CN104189107A - Chinese herbal medicine liver-protecting composition for fish - Google Patents
Chinese herbal medicine liver-protecting composition for fish Download PDFInfo
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- CN104189107A CN104189107A CN201410439763.6A CN201410439763A CN104189107A CN 104189107 A CN104189107 A CN 104189107A CN 201410439763 A CN201410439763 A CN 201410439763A CN 104189107 A CN104189107 A CN 104189107A
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Abstract
The invention provides a Chinese herbal medicine liver-protecting composition for fish. The composition comprises the following components in parts by weight: 30-70 parts of isatis root, 10-30 parts of rheum officinale, 10-30 parts of betaine and 1-5 parts of starch. The composition can be prepared into granules or powder. The invention also discloses application of the Chinese herbal medicine liver-protecting composition serving as a feed additive, wherein the feed is fish feed, and the fish refers to crucian carp, solver carp, bighead carp or grass carp. The composition disclosed by the invention has good effects of fundamentally treating liver and gall enlargement, colored liver, green liver, white liver, abdominal dropsy and hepatic necrosis caused by liver and gall syndromes of aquatic livestock as well as comprehensive diseases such as gill-rot disease, enteritis, rotted skin (red skin), bleeding and ulceration caused by secondary infection.
Description
Technical field
The invention belongs to technical field of aquaculture, be specifically related to a kind of Chinese herbal medicine fish with protecting the liver compositions.
Background technology
In recent years, the generation of fish diseases is day by day serious, has occurred take the fish disease that liver and gall are principal character, i.e. Fish " liver and gallbladder syndrome ".When the state of an illness is lighter, fish body does not generally have obvious symptom, and fish body colour, the bodily form etc. are without obvious change, and only inappetence, moves about unable, sometimes restless, the water surface of even scurrying out, and poor growth, mortality rate is not high; While being in a bad way, fish body colour blackout, color and luster is dark and gloomy, and fish body has edema sense, and scale is loosening easily to come off, move about irregular, disequilibrium, or be still in water, appetite declines, and reacts dull, dyspnea, and even stupor upset, just dead soon.Dissect and find that liver color changes, be graniphyric, khaki, yellowish-brown etc., gallbladder becomes large and bile blackening.Sometimes also with enteritis, abdominal cavity, there is the generation of the diseases such as hydrops, gill rot.This disease is the higher a kind of the farming disease harms of sickness rate in recent years, hazardness is larger, the adult fish of Ctenopharyngodon idellus, Mylopharyngodon piceus, Carassius auratus and fingerling all may occur, and treat compared with refractory, Yin Qichang is with symptoms such as gill rot, red skin, enteritis again, easily mistaken diagnosis, has caused certain economic loss directly or indirectly, has caused numerous friend's fishermen attention.
Prior art at present to Fish such as crucian carp, silver carp, flatheads after Drug therapy, can be controlled effectively and effect a radical cure, to Ctenopharyngodon idellus, be to control not to be completely cured, cause Ctenopharyngodon idellus to continue dead, so in the urgent need to a kind of medicament that can effect a radical cure Fish " liver and gallbladder syndrome ".The present invention proposes a kind of Chinese herbal medicine fish with protecting the liver compositions, at present, yet there are no relevant report.
Summary of the invention
The present invention is directed to the defect that prior art can not be cured completely to Fish " liver and gallbladder syndrome ", aim to provide the liver-protecting product that a kind of Chinese herbal medicine fish is used, thoroughly solve the problem of Fish " liver and gallbladder syndrome ".
The present invention is achieved through the following technical solutions:
Chinese herbal medicine fish is with protecting the liver a compositions, and parts by weights meter, comprises following component:
Be preferably, a kind of Chinese herbal medicine fish is with protecting the liver compositions, and parts by weights meter, comprises following component:
The present composition is prepared into granule or powder according to the characteristic of a component by well known to a person skilled in the art technological means.
The present invention also provides a kind of Chinese herbal medicine to protect the liver compositions as the application of feed additive, and described feedstuff is fish feed, and described Fish are Carassius auratus, Hypophthalmichthys molitrix, Aristichthys nobilis or Ctenopharyngodon idellus.
The present composition being added in an amount of in feedstuff: 1) short term therapy: mix bait and throw something and feed, aquatic animal is this product 100～200mg for every 1kg body weight, by 5% daily ration, feeding quantity, feedstuff per ton adds 2000～4000g, 3 times on the one, is used in conjunction 5～7 days.2) long-term interpolation prevents: mix bait and throw something and feed, aquatic animal is this product 50～100mg for every 1kg body weight, by 5% daily ration, feeding quantity, and this product 1000～2000g for feedstuff per ton.
Beneficial effect of the present invention is heat-clearing and toxic substances removing, hepatic cholagogic, and the syndrome diseases such as the caused liver and gall enlargement of aquatic animal liver and gallbladder syndrome, flower liver, green liver, white liver, ascites, hepatic necrosis and secondary infection causes thus gill rot, enteritis, beancurd sheet (red skin), hemorrhage, ulcer are had to good radical cure effect.
Accompanying drawing explanation
Fig. 1 is the section of positive controls grass carp liver;
Fig. 2 is the section of negative control group grass carp liver.
The specific embodiment
Below in conjunction with embodiment, the present invention is described further, the following stated, only to preferred embodiment of the present invention, not the present invention is done to other forms of restriction, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed to the equivalent embodiment of equal variation.Every the present invention program's content that do not depart from,, all drops in protection scope of the present invention any simple modification made for any of the above embodiments or equivalent variations according to technical spirit of the present invention.
One, Application Example
Embodiment 1
Chinese herbal medicine fish is with protecting the liver a compositions, with 100g metering, by dividing below component to form: Radix Isatidis 60g, Radix Et Rhizoma Rhei 19g, betanin 20g, starch 1g.
Embodiment 2
Chinese herbal medicine fish is with protecting the liver a compositions, with 100g metering, by dividing below component to form: Radix Isatidis 52g, Radix Et Rhizoma Rhei 22g, betanin 22g, starch 4g.
Embodiment 3
Chinese herbal medicine fish is with protecting the liver a compositions, with 100g metering, by dividing below component to form: Radix Isatidis 53g, Radix Et Rhizoma Rhei 22g, betanin 22g, starch 3g.
Embodiment 4
Chinese herbal medicine fish is with protecting the liver a compositions, with 100g metering, by dividing below component to form: Radix Isatidis 43g, Radix Et Rhizoma Rhei 22g, betanin 32g, starch 3g.
Embodiment 5
Chinese herbal medicine fish is with protecting the liver a compositions, with 100g metering, by dividing below component to form: Radix Isatidis 64g, Radix Et Rhizoma Rhei 21g, betanin 11g, starch 4g.
Two, experimentation
Test method: test Ctenopharyngodon idellus is from Bishan, Chongqing Ctenopharyngodon idellus seed multiplication farm.Raised in the indoor cement pit of 15 1.0m * 0.7m * 0.5m, each cement pit is put 40 tail Ctenopharyngodon idellus in a suitable place to breed.Test adopts the mode of being satiated with food, and throws something and feeds every day 3 times (8:30,12:30,17:30).All oxygenations (during bait throwing in) continuously during culture experiment.Before on-test, stopped to raise 24h, nearly (27.0 ± 1.5) g of selective body heavy phase, athletic Grass Carp Juveniles 600 tails, random assortment is in 15 culturing jars, every cylinder 40 tails.Test minute 5 processed group, are respectively positive controls, negative control group, group 1 (protecting the liver loose 1000g/t feedstuff), group 3 (protecting the liver loose 2000g/t feedstuff) and group 3 (protecting the liver loose 3000g/t feedstuff).25.0 ± 1.0 ℃ of duration of test water temperatures, pH7.5 ± 0.5, dissolved oxygen >=5mg/L, ammonia nitrogen < 0.2mg/L, chlorine residue < 0.1mg/L, culture experiment carries out 56d altogether.
Before test, measure in advance the Cu2+ median lethal concentration (LC50) of Ctenopharyngodon idellus 96h, 96h LC50 under this experimental condition carries out drug-induced liver disease modeling test again for (0.82 ± 0.13) mgL-1. designs Cu2+ concentration gradients according to LC50, and the 0.21mgL-1 (Cu2+ content) that selection hepatopathy phenomenon is obvious, zymetology index is changed significantly is as the modeling concentration of hepatopathy model.Cultivate the 3rd week, by Ctenopharyngodon idellus dipping bath 4d in the copper sulfate liquid of 0.21mgL-1 (Cu2+ content) of positive control, group 1, group 2 and group 3, change liquid every day to guarantee solution concentration.During copper sulfate dipping bath, feedstuff feeding suspends, intermittently oxygenation, and after dipping bath finishes, water body continuation raising to the 8th week culture experiment being placed in without copper sulfate finishes.
The impact of embodiment 6 herbal composites on Growth of Grass Carps Ctenopharyngodon Idellus performance
As shown in table 1, Ctenopharyngodon idellus is after the modeling of copper sulfate hepatopathy, Ctenopharyngodon idellus rate of body weight gain, specific growth rate, protein efficiency and the survival rate of positive controls are minimum, significantly lower than negative control group with protect the liver loose supplementation group (P < 0.05), and along with protecting the liver the increase of loose addition, each index is all improved trend; But group 1 indices is compared with negative control, all there is no significant difference (P > 0.05), rate of body weight gain, specific growth rate, protein efficiency ratio feminine gender and the negative control of group 2 and group 3 significantly improve (P < 0.05).Protect the liver feed of grass carp coefficient between loose group and negative control group without significant difference (P > 0.05), but all significantly lower than positive controls (P < 0.05).
Table 1 protects the liver the loose impact on Growth of Grass Carps Ctenopharyngodon Idellus performance
Same column shoulder marking-up mother has identical person to represent between two groups that, without significant difference (P > 0.05), same column shoulder marking-up mother has complete different person to represent that between two groups, there were significant differences (P < 0.05), following table with.
The impact of embodiment 7 herbal composites on full fish nutritional labeling regulating liver-QI fat
As shown in table 2, hepatopathy modeling and protecting the liver loose all has no significant effect full fish ash and moisture; Except group 1, protecting the liver falls apart significantly improves (P < 0.05) to full fish crude protein content compared with positive controls, crude fat is had to remarkable reduction, but there is no significant difference (P > 0.05) with negative control; The liver fat content of the positive control after hepatopathy modeling is significantly higher than all the other each groups, and protect the liver loose supplementing, has significantly reduced liver fat content (P < 0.05).
Table 2 protects the liver the loose impact (%) on the full fish nutritional labeling of Ctenopharyngodon idellus regulating liver-QI fat
The impact of embodiment 8 herbal composites on Ctenopharyngodon idellus body
As shown in table 3, the coefficient of condition of positive control is significantly lower than group 2 and group 3 (P < 0.05), and along with protecting the liver loose increase, coefficient of condition is improved trend, but compare all without significant difference (P > 0.05) with negative control.The grass carp liver body exponential sum internal organs index of positive control, and liver body ratio is significantly higher than group 2 and group 3 (P < 0.05).
Table 3 protects the liver loose on the impact of Ctenopharyngodon idellus body index (%)
The impact of embodiment 9 herbal composites on grass carp liver enzyme
Test is with Liver of Ctenopharyngodon Idellus superoxide dismutase (SOD) and catalase (CAT) activity, and malonaldehyde (MDA) growing amount judges its antioxygenic property, with lysozyme activity, judges its resistance against diseases.Hepatopathy modeling causes positive controls Liver of Ctenopharyngodon Idellus MDA growing amount and SOD specific activity negative control group to significantly improve, after positive controls interpolation protects the liver and falls apart, the active decrease to some degree of MDA growing amount and SOD, and lysozyme activity does not have significant difference between each group, specifically as shown in table 4:
Table 4 protects the liver the loose impact on grass carp liver enzyme
The impact of embodiment 10 herbal composites on grass carp liver intestinal digestion enzyme
The comparative result of lipase active is: intestinal > hindgut > liver pancreas in anterior intestine >, shows that digesting and assimilating mainly of fat carried out at front, middle intestinal in Ctenopharyngodon idellus digestive tract.Liver pancreas and anterior intestine lipase active, along with protecting the liver the loose trend that is added with rising, are significantly higher than positive control (P < 0.05), but with negative control without significant difference (P > 0.05); Between middle each group of intestinal lipase, there is no significant difference (P > 0.05); Hindgut group 1 and group 2 lipase actives are significantly higher than positive and negative control group (P < 0.05), as shown in table 5:
Each test group fish liver pancreas of table 5 and intestinal lipase active (μ gg
-1min
-1)
As can be seen from Table 6, Protease Activities In Digestive Tube comparative result is: intestinal > hindgut > liver pancreas in anterior intestine >, show in Ctenopharyngodon idellus digestive tract protein to digest and assimilate position the same with fat, before occurring in equally, middle intestinal.In liver pancreas protease index, test group is significantly higher than positive controls (P < 0.05), but there is no significant difference (P > 0.05) with negative control group; Between anterior intestine, middle intestinal and each group of rear erepsin, there is no significant difference (P > 0.05).
Active (the μ gg of each test group fish liver pancreas of table 6 and intestinal protease
-1min
-1)
The impact of embodiment 11 herbal composites on Liver of Ctenopharyngodon Idellus
With copper sulfate, make after hepatopathy model, positive controls grass carp liver is organized central vein endotheliocytic swelling, and part vanished cell causes vessel endothelium and induced endothelial, and hepatocyte comes off and enters central vein, as shown in Figure 1; Negative control group grass carp hepatocyte Cable Structure is complete, hepatocyte marshalling, and cellularity is more clear, as shown in Figure 2; After same hepatopathy modeling, group 1～group 3 grass carp hepatocytes become relatively normal, have the sign of obvious improvement.
In sum, in feedstuff, supplement and protect the liver after loose (1000～3000g/t feedstuff), can promote the growth performance of Ctenopharyngodon idellus and the raising of feed efficiency, and liver is had to obvious protective effect.But the suitableeest addition or best with 2000g/t feedstuff.
Claims (6)
1. Chinese herbal medicine fish, with protecting the liver a compositions, is characterized in that parts by weights meter, comprises following component:
2. a kind of Chinese herbal medicine fish according to claim 1, with protecting the liver compositions, is characterized in that parts by weights meter, comprises following component:
3. a kind of Chinese herbal medicine fish according to claim 1 and 2, with protecting the liver compositions, is characterized in that: described compositions is prepared into granule or powder.
4. the said a kind of Chinese herbal medicine fish of claim 1 is with protecting the liver compositions as the application of feed additive.
5. application according to claim 4, is characterized in that: described feedstuff is fish feed, and described Fish are Carassius auratus, Hypophthalmichthys molitrix, Aristichthys nobilis or Ctenopharyngodon idellus.
6. application according to claim 4, is characterized in that: during short term therapy, feedstuff per ton adds compositions 2000～4000g; During long-term interpolation prevention, feedstuff per ton adds compositions 1000～2000g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410439763.6A CN104189107A (en) | 2014-09-02 | 2014-09-02 | Chinese herbal medicine liver-protecting composition for fish |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410439763.6A CN104189107A (en) | 2014-09-02 | 2014-09-02 | Chinese herbal medicine liver-protecting composition for fish |
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| CN104189107A true CN104189107A (en) | 2014-12-10 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362411A (en) * | 2015-11-20 | 2016-03-02 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | Traditional Chinese medicine for treating swelling gallbladder |
| CN108853286A (en) * | 2018-08-17 | 2018-11-23 | 李宏利 | A kind of formula for treating fish disease |
-
2014
- 2014-09-02 CN CN201410439763.6A patent/CN104189107A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 汪建国等主编: "《鱼病防治用药指南》", 30 June 2012 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362411A (en) * | 2015-11-20 | 2016-03-02 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | Traditional Chinese medicine for treating swelling gallbladder |
| CN108853286A (en) * | 2018-08-17 | 2018-11-23 | 李宏利 | A kind of formula for treating fish disease |
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