CN104116901A

CN104116901A - Traditional Chinese medicine preparation for treating measles

Info

Publication number: CN104116901A
Application number: CN201410391737.0A
Authority: CN
Inventors: 冯令霞; 刘秀珍
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-08-03
Filing date: 2014-08-03
Publication date: 2014-10-29

Abstract

The invention discloses a traditional Chinese medicine preparation for treating measles. The traditional Chinese medicine preparation is prepared from the following raw medicines by weight: 10g-20g of antelope horn, 10g-20g of mint, 10g-20g of platycodon grandiflorum, 10g-20g of folium mori, 10g-20g of lampwick, 10g-20g of fructus forsythia, 10g-20g of rhizoma anemarrhenae, 8g-12g of radices lithospermi, 8g-15g of radix isatidis, 8g-12g of herba ephedrae, 8g-12g of fructus crataegi, 8g-12g of rhizoma cimicifugae, 8g-12g of arctium lappa, 8g-12g of radix rehmanniae, 8g-12g of ginseng and 5g-10g of periostracum cicada. All the medicines are precisely proportioned to together play the effects of dispelling wind, relieving exterior syndrome, clearing away heat, promoting diuresis, removing toxins, promoting eruption and the like. when used for treating measles, the traditional Chinese medicine preparation has the advantages of quick effect, short course of treatment, low price, high cure rate and no side effects, and is worthy of clinic popularization and application.

Description

A kind of Chinese medicine preparation for the treatment of measles

Technical field

The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation for the treatment of measles.

Background technology

Measles is the Acute respiratory infectious disease that Measles virus causes, infectiousness is extremely strong, in area densely populated and not general kind of vaccine, easily occurs popular.Morbillivirus paramyxovirus, by respiratory secretions droplet transmission.5 years old following child of epidemic situation chief threat, adult also has morbidity within approximately 2～3 years, to occur to be once very popular.China, from nineteen sixty-five, starts, after general kind of Measles Vaccine,Live, to have controlled and be very popular.

The clinical cardinal symptom of measles occurs there is measles mucous patch on red grouper pimple and cheek mucosa with heating, upper respiratory tract infection, eye conjunctivitis and skin, and rash is stepped back and left over pigmentation companion furfur sample desquamation is feature.Chang Bingfa respiratory tract disease, as otitis media, pharyngolaryngitis, bronchitis, pneumonia etc., the severe complications such as measles encephalitis, subacute sclerosing panencephalitis, therefore should find treatment, early in order to avoid affect the state of an illness adversely.

At present aspect treatment measles, much more general adopt the antibiotic medicines such as ribavirins, or hormone and physics mode treatment, though above-mentioned therapy all can respite symptom, but cure the symptoms, not the disease, and Western medicine side effect is larger, easily makes patient produce drug resistance.Existing Chinese medicine exists onset slow mostly, and drug effect is faint, and the course for the treatment of is long, the not high defect of cure rate.

Summary of the invention

The present invention has overcome at present in the technical deficiency existing aspect treatment measles, provide a kind of instant effect, short treating period, cheap, have no side effect and Chinese medicine preparation that cure rate is high.

The technical solution adopted in the present invention is: a kind of Chinese medicine preparation for the treatment of measles, it is characterized in that, and described Chinese medicine preparation is comprised of the Chinese herb of following weight portion:

Cornu Saigae Tataricae 10-20 gram, Herba Menthae 10-20 gram, Radix Platycodonis 10-20 gram, Folium Mori 10-20 gram, lampwick 10-20 gram, Fructus Forsythiae 10-20 gram, Rhizoma Anemarrhenae 10-20 gram, Radix Arnebiae (Radix Lithospermi) 8-12 gram, Radix Isatidis 8-15 gram, numb floss 8-12 gram, Fructus Crataegi 8-12 gram, Rhizoma Cimicifugae 8-12 gram, Fructus Arctii 8-12 gram, Radix Rehmanniae 8-12 gram, Radix Ginseng 8-12 gram, Periostracum Cicadae 5-10 gram.

As this kind of prioritization scheme:

Described Chinese medicine preparation is comprised of the Chinese herb of following weight portion:

10 grams of Cornu Saigae Tataricae, 10 grams of Herba Menthaes, 10 grams of Radix Platycodoniss, 10 grams, Folium Mori, 10 grams of lampwicks, 10 grams of Fructus Forsythiaes, 10 grams of the Rhizoma Anemarrhenaes, 8 grams of Radix Arnebiae (Radix Lithospermi)s, 8 grams of Radix Isatidis, 8 grams of numb flosss, 8 grams of Fructus Crataegis, 8 grams of Rhizoma Cimicifugaes, 8 grams of Fructus Arctii, 8 grams, the Radix Rehmanniae, 8 grams of Radix Ginsengs, 5 grams of Periostracum Cicadaes.

As this kind of prioritization scheme:

15 grams of Cornu Saigae Tataricae, 15 grams of Herba Menthaes, 15 grams of Radix Platycodoniss, 15 grams, Folium Mori, 15 grams of lampwicks, 15 grams of Fructus Forsythiaes, 15 grams of the Rhizoma Anemarrhenaes, 10 grams of Radix Arnebiae (Radix Lithospermi)s, 12 grams of Radix Isatidis, 10 grams of numb flosss, 10 grams of Fructus Crataegis, 10 grams of Rhizoma Cimicifugaes, 10 grams of Fructus Arctii, 10 grams, the Radix Rehmanniae, 10 grams of Radix Ginsengs, 8 grams of Periostracum Cicadaes.

As this kind of prioritization scheme:

20 grams of Cornu Saigae Tataricae, 20 grams of Herba Menthaes, 20 grams of Radix Platycodoniss, 20 grams, Folium Mori, 20 grams of lampwicks, 20 grams of Fructus Forsythiaes, 20 grams of the Rhizoma Anemarrhenaes, 12 grams of Radix Arnebiae (Radix Lithospermi)s, 15 grams of Radix Isatidis, 12 grams of numb flosss, 12 grams of Fructus Crataegis, 12 grams of Rhizoma Cimicifugaes, 12 grams of Fructus Arctii, 12 grams, the Radix Rehmanniae, 12 grams of Radix Ginsengs, 10 grams of Periostracum Cicadaes.

The instructions of taking of above-mentioned Chinese medicine preparation is: after the raw material Chinese medicine of above-mentioned weight proportion is mixed, according to the method for the fried Chinese medicine of tradition, get its medicine juice, 1 dose of every day, minutes 2～3 times oral.5 doses was 1 course for the treatment of.

The raw material Chinese medicine of above-mentioned Chinese medicine preparation:

Cornu Saigae Tataricae, salty in the mouth, cold in nature; GUIXIN, Liver Channel.There is suppressing the hyperactive liver to relieve the wind syndrome, liver heat removing and eyesight improving, the effect of removing pathogenic heat from blood and toxic substance from the body.

Herba Menthae, acrid in the mouth, cold in nature; Return lung, Liver Channel.There is heat radiation antipruritic, clearing throat, rash removing toxic substances, the effect of dispersing the stagnated live-QI to relieve the stagnation of QI.

Radix Platycodonis, bitter in the mouth, pungent, property is flat; Return lung meridian.There is expelling phlegm for arresting cough, the effect of lung qi dispersing evacuation of pus.

Folium Mori, sweet in the mouth, hardship, cold in nature; Return lung, Liver Channel.There is dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, the effect of cooling blood for hemostasis.

Lampwick, sweet in the mouth, cold nature; GUIXIN, lung, small intestine meridian.There is relieving stranguria by diuresis, the effect of clearing away heart-fire for tranquillization.

Fructus Forsythiae, bitter in the mouth, cold nature; GUIXIN, lung, small intestine meridian.There is heat-clearing and toxic substances removing, the effect of mass dissipating and swelling eliminating.

The Rhizoma Anemarrhenae, sweet in the mouth, warm in nature; Return spleen, stomach warp.There is heart tonifying the kidney invigorating, the effect of promoting the production of body fluid to quench thirst.

Radix Arnebiae (Radix Lithospermi), sweet in the mouth, salty, cold in nature; GUIXIN, Liver Channel.There is removing heat from blood and promoting blood circulation, the effect of removing toxic substances rash.

Radix Isatidis, bitter in the mouth, cold in nature; GUIXIN, stomach warp.There is heat-clearing and toxic substances removing, the effect of removing heat from blood sore-throat relieving.

Fiber crops floss, acrid in the mouth, micro-hardship, warm in nature; Return lung, urinary bladder channel.There is relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, the effect of inducing diuresis to remove edema.

Fructus Crataegi, sour in the mouth, sweet, slightly warm in nature; Return spleen, stomach, Liver Channel.There is promoting digestion and removing stagnation, the effect of promoting blood circulation to remove blood stasis.

Rhizoma Cimicifugae, acrid in the mouth, sweet, cold nature; Return lung, spleen, stomach, large intestine channel.There is the rash of delivering, heat-clearing and toxic substances removing, the effect of elevate a turnable ladder yang-energy.

Fructus Arctii, acrid in the mouth, hardship, cold in nature; Return lung, stomach, large intestine channel.There is dispelling wind and heat pathogens, sore-throat relieving eliminating stagnation, the effect of removing toxic substances rash.

The Radix Rehmanniae, sweet in the mouth, hardship, cold in nature; GUIXIN, liver, kidney channel.There is clearing away heat and cooling blood, the effect of YIN nourishing and the production of body fluid promoting.

Radix Ginseng, sweet in the mouth, micro-hardship, property is flat; Return spleen, lung, heart channel.Have strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, invigorating the spleen to benefit the lung, the effect of promoting the production of body fluid and inducing sedation of the mind.

Periostracum Cicadae, sweet in the mouth, cold in nature; Return lung, Liver Channel.There is loose wind heat extraction, sore-throat relieving rash, the effect of nebula removing spasmolytic.

Measles, belongs to the traditional Chinese medical science " epidemic febrile disease " category, and pathogen causing measles enters from mouth, nose, and first impairing the lung is defended and then accumulate in lung stomach, sends out in skin, and treatment is sent out thoroughly when take, removing toxic substances, yin nourishing are rule for the treatment of.In Chinese medicine preparation of the present invention, Cornu Saigae Tataricae, Herba Menthae, Radix Isatidis can heat-clearing and toxic substances removing, suppressing the hyperactive liver to relieve the wind syndrome, removing heat from blood sore-throat relieving; Radix Platycodonis, numb floss can relieving the exterior syndrome by diaphoresis, inducing diuresis to remove edema; Folium Mori, Periostracum Cicadae can dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, cooling blood for hemostasis; Lampwick, Fructus Forsythiae can heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, relieving stranguria by diuresis; Radix Arnebiae (Radix Lithospermi), the Radix Rehmanniae can hot removing heat from blood, YIN nourishing and the production of body fluid promoting, removing toxic substances rash; Fructus Arctii, Rhizoma Cimicifugae, the Fructus Crataegi expelling pathogenic factors from the exterior that can help digestion, dispelling wind and heat pathogens, removing toxic substances rash; Radix Ginseng, the Rhizoma Anemarrhenae can vital energy benefiting and the kidney invigorating, YIN nourishing and the production of body fluid promoting, strengthening the body resistance; All medicines totally 5, can play heat-clearing and toxic substances removing, deliver rash, dispelling wind to relieve the exterior syndrome, and the effects such as clearing away heat-damp and promoting diuresis, can effectively improve body's immunity, and by inner and table, treating both the principal and secondary aspects of a disease, reaches the object of thorough healing measles.

For further investigating clinical efficacy and the safety of medicine of the present invention, we have selected 66 routine patients with measles to carry out clinical trial, male 32 examples wherein, female's 34 examples, age 1-15 year, patient temperature >=39 ℃ when medical, the course of disease≤3 day.All patients are divided into treatment group and matched group at random, every group of 33 examples.Two groups of patients' age, sex, body weight, sick time, disease symptom isobase data be Epidemiological Analysis by statistics, and difference not statistically significant (P > 0.05), has comparability.

Diagnostic criteria: 1., have and patients with measles contact history.2., there is measles face: heating, cough, light vexation, sneeze, watery nasal discharge, conjunctival congestion swelling of the eyelid, the many photophobias of the corner of the eyes.Dermexanthesis has a definite sequence: from both sides cheek in oral cavity, start, do not have after ear, face, neck, breast, abdomen, the back of the body, extremity, brothers' heart.3., having a blood test resembles routine blood test: total white blood cells is normal or lower, and neutrophilic granulocyte lowers, and lymphocyte increases.

Criterion of therapeutical effect

Cure: patient's erythra is eliminated, and temperature recovery is normal, without otherwise syndrome.

Effective: patient's erythra obviously reduces, body temperature normal, every syndrome has obtained obvious control.

Invalid: patient's erythra does not obviously reduce, and body temperature is still higher, and every syndrome is not eased.

Therapeutic Method:

Treatment group is taken the Chinese medicine preparation of embodiment 2, takes after adding decocting system, and 1 dose of every day, minutes 2～3 times oral.5 doses was 1 course for the treatment of.Matched group is dissolved in 5% glucose injection 100-250ml iv drip, every day 1 time with ribavirin injection (Shanghai modern Ha Sen pharmaceutcal corporation, Ltd, the accurate word of traditional Chinese medicines H9993528,10mg/mg).All treat 5 days for two groups.

Symptomatic treatment: if infant body temperature surpasses 39 ℃, continue the above person of 2h, can use nonsteroidal anti inflammatory antipyretic, can vein liquid make-up when high temperature continues.

Efficacy result

1. Clinical efficacy comparison:

After treatment, treatment group is cured 16 examples, effective 15 examples, and invalid 2 examples, effective percentage is 93.9%.Matched group is cured 7 examples, 15 examples that take a turn for the better, and invalid 11 examples, effective percentage is 66.7%.Compared significant difference for two groups, the curative effect for the treatment of group is significantly better than matched group (P < 0.05).Detailed results is in Table 1.

Table 1: the curative effect comparision result table after two groups of case treatments

Group	Number of cases	Cure n (%)	Effective n (%)	Invalid n (%)	Effective percentage n (%)
						Treatment group	33	16(48.5)	15(45.5)	2(6.1)	31(93.9)
Matched group	33	7(21.2)	15(45.5)	11(33.3)	22(66.7)

2. a liang group symptom is eliminated time comparison:

Treatment discovery, treatment group fever time and erythra, herpes of mouth regression time have been compared significant difference with matched group, and the resolution of symptoms time for the treatment of group is significantly better than matched group (P < 0.05).Detailed results is in Table 2.

Table 2: two groups of case transference cure time results of comparison tables

Group	Number of cases	Fever time	Erythra and herpes of mouth
				Treatment group	33	2.0±1.0	4.0±1.0
Matched group	33	2.5±1.0	6.5±1.0

3. bad should be compared:

Adding up the side effect reaction of two groups of patients in therapeutic process, there is not obvious adverse reaction in treatment group, and drowsiness 7 examples appear in matched group, nervous, cardiopalmus 8 examples, dizziness, malaise 4 examples.Have a blood test routine, routine urinalysis and electrocardiogram before and after two groups of treatments, all Non Apparent Abnormality.

Result shows, Chinese medicine preparation treatment measles determined curative effect of the present invention, safe and reliable, cheap, have no side effect, aspect heating, deflorescence time and clinical general curative effect, be all better than western medicine, clinic promotion and application.

The specific embodiment

Embodiment 1: a kind of Chinese medicine preparation for the treatment of measles, choose 10 grams of Cornu Saigae Tataricae, 10 grams of Herba Menthaes, 10 grams of Radix Platycodoniss, 10 grams, Folium Mori, 10 grams of lampwicks, 10 grams of Fructus Forsythiaes, 10 grams of the Rhizoma Anemarrhenaes, 8 grams of Radix Arnebiae (Radix Lithospermi)s, 8 grams of Radix Isatidis, 8 grams of numb flosss, 8 grams of Fructus Crataegis, 8 grams of Rhizoma Cimicifugaes, 8 grams of Fructus Arctii, 8 grams, the Radix Rehmanniae, 8 grams of Radix Ginsengs, 5 grams of Periostracum Cicadaes.

Embodiment 2: a kind of Chinese medicine preparation of measles, choose 15 grams of Cornu Saigae Tataricae, 15 grams of Herba Menthaes, 15 grams of Radix Platycodoniss, 15 grams, Folium Mori, 15 grams of lampwicks, 15 grams of Fructus Forsythiaes, 15 grams of the Rhizoma Anemarrhenaes, 10 grams of Radix Arnebiae (Radix Lithospermi)s, 12 grams of Radix Isatidis, 10 grams of numb flosss, 10 grams of Fructus Crataegis, 10 grams of Rhizoma Cimicifugaes, 10 grams of Fructus Arctii, 10 grams, the Radix Rehmanniae, 10 grams of Radix Ginsengs, 8 grams of Periostracum Cicadaes.

Embodiment 3: a kind of Chinese medicine preparation of measles, choose 20 grams of Cornu Saigae Tataricae, 20 grams of Herba Menthaes, 20 grams of Radix Platycodoniss, 20 grams, Folium Mori, 20 grams of lampwicks, 20 grams of Fructus Forsythiaes, 20 grams of the Rhizoma Anemarrhenaes, 12 grams of Radix Arnebiae (Radix Lithospermi)s, 15 grams of Radix Isatidis, 12 grams of numb flosss, 12 grams of Fructus Crataegis, 12 grams of Rhizoma Cimicifugaes, 12 grams of Fructus Arctii, 12 grams, the Radix Rehmanniae, 12 grams of Radix Ginsengs, 10 grams of Periostracum Cicadaes.

Below by concrete case, Chinese medicine preparation curative effect of the present invention is further verified:

Case 1

Cai, man, 7 years old.In July, 2012, patient has a fever suddenly, and body temperature continues at 38～39 ℃, and wake tears, drop tears, and cerise erythra appears in Head And Face, spreads to gradually whole body, does not itch, and infant spirit is poor, slightly cough, and without expectorant, local hospital is diagnosed as measles.By intravenous drip " albomycin " treatment, poor effect.Through friend, introduce, take Chinese medicine preparation of the present invention and treat.After 1 day, heating paresthesia disappears, and the symptoms such as cough, watery nasal discharge alleviate; Take after 3 days, measles disappears obviously, and it is normal that body temperature keeps, and the mental status greatly takes a turn for the better; Take 5, all diseases all disappear, and examination in hospital is diagnosed as recovery from illness.

Case 2

Ji, female, 6 months.In March, 2013, heating suddenly, after ear, maculopapule appears in hairline, neck surface, companion's sneeze, watery nasal discharge, dry cough, cough gradually increases the weight of, and is irritable cough, and conjunctival congestion, is measles by hospital diagnosis.First take anti-pestilence and fever powder, Radix Bupleuri, powder for clearing heat and detoxicating treatment, have no improvement.Under friend's recommendation, take Chinese medicine preparation of the present invention and treat.Take after 1 day, temperature recovery is after normal 3 days, and the symptoms such as cough, watery nasal discharge are improved; Take after 6 days, erythra all disappears, and it is normal that body temperature keeps, and all diseases all disappear, and examination in hospital is diagnosed as recovery from illness.

Case 3

Guo, man, 4 years old.In June, 2011, there is suddenly the symptoms such as heating, the existing red grouper pimple stream of skin in patient, simultaneously with cough, watery nasal discharge.By local hospital, be diagnosed as measles.Take intravenous drip after 3 days, effect is not improved.Upon somebody's introduction, take Chinese medicine preparation of the present invention and treat, take medicine after 1 day, body temperature recovers normally gradually, and after 3 days, deflorescence is obvious, and the symptoms such as cough, watery nasal discharge all disappear; Take the 5th, all diseases all disappear.Through examination in hospital, be diagnosed as recovery from illness.

Case 4

Lin, man, 17 years old.Patient appears the symptoms such as heating, rhinorrhea, cough suddenly in May, 2013, occurs special Koplik spot and skin wrinkle pimple widely, removes examination in hospital, is diagnosed as measles.By Dioxopromethazine Hydrochloride Granules, ribavirin therapy, symptom is not obviously improved, and the state of an illness has no sign of improvement.Taking upon somebody's introduction Chinese medicine preparation of the present invention treats.After 2 days, rhinorrhea, cough symptom obviously alleviate, and temperature recovery is normal; Continue to take 3, deflorescence is obvious, and cough, watery nasal discharge disappear; The after treatment in addition on the 1st that continues to take medicine, examination in hospital is diagnosed as recovery from illness.

Claims

1. a Chinese medicine preparation for the treatment of measles, is characterized in that, described Chinese medicine preparation is comprised of the Chinese herb of following weight portion:

2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is comprised of the raw material of following weight portion:

3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is comprised of the raw material of following weight portion:

4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is comprised of the raw material of following weight portion: