CN102197805A - High-concentration high-stability dibromohydantoin disinfectant - Google Patents
High-concentration high-stability dibromohydantoin disinfectant Download PDFInfo
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- CN102197805A CN102197805A CN2011100810791A CN201110081079A CN102197805A CN 102197805 A CN102197805 A CN 102197805A CN 2011100810791 A CN2011100810791 A CN 2011100810791A CN 201110081079 A CN201110081079 A CN 201110081079A CN 102197805 A CN102197805 A CN 102197805A
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- thimerosal
- stability
- high concentration
- high stability
- dibromohydantoin
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Abstract
The invention relates to high-concentration high-stability dibromohydantoin disinfectant. The high-concentration high-stability dibromohydantoin disinfectant comprises the following components in part by weight: 1 to 20 parts of dibromohydantoin, 0.1 to 10 parts of cosolvent, 1 to 10 parts of stabilizing agent, 0.1 to 2 parts of synergistic agent, 1 to 5 parts of pH regulating agent and 50 to 90 parts of water. The high-concentration high-stability dibromohydantoin disinfectant is prepared by the following steps of: dissolving the cosolvent into water; adding dibromohydantoin to mix; adding the stabilizing agent, the synergistic agent and the pH regulating agent; and mixing uniformly to obtain the dibromohydantoin disinfectant. The high-concentration high-stability dibromohydantoin disinfectant solves the problem of dissolution of the dibromohydantoin, provides conditions for sterilization in various places, has the stability more excellent than the using effect of the like disinfectant in the conventional market, and can wet the surface of microorganisms so as to achieve the synergistic effect.
Description
Technical field
The present invention relates to a kind of thimerosal, especially a kind of C5H6Br2N2O2 thimerosal of high concentration high stability.
Background technology
C5H6Br2N2O2 is the novel release property disinfectant of a class, and itself has the good sterilization effect because of discharging active ingredient.Effective bromine in the C5H6Br2N2O2 is the main component of killing microorganisms, and in the aqueous solution, C5H6Br2N2O2 can generate hypobromous acid and free bromine with the water reaction.Hypobromous acid and free bromine have strong oxidizing property, the biology enzyme oxidation Decomposition in the microbial body can be lost efficacy, thereby reach the effect of the elimination of micro-organisms.Hypobromous acid, free bromine can also with the nitrogen-containing compound generation amine bromide that reacts, still have certain bactericidal action.As 5 of carrier, the 5-dimethyl hydantion, it under field conditions (factors) can be by light, oxygen, microorganisms etc. are resolved into nitrogen and carbonic acid gas in the short period of time, can be because of residual and contaminated environment, can the toxigenicity material.So C5H6Br2N2O2 more and more receives the concern of each sterilization industry of the whole world now.
Though C5H6Br2N2O2 has many advantages as above, because C5H6Br2N2O2 solvability in water is very low, dissolution velocity is slow, and stable very poor after being dissolved in the water is so caused the utilization of present C5H6Br2N2O2 to be subjected to very large restriction.Xue Guangbo (CN1379984A) discloses C5H6Br2N2O2 and solubilizer, synergist, and disintegrants etc. are composite, solve the problem of C5H6Br2N2O2 poorly water-soluble.But the solvability of C5H6Br2N2O2 is still very little in this invention, and solid disinfecting agent in use has the harm of dust, sterilization operator's health is produced threaten.Wherein related to solubilizer in addition, disintegrant and some other auxiliary agent, it is loaded down with trivial details that technology compares, and cost also can be very high.CN10123142.8 passes through to add solubilizer, synergist, and stabilizing agent and water have been made the aqua disinfectant of C5H6Br2N2O2, but with the C5H6Br2N2O2 thimerosal poor stability that the method produces, can not have been satisfied the production needs in the reality at all.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, a kind of C5H6Br2N2O2 thimerosal of high concentration high stability is provided, in the transportation storing process, can produce safety problem, good stability, in use simple and convenient, and have good bactericidal effect.
According to technical scheme provided by the invention, the C5H6Br2N2O2 thimerosal of described high concentration high stability, its component ratio is counted by weight, comprises following component: 1～20 part of C5H6Br2N2O2,0.1～15 part of cosolvent, 1～10 part of stabilizing agent, 0.1～2 part of synergist, 1～5 part of pH regulator agent, 50～90 parts in water;
After being dissolved in cosolvent in the water, after the adding C5H6Br2N2O2 mixes, add stabilizing agent, synergist and pH regulator agent again, promptly obtain described C5H6Br2N2O2 thimerosal after mixing.
Described cosolvent is one or both in urea, dimethyl formamide (DMF), the dimethylacetylamide (DMAC).
Described stabilizing agent is a sodium polyphosphate.
Described synergist is one or both in alkyl trimethyl ammonium halide, two alkyl dimethyl ammonium halide, the benzyl trimethyl ammonium halide.
Described alkyl trimethyl ammonium halide is Dodecyl trimethyl ammonium chloride or DTAB.Described pair of alkyl dimethyl ammonium halide is benzyltrimethylammonium chloride for two described benzyl trimethyl ammonium halides of dodecyl dimethyl ammonium chloride
Described pH regulator agent is one or both in citric acid, tartaric acid, sodium dihydrogen phosphate, sulfuric acid, sulfamic acid, the hydrochloric acid.
The solvability of C5H6Br2N2O2 is 1%～20% in the described C5H6Br2N2O2 thimerosal.
After placing 14 days under 54 ℃ the condition, the concentration of C5H6Br2N2O2 reduces less than 10% in the described C5H6Br2N2O2 thimerosal.
Beneficial effect of the present invention is:
(1) the invention provides the thimerosal of C5H6Br2N2O2, under the room temperature, the solvability of C5H6Br2N2O2 in water can be increased to 1%～20%.Therefore, the present invention has at first solved the problems of dissolution of C5H6Br2N2O2, for the sterilization that can carry out disinfection in each place of C5H6Br2N2O2 thimerosal provides condition;
(2) stability of DBDMH disinfecting agent of the present invention is far superior to the result of use of similar disinfectant in the market.Under the normal condition, the C5H6Br2N2O2 thimerosal that additive method is made may not pass through the requirement of the stability experiment on the disinfection technology standard (2002 editions); But the thimerosal that this method is made was placed in 54 degrees centigrade baking oven after 14 days, and the reduction of its valid density can be satisfied the stability requirement of the Ministry of Public Health to thimerosal less than 10%;
(3) DBDMH disinfecting agent of the present invention has also carried out synergy to surperficial sterilization effects.The present invention can have better surface sterilization effect in order to make DBDMH disinfecting agent, adds synergist the surface tension of disinfectant is reduced to below the 40dyne/cm, thereby make disinfectant can be good at the effect that wetting microorganism surface arrives synergy.
Embodiment
The invention will be further described below in conjunction with specific embodiment.
C5H6Br2N2O2 chemical name of the present invention is 1,3-two bromo-5, and the 5-dimethyl hydantoin, be called for short: DBDMH, molecular formula is C
5H
6O
2N
2Br
2C5H6Br2N2O2 is a light yellow crystalline powder, be slightly soluble in water, be dissolved in chloroform, organic solvents such as ethanol, stable when dry, easily decompose in strong acid or highly basic, can further be processed into particle and tablet, its sterilization optimal pH is 5～7, the biological degradation at short notice of sterilization back residue does not have any pollution to environment.C5H6Br2N2O2 can constantly discharge Br in water
-Ion forms hypobromous acid, and reaction equation is: C
5H
6O
2N
2Br
2+ 2H
2O → C
5H
8N
2O
2+ 2HOBr.Hypobromous acid can be with the Microcystin oxidation Decomposition that produces after the algae death and was lost efficacy, and plays bactericidal effect.C5H6Br2N2O2 is a carboxylic acid halides class material, so cosolvent is selected amide substance, according to the similar principle that mixes, amide substance can well the dissolving of hydrotropy C5H6Br2N2O2 in water.Sodium polyphosphate can make the N-Br key on the C5H6Br2N2O2 more stable, thereby makes disinfectant more stable.Synergist can reduce the surface tension of solution, is that thimerosal can better wetting microorganism, makes more effectively killing microorganisms of thimerosal.The pH regulator agent is to make the pH value of thimerosal between 4～7, and this pH value scope can make the stability of thimerosal and bactericidal property all be guaranteed.
Table 1 is the composition of the C5H6Br2N2O2 thimerosal of different formulations.
Table 1
One, the sterilization experiment of C5H6Br2N2O2 thimerosal:
Be mixed with the solution of each effective bromine concentration with the C5H6Br2N2O2 thimerosal of above-mentioned each prescription, according to the requirement on the disinfection technology standard (2002 editions) of the Ministry of Public Health, carry out the suspension quantitative disinfecting test of bacillus subtilis black variety gemma, the concentration of bacteria suspension is 1.8 * 108cfu/mL.Can learn that by table 2 effectively disinfectant effect half an hour of embodiment 7 prescriptions of bromine 100mg/L can meet the requirement on the disinfection technology standard, than low a lot of of the concentration 2000mg/L that kills gemma of the disinfectant that has only C5H6Br2N2O2.
The minimum concentration of killing gemma of the DBDMH disinfecting agent of each prescription of table 2
Two, DBDMH disinfecting agent is at the synergism test of surface sterilization;
The DBDMH disinfecting agent of above-mentioned various prescriptions is mixed with the solution that effective bromine concentration is 400ppm, with the around-France surface tension that detects each DBDMH disinfecting agent solution of Du Nouy.Learn that by table 3 surface tension that adds behind the synergist is greatly reduced, can guarantee DBDMH disinfecting agent wetting on the oiliness surface, thereby increase the synergy of DBDMH disinfecting agent in surface sterilization.
The surface tension of each embodiment DBDMH disinfecting agent of table 3
Three, the stability experiment of C5H6Br2N2O2 thimerosal:
With the C5H6Br2N2O2 thimerosal of above-mentioned each prescription,, carry out the fast and stable test according to the requirement on the disinfection technology standard (2002 editions) of the Ministry of Public Health.Can learn that by table 4 reduction of the concentration of embodiment 5 has reached the stability requirement of Ministry of Public Health's disinfectant less than 10%.
The C5H6Br2N2O2 thimerosal of each embodiment of table 4 is at 54 degrees centigrade of concentration rates of descent after following 14 days
The resulting C5H6Br2N2O2 thimerosal of the present invention can dilute with arbitrary proportion with water, be mixed with the thimerosal of any concentration according to the needs that use, this thimerosal can apply to the sterilization of the pipe-line equipment in air sterillization, surface of solids sterilization and the industrial production.
Claims (10)
1. the C5H6Br2N2O2 thimerosal of a high concentration high stability, it is characterized in that, its component ratio is counted by weight, comprises following component: 1～20 part of C5H6Br2N2O2,0.1～15 part of cosolvent, 1～10 part of stabilizing agent, 0.1～2 part of synergist, 1～5 part of pH regulator agent, 50～90 parts in water;
After being dissolved in cosolvent in the water, after the adding C5H6Br2N2O2 mixes, add stabilizing agent, synergist and pH regulator agent again, promptly obtain described C5H6Br2N2O2 thimerosal after mixing.
2. the C5H6Br2N2O2 thimerosal of high concentration high stability as claimed in claim 1 is characterized in that: described cosolvent is one or both in urea, dimethyl formamide, the dimethylacetylamide.
3. the C5H6Br2N2O2 thimerosal of high concentration high stability as claimed in claim 1 is characterized in that: described stabilizing agent is a sodium polyphosphate.
4. the C5H6Br2N2O2 thimerosal of high concentration high stability as claimed in claim 1 is characterized in that: described synergist is one or both in alkyl trimethyl ammonium halide, two alkyl dimethyl ammonium halide, the benzyl trimethyl ammonium halide.
5. the C5H6Br2N2O2 thimerosal of high concentration high stability as claimed in claim 1 is characterized in that: described pH regulator agent is one or both in citric acid, tartaric acid, sodium dihydrogen phosphate, sulfuric acid, sulfamic acid, the hydrochloric acid.
6. the C5H6Br2N2O2 thimerosal of high concentration high stability as claimed in claim 4 is characterized in that: described alkyl trimethyl ammonium halide is Dodecyl trimethyl ammonium chloride or DTAB.
7. the C5H6Br2N2O2 thimerosal of high concentration high stability as claimed in claim 4 is characterized in that: described pair of alkyl dimethyl ammonium halide is two dodecyl dimethyl ammonium chlorides.
8. the C5H6Br2N2O2 thimerosal of high concentration high stability as claimed in claim 4 is characterized in that: described benzyl trimethyl ammonium halide is a benzyltrimethylammonium chloride.
9. the C5H6Br2N2O2 thimerosal of high concentration high stability as claimed in claim 1 is characterized in that: the solvability of C5H6Br2N2O2 is 1%～20% in the described C5H6Br2N2O2 thimerosal.
10. the C5H6Br2N2O2 thimerosal of high concentration high stability as claimed in claim 1 is characterized in that: after placing 14 days under 54 ℃ the condition, the concentration of C5H6Br2N2O2 reduces less than 10% in the described C5H6Br2N2O2 thimerosal.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102613171A (en) * | 2012-03-12 | 2012-08-01 | 莫光浩 | Application of sulfamate in preparing halogenated dialkyl hydantoin disinfectant and disinfectant of sulfamate |
| CN104115864A (en) * | 2014-06-27 | 2014-10-29 | 江苏丽莎环保科技有限公司 | Stable bromochlorohydantoin disinfection liquid |
| CN104938497A (en) * | 2015-06-15 | 2015-09-30 | 山东大明消毒科技有限公司 | Dibromohydantoin disinfectant used for recycled paper production process and preparation method thereof |
| CN105379719A (en) * | 2015-10-08 | 2016-03-09 | 山东大明消毒科技有限公司 | Preparation method of high-stability dibromohydantoin disinfection solution |
| CN106698640A (en) * | 2017-01-14 | 2017-05-24 | 冯志祥 | Wastewater deodorant and preparation method thereof |
| CN106889060A (en) * | 2017-03-08 | 2017-06-27 | 陕西理工学院 | A kind of preparation method of bactericide |
| CN107162129A (en) * | 2017-06-02 | 2017-09-15 | 兴化市恒威生物技术有限公司 | A kind of water quality of aquaculture pond inorganic agent |
| CN111296458A (en) * | 2020-04-07 | 2020-06-19 | 上海中孚特种油品有限公司 | Environment-friendly high-concentration dibromohydantoin disinfectant and preparation method thereof |
| CN112586498A (en) * | 2020-12-18 | 2021-04-02 | 湖南幻影三陆零科技有限公司 | Compound disinfectant, composition containing disinfectant and application of composition |
| CN113412837A (en) * | 2021-07-14 | 2021-09-21 | 江南大学 | High-solubility binary disinfection powder combination product and preparation method and application thereof |
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| CN1164177C (en) * | 2002-04-11 | 2004-09-01 | 上海海金消毒技术有限公司 | Application of dibromodimethyl hydantoin as disinfectant |
| CN1682592A (en) * | 2004-04-15 | 2005-10-19 | 李新建 | Preparation of sterilizing agent using nano material as carrier and use |
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2011
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Patent Citations (3)
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| CN1164177C (en) * | 2002-04-11 | 2004-09-01 | 上海海金消毒技术有限公司 | Application of dibromodimethyl hydantoin as disinfectant |
| CN1682592A (en) * | 2004-04-15 | 2005-10-19 | 李新建 | Preparation of sterilizing agent using nano material as carrier and use |
| CN101103728A (en) * | 2007-08-17 | 2008-01-16 | 王安林 | Agricultural sterilizing and disinfecting composition, preparation method and application thereof |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102613171A (en) * | 2012-03-12 | 2012-08-01 | 莫光浩 | Application of sulfamate in preparing halogenated dialkyl hydantoin disinfectant and disinfectant of sulfamate |
| CN104115864A (en) * | 2014-06-27 | 2014-10-29 | 江苏丽莎环保科技有限公司 | Stable bromochlorohydantoin disinfection liquid |
| CN104938497A (en) * | 2015-06-15 | 2015-09-30 | 山东大明消毒科技有限公司 | Dibromohydantoin disinfectant used for recycled paper production process and preparation method thereof |
| CN104938497B (en) * | 2015-06-15 | 2017-06-16 | 山东大明消毒科技有限公司 | A kind of 1,3-dibromo-5,5-dimedisinfectantn disinfectantn in the production process for recycled writing paper and preparation method thereof |
| CN105379719A (en) * | 2015-10-08 | 2016-03-09 | 山东大明消毒科技有限公司 | Preparation method of high-stability dibromohydantoin disinfection solution |
| CN105379719B (en) * | 2015-10-08 | 2018-03-27 | 山东大明消毒科技有限公司 | A kind of preparation method of high stable 1,3-dibromo-5,5-dimedisinfectantn disinfectantn |
| CN106698640A (en) * | 2017-01-14 | 2017-05-24 | 冯志祥 | Wastewater deodorant and preparation method thereof |
| CN106889060A (en) * | 2017-03-08 | 2017-06-27 | 陕西理工学院 | A kind of preparation method of bactericide |
| CN107162129A (en) * | 2017-06-02 | 2017-09-15 | 兴化市恒威生物技术有限公司 | A kind of water quality of aquaculture pond inorganic agent |
| CN111296458A (en) * | 2020-04-07 | 2020-06-19 | 上海中孚特种油品有限公司 | Environment-friendly high-concentration dibromohydantoin disinfectant and preparation method thereof |
| CN112586498A (en) * | 2020-12-18 | 2021-04-02 | 湖南幻影三陆零科技有限公司 | Compound disinfectant, composition containing disinfectant and application of composition |
| CN113412837A (en) * | 2021-07-14 | 2021-09-21 | 江南大学 | High-solubility binary disinfection powder combination product and preparation method and application thereof |
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| CN102197805B (en) | 2013-08-28 |
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