及其应用
PCT/CN2014/078108 WO2014190871A1 (zh) 2013-05-29 2014-05-22 人凝血因子轻链蛋白及其应用
JP2016515629A JP6441906B2 (ja) 2013-05-29 2014-05-22 ヒト凝固因子軽鎖タンパク質及びその使用
EP14804149.4A EP3006461A4 (en) 2013-05-29 2014-05-22 Human coagulation factor light-chain protein and application of same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310206823.5A CN104211802B (zh) 2013-05-29 2013-05-29 人凝血因子轻链蛋白及其应用

Publications (2)

Publication Number Publication Date
CN104211802A CN104211802A (zh) 2014-12-17
CN104211802B true CN104211802B (zh) 2018-07-27

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CN201310206823.5A Active CN104211802B (zh) 2013-05-29 2013-05-29 人凝血因子轻链蛋白及其应用
CN201480042517.5A Active CN105473611B (zh) 2013-05-29 2014-05-22 人凝血因子轻链蛋白及其应用

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US (1) US9782461B2 (cg-RX-API-DMAC10.html)
EP (1) EP3006461A4 (cg-RX-API-DMAC10.html)
JP (1) JP6441906B2 (cg-RX-API-DMAC10.html)
CN (2) CN104211802B (cg-RX-API-DMAC10.html)
WO (1) WO2014190871A1 (cg-RX-API-DMAC10.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111272889B (zh) * 2020-02-10 2022-02-25 济宁学院 基于蛋白质组学定量技术分析嗜水气单胞菌感染日本沼虾血细胞差异表达蛋白质的方法
CN116539893B (zh) * 2023-04-23 2026-02-13 天津医科大学总医院 一种细胞内凝血因子ⅹ的质谱检测方法、应用

Citations (1)

* Cited by examiner, † Cited by third party
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CN103079588A (zh) * 2010-07-22 2013-05-01 德国杰特贝林生物制品有限公司 祖先丝氨酸蛋白酶凝血级联在早期免疫防御中发挥新功能

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AU5940799A (en) * 1994-10-24 2000-02-17 Novo Nordisk A/S Modified factor VII
WO2002102319A2 (en) * 2001-06-14 2002-12-27 Bristol-Myers Squibb Company Polynucleotide encoding a novel human growth factor with homology to epidermal growth factor, bgs-8, expressed highly in immune tissue
US6861236B2 (en) * 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
WO2004108763A2 (en) * 2003-06-05 2004-12-16 Canadian Blood Services Mutants of the factor vii epidermal growth factor domain
JP4915918B2 (ja) * 2003-06-19 2012-04-11 バイエル ヘルスケア エルエルシー 第ＶＩＩ因子または第ＶＩＩａ因子のＧｌａドメイン変種
CN101384613A (zh) * 2006-02-10 2009-03-11 德玛根股份公司 新型抗微生物肽及其应用
US7968683B1 (en) * 2008-05-07 2011-06-28 Schering Corporation Factor IXa crystals, related complexes and methods
FR2972114B1 (fr) * 2011-03-01 2013-03-15 Univ Grenoble 1 Un nouveau leurre moleculaire procoagulant pour le traitement des hemophiles a ou b avec ou sans inhibiteur
CN102875685B (zh) * 2012-09-29 2013-12-25 郑骏年 嵌合抗原受体hFⅦL-CD8-OX40-CD3ζ及其用途

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN103079588A (zh) * 2010-07-22 2013-05-01 德国杰特贝林生物制品有限公司 祖先丝氨酸蛋白酶凝血级联在早期免疫防御中发挥新功能

Non-Patent Citations (5)

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Blood coagulation factor activity in experimental endotoxemia;R L West;《Ann Surg.》;19660430;第163卷(第4期);567–572 *
No.1O5D_L;NCBI;《GenBank》;20121010 *
No.AAA51981.1，;NCBI;《GenBank》;19941101 *
No.XP_004054811.1;NCBI;《GenBank》;20121203 *
凝血系统在细菌感染性疾病中的临床意义;李婧;《中华医学会第七次全国检验医学学术会议资料汇编》;20080501;384-385 *

Also Published As

Publication number Publication date
CN105473611A (zh) 2016-04-06
CN104211802A (zh) 2014-12-17
US9782461B2 (en) 2017-10-10
JP2016521685A (ja) 2016-07-25
EP3006461A1 (en) 2016-04-13
WO2014190871A1 (zh) 2014-12-04
JP6441906B2 (ja) 2018-12-19
CN105473611B (zh) 2020-03-20
EP3006461A4 (en) 2017-01-25
US20160106818A1 (en) 2016-04-21

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Effective date of registration: 20151208

Address after: Science Park Road Chengdu city Sichuan province 610041 No. 9 of No. 2 East Building 2 floor

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