CN104185661B - 低微粒的润滑性医疗装置涂层 - Google Patents
低微粒的润滑性医疗装置涂层 Download PDFInfo
- Publication number
- CN104185661B CN104185661B CN201380005717.9A CN201380005717A CN104185661B CN 104185661 B CN104185661 B CN 104185661B CN 201380005717 A CN201380005717 A CN 201380005717A CN 104185661 B CN104185661 B CN 104185661B
- Authority
- CN
- China
- Prior art keywords
- coating
- photoreactive group
- group
- ground floor
- linking agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000576 coating method Methods 0.000 title claims abstract description 232
- 239000011248 coating agent Substances 0.000 title claims abstract description 224
- 239000004531 microgranule Substances 0.000 title claims description 16
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 87
- 238000001212 derivatisation Methods 0.000 claims abstract description 43
- 229920000642 polymer Polymers 0.000 claims abstract description 37
- 229920002401 polyacrylamide Polymers 0.000 claims abstract description 21
- 239000000758 substrate Substances 0.000 claims description 91
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 70
- -1 4-benzoylbenzoyl amine Chemical class 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- 238000003618 dip coating Methods 0.000 claims description 36
- 238000012360 testing method Methods 0.000 claims description 27
- 239000002904 solvent Substances 0.000 claims description 26
- 229910052751 metal Inorganic materials 0.000 claims description 19
- 239000002184 metal Substances 0.000 claims description 19
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- 229920001223 polyethylene glycol Polymers 0.000 claims description 13
- 230000005855 radiation Effects 0.000 claims description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 229920001903 high density polyethylene Polymers 0.000 claims description 10
- 239000004700 high-density polyethylene Substances 0.000 claims description 10
- 125000001424 substituent group Chemical group 0.000 claims description 10
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical group C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims description 9
- 239000012965 benzophenone Substances 0.000 claims description 9
- 125000003118 aryl group Chemical group 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- NUVLJKRAFAQGAQ-UHFFFAOYSA-N P(=O)(O)(O)O.C(C1=CC=CC=C1)(=O)OC1=CC=C(C=C1)[Na] Chemical class P(=O)(O)(O)O.C(C1=CC=CC=C1)(=O)OC1=CC=C(C=C1)[Na] NUVLJKRAFAQGAQ-UHFFFAOYSA-N 0.000 claims description 7
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 6
- 229920002614 Polyether block amide Polymers 0.000 claims description 6
- 125000005647 linker group Chemical group 0.000 claims description 6
- 229920002647 polyamide Polymers 0.000 claims description 6
- 229920002530 polyetherether ketone Polymers 0.000 claims description 6
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 6
- 229910052711 selenium Inorganic materials 0.000 claims description 6
- 239000004698 Polyethylene Substances 0.000 claims description 5
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical group CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims description 5
- 229920000573 polyethylene Polymers 0.000 claims description 5
- 239000004814 polyurethane Substances 0.000 claims description 5
- 229920002635 polyurethane Polymers 0.000 claims description 5
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 4
- 239000004952 Polyamide Substances 0.000 claims description 4
- 150000001336 alkenes Chemical class 0.000 claims description 4
- 125000001118 alkylidene group Chemical group 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- IJBXHSUZEBBJJG-UHFFFAOYSA-N (4-benzoylphenyl)methyl-[2-[(4-benzoylphenyl)methyl-dimethylazaniumyl]ethyl]-dimethylazanium Chemical class C=1C=C(C(=O)C=2C=CC=CC=2)C=CC=1C[N+](C)(C)CC[N+](C)(C)CC(C=C1)=CC=C1C(=O)C1=CC=CC=C1 IJBXHSUZEBBJJG-UHFFFAOYSA-N 0.000 claims description 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 125000005842 heteroatom Chemical group 0.000 claims description 3
- 238000006116 polymerization reaction Methods 0.000 claims description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 238000006640 acetylation reaction Methods 0.000 claims description 2
- 150000002118 epoxides Chemical class 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 125000004437 phosphorous atom Chemical group 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical class OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 claims 1
- 150000002466 imines Chemical class 0.000 claims 1
- 238000003892 spreading Methods 0.000 claims 1
- 239000010410 layer Substances 0.000 description 61
- 239000002585 base Substances 0.000 description 22
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 21
- 235000019602 lubricity Nutrition 0.000 description 20
- 150000001875 compounds Chemical class 0.000 description 19
- 230000002186 photoactivation Effects 0.000 description 19
- 239000000203 mixture Substances 0.000 description 18
- 230000008859 change Effects 0.000 description 14
- 229910052736 halogen Inorganic materials 0.000 description 12
- 150000002367 halogens Chemical class 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 11
- 241000894007 species Species 0.000 description 11
- 239000003153 chemical reaction reagent Substances 0.000 description 10
- 238000012956 testing procedure Methods 0.000 description 10
- 239000008187 granular material Substances 0.000 description 9
- 230000001050 lubricating effect Effects 0.000 description 8
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 7
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 7
- 239000007943 implant Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical class C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 239000004971 Cross linker Substances 0.000 description 5
- RYULULVJWLRDQH-UHFFFAOYSA-N [4-(bromomethyl)phenyl]-phenylmethanone Chemical compound C1=CC(CBr)=CC=C1C(=O)C1=CC=CC=C1 RYULULVJWLRDQH-UHFFFAOYSA-N 0.000 description 5
- RJGDLRCDCYRQOQ-UHFFFAOYSA-N anthrone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 RJGDLRCDCYRQOQ-UHFFFAOYSA-N 0.000 description 5
- 230000004087 circulation Effects 0.000 description 5
- 125000000623 heterocyclic group Chemical group 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 4
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000004913 activation Effects 0.000 description 4
- 125000000129 anionic group Chemical group 0.000 description 4
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 4
- 239000012954 diazonium Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000011010 flushing procedure Methods 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 150000002576 ketones Chemical class 0.000 description 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 208000035478 Interatrial communication Diseases 0.000 description 3
- 241001597008 Nomeidae Species 0.000 description 3
- 229920000299 Nylon 12 Polymers 0.000 description 3
- 208000001910 Ventricular Heart Septal Defects Diseases 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 208000013914 atrial heart septal defect Diseases 0.000 description 3
- 206010003664 atrial septal defect Diseases 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 238000001125 extrusion Methods 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- 238000007711 solidification Methods 0.000 description 3
- 230000008023 solidification Effects 0.000 description 3
- 201000003130 ventricular septal defect Diseases 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical class C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- TZRXHJWUDPFEEY-UHFFFAOYSA-N Pentaerythritol Tetranitrate Chemical compound [O-][N+](=O)OCC(CO[N+]([O-])=O)(CO[N+]([O-])=O)CO[N+]([O-])=O TZRXHJWUDPFEEY-UHFFFAOYSA-N 0.000 description 2
- 229920003082 Povidone K 90 Polymers 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- XNOMWKDAQZCFGK-UHFFFAOYSA-N [4-[(4-benzoylphenyl)methoxymethyl]phenyl]-phenylmethanone Chemical class C=1C=C(COCC=2C=CC(=CC=2)C(=O)C=2C=CC=CC=2)C=CC=1C(=O)C1=CC=CC=C1 XNOMWKDAQZCFGK-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 2
- 150000004056 anthraquinones Chemical class 0.000 description 2
- 150000001540 azides Chemical class 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- WRUAHXANJKHFIL-UHFFFAOYSA-N benzene-1,3-disulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC(S(O)(=O)=O)=C1 WRUAHXANJKHFIL-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
- 238000009675 coating thickness measurement Methods 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-O diazynium Chemical class [NH+]#N IJGRMHOSHXDMSA-UHFFFAOYSA-O 0.000 description 2
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000005461 lubrication Methods 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229940059574 pentaerithrityl Drugs 0.000 description 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 238000006068 polycondensation reaction Methods 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000007420 reactivation Effects 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 2
- AXVOAMVQOCBPQT-UHFFFAOYSA-N triphos Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCP(C=1C=CC=CC=1)CCP(C=1C=CC=CC=1)C1=CC=CC=C1 AXVOAMVQOCBPQT-UHFFFAOYSA-N 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 229910052727 yttrium Inorganic materials 0.000 description 2
- IUJIWCHHVPBMRQ-UHFFFAOYSA-N (4-phosphonooxyphenyl) benzoate Chemical class OP(O)(=O)Oc1ccc(OC(=O)c2ccccc2)cc1 IUJIWCHHVPBMRQ-UHFFFAOYSA-N 0.000 description 1
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 1
- PGRNEGLBSNLPNP-UHFFFAOYSA-N 1,6-dichloro-3-methylhex-1-ene Chemical compound ClC=CC(C)CCCCl PGRNEGLBSNLPNP-UHFFFAOYSA-N 0.000 description 1
- UUORGSXWPOMXJJ-UHFFFAOYSA-N 1-[azido(ethyl)phosphoryl]ethane Chemical compound CCP(=O)(CC)N=[N+]=[N-] UUORGSXWPOMXJJ-UHFFFAOYSA-N 0.000 description 1
- OWPUOLBODXJOKH-UHFFFAOYSA-N 2,3-dihydroxypropyl prop-2-enoate Chemical compound OCC(O)COC(=O)C=C OWPUOLBODXJOKH-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- JBVSBLLOZVDAAZ-UHFFFAOYSA-N 2-diazonio-1-[(2-methylpropan-2-yl)oxy]ethenolate Chemical compound CC(C)(C)OC([O-])=C[N+]#N JBVSBLLOZVDAAZ-UHFFFAOYSA-N 0.000 description 1
- UWBALSPTLHOGFE-UHFFFAOYSA-N 2-diazonio-1-phenoxyethenolate Chemical compound [N-]=[N+]=CC(=O)OC1=CC=CC=C1 UWBALSPTLHOGFE-UHFFFAOYSA-N 0.000 description 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
- LPLLVINFLBSFRP-UHFFFAOYSA-N 2-methylamino-1-phenylpropan-1-one Chemical compound CNC(C)C(=O)C1=CC=CC=C1 LPLLVINFLBSFRP-UHFFFAOYSA-N 0.000 description 1
- IRLPACMLTUPBCL-KQYNXXCUSA-N 5'-adenylyl sulfate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](O)[C@H]1O IRLPACMLTUPBCL-KQYNXXCUSA-N 0.000 description 1
- GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 description 1
- 206010002329 Aneurysm Diseases 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- GYVFPNORVGZOPH-UHFFFAOYSA-N C(C)C(=O)CC.[N+](=[N-])=C1CC=CC=C1 Chemical compound C(C)C(=O)CC.[N+](=[N-])=C1CC=CC=C1 GYVFPNORVGZOPH-UHFFFAOYSA-N 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 244000293323 Cosmos caudatus Species 0.000 description 1
- 235000005956 Cosmos caudatus Nutrition 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241001481828 Glyptocephalus cynoglossus Species 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229910000575 Ir alloy Inorganic materials 0.000 description 1
- VHOQXEIFYTTXJU-UHFFFAOYSA-N Isobutylene-isoprene copolymer Chemical compound CC(C)=C.CC(=C)C=C VHOQXEIFYTTXJU-UHFFFAOYSA-N 0.000 description 1
- DJOWTWWHMWQATC-KYHIUUMWSA-N Karpoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1(O)C(C)(C)CC(O)CC1(C)O)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C DJOWTWWHMWQATC-KYHIUUMWSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical class NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 229910000990 Ni alloy Inorganic materials 0.000 description 1
- 229920002292 Nylon 6 Polymers 0.000 description 1
- 229920002302 Nylon 6,6 Polymers 0.000 description 1
- BXEFQPCKQSTMKA-UHFFFAOYSA-N OC(=O)C=[N+]=[N-] Chemical class OC(=O)C=[N+]=[N-] BXEFQPCKQSTMKA-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 229910001260 Pt alloy Inorganic materials 0.000 description 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical class OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- AWWMYIFREIUBNZ-UHFFFAOYSA-N [4-[(dimethylamino)methyl]phenyl]-phenylmethanone Chemical class C1=CC(CN(C)C)=CC=C1C(=O)C1=CC=CC=C1 AWWMYIFREIUBNZ-UHFFFAOYSA-N 0.000 description 1
- ITLHXEGAYQFOHJ-UHFFFAOYSA-N [diazo(phenyl)methyl]benzene Chemical compound C=1C=CC=CC=1C(=[N+]=[N-])C1=CC=CC=C1 ITLHXEGAYQFOHJ-UHFFFAOYSA-N 0.000 description 1
- 208000002223 abdominal aortic aneurysm Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 description 1
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 description 1
- 238000012644 addition polymerization Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127217 antithrombotic drug Drugs 0.000 description 1
- 208000007474 aortic aneurysm Diseases 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- OATNQHYJXLHTEW-UHFFFAOYSA-N benzene-1,4-disulfonic acid Chemical compound OS(=O)(=O)C1=CC=C(S(O)(=O)=O)C=C1 OATNQHYJXLHTEW-UHFFFAOYSA-N 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- PJHUABJTDFXYRQ-UHFFFAOYSA-N benzoyl azide Chemical compound [N-]=[N+]=NC(=O)C1=CC=CC=C1 PJHUABJTDFXYRQ-UHFFFAOYSA-N 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- BGECDVWSWDRFSP-UHFFFAOYSA-N borazine Chemical compound B1NBNBN1 BGECDVWSWDRFSP-UHFFFAOYSA-N 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical group OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 150000001649 bromium compounds Chemical group 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 125000002837 carbocyclic group Chemical group 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 150000001989 diazonium salts Chemical class 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- XXBDWLFCJWSEKW-UHFFFAOYSA-N dimethylbenzylamine Chemical class CN(C)CC1=CC=CC=C1 XXBDWLFCJWSEKW-UHFFFAOYSA-N 0.000 description 1
- ZWJPCOALBPMBIC-UHFFFAOYSA-N diphenylketene Chemical compound C=1C=CC=CC=1C(=C=O)C1=CC=CC=C1 ZWJPCOALBPMBIC-UHFFFAOYSA-N 0.000 description 1
- FRQBASCARWSPLE-UHFFFAOYSA-N diphenylmethanone;phosphoric acid Chemical class OP(O)(O)=O.C=1C=CC=CC=1C(=O)C1=CC=CC=C1 FRQBASCARWSPLE-UHFFFAOYSA-N 0.000 description 1
- MKRTXPORKIRPDG-UHFFFAOYSA-N diphenylphosphoryl azide Chemical compound C=1C=CC=CC=1P(=O)(N=[N+]=[N-])C1=CC=CC=C1 MKRTXPORKIRPDG-UHFFFAOYSA-N 0.000 description 1
- 238000001548 drop coating Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- CCGKOQOJPYTBIH-UHFFFAOYSA-N ethenone Chemical compound C=C=O CCGKOQOJPYTBIH-UHFFFAOYSA-N 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000003827 glycol group Chemical group 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000005283 ground state Effects 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 229920005555 halobutyl Polymers 0.000 description 1
- 230000026030 halogenation Effects 0.000 description 1
- 238000005658 halogenation reaction Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- 239000004312 hexamethylene tetramine Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 150000002561 ketenes Chemical class 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229910001507 metal halide Inorganic materials 0.000 description 1
- 150000005309 metal halides Chemical class 0.000 description 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical class [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 description 1
- VLCAYQIMSMPEBW-UHFFFAOYSA-N methyl 3-hydroxy-2-methylidenebutanoate Chemical compound COC(=O)C(=C)C(C)O VLCAYQIMSMPEBW-UHFFFAOYSA-N 0.000 description 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 1
- 210000004115 mitral valve Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 229910021652 non-ferrous alloy Inorganic materials 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000000661 pacemaking effect Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- CTRLRINCMYICJO-UHFFFAOYSA-N phenyl azide Chemical compound [N-]=[N+]=NC1=CC=CC=C1 CTRLRINCMYICJO-UHFFFAOYSA-N 0.000 description 1
- JNNRHQSSRWRLJQ-UHFFFAOYSA-N phenyl-[4-(piperazin-1-ylmethyl)phenyl]methanone Chemical compound C=1C=C(CN2CCNCC2)C=CC=1C(=O)C1=CC=CC=C1 JNNRHQSSRWRLJQ-UHFFFAOYSA-N 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920001643 poly(ether ketone) Polymers 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000005588 protonation Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 150000004053 quinones Chemical class 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229910052702 rhenium Inorganic materials 0.000 description 1
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 description 1
- 229910052703 rhodium Inorganic materials 0.000 description 1
- 239000010948 rhodium Substances 0.000 description 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- JKUYRAMKJLMYLO-UHFFFAOYSA-N tert-butyl 3-oxobutanoate Chemical compound CC(=O)CC(=O)OC(C)(C)C JKUYRAMKJLMYLO-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- YRHRIQCWCFGUEQ-UHFFFAOYSA-N thioxanthen-9-one Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3SC2=C1 YRHRIQCWCFGUEQ-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229940117958 vinyl acetate Drugs 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- JNELGWHKGNBSMD-UHFFFAOYSA-N xanthone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3OC2=C1 JNELGWHKGNBSMD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Paints Or Removers (AREA)
- Materials For Medical Uses (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Laminated Bodies (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261587944P | 2012-01-18 | 2012-01-18 | |
| US201261587929P | 2012-01-18 | 2012-01-18 | |
| US61/587,944 | 2012-01-18 | ||
| US61/587,929 | 2012-01-18 | ||
| PCT/US2013/022202 WO2013109930A1 (en) | 2012-01-18 | 2013-01-18 | Lubricious medical device coating with low particulates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104185661A CN104185661A (zh) | 2014-12-03 |
| CN104185661B true CN104185661B (zh) | 2016-08-17 |
Family
ID=47714540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380005717.9A Active CN104185661B (zh) | 2012-01-18 | 2013-01-18 | 低微粒的润滑性医疗装置涂层 |
Country Status (10)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9999675B2 (en) | 2012-11-05 | 2018-06-19 | Surmodics, Inc. | Composition and method for delivery of hydrophobic active agents |
| US10213528B2 (en) | 2011-05-20 | 2019-02-26 | Surmodics, Inc. | Delivery of hydrophobic active agent particles |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105214143A (zh) | 2009-04-28 | 2016-01-06 | 苏尔莫迪克斯公司 | 用于递送生物活性剂的装置和方法 |
| US10213529B2 (en) | 2011-05-20 | 2019-02-26 | Surmodics, Inc. | Delivery of coated hydrophobic active agent particles |
| CN104185661B (zh) | 2012-01-18 | 2016-08-17 | 苏尔莫迪克斯公司 | 低微粒的润滑性医疗装置涂层 |
| US11246963B2 (en) | 2012-11-05 | 2022-02-15 | Surmodics, Inc. | Compositions and methods for delivery of hydrophobic active agents |
| CA2896107C (en) * | 2013-01-04 | 2021-11-23 | Surmodics, Inc. | Low particulate lubricious coating with vinyl pyrrolidone and acidic polymer-containing layers |
| AU2014311454A1 (en) * | 2013-08-25 | 2016-03-24 | Biotectix, LLC | Conductive polymeric coatings, medical devices, coating solutions and methods |
| US10124088B2 (en) * | 2014-09-29 | 2018-11-13 | Surmodics, Inc. | Lubricious medical device elements |
| CA2982591C (en) | 2015-04-16 | 2024-04-30 | Hollister Incorporated | Hydrophilic coatings and methods of forming the same |
| CN105251095B (zh) * | 2015-10-22 | 2018-05-15 | 江苏康诺医疗器械有限公司 | Pvc超滑导尿管及其制备方法 |
| US11174447B2 (en) | 2015-12-29 | 2021-11-16 | Surmodics, Inc. | Lubricious coatings with surface salt groups |
| US10342898B2 (en) | 2015-12-29 | 2019-07-09 | Surmodics, Inc. | Lubricious coatings with surface salt groups |
| EP3436096B1 (en) * | 2016-03-31 | 2025-04-16 | Surmodics, Inc. | Lubricious coating for medical device |
| US10898446B2 (en) | 2016-12-20 | 2021-01-26 | Surmodics, Inc. | Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces |
| WO2020004385A1 (ja) * | 2018-06-27 | 2020-01-02 | テルモ株式会社 | 親水性共重合体および医療用具 |
| US12226552B2 (en) | 2019-09-30 | 2025-02-18 | Surmodics, Inc. | Active agent depots formed in situ |
| JP7621347B2 (ja) * | 2019-10-21 | 2025-01-24 | バイオコート、インコーポレイテッド | 医療機器用ｕｖ硬化コーティング |
| US12037560B2 (en) | 2019-10-21 | 2024-07-16 | Biocoat, Incorporated | UV cure topcoatings for medical devices |
| US11359156B2 (en) | 2019-10-21 | 2022-06-14 | Biocoat, Inc. | UV cure basecoatings for medical devices |
| US12214146B2 (en) | 2019-12-11 | 2025-02-04 | Biocoat, Incorporated | Controlled release of a hydrophilic agent from a coated surface |
| EP4489804A1 (en) * | 2022-03-09 | 2025-01-15 | Surmodics Coatings, LLC | Thromboresistant coatings, coated devices, and methods |
| WO2024148271A1 (en) | 2023-01-05 | 2024-07-11 | Surmodics, Inc. | Lubricious coatings for medical devices with enhanced durability |
| WO2025176284A1 (en) | 2024-02-20 | 2025-08-28 | Basf Coatings Gmbh | Polyurethane-based polymer comprising n-vinylpyrrolidone-based moieties |
| WO2025176286A1 (en) | 2024-02-20 | 2025-08-28 | Basf Coatings Gmbh | Polyurethane-based polymer comprising n-vinylpyrrolidone-based moieties |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813059A (zh) * | 2003-05-02 | 2006-08-02 | 西格玛-奥尔德利希公司 | 固相细胞裂解和捕获平台 |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4156065A (en) | 1977-01-21 | 1979-05-22 | The Upjohn Company | Catalytic condensation of isocyanates and carboxylic acids or anhydrides |
| CH616337A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-10-21 | 1980-03-31 | Schneider Medintag Ag | |
| US5512329A (en) | 1982-09-29 | 1996-04-30 | Bsi Corporation | Substrate surface preparation |
| US5002582A (en) | 1982-09-29 | 1991-03-26 | Bio-Metric Systems, Inc. | Preparation of polymeric surfaces via covalently attaching polymers |
| US4973493A (en) | 1982-09-29 | 1990-11-27 | Bio-Metric Systems, Inc. | Method of improving the biocompatibility of solid surfaces |
| AU566085B2 (en) | 1984-06-04 | 1987-10-08 | Terumo Kabushiki Kaisha | Medical instrument with surface treatment |
| US5263992A (en) | 1986-10-17 | 1993-11-23 | Bio-Metric Systems, Inc. | Biocompatible device with covalently bonded biocompatible agent |
| US4979959A (en) | 1986-10-17 | 1990-12-25 | Bio-Metric Systems, Inc. | Biocompatible coating for solid surfaces |
| US5001009A (en) | 1987-09-02 | 1991-03-19 | Sterilization Technical Services, Inc. | Lubricious hydrophilic composite coated on substrates |
| US5041089A (en) | 1987-12-11 | 1991-08-20 | Devices For Vascular Intervention, Inc. | Vascular dilation catheter construction |
| US5087246A (en) | 1988-12-29 | 1992-02-11 | C. R. Bard, Inc. | Dilation catheter with fluted balloon |
| US5091205A (en) | 1989-01-17 | 1992-02-25 | Union Carbide Chemicals & Plastics Technology Corporation | Hydrophilic lubricious coatings |
| US4990357A (en) | 1989-05-04 | 1991-02-05 | Becton, Dickinson And Company | Elastomeric segmented hydrophilic polyetherurethane based lubricious coatings |
| US5318587A (en) | 1989-08-25 | 1994-06-07 | C. R. Bard, Inc. | Pleated balloon dilatation catheter and method of use |
| US5135516A (en) | 1989-12-15 | 1992-08-04 | Boston Scientific Corporation | Lubricious antithrombogenic catheters, guidewires and coatings |
| US5039485A (en) | 1990-09-26 | 1991-08-13 | Union Carbide Industrial Gases Technology Corporation | Sterilization method |
| ATE121303T1 (de) | 1990-10-04 | 1995-05-15 | Schneider Europ Ag | Ballondilationskatheter. |
| US5414075A (en) | 1992-11-06 | 1995-05-09 | Bsi Corporation | Restrained multifunctional reagent for surface modification |
| US5382234A (en) | 1993-04-08 | 1995-01-17 | Scimed Life Systems, Inc. | Over-the-wire balloon catheter |
| US5344402A (en) | 1993-06-30 | 1994-09-06 | Cardiovascular Dynamics, Inc. | Low profile perfusion catheter |
| US6896842B1 (en) | 1993-10-01 | 2005-05-24 | Boston Scientific Corporation | Medical device balloons containing thermoplastic elastomers |
| CA2188407A1 (en) | 1994-04-20 | 1995-11-02 | Ronald J. Solar | Active perfusion dilatation catheter |
| US5670558A (en) | 1994-07-07 | 1997-09-23 | Terumo Kabushiki Kaisha | Medical instruments that exhibit surface lubricity when wetted |
| US5554120A (en) | 1994-07-25 | 1996-09-10 | Advanced Cardiovascular Systems, Inc. | Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters |
| US5849846A (en) | 1994-07-25 | 1998-12-15 | Advanced Cardiovascular Systems, Inc. | Balloons for medical catheters |
| US5667493A (en) | 1994-12-30 | 1997-09-16 | Janacek; Jaroslav | Dilation catheter |
| US5662960A (en) | 1995-02-01 | 1997-09-02 | Schneider (Usa) Inc. | Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel |
| US5731087A (en) | 1995-06-07 | 1998-03-24 | Union Carbide Chemicals & Plastics Technology Corporation | Lubricious coatings containing polymers with vinyl and carboxylic acid moieties |
| US5714360A (en) | 1995-11-03 | 1998-02-03 | Bsi Corporation | Photoactivatable water soluble cross-linking agents containing an onium group |
| JP3336600B2 (ja) | 1996-04-18 | 2002-10-21 | ニプロ株式会社 | 医療用ガイドワイヤーおよびその製造方法 |
| SE9602529D0 (sv) * | 1996-06-26 | 1996-06-26 | Astra Ab | Medical device |
| JP3362186B2 (ja) | 1996-08-09 | 2003-01-07 | ニプロ株式会社 | 医療用具およびその製造方法 |
| US5858653A (en) | 1997-09-30 | 1999-01-12 | Surmodics, Inc. | Reagent and method for attaching target molecules to a surface |
| JP4183024B2 (ja) | 1997-10-20 | 2008-11-19 | 日本シャーウッド株式会社 | 潤滑性被覆を有する医療用具及びその製造方法 |
| US6221425B1 (en) | 1998-01-30 | 2001-04-24 | Advanced Cardiovascular Systems, Inc. | Lubricious hydrophilic coating for an intracorporeal medical device |
| US6517515B1 (en) | 1998-03-04 | 2003-02-11 | Scimed Life Systems, Inc. | Catheter having variable size guide wire lumen |
| US6007833A (en) | 1998-03-19 | 1999-12-28 | Surmodics, Inc. | Crosslinkable macromers bearing initiator groups |
| CA2330134A1 (en) | 1998-05-15 | 1999-11-25 | Medgination, Inc. | Enhanced balloon dilatation system |
| US6176849B1 (en) | 1999-05-21 | 2001-01-23 | Scimed Life Systems, Inc. | Hydrophilic lubricity coating for medical devices comprising a hydrophobic top coat |
| JP4143883B2 (ja) | 1999-07-06 | 2008-09-03 | 日本シャーウッド株式会社 | 医療用具およびその製造方法 |
| US6278018B1 (en) | 1999-12-14 | 2001-08-21 | Surmodics, Inc. | Surface coating agents |
| CA2419379C (en) | 2000-08-15 | 2011-10-11 | Surmodics, Inc. | Medicament incorporation matrix |
| US6623504B2 (en) | 2000-12-08 | 2003-09-23 | Scimed Life Systems, Inc. | Balloon catheter with radiopaque distal tip |
| US7348055B2 (en) | 2001-12-21 | 2008-03-25 | Surmodics, Inc. | Reagent and method for providing coatings on surfaces |
| AU2003224099B2 (en) | 2002-04-19 | 2006-11-09 | Novartis Ag | Novel biomaterials, their preparation and use |
| US7192484B2 (en) | 2002-09-27 | 2007-03-20 | Surmodics, Inc. | Advanced coating apparatus and method |
| ES2325398T3 (es) | 2003-02-26 | 2009-09-03 | Boston Scientific Limited | Cateter de balon. |
| EP2329852A1 (en) | 2004-03-26 | 2011-06-08 | SurModics, Inc. | Composition and method for preparing biocompatible surfaces |
| JP2008522670A (ja) * | 2004-12-06 | 2008-07-03 | サーモディクス，インコーポレイティド | 多機能医療物品 |
| US7691476B2 (en) | 2005-06-02 | 2010-04-06 | Surmodics, Inc. | Hydrophilic polymeric coatings for medical articles |
| US7772393B2 (en) | 2005-06-13 | 2010-08-10 | Innovative Surface Technologies, Inc. | Photochemical crosslinkers for polymer coatings and substrate tie-layer |
| US20100119833A1 (en) | 2006-07-25 | 2010-05-13 | Niels Jorgen Madsen | Photo-curing of thermoplastic coatings |
| US20080213334A1 (en) * | 2006-09-29 | 2008-09-04 | Lockwood Nathan A | Polyelectrolyte media for bioactive agent delivery |
| MY148410A (en) | 2007-02-28 | 2013-04-30 | Dsm Ip Assets Bv | Hydrophilic coating |
| US8809411B2 (en) | 2007-02-28 | 2014-08-19 | Dsm Ip Assets B.V. | Hydrophilic coating |
| WO2009091812A2 (en) | 2008-01-14 | 2009-07-23 | Surmodics, Inc. | Devices and methods for elution of nucleic acid delivery complexes |
| CN101970583B (zh) | 2008-03-12 | 2012-11-28 | 帝斯曼知识产权资产管理有限公司 | 亲水性涂层 |
| WO2009126830A2 (en) | 2008-04-09 | 2009-10-15 | Surmodics, Inc. | Delivery of nucleic acid complexes from materials including negatively charged groups |
| CN105214143A (zh) | 2009-04-28 | 2016-01-06 | 苏尔莫迪克斯公司 | 用于递送生物活性剂的装置和方法 |
| US20110144373A1 (en) * | 2009-12-10 | 2011-06-16 | Surmodics, Inc. | Water-soluble degradable photo-crosslinker |
| US8889760B2 (en) * | 2010-03-30 | 2014-11-18 | Surmodics, Inc. | Photoactivatable crosslinker |
| JP5984806B2 (ja) * | 2010-06-30 | 2016-09-06 | サーモディクス，インコーポレイティド | 生体活性剤を送達する医療デバイスのための脂質コーティング |
| US10315987B2 (en) | 2010-12-13 | 2019-06-11 | Surmodics, Inc. | Photo-crosslinker |
| JP5690631B2 (ja) | 2011-03-30 | 2015-03-25 | 日本コヴィディエン株式会社 | 潤滑性を有する医療用具およびその製造方法 |
| US9861727B2 (en) * | 2011-05-20 | 2018-01-09 | Surmodics, Inc. | Delivery of hydrophobic active agent particles |
| WO2012170706A2 (en) | 2011-06-08 | 2012-12-13 | Surmodics, Inc. | Photo-vinyl linking agents |
| CN104185661B (zh) | 2012-01-18 | 2016-08-17 | 苏尔莫迪克斯公司 | 低微粒的润滑性医疗装置涂层 |
| JP6549482B2 (ja) | 2012-06-01 | 2019-07-24 | サーモディクス，インコーポレイテッド | バルーンカテーテルをコーティングするための装置および方法 |
| WO2014004997A1 (en) | 2012-06-29 | 2014-01-03 | Surmodics, Inc. | Cell attachment coatings and methods using phosphorous-containing photoreagent |
| EP2692365A1 (en) | 2012-08-03 | 2014-02-05 | MaRVis Medical GmbH | Implantable or insertable MRI-detectable medical device having a coating comprising paramagnetic ions and a process for preparing it |
| US9629945B2 (en) | 2012-12-12 | 2017-04-25 | Surmodics, Inc. | Stilbene-based reactive compounds, polymeric matrices formed therefrom, and articles visualizable by fluorescence |
| US9340876B2 (en) | 2012-12-12 | 2016-05-17 | Applied Materials, Inc. | Mask for deposition process |
| CA2896107C (en) * | 2013-01-04 | 2021-11-23 | Surmodics, Inc. | Low particulate lubricious coating with vinyl pyrrolidone and acidic polymer-containing layers |
| WO2015029625A1 (ja) | 2013-09-02 | 2015-03-05 | テルモ株式会社 | 医療用具およびその製造方法 |
| EP3071250B1 (en) | 2013-11-20 | 2019-06-05 | DSM IP Assets B.V. | Reducing the deterioration of wetted hydrophilic coatings subjected to sterilization by radiation |
| US10124088B2 (en) | 2014-09-29 | 2018-11-13 | Surmodics, Inc. | Lubricious medical device elements |
| US10342898B2 (en) | 2015-12-29 | 2019-07-09 | Surmodics, Inc. | Lubricious coatings with surface salt groups |
| US11174447B2 (en) | 2015-12-29 | 2021-11-16 | Surmodics, Inc. | Lubricious coatings with surface salt groups |
-
2013
- 2013-01-18 CN CN201380005717.9A patent/CN104185661B/zh active Active
- 2013-01-18 JP JP2014553466A patent/JP6117824B2/ja active Active
- 2013-01-18 EP EP13704280.0A patent/EP2804915B1/en active Active
- 2013-01-18 EP EP15198514.0A patent/EP3012301B1/en active Active
- 2013-01-18 RU RU2014133462A patent/RU2627390C2/ru active
- 2013-01-18 MX MX2014008670A patent/MX356582B/es active IP Right Grant
- 2013-01-18 US US13/745,397 patent/US9375517B2/en active Active
- 2013-01-18 BR BR112014017675-2A patent/BR112014017675B1/pt active IP Right Grant
- 2013-01-18 CA CA2861314A patent/CA2861314C/en active Active
- 2013-01-18 WO PCT/US2013/022202 patent/WO2013109930A1/en active Application Filing
-
2014
- 2014-07-21 CR CR20140349A patent/CR20140349A/es unknown
-
2016
- 2016-05-26 US US15/165,650 patent/US9737639B2/en active Active
-
2017
- 2017-03-23 JP JP2017057269A patent/JP6408056B2/ja active Active
- 2017-07-07 US US15/643,564 patent/US10905802B2/en active Active
-
2018
- 2018-09-19 JP JP2018174717A patent/JP6675459B2/ja active Active
-
2021
- 2021-01-28 US US17/161,396 patent/US11872325B2/en active Active
-
2024
- 2024-01-15 US US18/412,843 patent/US20240342345A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813059A (zh) * | 2003-05-02 | 2006-08-02 | 西格玛-奥尔德利希公司 | 固相细胞裂解和捕获平台 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10213528B2 (en) | 2011-05-20 | 2019-02-26 | Surmodics, Inc. | Delivery of hydrophobic active agent particles |
| US9999675B2 (en) | 2012-11-05 | 2018-06-19 | Surmodics, Inc. | Composition and method for delivery of hydrophobic active agents |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6117824B2 (ja) | 2017-04-19 |
| BR112014017675B1 (pt) | 2021-06-22 |
| JP6675459B2 (ja) | 2020-04-01 |
| US10905802B2 (en) | 2021-02-02 |
| BR112014017675A8 (pt) | 2017-07-11 |
| JP2017127669A (ja) | 2017-07-27 |
| RU2014133462A (ru) | 2016-03-10 |
| CA2861314C (en) | 2021-03-16 |
| MX356582B (es) | 2018-06-05 |
| EP3012301A1 (en) | 2016-04-27 |
| US20170304506A1 (en) | 2017-10-26 |
| JP2018198983A (ja) | 2018-12-20 |
| JP6408056B2 (ja) | 2018-10-17 |
| US20160271300A1 (en) | 2016-09-22 |
| CA2861314A1 (en) | 2013-07-25 |
| BR112014017675A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2017-06-20 |
| US11872325B2 (en) | 2024-01-16 |
| JP2015503998A (ja) | 2015-02-05 |
| EP2804915B1 (en) | 2016-03-30 |
| EP3012301B1 (en) | 2023-08-16 |
| CR20140349A (es) | 2014-11-24 |
| MX2014008670A (es) | 2014-10-14 |
| US9737639B2 (en) | 2017-08-22 |
| US9375517B2 (en) | 2016-06-28 |
| US20130197433A1 (en) | 2013-08-01 |
| EP2804915A1 (en) | 2014-11-26 |
| WO2013109930A1 (en) | 2013-07-25 |
| RU2627390C2 (ru) | 2017-08-08 |
| CN104185661A (zh) | 2014-12-03 |
| US20210220525A1 (en) | 2021-07-22 |
| US20240342345A1 (en) | 2024-10-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104185661B (zh) | 低微粒的润滑性医疗装置涂层 | |
| JP7224409B2 (ja) | 医療デバイス用潤滑コーティング | |
| CN102947376B (zh) | 用于制备亲水性涂层的涂料配制品 | |
| EP3397296B1 (en) | Lubricious coatings with surface salt groups | |
| WO2013017547A1 (en) | Medical device comprising a wetted hydrophilic coating | |
| US10098989B2 (en) | Coatings for controlled release of water soluble drugs |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |