CN104189572A - Traditional Chinese medicine composition for treating chronic pharyngitis, as well as aerosol and preparation thereof - Google Patents
Traditional Chinese medicine composition for treating chronic pharyngitis, as well as aerosol and preparation thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating chronic pharyngitis. The composition is mainly prepared from the following raw medicinal materials in parts by weight: rabdosia rubescens, coptis chinensis, scutellaria baicalensis, donkey-hide gelatin, pinellia ternata, radix aconiti carmichaeli, radix bupleuri, folium phyllostachys, licorice root, caulis akebiae, ligusticum wallichii, angelica sinensis and astragalus membranaceus. The traditional Chinese medicine composition has a good treatment effect, has an effective rate of 100 percent, and is low in side effect, and difficult to repeat or relapse.
Description
Technical field
The invention belongs to the field of Chinese medicines, particularly a kind of Chinese medicine composition and aerosol and method for making for the treatment of chronic pharyngitis.
Background technology
Chronic pharyngitis is a kind of commonly encountered diseases, frequently-occurring disease, while being apt to occur in season alternation; When morbidity, General Symptoms is all not obvious, and taking local symptom as main; Common disease is pharyngeal sense of discomfort, and foreign body sensation, gargalesthesia, burning sensation, dry sensation or excitement also can have hypodynia sense etc.; Due to mainly being stimulated by its secretions and loose lymph follicle.
The drug main for the treatment of chronic pharyngitis will be divided into two large classes at present, and a class is Western medicine, and well-known, Western medicine is cured the symptoms, not the disease, and the state of an illness easily repeatedly; Chinese medicine, because side effect is low, is having a wide range of applications aspect treatment chronic pharyngitis.
For example, CN103830601 discloses a kind of Chinese medicine for the treatment of chronic pharyngitis, and this Chinese medicine is made up of 18 taste Chinese herbal medicine such as Herba Scutellariae Barbatae, Pseudobulbus Cremastrae Seu Pleiones and Spica Prunellaes; CN103735626 discloses a kind of medicine of the treatment chronic pharyngitis being made up of Rhizoma Nelumbinis joint, white sugar and Mentholum three taste medicines; Disclosed Chinese medicine has certain therapeutical effect to chronic pharyngitis above, but effect is not remarkable, also easily repeatedly, so be badly in need of providing at present a kind of Chinese medicine composition of effective treatment chronic pharyngitis.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition and aerosol and method for making for the treatment of chronic pharyngitis, said composition and aerosol thereof have good therapeutic effect to chronic pharyngitis, are difficult for repeatedly, are difficult for recurrence, and side effect is low.
The invention provides a kind of Chinese medicine composition for the treatment of chronic pharyngitis, this Chinese medicine composition is mainly prepared from by the crude drug of following parts by weight:
The Chinese medicine composition for the treatment of chronic pharyngitis provided by the invention has good therapeutic effect to chronic pharyngitis, and side effect is low, is difficult for repeatedly, is difficult for recurrence.
Further improve, this Chinese medicine composition is mainly prepared from by the crude drug of following parts by weight:
The present invention further makes aerosol by Chinese medicine composition and the additives for the treatment of chronic pharyngitis, and wherein, the ratio of weight and number of Chinese medicine composition and additives is 1:0.2-0.5.
Preferably, these additives comprise pH adjusting agent.
Preferably, these additives also comprise the mixture of triethanolamine stearate and methylcellulose, and wherein, the ratio of weight and number of triethanolamine stearate and methylcellulose is 5-7:1.
The present invention adds the mixture of triethanolamine stearate and methylcellulose in aerosol, not only plays good emulsifying effectiveness; The dissolution that can improve Chinese medicine composition simultaneously, makes Chinese medicine composition give full play to curative effect.
In order to improve the stability of aerosol, additives of the present invention also comprise the mixture of potassium sorbate and sodium lauryl sulphate, and wherein, the ratio of weight and number of potassium sorbate and sodium lauryl sulphate is 2-3:1.
On the other hand, the present invention also provides a kind of preparation method of Chinese medicine composition for the treatment of chronic pharyngitis, and the method comprises the steps:
Described method comprises the steps:
A. the Folium Bambusae, Radix Glycyrrhizae, Caulis Akebiae, Rhizoma Chuanxiong and the Radix Angelicae Sinensis that take recipe quantity are pulverized, and are placed in seepage bucket, add 60-80% alcoholic solution, soak, and collect effusion, concentrated, dry, make fine powder;
B. the Rabdosia rubescens, Rhizoma Coptidis, Radix Scutellariae, Colla Corii Asini, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata and the Radix Bupleuri that take recipe quantity, add water, soaks after 1-3h, then decoct with water three times, collects decoction liquor, filters, and adds dehydrated alcohol, stirs, and leaves standstill, and collects supernatant, concentrated, makes mixed powder;
C. take the Radix Astragali of recipe quantity, micronizing, makes superfine powder;
D. the superfine powder mix homogeneously that fine powder step a being made, the mixed powder that step b makes and step c make, makes Chinese medicine composition.
Preferably, the preparation method of Chinese medicine composition comprises the steps:
1) Folium Bambusae, Radix Glycyrrhizae, Caulis Akebiae, Rhizoma Chuanxiong and the Radix Angelicae Sinensis that take recipe quantity are pulverized, and are placed in seepage bucket, add 75% alcoholic solution 2500ml, soak after 72h, and reflux, extract, 5h, filters, and collects extracting solution; In medicinal residues, add 75% alcoholic solution 2500ml again, reflux, extract, 3h, collects extracting solution, and extracted twice liquid is merged, concentrated, dry, makes fine powder;
2) take Rabdosia rubescens, Rhizoma Coptidis, Radix Scutellariae, Colla Corii Asini, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata and the Radix Bupleuri of recipe quantity, add 2000ml water, soak after 1h, after the boiled 10min of big fire, then slow fire boiling 45min; Filter, collect medicinal liquid for the first time; In medicinal residues, add 2000ml water, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the second time; In medicinal residues, add 2000ml water again, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the third time; Merge three times medicinal liquid, add 3000ml dehydrated alcohol, stir, leave standstill 24h, collect supernatant, concentrated, make mixed powder;
3) take the Radix Astragali of recipe quantity, micronizing, makes superfine powder;
4) by step 1) fine powder, the step 2 that make) mixed powder and the step 3 that make) the superfine powder mix homogeneously that makes, make Chinese medicine composition.
The present invention, by said method, can extract the active component in each crude drug fully, and the amount of the active component in the Chinese medicine composition that makes to prepare significantly improves, and the Chinese medicine composition making can be brought into play drug effect fully.
The present invention also provides the preparation method of aerosol on the other hand, and the method comprises the steps:
A) Folium Bambusae, Radix Glycyrrhizae, Caulis Akebiae, Rhizoma Chuanxiong and the Radix Angelicae Sinensis that take recipe quantity are pulverized, and are placed in seepage bucket, add 75% alcoholic solution 2500ml, soak after 72h, collect effusion, for subsequent use;
B) take Rabdosia rubescens, Rhizoma Coptidis, Radix Scutellariae, Colla Corii Asini, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata and the Radix Bupleuri of recipe quantity, add 2000ml water, soak after 1h, after the boiled 10min of big fire, then slow fire boiling 45min; Filter, collect medicinal liquid for the first time; In medicinal residues, add 2000ml water, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the second time; In medicinal residues, add 2000ml water again, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the third time; Merge three times medicinal liquid, add 3000ml dehydrated alcohol, stir, leave standstill 24h, collect supernatant, reclaim ethanol to medicinal liquid 600ml, then adding distil water is to 2500ml, makes reserve liquid;
C) take the Radix Astragali of recipe quantity, micronizing, makes superfine powder;
D) reserve liquid that effusion step a) being made and step b) make merges, and makes mixed liquor, adds dehydrated alcohol, makes to reach 15%-20% containing alcohol amount in mixed liquor, adds pH adjusting agent, and adjusting pH value is 5-8; The superfine powder that adds step c) to make, mix homogeneously, makes.
The Chinese medicine composition for the treatment of chronic pharyngitis provided by the invention can be for the preparation of the medicine for the treatment of chronic pharyngitis simultaneously.
The invention provides a kind of evident in efficacy, the Chinese medicine composition of the low treatment chronic pharyngitis of side effect, its effective percentage to chronic pharyngitis has reached 100%; The aerosol stable in properties making, the stripping of Chinese medicine composition is remarkable, and curative effect is high; The preparation method providing can extract the active component in each crude drug effectively.
Detailed description of the invention
Embodiment 1
Treat a Chinese medicine composition for chronic pharyngitis, this Chinese medicine composition is mainly prepared from by the crude drug of following parts by weight:
Preparation method:
1) Folium Bambusae, Radix Glycyrrhizae, Caulis Akebiae, Rhizoma Chuanxiong and the Radix Angelicae Sinensis that take recipe quantity are pulverized, and are placed in seepage bucket, add 75% alcoholic solution 2500ml, soak after 72h, and reflux, extract, 5h, filters, and collects extracting solution; In medicinal residues, add 75% alcoholic solution 2500ml again, reflux, extract, 3h, collects extracting solution, and extracted twice liquid is merged, concentrated, dry, makes fine powder;
2) take Rabdosia rubescens, Rhizoma Coptidis, Radix Scutellariae, Colla Corii Asini, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata and the Radix Bupleuri of recipe quantity, add 2000ml water, soak after 1h, after the boiled 10min of big fire, then slow fire boiling 45min; Filter, collect medicinal liquid for the first time; In medicinal residues, add 2000ml water, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the second time; In medicinal residues, add 2000ml water again, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the third time; Merge three times medicinal liquid, add 3000ml dehydrated alcohol, stir, leave standstill 24h, collect supernatant, concentrated, make mixed powder;
3) take the Radix Astragali of recipe quantity, micronizing, makes superfine powder;
4) by step 1) fine powder, the step 2 that make) mixed powder and the step 3 that make) the superfine powder mix homogeneously that makes, make Chinese medicine composition.
Embodiment 2
Treat a Chinese medicine composition for chronic pharyngitis, this Chinese medicine composition is prepared from by the crude drug of following parts by weight:
Preparation method:
A. the Folium Bambusae, Radix Glycyrrhizae, Caulis Akebiae, Rhizoma Chuanxiong and the Radix Angelicae Sinensis that take recipe quantity are pulverized, and are placed in seepage bucket, add 60-80% alcoholic solution, soak, and collect effusion, concentrated, dry, make fine powder;
B. the Rabdosia rubescens, Rhizoma Coptidis, Radix Scutellariae, Colla Corii Asini, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata and the Radix Bupleuri that take recipe quantity, add water, soaks after 1-3h, then decoct with water three times, collects decoction liquor, filters, and adds dehydrated alcohol, stirs, and leaves standstill, and collects supernatant, concentrated, makes mixed powder;
C. take the Radix Astragali of recipe quantity, micronizing, makes superfine powder;
D. the superfine powder mix homogeneously that fine powder step a being made, the mixed powder that step b makes and step c make, makes Chinese medicine composition.
Embodiment 3
Treat a Chinese medicine composition for chronic pharyngitis, this Chinese medicine composition is mainly prepared from by the crude drug of following parts by weight:
Preparation method: according to the method preparation of embodiment 1.
Embodiment 4
Treat a Chinese medicine composition for chronic pharyngitis, this Chinese medicine composition is prepared from by the crude drug of following parts by weight:
Preparation method: according to the method preparation of embodiment 1.
Embodiment 5
Treat a Chinese medicine composition for chronic pharyngitis, this Chinese medicine composition is mainly prepared from by the crude drug of following parts by weight:
Preparation method: according to the method preparation of embodiment 1.
Embodiment 6 aerosols
The compositions 100g that embodiment 1 is prepared
Additive: pH adjusting agent is appropriate
Preparation method:
A) Folium Bambusae, Radix Glycyrrhizae, Caulis Akebiae, Rhizoma Chuanxiong and the Radix Angelicae Sinensis that take recipe quantity are pulverized, and are placed in seepage bucket, add 75% alcoholic solution 2500ml, soak after 72h, collect effusion, for subsequent use;
B) take Rabdosia rubescens, Rhizoma Coptidis, Radix Scutellariae, Colla Corii Asini, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata and the Radix Bupleuri of recipe quantity, add 2000ml water, soak after 1h, after the boiled 10min of big fire, then slow fire boiling 45min; Filter, collect medicinal liquid for the first time; In medicinal residues, add 2000ml water, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the second time; In medicinal residues, add 2000ml water again, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the third time; Merge three times medicinal liquid, add 3000ml dehydrated alcohol, stir, leave standstill 24h, collect supernatant, reclaim ethanol to medicinal liquid 600ml, then adding distil water is to 2500ml, makes reserve liquid;
C) take the Radix Astragali of recipe quantity, micronizing, makes superfine powder;
D) reserve liquid that effusion step a) being made and step b) make merges, and makes mixed liquor, adds dehydrated alcohol, makes to reach 15%-20% containing alcohol amount in mixed liquor, adds pH adjusting agent, and adjusting pH value is 5-8; The superfine powder that adds step c) to make, mix homogeneously, makes.
Embodiment 7 aerosols
The compositions 100g that embodiment 1 is prepared
Additive: triethanolamine stearate 17g
Methylcellulose 3.4g
Preparation method:
A) Folium Bambusae, Radix Glycyrrhizae, Caulis Akebiae, Rhizoma Chuanxiong and the Radix Angelicae Sinensis that take recipe quantity are pulverized, and are placed in seepage bucket, add 75% alcoholic solution 2500ml, soak after 72h, collect effusion, for subsequent use;
B) take Rabdosia rubescens, Rhizoma Coptidis, Radix Scutellariae, Colla Corii Asini, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata and the Radix Bupleuri of recipe quantity, add 2000ml water, soak after 1h, after the boiled 10min of big fire, then slow fire boiling 45min; Filter, collect medicinal liquid for the first time; In medicinal residues, add 2000ml water, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the second time; In medicinal residues, add 2000ml water again, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the third time; Merge three times medicinal liquid, add 3000ml dehydrated alcohol, stir, leave standstill 24h, collect supernatant, reclaim ethanol to medicinal liquid 600ml, then adding distil water is to 2500ml, makes reserve liquid;
C) take the Radix Astragali of recipe quantity, micronizing, makes superfine powder;
D) reserve liquid that effusion step a) being made and step b) make merges, and makes mixed liquor, adds dehydrated alcohol, makes to reach 15%-20% containing alcohol amount in mixed liquor; The superfine powder that adds step c) to make, mix homogeneously, makes Chinese medicine mixed liquor;
E) triethanolamine stearate and methylcellulose being added to ratio of weight and number is in the dehydrated alcohol of 1:1, stirs, and adds Chinese medicine mixed liquor, continues to stir 30min, makes.
Embodiment 8 aerosols
The compositions 100g that embodiment 1 is prepared
Additive: triethanolamine stearate 30g
Methylcellulose 5g
Preparation method: according to the method preparation of embodiment 7.
Embodiment 9 aerosols
Preparation method:
A) Folium Bambusae, Radix Glycyrrhizae, Caulis Akebiae, Rhizoma Chuanxiong and the Radix Angelicae Sinensis that take recipe quantity are pulverized, and are placed in seepage bucket, add 75% alcoholic solution 2500ml, soak after 72h, collect effusion, for subsequent use;
B) take Rabdosia rubescens, Rhizoma Coptidis, Radix Scutellariae, Colla Corii Asini, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata and the Radix Bupleuri of recipe quantity, add 2000ml water, soak after 1h, after the boiled 10min of big fire, then slow fire boiling 45min; Filter, collect medicinal liquid for the first time; In medicinal residues, add 2000ml water, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the second time; In medicinal residues, add 2000ml water again, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the third time; Merge three times medicinal liquid, add 3000ml dehydrated alcohol, stir, leave standstill 24h, collect supernatant, reclaim ethanol to medicinal liquid 600ml, then adding distil water is to 2500ml, makes reserve liquid;
C) take the Radix Astragali of recipe quantity, micronizing, makes superfine powder;
D) reserve liquid that effusion step a) being made and step b) make merges, and makes mixed liquor, adds dehydrated alcohol, makes to reach 15%-20% containing alcohol amount in mixed liquor; The superfine powder that adds step c) to make, mix homogeneously, makes Chinese medicine mixed liquor;
E) triethanolamine stearate and methylcellulose being added to ratio of weight and number is in the dehydrated alcohol of 1:1, stirs, and adds Chinese medicine mixed liquor, continues to stir 30min, adding potassium sorbate and sodium lauryl sulphate, stirs, and makes.
Embodiment 10 aerosols
Preparation method: according to the method preparation of embodiment 9.
Test example 1 emulsifying effectiveness is measured
1. emulsifying agent is joined in the Chinese medicine composition-aqueous systems for the treatment of chronic pharyngitis to emulsifying under certain pressure, and then 3000rmin
-1lower centrifugal 15min, gets subnatant, under 540nm wavelength, surveys its light transmittance, and light transmittance is less, and effect is better.
2. the emulsifying effectiveness of the Chinese medicine composition of different emulsifiers to treatment chronic pharyngitis
Select triethanolamine stearate and the methylcellulose of triethanolamine stearate, methylcellulose and different proportionings, survey the emulsifying effectiveness of its Chinese medicine composition to treatment chronic pharyngitis, the results are shown in Table 1;
The emulsifying effectiveness of the Chinese medicine composition of table 1 different emulsifiers to treatment chronic pharyngitis
As can be seen from the table, adopt the emulsifying effectiveness of triethanolamine stearate and the methylcellulose blended emulsifier Chinese medicine composition to treatment chronic pharyngitis to be better than single emulsifying agent, and when triethanolamine stearate and methylcellulose mix for 5-7:1 by ratio of weight and the number of copies, emulsifying effectiveness is best.
Test example 2 curative effect comparisons
1. selected crowd
Select patients with chronic pharyngitis 55 examples, the age is that between 25-60 year, men and women does not limit.
2. grouping and administration
55 routine patients with chronic pharyngitis are divided into treatment group 31 people at random, matched group 24 people; Treatment group gives the aerosol described in the embodiment of the present invention 6, and one for several times; Matched group gives JINHOUJIAN PENWUJI (main component: Oleum Blumeae Balsamiferae, Fructus cinnamomi camphorae oil, Mentholum, ammonium glycyrrhizinate), and two groups of equal administrations 7 days were a course for the treatment of for several times on 1st.
3. criterion
Recovery from illness: clinical symptoms all disappears;
Effective: clinical symptoms is clearly better;
Effective: clinical symptoms takes a turn for the better to some extent;
Invalid: unchanged before and after treatment.
4. result
2 courses for the treatment of of the equal administration for the treatment of group and matched group, two groups to the therapeutic effect of chronic pharyngitis in table 2;
The curative effect comparison of table 2 liang group to chronic pharyngitis
5. conclusion
Aerosol provided by the invention has good curative effect to chronic pharyngitis, and effective percentage reaches 100%, evident in efficacy higher than matched group, and does not recur.
Model case
Zhang, man, 50 years old, throat was dry and astringent, had foreign body sensation, burning sensation, always had expectorant, was diagnosed as chronic pharyngitis; Use the aerosol of the embodiment of the present invention 6, uses 1 the course for the treatment of symptom all disappear, continue to use after 1 course for the treatment of, recovery from illness, paid a return visit after half a year, did not recur.
Grandson, female, 30 years old, suffer from chronic pharyngitis for many years, it is dark red that pharyngeal inspection is shown in that mucosa fills the air hyperemia, vasodilation, color, with a small amount of sticky secretions; Take aerosol of the present invention, for several times, after two courses for the treatment of, fully recover every day; After 1 year, follow up a case by regular visits to not recurrence.
Claims (10)
1. a Chinese medicine composition for the treatment of chronic pharyngitis, is characterized in that, described Chinese medicine composition is mainly prepared from by the crude drug of following parts by weight:
2. the Chinese medicine composition for the treatment of chronic pharyngitis as claimed in claim 1, is characterized in that, described Chinese medicine composition is mainly prepared from by the crude drug of following parts by weight:
3. the aerosol being made up of Chinese medicine composition and the additives for the treatment of chronic pharyngitis claimed in claim 1, is characterized in that, the ratio of weight and number of described Chinese medicine composition and additives is 1:0.2-0.5.
4. aerosol as claimed in claim 1, is characterized in that, described additives comprise pH adjusting agent.
5. aerosol as claimed in claim 1, is characterized in that, described additives also comprise the mixture of triethanolamine stearate and methylcellulose, and the ratio of weight and number of described triethanolamine stearate and methylcellulose is 5-7:1.
6. aerosol as claimed in claim 5, is characterized in that, described additives also comprise the mixture of potassium sorbate and sodium lauryl sulphate, and the ratio of weight and number of described potassium sorbate and sodium lauryl sulphate is 2-3:1.
7. a preparation method for the Chinese medicine composition for the treatment of chronic pharyngitis claimed in claim 1, is characterized in that, described method comprises the steps:
A. the Folium Bambusae, Radix Glycyrrhizae, Caulis Akebiae, Rhizoma Chuanxiong and the Radix Angelicae Sinensis that take recipe quantity are pulverized, and are placed in seepage bucket, add 60-80% alcoholic solution, soak, and collect effusion, concentrated, dry, make fine powder;
B. the Rabdosia rubescens, Rhizoma Coptidis, Radix Scutellariae, Colla Corii Asini, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata and the Radix Bupleuri that take recipe quantity, add water, soaks after 1-3h, then decoct with water three times, collects decoction liquor, filters, and adds dehydrated alcohol, stirs, and leaves standstill, and collects supernatant, concentrated, makes mixed powder;
C. take the Radix Astragali of recipe quantity, micronizing, makes superfine powder;
D. the superfine powder mix homogeneously that fine powder step a being made, the mixed powder that step b makes and step c make, makes Chinese medicine composition.
8. a preparation method for the Chinese medicine composition for the treatment of chronic pharyngitis claimed in claim 1, is characterized in that, described method comprises the steps:
1) Folium Bambusae, Radix Glycyrrhizae, Caulis Akebiae, Rhizoma Chuanxiong and the Radix Angelicae Sinensis that take recipe quantity are pulverized, and are placed in seepage bucket, add 75% alcoholic solution 2500ml, soak after 72h, and reflux, extract, 5h, filters, and collects extracting solution; In medicinal residues, add 75% alcoholic solution 2500ml again, reflux, extract, 3h, collects extracting solution, and extracted twice liquid is merged, concentrated, dry, makes fine powder;
2) take Rabdosia rubescens, Rhizoma Coptidis, Radix Scutellariae, Colla Corii Asini, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata and the Radix Bupleuri of recipe quantity, add 2000ml water, soak after 1h, after the boiled 10min of big fire, then slow fire boiling 45min; Filter, collect medicinal liquid for the first time; In medicinal residues, add 2000ml water, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the second time; In medicinal residues, add 2000ml water again, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the third time; Merge three times medicinal liquid, add 3000ml dehydrated alcohol, stir, leave standstill 24h, collect supernatant, concentrated, make mixed powder;
3) take the Radix Astragali of recipe quantity, micronizing, makes superfine powder;
4) by step 1) fine powder, the step 2 that make) mixed powder and the step 3 that make) the superfine powder mix homogeneously that makes, make Chinese medicine composition.
9. a preparation method for aerosol claimed in claim 4, is characterized in that, described method comprises the steps:
A) Folium Bambusae, Radix Glycyrrhizae, Caulis Akebiae, Rhizoma Chuanxiong and the Radix Angelicae Sinensis that take recipe quantity are pulverized, and are placed in seepage bucket, add 75% alcoholic solution 2500ml, soak after 72h, collect effusion, for subsequent use;
B) take Rabdosia rubescens, Rhizoma Coptidis, Radix Scutellariae, Colla Corii Asini, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata and the Radix Bupleuri of recipe quantity, add 2000ml water, soak after 1h, after the boiled 10min of big fire, then slow fire boiling 45min; Filter, collect medicinal liquid for the first time; In medicinal residues, add 2000ml water, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the second time; In medicinal residues, add 2000ml water again, after the boiled 10min of big fire, then slow fire boiling 45min, filter, collect medicinal liquid for the third time; Merge three times medicinal liquid, add 3000ml dehydrated alcohol, stir, leave standstill 24h, collect supernatant, reclaim ethanol to medicinal liquid 600ml, then adding distil water is to 2500ml, makes reserve liquid;
C) take the Radix Astragali of recipe quantity, micronizing, makes superfine powder;
D) reserve liquid that effusion step a) being made and step b) make merges, and makes mixed liquor, adds dehydrated alcohol, makes to reach 15%-20% containing alcohol amount in mixed liquor, adds pH adjusting agent, and adjusting pH value is 5-8; The superfine powder that adds step c) to make, mix homogeneously, makes.
10. the application of the Chinese medicine composition of the treatment chronic pharyngitis as described in as arbitrary in claim 1-2 in the medicine for the preparation for the treatment of chronic pharyngitis.
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| 冯子彦等: "复方冬凌草含片治疗急性咽炎、扁桃体炎的疗效观察", 《右江医学》 * |
| 刘福平等: "冰凌草合剂治慢性咽炎", 《河南赤脚医生》 * |
| 王良波等: "1350首治疗慢性咽炎中药复方用药规律研究", 《北方药学》 * |
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