CN104115864A - Stable bromochlorohydantoin disinfection liquid - Google Patents
Stable bromochlorohydantoin disinfection liquid Download PDFInfo
- Publication number
- CN104115864A CN104115864A CN201410302447.4A CN201410302447A CN104115864A CN 104115864 A CN104115864 A CN 104115864A CN 201410302447 A CN201410302447 A CN 201410302447A CN 104115864 A CN104115864 A CN 104115864A
- Authority
- CN
- China
- Prior art keywords
- bcdmh
- thimerosal
- disinfection liquid
- parts
- stability according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses stable bromochlorohydantoin disinfection liquid. The stable bromochlorohydantoin disinfection liquid comprises the following components in parts by weight: 1-20 parts of bromochlorohydantoin, 0.1-15 parts of a cosolvent, 1-10 parts of a stabilizing agent, 0.1-2 parts of a synergist, 1-5 parts of a pH regulating agent and 50-90 parts of water. The stable bromochlorohydantoin disinfection liquid has the beneficial effects that the stability is far superior to the use effects of similar disinfectants in the current market, the reduction of the effective concentration of the disinfection liquid is smaller than 10% after the disinfection liquid is put into a drying oven with temperature of 54 DEG C to be preserved for 14 days, and thus the disinfection liquid can meet the stability requirement of Ministry of Health on the disinfection liquid; a surface disinfection effect is enhanced; for achieving the preferable surface disinfection effect, the synergist is added to reduce the surface tension of the disinfection liquid to be below 40 dyne/cm, so that the disinfection liquid can well wet the surfaces of microorganisms to achieve the synergistic effect.
Description
Technical field
The present invention relates to sterilization field, be specifically related to a kind of BCDMH thimerosal of stability.
Background technology
BCDMH is a kind of novel release type disinfectant, and itself has good bactericidal effect because discharging active ingredient.Effective bromine in BCDMH is the main component of killing microorganisms, and in the aqueous solution, BCDMH can be reacted with water and be generated hypobromous acid and free bromine.Hypobromous acid and free bromine have strong oxidizing property, the biology enzyme oxidation Decomposition in microbial body can be lost efficacy, thereby reach the effect of the elimination of micro-organisms.Hypobromous acid, free bromine can also with the nitrogen-containing compound generation amine bromide that reacts, still there is certain bactericidal action.As 5 of carrier, 5-dimethyl hydantion, it can be resolved into nitrogen and carbonic acid gas in the short period of time by light, oxygen, microorganism etc. under field conditions (factors), can be because of not residual and contaminated environment can not produce toxicant.So BCDMH more and more receives the concern of each sterilization industry of the whole world now.
Although BCDMH has many advantages as above, because BCDMH solvability in water is very low, dissolution velocity is slow, and the stability after being dissolved in water is very poor, so caused the utilization of present BCDMH to be subject to very large restriction.Chinese patent CN102726402A discloses BCDMH and dimethyl hydantion, chloramines bromo-amine distintegrant, and anhydrous sodium sulfates etc. are composite, solve the problem of BCDMH poorly water-soluble.But the solvability of BCDMH is still very little in this invention, said preparation is also finally to achieve the goal with slowly-releasing, does not accomplish instant.And in production process, need strict controlled humidity, and the bad control of end product quality, cost also can be very high.Chinese patent CN101755757 is by adding Peracetic acid etc. and the composite aqua disinfectant of having made BCDMH of water, but the BCDMH thimerosal concentration producing by the method is low, and poor stability can not meet the need of production in reality at all.
Summary of the invention
Goal of the invention: the solvability for bromine-chlorine-dimethyl hydantoin disinfectant in prior art is little, the problem such as dissolution velocity is slow, poor stability, bactericidal effect are poor, the object of this invention is to provide a kind of stable BCDMH thimerosal.BCDMH chemical name of the present invention is that the bromo-3-of 1-is chloro-5, and 5-dimethyl hydantoin is called for short: BCDMH, molecular formula is C
5h
6o
2n
2clBr, BCDMH is light yellow crystalline powder, be slightly soluble in water, be dissolved in chloroform, the organic solvents such as ethanol, stable when dry, in strong acid or highly basic, easily decompose, can further be processed into particle and tablet, its sterilization optimal pH is 5～7, sterilization after residue biological degradation at short notice, to environment without any pollution.BCDMH can constantly discharge Br-ion in water, forms hypobromous acid.The Microcystin oxidation Decomposition that hypobromous acid can produce algae death afterwards and losing efficacy, plays bactericidal effect.BCDMH is carboxylic acid halides class material, so cosolvent is selected amide substance, according to the similar principle mixing, amide substance can well the dissolving of hydrotropy BCDMH in water.Phosphate can make the N-Br key in BCDMH more stable, thereby makes disinfectant more stable.Synergist can reduce the surface tension of solution, is that thimerosal can better soak microorganism, makes more effectively killing microorganisms of thimerosal.PH adjusting agent is to make the pH value of thimerosal between 4～7, and this pH value scope can make the stability of thimerosal and bactericidal property all be guaranteed.
Technical scheme: in order to address the above problem, technical scheme of the present invention is to provide a kind of BCDMH thimerosal of stability, comprises by weight following component: 1～20 part of BCDMH, 0.1～15 part of cosolvent, 50～90 parts, water.
As preferably, also comprise by weight following component: 1～10 part of stabilizing agent, 0.1～2 part of synergist, 1～5 part of pH adjusting agent.A BCDMH thimerosal for stability, comprises following component by weight: 1～20 part of BCDMH, 0.1～15 part of cosolvent, 1～10 part of stabilizing agent, 0.1～2 part of synergist, 1～5 part of pH adjusting agent, 50～90 parts, water.
Wherein, above-mentioned cosolvent is one or both in urea, formamide, acetamide.
Wherein, aforementioned stable agent is one or more in sodium phosphate, sodium metaphosphate, sodium phosphate trimer or sodium polyphosphate.
Wherein, above-mentioned synergist is one or both in alkyl trimethyl ammonium halide, two alkyl dimethyl ammonium halide, benzyl trimethyl ammonium halide.
Wherein, abovementioned alkyl trimethyl-ammonium halide is Dodecyl trimethyl ammonium chloride or DTAB.
Wherein, above-mentioned pair of alkyl dimethyl ammonium halide is two dodecyl dimethyl ammonium chlorides.
Wherein, above-mentioned benzyl trimethyl ammonium halide is benzyltrimethylammonium chloride.
Wherein, above-mentioned pH adjusting agent is one or both in citric acid, tartaric acid, sodium dihydrogen phosphate, sulfuric acid, sulfamic acid, hydrochloric acid.
After above-mentioned cosolvent is dissolved in water, after adding BCDMH to mix, then add stabilizing agent, synergist and pH adjusting agent, after mixing, obtain described BCDMH thimerosal.
Beneficial effect: the solvability under the thimerosal room temperature of (1) BCDMH provided by the invention in water can be increased to 1%～20%, therefore, first the present invention has solved the problems of dissolution of BCDMH, for the sterilization that can carry out disinfection in each place of BCDMH thimerosal provides condition;
(2) stability of bromine-chlorine-dimethyl hydantoin disinfectant of the present invention is far superior to the result of use of similar disinfectant in the market.Under normal circumstances, the BCDMH thimerosal that additive method is made may not pass through the requirement of the stability experiment on disinfection technology standard (2002 editions); But the thimerosal that this method is made was placed after 14 days in the baking oven of 54 degrees Celsius, and the reduction of its valid density is less than 10%, can meet the stability requirement of the Ministry of Public Health to thimerosal;
(3) bromine-chlorine-dimethyl hydantoin disinfectant of the present invention also the effect of effects on surface sterilization carried out synergy.The present invention, in order to make bromine-chlorine-dimethyl hydantoin disinfectant can have better surface sterilization effect, adds synergist that the surface tension of disinfectant is reduced to below 40dyne/cm, thereby makes disinfectant can be good at the effect of wetting microorganism surface arrival synergy.
Embodiment
Below in conjunction with embodiment, further set forth the present invention.
Table 1 is the composition of the BCDMH thimerosal of different formulations
Table 1
Experimental example:
One, the sterilization experiment of BCDMH thimerosal:
The BCDMH thimerosal of each formula of above embodiment 1～7 is mixed with the solution of each effective bromine concentration, according to the requirement on the disinfection technology standard of the Ministry of Public Health (2002 editions), carry out the suspension quantitative disinfecting test of bacillus subtilis black variety gemma, the concentration of bacteria suspension is 1.3 × 10
8cfu/mL.Can be learnt by table 2, the disinfectant effect half an hour that effectively embodiment 7 of bromine 100mg/L fills a prescription, can meet the requirement on disinfection technology standard, than low a lot of of the concentration 2000mg/L that kills gemma of disinfectant that only has BCDMH.
The minimum concentration of killing gemma of the bromine-chlorine-dimethyl hydantoin disinfectant of each formula of table 2
Two, bromine-chlorine-dimethyl hydantoin disinfectant is at the synergism test of surface sterilization;
The bromine-chlorine-dimethyl hydantoin disinfectant of upper embodiment 1～7 various formulas is mixed with to the solution that effective bromine concentration is 400ppm, with the around-France surface tension that detects each bromine-chlorine-dimethyl hydantoin disinfectant solution of Du Nouy.Learnt by table 3, add the surface tension after synergist to be greatly reduced, can ensure wetting on oiliness surface of bromine-chlorine-dimethyl hydantoin disinfectant, thereby increase the synergy of bromine-chlorine-dimethyl hydantoin disinfectant in surface sterilization.
The surface tension of each embodiment bromine-chlorine-dimethyl hydantoin disinfectant of table 3
Three, the stability experiment of BCDMH thimerosal:
The BCDMH thimerosal of above embodiment 1～7 each formula, according to the requirement on the disinfection technology standard of the Ministry of Public Health (2002 editions), carries out fast and stable test.Can be learnt by table 4, the reduction of the concentration of embodiment 5 is less than 10%, has reached the stability requirement of Ministry of Public Health's disinfectant.
The BCDMH thimerosal of each embodiment of table 4 is the concentration rate of descent after lower 14 days at 54 degrees Celsius
The BCDMH thimerosal that the present invention obtains can dilute with arbitrary proportion with water, according to the thimerosal that need to be mixed with any concentration using, this thimerosal can apply to the sterilization of the pipe-line equipment in air sterillization, surface of solids sterilization and industrial production.
The above is only the preferred embodiment of the present invention; be noted that for those skilled in the art; under the premise without departing from the principles of the invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (9)
1. a BCDMH thimerosal for stability, is characterized in that, comprises by weight following component: 1～20 part of BCDMH, 0.1～15 part of cosolvent, 50～90 parts, water.
2. the BCDMH thimerosal of a kind of stability according to claim 1, is characterized in that, also comprises by weight following component: 1～10 part of stabilizing agent, 0.1～2 part of synergist, 1～5 part of pH adjusting agent.
3. the BCDMH thimerosal of a kind of stability according to claim 1, is characterized in that, described cosolvent is one or both in urea, formamide, acetamide.
4. the BCDMH thimerosal of a kind of stability according to claim 2, is characterized in that, described stabilizing agent is one or more in sodium phosphate, sodium metaphosphate, sodium phosphate trimer or sodium polyphosphate.
5. the BCDMH thimerosal of a kind of stability according to claim 2, is characterized in that, described synergist is one or both in alkyl trimethyl ammonium halide, two alkyl dimethyl ammonium halide, benzyl trimethyl ammonium halide.
6. the BCDMH thimerosal of a kind of stability according to claim 5, is characterized in that, described alkyl trimethyl ammonium halide is Dodecyl trimethyl ammonium chloride or DTAB.
7. the BCDMH thimerosal of a kind of stability according to claim 5, is characterized in that, described pair of alkyl dimethyl ammonium halide is two dodecyl dimethyl ammonium chlorides.
8. the BCDMH thimerosal of a kind of stability according to claim 5, is characterized in that, described benzyl trimethyl ammonium halide is benzyltrimethylammonium chloride.
9. the BCDMH thimerosal of a kind of stability according to claim 2, is characterized in that, described pH adjusting agent is one or both in citric acid, tartaric acid, sodium dihydrogen phosphate, sulfuric acid, sulfamic acid, hydrochloric acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410302447.4A CN104115864A (en) | 2014-06-27 | 2014-06-27 | Stable bromochlorohydantoin disinfection liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410302447.4A CN104115864A (en) | 2014-06-27 | 2014-06-27 | Stable bromochlorohydantoin disinfection liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104115864A true CN104115864A (en) | 2014-10-29 |
Family
ID=51761674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410302447.4A Pending CN104115864A (en) | 2014-06-27 | 2014-06-27 | Stable bromochlorohydantoin disinfection liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104115864A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104621180A (en) * | 2015-02-02 | 2015-05-20 | 山东威高药业股份有限公司 | Novel sterilization powder |
| CN104938497A (en) * | 2015-06-15 | 2015-09-30 | 山东大明消毒科技有限公司 | Dibromohydantoin disinfectant used for recycled paper production process and preparation method thereof |
| CN106889060A (en) * | 2017-03-08 | 2017-06-27 | 陕西理工学院 | A kind of preparation method of bactericide |
| CN111296458A (en) * | 2020-04-07 | 2020-06-19 | 上海中孚特种油品有限公司 | Environment-friendly high-concentration dibromohydantoin disinfectant and preparation method thereof |
| CN112586498A (en) * | 2020-12-18 | 2021-04-02 | 湖南幻影三陆零科技有限公司 | Compound disinfectant, composition containing disinfectant and application of composition |
| CN114557368A (en) * | 2022-03-09 | 2022-05-31 | 龚军旗 | Bromine-chlorine hydantoin disinfectant for soil treatment and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1788564A (en) * | 2005-12-19 | 2006-06-21 | 南京工业大学 | Sterilization disinfectant and application thereof |
| CN102197805A (en) * | 2011-04-01 | 2011-09-28 | 秦震毅 | High-concentration high-stability dibromohydantoin disinfectant |
-
2014
- 2014-06-27 CN CN201410302447.4A patent/CN104115864A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1788564A (en) * | 2005-12-19 | 2006-06-21 | 南京工业大学 | Sterilization disinfectant and application thereof |
| CN102197805A (en) * | 2011-04-01 | 2011-09-28 | 秦震毅 | High-concentration high-stability dibromohydantoin disinfectant |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104621180A (en) * | 2015-02-02 | 2015-05-20 | 山东威高药业股份有限公司 | Novel sterilization powder |
| CN104938497A (en) * | 2015-06-15 | 2015-09-30 | 山东大明消毒科技有限公司 | Dibromohydantoin disinfectant used for recycled paper production process and preparation method thereof |
| CN104938497B (en) * | 2015-06-15 | 2017-06-16 | 山东大明消毒科技有限公司 | A kind of 1,3-dibromo-5,5-dimedisinfectantn disinfectantn in the production process for recycled writing paper and preparation method thereof |
| CN106889060A (en) * | 2017-03-08 | 2017-06-27 | 陕西理工学院 | A kind of preparation method of bactericide |
| CN111296458A (en) * | 2020-04-07 | 2020-06-19 | 上海中孚特种油品有限公司 | Environment-friendly high-concentration dibromohydantoin disinfectant and preparation method thereof |
| CN112586498A (en) * | 2020-12-18 | 2021-04-02 | 湖南幻影三陆零科技有限公司 | Compound disinfectant, composition containing disinfectant and application of composition |
| CN114557368A (en) * | 2022-03-09 | 2022-05-31 | 龚军旗 | Bromine-chlorine hydantoin disinfectant for soil treatment and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102197805B (en) | High-concentration high-stability dibromohydantoin disinfectant | |
| CN104115864A (en) | Stable bromochlorohydantoin disinfection liquid | |
| CN100407923C (en) | Sterilization disinfectant and application thereof | |
| CN103891727A (en) | Preparation method of stable compound halogen organic disinfectant | |
| CN108617650A (en) | A kind of compound disinfectant and preparation method thereof | |
| BRPI0613337A2 (en) | method for controlling the growth of at least one microorganism in an aqueous system or substrate, method for killing or inhibiting the growth of microorganisms in an aqueous system or substrate, composition and method for controlling the growth of at least one microorganism | |
| JP2008505083A (en) | Stable bromine oxide composition for inhibiting biofouling, and method for producing and using the same | |
| CN107853295A (en) | A kind of controllable type sustained release air purifying preparation and preparation method thereof | |
| CN105836860B (en) | A kind of stable type dioxygen aqueous disinfectant and its application in drinking water disinfection | |
| CN108633888B (en) | A kind of sodium dichloroisocyanuratepowder powder and preparation method thereof | |
| US8691285B2 (en) | Anti-microbial applications for acidic composition of matter | |
| CN109954396A (en) | A kind of sterilizing deodorization agent of livestock and poultry cultivation | |
| JPH02104509A (en) | Aqueous bactericidal composition | |
| US20070166403A1 (en) | Method and Compound for Treating Mold | |
| CN113133462A (en) | Chlorine-containing disinfectant in low-temperature environment and preparation method thereof | |
| CN101606534B (en) | Bromine-containing disinfecting agent | |
| CN112120042A (en) | Hypochlorous acid disinfectant with efficient sterilization function and preparation method thereof | |
| CN112640912A (en) | Active oxygen composite bactericide and preparation method thereof | |
| CN105211089B (en) | A kind of Multifunctional anti-fungus antiseptic | |
| CN107079907A (en) | A kind of cationic anionic surfactant combination disinfectant technology | |
| CN106689198A (en) | Compound hydrogen peroxide disinfectant as well as preparation method and application thereof<0} | |
| CN108013072B (en) | High-efficiency sterilizing disinfectant and preparation method thereof | |
| CN104430510B (en) | A kind of chlorine-containing disinfectant with corrosion-mitigation scale-inhibition effect of stabilization | |
| CN117715525A (en) | Hypochlorite disinfectant aqueous solution with good stability and antimicrobial activity and application thereof | |
| CN114946890A (en) | Biological environment-friendly disinfectant product for efficiently killing new coronavirus and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141029 |