CN104173498A - KEKE spray used for oral cavity cleaning and bacteriostasis and preparation method thereof - Google Patents

Abstract

The invention discloses a KEKE spray used for oral cavity cleaning and bacteriostasis and a preparation method thereof. The spray is prepared from the following raw materials in parts by weight: 136.67-205.00 parts of radix glycyrrhizae, 136.67-205.00 parts of semen armeniacae amarum, 42.69-64.03 parts of semen raphani, 42.69-64.03 parts of radix platycodonis, 42.69-64.03 parts of flos lonicerae, and 14.32-21.48 parts of semen sterculiae lychnophorae. The spray also comprises 2.0-3.0 parts of an efficient cooling agent, 24-36 parts of mint, 1.2-1.8 parts of eucalyptus oil, 240-360 parts of xylitol, 120-180 parts of glycerin, 2.4-3.6 parts of potassium sorbate, and 0.06-0.09 part of ethanol with the concentration of 5%. The spray employs a plant formula, has the characteristics of cleaning oral cavity, bacteriostasis and the like, is capable of refreshing breath and mitigating oral cavity peculiar smell, and has especially obvious effects on oral cavity peculiar smell problems caused by immunity and internal organ function imbalance.

Description

For oral cavity cleaning, antibacterial cough-relieving spray and preparation method thereof

Technical field

The invention belongs to daily living article field, be specifically related to a kind of oral cavity fresh and cool spray that contains Chinese medicine extract and preparation method thereof.

Background technology

Halitosis (halitosis) has a strong impact on people's social communication and healthy at heart, and WHO reports halitosis as a kind of disease, investigation demonstration, and the whole world approximately has 10% ~ 65% people once to suffer from halitosis, Chinese halitosis prevalence 27.5%.The reason that may cause halitosis is a lot, as excessive in oral cavity, nasopharynx, gastroenteropathy and constipation, smoking, drink, go on a diet fat-reducing, insomnia and mental pressure etc.A lot of research in the past thought, most halitosis derive from oral cavity, relevant with many oral diseases and situation, in close relations with periodontal disease, tongue fur.Recent study shows and causes that the main matter of halitosis is volatile sulfur compounds, and hydrogen sulfide and methyl mercaptan are topmost compositions (accounting for more than 90%) wherein.Volatile sulfur compounds level and periodontal disease do not have obvious dependency, and in halitosis person, the overwhelming majority has gastroenteropathy, and halitosis and Helicobacter pylori infect obvious dependency.Study and show recently, helicobacter pylori can produce ammonia by decomposing urea, and this bacterium can also produce hydrogen sulfide and methanthiol, and two kinds of main components that gas is halitosis.

Halitosis is mainly divided into two large types, and a class is that immunity, visceral dysfunction cause halitosis; The secondth, pure oral cavity halitosis disease.The traditional Chinese medical science thinks that the generation of halitosis comes from the various acute and chronic diseases of human body, says in Qing Dynasty's " quiet candle of miscellaneous diseases source and course ": " asthenic fire is hot and suffocating, accumulates between breast stomach halitosis, or also halitosis of the people of the stomach of working with one's mind, or fertilizer is fiery bright halitosis." by the dialectical discussion of the traditional Chinese medical science, breast abdomen is not smooth, adverse flow of turbid QI, stomach-Yin consumption wound, raw in deficiency-heat, stomach-Yin is impaired, and deficiency of body fluid steams in asthenic fire; The impaired QI rising in reverse order of lung yin upper punch; The hot and suffocating interior knot of the impaired asthenic fire of vital essence blood, the hot and suffocating upper steaming of Yin and fluid deficiency gastrointestinal liver and gall asthenic fire, liver-fire invading the stomach, scorching in fire of moxibustion, the insufficiency of the spleen stagnation of QI, cold and heat are tied mutually, disorder in ascending and descending institute and cause halitosis.

Release in the market and be no less than the product that oral cavity health is relevant, as chewing gum, suck bag, collutory etc., major part is by covering halitosis by chewing gum and alcoholic collutory or flavorants, this series products poor durability, cannot keep for a long time clear-headed effect, can not fundamentally treat the halitosis problem that solves, thereby existing treatment oral disease is improved the report of halitosis problem correlational study at present, as: a kind of anticariogenic IgY antibody oral spray (CN201010561959.4).But cause the product of halitosis problem for immunity, visceral dysfunction, there is no at present correlational study report, for the deficiencies in the prior art, the invention provides the halitosis problem of technical scheme a kind of solution causes to(for) immunity, visceral dysfunction.

Summary of the invention

The object of the invention is to overcome the deficiencies in the prior art, provide a kind of and carve spray for oral cavity cleaning, antibacterial gram.This spray can keep that lasting ice is refreshing, breath freshening, has cleaning oral cavity, antibacterial texts, and the halitosis problem effect especially causing for immunity, visceral dysfunction is obvious, its definite ingredients, safe, and exist with the form of spraying, there is instant effect, the advantage such as easy to use.Another object of the present invention is to provide the preparation method of this oral spray.

Object of the present invention is achieved by following technical proposals: a kind of for oral cavity cleaning, antibacterial cough-relieving spray, primary raw material and adjuvant by following weight parts are made: 136.67～205.00 parts, Radix Glycyrrhizae, 136.67～205.00 parts of Semen Armeniacae Amarums, 42.69～64.03 parts of Semen Raphanis, 42.69～64.03 parts of Radix Platycodoniss, 42.69～64.03 parts of Flos Loniceraes, 14.32～21.48 parts of Semen Sterculiae Lychnophoraes, 2.0～3.0 parts of efficient fresheners, 24～36 parts of Herba Menthaes, 1.2～1.8 parts of Oleum Eucalyptis, 240～360 parts of xylitol, 120～180 parts of glycerol, 2.4～3.6 parts of potassium sorbate, 5% 0.06～0.09 part of ethanol.

The consumption of preferred above-mentioned each primary raw material is: 170.84 parts, Radix Glycyrrhizae, 170.84 parts of Semen Armeniacae Amarums, 53.36 parts of Semen Raphanis, 53.36 parts of Radix Platycodoniss, 53.36 parts of Flos Loniceraes, 17.9 parts of Semen Sterculiae Lychnophoraes.

2.5 parts of preferably efficient fresheners, 30 parts of Herba Menthaes, 1.5 parts of Oleum Eucalyptis, 300 parts of xylitol, 150 parts of glycerol, 3 parts of potassium sorbate, 0.075 part of 5% ethanol.

A kind of for oral cavity cleaning, the preparation method of antibacterial cough-relieving spray, press formula proportion extracting liquorice, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Flos Lonicerae, Semen Sterculiae Lychnophorae Six-element medical material, weight in gram, adding 4～6 times of water gaging streams extracts 3～5 hours, Semen Sterculiae Lychnophorae is decocted a drug wrapped with 200 order filter clothes, extracting solution filters, merging filtrate, it is 1.10～1.20 that filtrate is concentrated into relative density in the time of 60 DEG C, alcohol is sink to alcohol content 60～80%, leave standstill 8～14 hours, get supernatant, 200 orders filter, reclaim ethanol, it is 1.25～1.30 that filtrate is concentrated into relative density in the time of 60 DEG C, obtain cough-relieving extractum, be diluted with water to 1.2～1.8L, add xylitol, Mentholum, efficient freshener, Oleum Eucalypti, ethanol, glycerol, potassium sorbate, fully mix, aseptic filtration, filtrate subpackage, obtain.

More specifically, the preparation method of spray of the present invention is: by formula proportion extracting liquorice, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Flos Lonicerae, Semen Sterculiae Lychnophorae Six-element medical material, weight in gram, adding 5 times of water gaging streams extracts 4 hours, Semen Sterculiae Lychnophorae is decocted a drug wrapped with 200 order filter clothes, extracting solution filters, merging filtrate, it is 1.20 that filtrate is concentrated into relative density in the time of 60 DEG C, alcohol is sink to alcohol content 70%, leave standstill 12 hours, get supernatant, 200 orders filter, reclaim ethanol, it is 1.28 that filtrate is concentrated into relative density in the time of 60 DEG C, obtain cough-relieving extractum, be diluted with water to 1.5L, add xylitol, Mentholum, efficient freshener, Oleum Eucalypti, ethanol, glycerol, potassium sorbate, fully mix, aseptic filtration, filtrate subpackage, obtain.

In prescription of the present invention, the pharmaceutical component of each Chinese medicine ingredients is as follows:

Flos Lonicerae, caprifoliaceae plant Radix Ophiopogonis and belong to the dry flower of various plants together is traditional Chinese medical science common medicine, function is heat-clearing and toxic substances removing, cool dispersing wind and cold.Along with deepening continuously of chemical composition and modern pharmacology effect research, Flos Lonicerae and congener Content of Chlorogenic Acid class (comprising chlorogenic acid and isochlorogenic acid) thereof, flavonoid, triterpene saponin, iridoids, volatilization wet goods compound are proved to be its effective ingredient, have multiple pharmacological effect.

Semen Sterculiae Lychnophorae, the dry mature seed of Sterculiaceae plant Semen Sterculiae Lychnophorae Sterculia lychnophora Hance.Clearing heat and moistening lung, liyan jiedu, loosening bowel to relieve constipation.For lung-heat celostomia, dry cough without phlegm, pharyngodynia with dryness, accumulation of heat just closes, headache conjunctival congestion.

Radix Glycyrrhizae, dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. G. inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G. glabra L..There is antiinflammatory, antiviral, and protecting liver and detoxication and strengthen the effect such as immunologic function.Without serious adverse reaction, clinical be widely used in treating various acute, chronic hepatitis, bronchitis and acquired immune deficiency syndrome (AIDS) because glycyrrhizic acid has the pharmacological action of glucocorticoid sample, also there is the functions such as anti-cancer and cancer-preventing, interferon inducer and cell immunomodulator.

Semen Armeniacae Amarum, rosaceous plant Prunus armeniaca L.var.ansu Maxim., the mature fruit of gathering summer, removes sarcocarp and nucleocapsid, takes out seed, dries.Another name: Semen Armeniacae Amarum.Cure mainly function and have sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.

Semen Raphani has another name called Semen Raphani, trailing plants white chessman, Semen Raphani etc., is the mature seed of crucifer Radix Raphani.Generally cultivate all parts of the country.Enter spleen, stomach, lung meridian, the de-swelling that can help digestion, effect is remarkable, has the title of " rush wall fall wall ".Can be used for being used for the treatment of retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant stops up and breathes with cough etc.

Radix Platycodonis, the root of dicotyledon campanulaceae Campanulaceae Radix Platycodonis Platycodon grandiflorum (Jacq.) A.DC., bitter in the mouth, pungent, slightly warm in nature.Enter lung meridian.Energy expelling phlegm for arresting cough, and have lung qi dispersing, evacuation of pus effect.

Below data declaration beneficial effect of the present invention by experiment:

One, pharmacodynamic study

Experimental example 1 is treated halitosis effect experimental example

Physical data: choose because immunity, visceral dysfunction cause halitosis halitosis patient 120 examples, male's 70 examples, women's 50 examples, age 20-50 year, all without serious general systemic disease, in 2 weeks, do not take antibiotic, antibiotic medicine and stomach medicine, without serious gingivitis, periodontitis, oral mucosal disease, do not wear appliance.Get rid of the systemic disease that smoking, tumor (digestive tract, respiratory tract etc.), hepatopathy, diabetes, nephropathy, blood system and other can cause halitosis.120 routine patients are divided into experimental group cough-relieving spray group and matched group ZHIYA breath freshening spray group at random, each group basic identical in health, age, sex ratio, cough-relieving spray group is taken the treatment of embodiment 1-5 product, contrast cough-relieving spray group 1-2 takes respectively fact Example 6-7 product quality, matched group is taken ZHIYA breath freshening spray group, provided by Southern Co. LiJinJi Co., Ltd, experimental group and matched group are taken respectively for product, one for several times, each appropriate, within 30 days, be a course for the treatment of.

Criterion of therapeutical effect: clinical cure: 3 courses for the treatment of of continuous use, or 6 courses for the treatment of of intermittent use, conscious and he feel that halitosis disappears: 3 courses for the treatment of of continuous use, or 6 courses for the treatment of of intermittent use, conscious and he feel that halitosis alleviates; Invalid: 3 courses for the treatment of of continuous use, halitosis is without alleviating or increasing the weight of.Result: the comparison of two kinds of product therapeutic outcomes, in table 1.

Table 1 is treated halitosis effect table

Group	Number of cases	Clinical cure	Effectively	Invalid	Total effective rate %
						Cough-relieving spray group 1	30	13	14	3	90.0?
Cough-relieving spray group 2	10	4	3	3	70.0?
						Cough-relieving spray group 3	10	3	5	3	80.0?
Cough-relieving spray group 4	10	5	4	1	90.0?
						Cough-relieving spray group 5	10	4	4	3	80.0?
Contrast cough-relieving spray group 1	10	3	3	4	60.0
						Contrast cough-relieving spray group 2	10	2	4	4	60.0
ZHIYA breath freshening spray group	30	6	11	13	56.7

Cough-relieving spray group 1-5 and the comparison of ZHIYA breath freshening spray group, P<0.05, result has statistical significance; Therapeutic outcome comparison between cough-relieving spray group 1-5, P>0.05, not obviously difference.Illustrate cough-relieving spray of the present invention at cleaning oral cavity, keep on the basis of oral cavity fresh and cool, also there is the halitosis effect that obvious Immunosuppression, visceral dysfunction cause.

In addition, the product cough-relieving spray group 1-5 therapeutic effect contrast cough-relieving spray group 1-2 that is better than writing out a prescription outside model proportion in prescription proportion, illustrates that the present invention writes out a prescription in scope to obtain product effect optimum.

Experimental example 2 In Vitro Bacteriostasis effect experimental examples

Adopt agar dilution.Agar culture medium is mixed with spray of the present invention or JINHOUJIAN PENWUJI (Hongyu Pharmaceutical Co., Ltd., Guizhou Prov.) medicinal liquid, content is respectively 50.0,25.0,12.5,6.2,3.1,1.5,0.8,0.4mg/ml, be chilled to 50 DEG C, pour plate, agar culture medium thickness is 4mm, and inoculating loop is got bacterium liquid (concentration 10 ⁶cFU/ml) 1 articulating kind.Streptococcus adopts containing 5% Sanguis caprae seu ovis MH agar, and other bacterium are used MH agar, and each bacterial strain is established the not blank containing medicinal liquid.Put after 35 DEG C of incubators are hatched 20h and observe, using the not long bacterium person of lowest concentration of drug as this bacterial strain minimum inhibitory concentration (MIC) value.Result demonstration, blank plate all has bacterial growth, shows reliable results.Spray of the present invention all has better inhibitory action to each bacterium, and the inhibitory action of helicobacter pylori is better than to JINHOUJIAN PENWUJI, and staphylococcus aureus, escherichia coli, Candida albicans are had to stronger inhibitory action.

Two, technical study

Experimental example 3: the choice experiment of freshener

The additive that conventionally can increase refrigerant sense has, Herba Menthae, Oleum Eucalypti etc., and have on the market a variety of energy to increase refrigerant additives, majority is the derivant of Herba Menthae, select a kind of efficient freshener and Herba Menthae, Oleum Eucalypti on the market to carry out the experiment of table 2 ratio, spray is possessed keep that oral cavity ice is refreshing, the effect of breath freshening, the results are shown in Table 3.

Table 2 supplementary material prescription screening scheme

Prescription	Prescription 1	Prescription 2	Prescription 3	Prescription 4
					Medicinal liquid (ml)	120	120	120	120
Efficient freshener (mg)	0	80-120	160-220	25-3600
					Herba Menthae (mg)	0	960-1440	1920-2600	2900-4300
Oleum Eucalypti (mg)	0	62-93	124-180	200-280

By above prescription by above prescription preparating liquid, aseptic filtration, filtrate is sub-packed in (20ml/ bottle) in aerosol container, rolls lid, mouthfeel result is as table 3:

Table 3 freshener choice experiment result

Conclusion: visible, add efficient freshener 1.3-1.8mg/ml by prescription 3, Herba Menthae 16-22mg/ml, Oleum Eucalypti 1.0-1.5mg/ml, the refrigerant sense of product is more lasting, and flavour of a drug are not obvious, and mouthfeel is moderate.Be 1.7mg/ml when adding efficient refrigerant dosage, Herba Menthae 20mg/ml, when Oleum Eucalypti 1.3mg/ml, best results.

The choice experiment of experimental example 4 sweeting agents

Spray of the present invention is to be made by Chinese medicine extraction, there is heavier Chinese medicine bitterness, need add sweeting agent for improving mouthfeel, sweeting agent kind is more at present, conventional natural sweetener has glucose on the market, fructose, sucrose, maltose, starch sugar and lactose etc., but after these sweeting agents are eaten by people, in gastrointestinal, change into glucose and fructose by invertase, and for diabetics, in body, lack insulin, picked-up and the utilization of histiocyte to glucose reduced, blood sugar increasing, therefore diabetics can not use the product that contains these sweeting agents.

The antibacterial in oral cavity can convert the sucrose composition in food to acid in addition, thereby corrodes the enamel of tooth, causes decayed tooth.And xylitol can not be produced cariogenic bacterial fermentation and utilizes in oral cavity, suppress the generation of streptococcus growth and acid; Thereby reduce the acid etching of tooth, prevented the generation of dental caries and minimizing dental plaque, consolidated tooth.

Glycerol, normally as a kind of sweeting agent and moisturizing material, makes food smooth good to eat, can not change blood glucose and insulin level after absorption of human body.Can relievedly use for diabetics.

Therefore 3 prepare to obtain medicinal liquid 1 by writing out a prescription in experimental example 3, add xylitol and glycerol to test in table 4 ratio.Reduce in medicinal liquid, the bitterness of Chinese medicine, improves mouthfeel, and energy cleaning oral cavity, takes care of one's teeth simultaneously.The results are shown in Table 5

Table 4 sweeting agent kind selection scheme

Prescription	Prescription 5	Prescription 6	Prescription 7	Prescription 8
					Medicinal liquid 1(ml)	120	120	120	120
Xylitol (g)	0	9.6-14.4	19.2-28.8	36.8-55.2
					Glycerol (g)	0	4.8-7.2	9.6-14.4	19.228.8

Press above prescription preparating liquid by above prescription, aseptic filtration, filtrate is sub-packed in (20ml/ bottle) in aerosol container, rolls lid, and mouthfeel result is as follows:

Table 5 sweeting agent selection result

Conclusion: visible, add xylitol 0.16-0.24g/ml by prescription 7, glycerol-0.08-0.12g/ml, product bitterness obviously improves, and sweet taste is moderate, and mouthfeel is smooth.Be 0.2g/ml when adding xylitol consumption, when glycerol 0.1g/ml, best results.

The choice experiment of experimental example 5 antibacterial

In spray, add a certain amount of antibacterial can reach antibacterial and antiseptical effect.Prepare to obtain medicinal liquid 2 by the prescription 7 in prescription 3 and experimental example 4 in experimental example 3, in table 6 with table 7 ratio adds sodium benzoate and potassium sorbate is tested, select wherein a kind of antiseptic.The results are shown in Table 8

Table 6 antiseptic kind selection scheme

Prescription	Prescription 9	Prescription 10	Prescription 11
				Medicinal liquid 2(ml)	120	120	120
Sodium benzoate (mg)	0	96.0-144.0	192.0-288.0

Table 7 antiseptic kind selection scheme

Prescription	Prescription 12	Prescription 13	Prescription 14
				Medicinal liquid 2(ml)	120	120	120
Potassium sorbate (mg)	0	96.0-144.0	192.0-288.0

By above prescription preparating liquid, aseptic filtration, filtrate is sub-packed in (20ml/ bottle) in aerosol container, rolls lid, and mouthfeel result is as follows:

Table 8 antiseptic kind selection result

Prescription	9	10	11	12	13	14
							Fungistatic effect	Nothing	Do not reach standard-required	Reach standard-required	Nothing	Do not reach standard-required	Reach standard-required

Conclusion: visible, add sodium benzoate 1.6-2.4mg/ml and prescription 14 to add potassium sorbate 1.6-2.4mg/ml can reach the fungistatic effect of standard-required by prescription 11, in the time adding potassium sorbate amount to be 2mg/ml, best results.Because sodium benzoate has certain toxic and side effects to human body, so select safer potassium sorbate.

The choice experiment of experimental example 6 ethanol

In spray, add a certain amount of ethanol, Herba Menthae is better dissolved, do not affect mouthfeel simultaneously.By prescription 3, prescription 7, prescription 14 is prepared to obtain medicinal liquid 3, adds ethanol to test in table 9 ratio, the results are shown in Table 10

Table 10 concentration of alcohol and consumption selection scheme

Prescription	Prescription 15	Prescription 16	Prescription 17	Prescription 18	Prescription 19
						Medicinal liquid 3(ml)	120	120	120	120	120
Concentration of alcohol (%)	0	10.8-1.2	2.4-3.6	4.0-6.0	6.0-8.4
						Consumption	0	0.96-1.44	2.9-4.3	4.8-7.2	6.72-10.0

By above prescription by above prescription preparating liquid, aseptic filtration, filtrate is sub-packed in (20ml/ bottle) in aerosol container, rolls lid, mouthfeel result is as table 11:

Table 11 concentration of alcohol and consumption selection result

Conclusion: visible, the ethanol 4.8-7.2ml that adds 4-6% by prescription 18, Herba Menthae is almost dissolved, and does not affect mouthfeel, in the time adding 5% concentration of alcohol 6ml, best results.

Below, the technical characterictic of spray of the present invention is described further in conjunction with the embodiments.

Detailed description of the invention

Embodiment 1 cough-relieving spray

Composition of raw materials: 170.84 grams, Radix Glycyrrhizae, 170.84 grams of Semen Armeniacae Amarums, 53.36 grams of Semen Raphanis, 53.36 grams of Radix Platycodoniss, 53.36 grams of Flos Loniceraes, 17.9 grams of Semen Sterculiae Lychnophoraes.

Manufacture method: extracting liquorice, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Flos Lonicerae, Semen Sterculiae Lychnophorae Six-element medical material, adding 5 times of water gaging streams extracts 4 hours, Semen Sterculiae Lychnophorae is decocted a drug wrapped with 200 order filter clothes, extracting solution filters, merging filtrate, it is 1.20 that filtrate is concentrated into relative density in the time of 60 DEG C, alcohol is sink to alcohol content 70%, leave standstill 12 hours, get supernatant, 200 orders filter, reclaim ethanol, it is 1.28 that filtrate is concentrated into relative density in the time of 60 DEG C, obtain cough-relieving extractum, be diluted with water to 1.5L, add 2.5 grams of efficient fresheners, 30 grams of Herba Menthaes, 1.5 grams of Oleum Eucalyptis, 300 grams of xylitol, 150 grams of glycerol, 3 grams of potassium sorbate, 5% 75 milliliters of ethanol, aseptic filtration, filtrate subpackage, roll lid, make 75 bottles, 20 milliliters every bottle, obtain.

Embodiment 2 cough-relieving sprays

Composition of raw materials: 180.60 grams, Radix Glycyrrhizae, 180.50 grams of Semen Armeniacae Amarums, 50.30 grams of Semen Raphanis, 55.50 grams of Radix Platycodoniss, 53.30 grams of Flos Loniceraes, 15.9 grams of Semen Sterculiae Lychnophoraes.

Manufacture method: extracting liquorice, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Flos Lonicerae, Semen Sterculiae Lychnophorae Six-element medical material, adding 4 times of water gaging streams extracts 3 hours, Semen Sterculiae Lychnophorae is decocted a drug wrapped with 200 order filter clothes, extracting solution filters, merging filtrate, it is 1.10 that filtrate is concentrated into relative density in the time of 60 DEG C, alcohol is sink to alcohol content 60%, leave standstill 8 hours, get supernatant, 200 orders filter, reclaim ethanol, it is 1.25 that filtrate is concentrated into relative density in the time of 60 DEG C, obtain cough-relieving extractum, be diluted with water to 1.5L, add 2.0 grams of efficient fresheners, 25 grams of Herba Menthaes, 1.3 grams of Oleum Eucalyptis, 250 grams of xylitol, 120 grams of glycerol, 2.4 grams of potassium sorbate, 5% 60 milliliters of ethanol, aseptic filtration, filtrate subpackage, roll lid, make 75 bottles, approximately 20 milliliters every bottle, obtain.

Embodiment 3 cough-relieving sprays

Composition of raw materials: 140.85 grams, Radix Glycyrrhizae, 150.44 grams of Semen Armeniacae Amarums, 60.35 grams of Semen Raphanis, 55.70 grams of Radix Platycodoniss, 60.45 grams of Flos Loniceraes, 20.32 grams of Semen Sterculiae Lychnophoraes.

Manufacture method: extracting liquorice, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Flos Lonicerae, Semen Sterculiae Lychnophorae Six-element medical material, adding 6 times of water gaging streams extracts 5 hours, Semen Sterculiae Lychnophorae is decocted a drug wrapped with 200 order filter clothes, extracting solution filters, merging filtrate, it is 1.20 that filtrate is concentrated into relative density in the time of 60 DEG C, alcohol is sink to alcohol content 80%, leave standstill 14 hours, get supernatant, 200 orders filter, reclaim ethanol, it is 1.30 that filtrate is concentrated into relative density in the time of 60 DEG C, obtain cough-relieving extractum, be diluted with water to 1.5L, add 3 grams of efficient fresheners, 36 grams of Herba Menthaes, 1.8 grams of Oleum Eucalyptis, 360 grams of xylitol, 180 grams of glycerol, 3.6 grams of potassium sorbate, 5% 90 milliliters of ethanol, aseptic filtration, filtrate subpackage, roll lid, make 75 bottles, approximately 20 milliliters every bottle, obtain.

Embodiment 4 cough-relieving sprays

Composition of raw materials: 140.23 grams, Radix Glycyrrhizae, 200.54 grams of Semen Armeniacae Amarums, 50.68 grams of Semen Raphanis, 43.12 grams of Radix Platycodoniss, 55.26 grams of Flos Loniceraes, 20.14 grams of Semen Sterculiae Lychnophoraes.

Manufacture method: extracting liquorice, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Flos Lonicerae, Semen Sterculiae Lychnophorae Six-element medical material, adding 5 times of water gaging streams extracts 5 hours, Semen Sterculiae Lychnophorae is decocted a drug wrapped with 200 order filter clothes, extracting solution filters, merging filtrate, it is 1.15 that filtrate is concentrated into relative density in the time of 60 DEG C, alcohol is sink to alcohol content 65%, leave standstill 10 hours, get supernatant, 200 orders filter, reclaim ethanol, it is 1.28 that filtrate is concentrated into relative density in the time of 60 DEG C, obtain cough-relieving extractum, be diluted with water to 1.5L, add 2.3 grams of efficient fresheners, 25 grams of Herba Menthaes, 1.3 grams of Oleum Eucalyptis, 350 grams of xylitol, 180 grams of glycerol, 3.5 grams of potassium sorbate, 5% 85 milliliters of ethanol, aseptic filtration, filtrate subpackage, roll lid, make 75 bottles, approximately 20 milliliters every bottle, obtain.

Embodiment 5 cough-relieving sprays

Composition of raw materials: 190.20 grams, Radix Glycyrrhizae, 160.38 grams of Semen Armeniacae Amarums, 56.25 grams of Semen Raphanis, 60.15 grams of Radix Platycodoniss, 45.19 grams of Flos Loniceraes, 18.25 grams of Semen Sterculiae Lychnophoraes.

Manufacture method: extracting liquorice, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Flos Lonicerae, Semen Sterculiae Lychnophorae Six-element medical material, adding 6 times of water gaging streams extracts 4 hours, Semen Sterculiae Lychnophorae is decocted a drug wrapped with 200 order filter clothes, extracting solution filters, merging filtrate, it is 1.20 that filtrate is concentrated into relative density in the time of 60 DEG C, alcohol is sink to alcohol content 80%, leave standstill 13 hours, get supernatant, 200 orders filter, reclaim ethanol, it is 1.30 that filtrate is concentrated into relative density in the time of 60 DEG C, obtain cough-relieving extractum, be diluted with water to 1.5L, add 3 grams of efficient fresheners, 35 grams of Herba Menthaes, 1.8 grams of Oleum Eucalyptis, 250 grams of xylitol, 130 grams of glycerol, 2.5 grams of potassium sorbate, 5% 60 milliliters of ethanol, aseptic filtration, filtrate subpackage, roll lid, make 75 bottles, approximately 20 milliliters every bottle, obtain.

Embodiment 6 cough-relieving sprays

Press composition of raw materials and the preparation method preparation of embodiment 1, wherein supplementary product consumption is 1.5 grams of efficient fresheners, 15 grams of Herba Menthaes, 0.9 gram of Oleum Eucalypti, 420 grams of xylitol, 240 grams of glycerol, 4.0 grams of potassium sorbate, 110 milliliters of 5% ethanol, makes contrast cough-relieving spray 1.

Embodiment 7 cough-relieving sprays

Composition of raw materials and the preparation method preparation of pressing embodiment 1, wherein supplementary product consumption is 3.5 grams of efficient fresheners, 46 grams of Herba Menthaes, 2.6 grams of Oleum Eucalyptis, 180 grams of xylitol, 100 grams of glycerol, 1.8 grams of potassium sorbate, 50 milliliters of 5% ethanol, makes Bick is carved to spray 2.

Claims (6)

1. a Chinese medicine cough-relieving spray, primary raw material by following weight parts is made: 136.67～205.00 parts, Radix Glycyrrhizae, 136.67～205.00 parts of Semen Armeniacae Amarums, 42.69～64.03 parts of Semen Raphanis, 42.69～64.03 parts of Radix Platycodoniss, 42.69～64.03 parts of Flos Loniceraes, 14.32～21.48 parts of Semen Sterculiae Lychnophoraes, it is characterized in that: in spray composition, also contain 2.0～3.0 parts of efficient fresheners, 24～36 parts of Herba Menthaes, 1.2～1.8 parts of Oleum Eucalyptis, 240～360 parts of xylitol, 120～180 parts of glycerol, 2.4～3.6 parts of potassium sorbate, 0.06～0.09 part of 5% ethanol.

2. cough-relieving spray as claimed in claim 1, is characterized in that being made up of the stock and adjunct of following weight parts: 170.84 parts, Radix Glycyrrhizae, 170.84 parts of Semen Armeniacae Amarums, 53.36 parts of Semen Raphanis, 53.36 parts of Radix Platycodoniss, 53.36 parts of Flos Loniceraes, 17.9 parts of Semen Sterculiae Lychnophoraes, 2.5 parts of efficient fresheners, 30 parts of Herba Menthaes, 1.5 parts of Oleum Eucalyptis, 300 parts of xylitol, 150 parts of glycerol, 3 parts of potassium sorbate, 0.075 part of 5% ethanol.

3. the preparation method of the arbitrary described cough-relieving spray of claim 1～2, it is characterized in that: by formula proportion extracting liquorice, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Flos Lonicerae, Semen Sterculiae Lychnophorae Six-element medical material, adding 4～6 times of water gaging streams extracts 3～5 hours, Semen Sterculiae Lychnophorae is decocted a drug wrapped with 200 order filter clothes, extracting solution filters, merging filtrate, it is 1.10～1.20 that filtrate is concentrated into relative density in the time of 60 DEG C, alcohol is sink to alcohol content 60～80%, leave standstill 8～14 hours, get supernatant, 200 orders filter, reclaim ethanol, it is 1.25～1.30 that filtrate is concentrated into relative density in the time of 60 DEG C, obtain cough-relieving extractum, be diluted with water to 1.2～1.8L, add xylitol, Mentholum, efficient freshener, Oleum Eucalypti, ethanol, glycerol, potassium sorbate, aseptic filtration, filtrate subpackage, obtain.

4. the preparation method of a cough-relieving spray claimed in claim 3, it is characterized in that: by formula proportion extracting liquorice, Semen Armeniacae Amarum, Semen Raphani, Radix Platycodonis, Flos Lonicerae, Semen Sterculiae Lychnophorae Six-element medical material, adding 5 times of water gaging streams extracts 4 hours, Semen Sterculiae Lychnophorae is decocted a drug wrapped with 200 order filter clothes, extracting solution filters, merging filtrate, it is 1.20 that filtrate is concentrated into relative density in the time of 60 DEG C, alcohol is sink to alcohol content 70%, leave standstill 12 hours, get supernatant, 200 orders filter, reclaim ethanol, it is 1.28 that filtrate is concentrated into relative density in the time of 60 DEG C, obtain cough-relieving extractum, be diluted with water to 1.5L, add xylitol, Mentholum, efficient freshener, Oleum Eucalypti, ethanol, glycerol, potassium sorbate, aseptic filtration, filtrate subpackage, obtain.

5. the spray as described in as arbitrary in claim 1-2 have in preparation keep that the lasting ice in oral cavity is refreshing, utilization in food, medicine or the daily living article of breath freshening, cleaning oral cavity, bacteriostasis.

6. spray as claimed in claim 5 acts on the utilization in food, medicine or the daily living article of the halitosis that immunity, visceral dysfunction cause in preparation.