CN104188849B - A kind of gentle effective anti-acne control fluid composition and preparation method thereof - Google Patents
A kind of gentle effective anti-acne control fluid composition and preparation method thereof Download PDFInfo
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- CN104188849B CN104188849B CN201410386421.2A CN201410386421A CN104188849B CN 104188849 B CN104188849 B CN 104188849B CN 201410386421 A CN201410386421 A CN 201410386421A CN 104188849 B CN104188849 B CN 104188849B
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Abstract
The invention discloses a kind of gentle effective anti-acne control fluid composition and preparation method thereof, by weight percentage, composed of the following components: component A: deionized water 67-94%, hyaluronate sodium 0.01-0.1%, glycerol 1-10%, propylene glycol 1-10%, hydroxyethyl-cellulose 0.1-1%, allantoin 0.05-0.2%; B component: D-panthenol 0.5-2%, totara tree extract 0.004-0.01%, ethanol 1-2%, white willow peel extract 1-3%, zinc paraphenol sulfonate 0.5-1%, Herba portulacae extract 0.5-1.5%; Component C: antiseptic 0.2-1%, essence 0.01-0.2%, Cremophor RH40 0.06-1%.The present invention possesses moisturizing, regulates the multi-efficiencies such as oils and fats balance, antiinflammatory and anti-acne, can improve acne cure rate simultaneously, be free from side effects.
Description
Technical field
The present invention relates to a kind of gentle effective anti-acne control fluid composition, also relate to a kind of method preparing the effective anti-acne control fluid composition of this gentleness.
Background technology
Acne is the dermatosis that a kind of sickness rate is very high, and the people in the whole world nearly 5% suffers from acne.The factors such as the generation of acne is main and hypersteatosis, pilosebaceous duct block, bacteriological infection and inflammatory reaction are closely related.After adolescing, in human body, the level of androgen particularly testosterone raises rapidly, promotes that sebaceous gland is grown and produces a large amount of sebum.The dyskeratosis of pilosebaceous duct causes catheter blockage, dyssebacia simultaneously, forms horn plug and micropowder thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction in hair follicle, the lipase that propionibacterium acnes produces decomposes sebum and generates free fatty, chemotactic inflammatory cell and medium simultaneously, final induction also exacerbate inflammation reaction, defines " acne ", " comedo ".Acne brings skin and flesh painful to patient, also the normal work of impact and doings, and everyone thirsts for the skin having smooth delicacy.Also medicine and the cosmetics of a lot of various Acne treatment are had on the market.These products have their own characteristics each in Acne treatment, have certain curative effect, but most DeGrain, easily recur, and mostly have and add the antibiotics such as chloromycetin, Clindamycin Hydrochloride, use easily to have side effects afterwards.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention aims to provide a kind of gentle effective anti-acne control fluid composition, possesses moisturizing, regulates the multi-efficiencies such as oils and fats balance, antiinflammatory and anti-acne, can improve acne cure rate simultaneously, be free from side effects.
Two of object of the present invention aims to provide the preparation method of a kind of gentleness effective anti-acne control fluid composition.
Realize an object of the present invention to reach by taking following technical scheme:
A kind of gentle effective anti-acne control fluid composition, is characterized in that, by weight percentage, composed of the following components:
Component A: deionized water 67-94%, hyaluronate sodium 0.01-0.1%, glycerol 1-10%, propylene glycol 1-10%, hydroxyethyl-cellulose 0.1-1%, allantoin 0.05-0.2%;
B component: D-panthenol 0.5-2%, totara tree extract 0.004-0.01%, ethanol 1-2%, white willow peel extract 1-3%, zinc paraphenol sulfonate 0.5-1%, Herba portulacae extract 0.5-1.5%;
Component C: antiseptic 0.2-1%, essence 0.01-0.2%, Cremophor RH40 0.06-1%;
The mass percent summation of above component is 100%.In gentleness effective anti-acne control fluid composition for 100%, described B component is 3.504-11.51%, and described component C is 0.27-2.2%, and surplus is component A.
Wherein, totara tree extract i.e. totarol, commodity are called Totarol, and the product of MENDEBIOTECHLTD. company of New Zealand uses supercritical CO
2the patent biologically active prod that technology extracts from the heartwood of totara tree, natural bactericide, the diluent of 0.005% concentration has the killing rate of 98.9% to propionibacterium acnes.
White willow peel extract, commodity are called ACBWhiteWillowBarkExtract.Be the product of Ai Tiwei company of the U.S., containing the natural beta-hydroxy acid of high concentration (BHA), peel off cutin successful, promote cell turnover, safe and non-stimulating.
Herba portulacae extract, commodity are called PortulacaExtract.Be the product of Lang De company of Korea S hundred, can ease pain by effective anti-inflammation detumescence, promote the recovery of inflammatory acne skin.Preferably, described antiseptic is the phenoxyethanol, the Sensiva SC50 that are mixed by any ratio; Preferably, described essence adopts Herba Lysimachiae foenum-graeci quintessence oil.
Realize object of the present invention two can reach by taking following technical scheme:
A preparation method for gentleness effective anti-acne control fluid composition, is characterized in that comprising the following steps:
1) component A is heated to 80-85 DEG C, enables agitator simultaneously and stir, treat that it dissolves completely;
2) component A completely will be dissolved and use cooling water temperature, and be cooled to 45-50 DEG C, add B component, stir;
3) treat that temperature drops to 40 DEG C, add the component C stirred in advance, after stirring, be cooled to 35 DEG C of dischargings, namely make gentle effective anti-acne control fluid composition.
Preferably, the mixing speed of described agitator is 200 revs/min.
The compositions prepared by above-mentioned formula, by improving the moistening effect of skin, the oils and fats balance of regulation of skin, suppresses the excessive secretion of sebum, suppresses the breeding of propionibacterium acnes to reach the effect controlling oily anti-acne.
Moistening effect: the hyaluronate sodium of use is the classic wetting agent of generally acknowledging so far, has strong water sorption, can reduce the percutaneous loss of moisture, make the water content that horny layer keeps certain.
Regulate the excessive secretion of oils and fats balance and suppression sebum: zinc paraphenol sulfonate has outstanding oil-control ability, effectively can regulate sebum secretion.
Suppress the breeding of propionibacterium acnes: the totara tree extract of use i.e. totarol are natural bactericides, and the diluent of 0.005% concentration has the killing rate of 98.9% to propionibacterium acnes.
Beneficial effect of the present invention is:
Anti-acne control fluid composition of the present invention is by carrying out rationally composite to A, B, C tri-kinds of components, by improving the moistening effect of skin, the oils and fats balance of regulation of skin, suppress the excessive secretion of sebum, suppress the breeding of propionibacterium acnes to reach the effect controlling oily anti-acne, possess moisturizing, regulate the multi-efficiencies such as oils and fats balance, antiinflammatory and anti-acne, acne cure rate can be improved simultaneously, be free from side effects.And the preparation process of this anti-acne control fluid composition is simple, do not need complicated machinery equipment.
Accompanying drawing explanation
Fig. 1 is that acne improves degree contrast schematic diagram.
Detailed description of the invention
Embodiment 1
A kind of gentle effective anti-acne control fluid composition, by weight percentage, composed of the following components:
Component A by deionized water 85.894%, hyaluronate sodium 0.05%, glycerol 4%, propylene glycol 3%, hydroxyethyl-cellulose 0.5%, allantoin 0.1% forms;
B component by D-panthenol 1%, totara tree extract 0.006%, ethanol 1%, white willow peel extract 2%, P-TOLUENE SULFO ACID 99's zinc 0.7%, Herba portulacae extract 1% forms;
Component C is by the phenoxyethanol be mixed by any ratio, Sensiva SC50 0.5%, and Herba Lysimachiae foenum-graeci quintessence oil 0.05%, Cremophor RH40 0.2% forms.
A preparation method for gentleness effective anti-acne control fluid composition, carry out according to the following steps:
1) component A is heated to 80-85 DEG C, enables agitator simultaneously and stir, treat that it dissolves completely;
2) component A completely will be dissolved and use cooling water temperature, and be cooled to 45-50 DEG C, add B component (totara tree extract dissolve with ethanol completely then add) successively, stir;
3) treat that temperature drops to 40 DEG C, add the component C stirred in advance, after stirring, be cooled to 35 DEG C of dischargings, namely make gentle effective anti-acne control fluid composition.
Embodiment 2
A kind of gentle effective anti-acne control fluid composition, by weight percentage, composed of the following components:
Component A by deionized water 82.845%, hyaluronate sodium 0.1%, glycerol 5%, propylene glycol 4%, hydroxyethyl-cellulose 0.6%, allantoin 0.15% forms;
B component by D-panthenol 0.8%, totara tree extract 0.005%, ethanol 1%, white willow peel extract 2.5%, P-TOLUENE SULFO ACID 99's zinc 0.8%, Herba portulacae extract 1.5% forms;
Component C is by the phenoxyethanol be mixed by any ratio, Sensiva SC50 0.4%, and Herba Lysimachiae foenum-graeci quintessence oil 0.06%, Cremophor RH40 0.24% forms.
A preparation method for gentleness effective anti-acne control fluid composition, carry out according to the following steps:
1) component A is heated to 80-85 DEG C, enables agitator simultaneously and stir, treat that it dissolves completely;
2) component A completely will be dissolved and use cooling water temperature, and be cooled to 45-50 DEG C, add B component (totara tree extract dissolve with ethanol completely then add) successively, stir;
3) treat that temperature drops to 40 DEG C, add the component C stirred in advance, after stirring, be cooled to 35 DEG C of dischargings, namely make gentle effective anti-acne control fluid composition.
Comparative example 1
By weight percentage, composed of the following components:
Component A by deionized water 83.26%, hyaluronate sodium 0.1%, glycerol 6%, propylene glycol 4%, hydroxyethyl-cellulose 0.45%, allantoin 0.18% forms;
B component by D-panthenol 1.5%, totara tree extract 0.01%, ethanol 1%, P-TOLUENE SULFO ACID 99's zinc 0.9%, Herba portulacae extract 1.5% forms;
Component C is by the phenoxyethanol be mixed by any ratio, Sensiva SC50 0.6%, and Herba Lysimachiae foenum-graeci quintessence oil 0.1%, Cremophor RH40 0.4% forms.
Carry out according to the following steps:
1) component A is heated to 80-85 DEG C, enables agitator simultaneously and stir, treat that it dissolves completely;
2) component A completely will be dissolved and use cooling water temperature, and be cooled to 45-50 DEG C, add B component (totara tree extract dissolve with ethanol completely then add) successively, stir;
3) treat that temperature drops to 40 DEG C, add the component C stirred in advance, after stirring, be cooled to 35 DEG C of dischargings, namely make gentle effective anti-acne control fluid composition.
Comparative example 2
By weight percentage, composed of the following components:
Component A by deionized water 80.27%, hyaluronate sodium 0.1%, glycerol 6%, propylene glycol 4%, hydroxyethyl-cellulose 0.45%, allantoin 0.18% forms;
B component by D-panthenol 1.5%, ethanol 1%, white willow peel extract 3%, P-TOLUENE SULFO ACID 99's zinc 0.9%, Herba portulacae extract 1.5% forms;
Component C is by the phenoxyethanol be mixed by any ratio, Sensiva SC50 0.6%, and Herba Lysimachiae foenum-graeci quintessence oil 0.1%, Cremophor RH40 0.4% forms.
Carry out according to the following steps:
1) component A is heated to 80-85 DEG C, enables agitator simultaneously and stir, treat that it dissolves completely;
2) component A completely will be dissolved and use cooling water temperature, and be cooled to 45-50 DEG C, add B component successively, stir;
3) treat that temperature drops to 40 DEG C, add the component C stirred in advance, after stirring, be cooled to 35 DEG C of dischargings, namely make gentle effective anti-acne control fluid composition.
Embodiment 1 and 2 with the addition of totara tree extract and the white willow peel extract of different proportion.Comparative example 1 adds separately totara tree extract.Comparative example 2 with the addition of separately white willow peel extract.As shown in Figure 1, embodiment 1 and 2 pairs of acnes are improved successful and are better than comparative example 1 and 2, illustrate that totara tree extract and the composite result of use of white willow peel extract are significantly better than being used alone.
The efficacy test that method of testing sees below.
Efficacy test:
1, Subject Population: totally 30
1) age is between 16 to 35 years old;
2) experimenter can be coordinated very well, can regularity in one's life be kept during studying;
3) 15 oiliness skin, 15 slight/moderate acne skin, totally 30.
2, method of testing:
Experiment septum reset left and right cheekbone, nose and pupil intersection place left and right cheek, temple and corners of the mouth intersection place left and right sides are as pilot region.Specification experimenter or care-giver adhere to using every day sooner or later, and half face test sample, half face only uses clear water wiping.Within 1 week, 2 weeks, follow up a case by regular visits to after experiment starts, test uses product and uses the skin moisture content of clear water, fat content change respectively, and the test of same volunteer is completed by same survey crew.
3, search time
Whole research 14 days by a definite date researcheres carried out clinical test results assessment at the 0th day, 7 days, 14 days.
4, testing standard
1) mensuration of skin oil and fat content: the skin oil and fat content measuring instrument Sebumeter using German Courage+Khazaka (CK) company to produce surveys 3 times and averages.
2) mensuration of skin moisture content: the moisture of skin tester CorneometerCM825 using German Courage+Khazaka (CK) company to produce surveys 5 times and is averaged.
5, test data
Use the said goods 14 days, carry out clinical test results assessment at the 0th day, 7 days, 14 days
1) oiliness skin efficacy test change, test result is see table 1.
Table 1 oiliness skin efficacy test result
2) slight/moderate acne skin efficacy test change, test result is see table 2.
Table 2 is slight/moderate acne skin efficacy test result
6, experimental result
6.1 skin oil and fat content, moisture content change
1) oiliness skin uses sample after 14 days, and fat content have dropped 47.93% moisture and rises 34.15%.
2) slight/moderate acne skin uses sample after 14 days, and fat content have dropped 17.33% moisture and rises 17.66%.
6.2 efficiency assessment
1) glossy problem 22 people is wherein had, corse sweat pore 18 people, acne inflammation 15 people
2) within the 7th day, observe, glossy problem improves significance 53.13%, and corse sweat pore improves significance 40.00%, and acne inflammation improves significance 31.82%.
3) within the 14th day, observe, glossy problem improves significance 96.88%, and corse sweat pore improves significance 96.00%, and acne inflammation improves significance 95.45%.
From above-mentioned test result, the effective anti-acne control of the gentleness in the present invention fluid composition possesses moisturizing, regulates the multi-efficiencies such as oils and fats balance, antiinflammatory and anti-acne.
Above-described embodiment is only the preferred case study on implementation of the present invention, can not limit the present invention's scope required for protection with this, any unsubstantiality that those skilled in the art does on basis of the present invention and replace all belong to the scope of protection of present invention.
Claims (5)
1. a gentleness effective anti-acne control fluid composition, is characterized in that, by weight percentage, composed of the following components:
Component A: deionized water 67-94%, hyaluronate sodium 0.01-0.1%, glycerol 1-10%, propylene glycol 1-10%, hydroxyethyl-cellulose 0.1-1%, allantoin 0.05-0.2%;
B component: D-panthenol 0.5-2%, totara tree extract 0.004-0.01%, ethanol 1-2%, white willow peel extract 1-3%, zinc paraphenol sulfonate 0.5-1%, Herba portulacae extract 0.5-1.5%;
Component C: antiseptic 0.2-1%, essence 0.01-0.2%, Cremophor RH40 0.06-1%;
The mass percent summation of above component is 100%.
2. gentleness according to claim 1 effective anti-acne control fluid composition, is characterized in that: described antiseptic is the phenoxyethanol, the Sensiva SC50 that are mixed by any ratio.
3. gentleness according to claim 1 effective anti-acne control fluid composition, is characterized in that: described essence adopts Herba Lysimachiae foenum-graeci quintessence oil.
4. according to the preparation method of the effective anti-acne control of the gentleness in claim 1-3 described in any one fluid composition, it is characterized in that, carry out according to the following steps:
1) component A is heated to 80-85 DEG C, enables agitator simultaneously and stir, treat that it dissolves completely;
2) component A completely will be dissolved and use cooling water temperature, and be cooled to 45-50 DEG C, add B component, stir;
3) treat that temperature drops to 40 DEG C, add the component C stirred in advance, after stirring, be cooled to 35 DEG C of dischargings, namely make gentle effective anti-acne control fluid composition.
5. the preparation method of gentleness according to claim 4 effective anti-acne control fluid composition, is characterized in that: the mixing speed of described agitator is 200 revs/min.
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| CN112516044A (en) * | 2020-12-10 | 2021-03-19 | 广东诗妃化妆品有限公司 | Traditional Chinese medicine acne-removing and oil-controlling essence and preparation method thereof |
| CN113057931B (en) * | 2021-04-16 | 2022-08-30 | 雅威盛(北京)科技发展有限公司 | Plant composition for preparing acne-removing preparation, acne-removing preparation and preparation method of acne-removing preparation |
| CN113693979B (en) * | 2021-08-26 | 2023-08-11 | 广州上悦生物科技有限公司 | Oil-control acne-removing composition and application thereof |
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