CN103891727A - Preparation method of stable compound halogen organic disinfectant - Google Patents

Preparation method of stable compound halogen organic disinfectant Download PDF

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Publication number
CN103891727A
CN103891727A CN 201210566221 CN201210566221A CN103891727A CN 103891727 A CN103891727 A CN 103891727A CN 201210566221 CN201210566221 CN 201210566221 CN 201210566221 A CN201210566221 A CN 201210566221A CN 103891727 A CN103891727 A CN 103891727A
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sodium
disinfectant
anhydrous sodium
dbdmh
halogen compound
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CN 201210566221
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Chinese (zh)
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陈新
姚竣耀
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南京莱因医药科技有限公司
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Abstract

The invention discloses a preparation method of a stable compound halogen organic disinfectant. The stable compound organic disinfectant provided by the invention comprises main effective components of 1,3-dibromo-5,5-dimethylhydantoin (or 1,3-dichloro-5,5-dimethylhydantoin or 1-bromo-3-chloro-5,5-dimethylhydantoin) and trichloroisocyanuric acid (or sodium dichloroisocyanurate); necessary auxiliary additives (anhydrous sodium sulfate, sodium chloride or sodium bromide, sodium carbonate or sodium bicarbonate and sodium alkyl benzene sulfonate) are added; and dosage forms include powder, granules and tablets.

Description

一种稳定的复方卤素有机消毒剂的制备方法 The method of preparing a stable organic halogen compound disinfectant

技术领域 FIELD

[0001] 本发明涉及有机化学领域,具体而言涉及到一种稳定的复方卤素有机消毒剂的制备方法。 [0001] The present invention relates to the field of organic chemistry, specifically relates to a method for preparing a stable organic halogen compound disinfectant.

背景技术 Background technique

[0002] 卤素有机化合物二溴海因和三氯异氰尿酸都是一种国际上公认推荐的一种外用广谱消毒、灭菌、杀藻除臭剂。 [0002] halogenated organic compounds DBDMH and TCCA is a kind of internationally recognized recommended a topical broad-spectrum disinfection, sterilization, kill algae deodorant. 广泛用于饮用水消毒、宾馆、饭店、医院的消毒灭菌。 Widely used for drinking water disinfection, hotels, restaurants, hospitals and sterilization.

[0003] 二溴海因在水中能通过溶解不断的释放出新生态Br离子,生成具有强氧化性的次溴酸.将微生物体内的生物酶氧化分解而失效,起到很强的杀菌效果,广泛用于工业用水处理系统、室内外游泳(浴)池、卫生系统及养殖水环境的消毒处理.可杀死多种病菌及病毒.可预防及治疗由于细菌及病毒引发有水产养殖动物疾病.使用后的残留物是5, [0003] DBDMH was dissolved in water can continue to release new ecological Br ion, hypobromous acid generating a strong oxidizing The enzymatic oxidation in vivo biodegradable and microorganisms fail, play a strong bactericidal effect, widely used in industrial water treatment systems, indoor and outdoor swimming (bath) pool, health systems and breeding water disinfection environment. can kill a variety of bacteria and viruses may be due to the prevention and treatment of bacterial and viral diseases of aquaculture animals have caused. residue after 5 is used,

5- 二甲基海因,为碳、氢、氧化合物.对环境无任何残留毒害作用,不破坏水质环境。 5- dimethyl hydantoin, carbon, hydrogen, oxygen compounds. Without any residual toxic effects on the environment, does not destroy the water quality.

[0004] 三氯异氰尿酸溶解于水生成新生态Cl离子,形成具有强氧化次氯酸,可使病原菌的蛋白质氧化变性致死。 [0004] Trichloroisocyanuric acid was dissolved in water to generate a new Eco Cl ion, hypochlorous acid is formed having a strong oxidation, oxidative denaturation of proteins can lethal pathogens. 杀菌效果相当于漂白粉的80-100倍,它能快速地杀灭各种细菌繁殖体、病毒、真菌、芽孢及藻类微生物等。 Bleach bactericidal effect equivalent to 80-100 times, it can quickly kill all bacteria, viruses, fungi, and algae spores and other microorganisms. 广泛用于工业用水处理系统、室内外游泳(浴)池、卫生系统及养殖水环境的消毒处理.可杀死多种病菌及病毒,可预防及治疗由于细菌及病毒引发有水产养殖动物疾病.。 Widely used in industrial water treatment systems, indoor and outdoor swimming (bath) pool, health systems and breeding water disinfection environment. Can kill a variety of bacteria and viruses, can prevent and treat because the bacteria and viruses have caused aquaculture animal diseases. . 使用三氯异氰尿酸水处理后,对人体无毒性影响,其释放有效氯后的残留物异氰尿酸,被微生物分解成氮气和二氧化碳,故无残留物和残毒。 After using trichloroisocyanuric acid treatment, no toxic effects on the human body, which is released after the chlorine residue isocyanurate, microorganisms are decomposed into nitrogen and carbon dioxide, so no residues and residues. 以上两者都具有安全、无残留和用量少、节时省力成本低等特点。 Both are above safe, no residue and with less effort and low cost while section. 特别是能氧化鸭毛羽绒中含有的巯基而除去臭味,使羽绒服装消毒清洁无异味。 In particular, capable of oxidizing a mercapto group contained in duckwool down to remove the odor, so that no disinfection odor down clothing.

[0005] 二溴海因和三氯异氰尿酸,在干燥密闭状态下时比较稳定,但是易吸潮,遇到水或空气中的湿气,容易分解,严重影响其药效,因其稳定性差也不易运输保存,影响其推广使用。 [0005] DBDMH and trichloroisocyanuric acid, relatively stable when confined in a dry state, but easy to absorb moisture, is subjected to water or moisture in the air, easily decomposed seriously affect its efficacy, its stability poor transportation is not easy to save, promote the use of its influence.

[0006] 二溴海因在水中溶解度为0.12克/100克(20°C),0.1 %水溶液的pH值为2.6 ;三氯异氰尿酸在水中溶解度为1.2克/100克(25°C ).I %水溶液pH值为2.3-2.9,即都在水中溶解度低,而且有较强的腐蚀性。 [0006] DBDMH solubility in water of 0.12 g / 100 g (20 ° C), pH 0.1% aqueous solution is 2.6; trichloroisocyanuric acid solubility in water of 1.2 g / 100 g (25 ° C) .I% aqueous solution pH 2.3-2.9, i.e. have a low solubility in water, and there is a strong corrosive. 这些性质限制了二溴海因和三氯异氰尿酸的利用率。 These properties limit the DBDMH and TCCA utilization.

发明内容 SUMMARY

[0007] 本发明的技术方案为:一种复方稳定的卤素有机消毒剂的制备,其特征在于消毒剂主要有效成分是卤素有机化合物二溴海因(或二氯海因,或氯溴海因)和三氯异氰尿酸(或二氯异氰尿酸钠)。 [0007] aspect of the present invention is: preparing an organic halogen compound stable disinfectant, characterized in that the main active ingredient is a halogenated organic compounds disinfectant DBDMH (or dichloro hydantoin, chlorine or bromine hydantoin ) and trichloroisocyanuric acid (or sodium dichloroisocyanurate). 二者总有效含量20-38%或45-55%,用于不同水质处理、环境卫生和羽绒羊绒处理。 The total effective content of 20-38%, 45-55%, or both, for different water treatment, sanitation and feather cashmere processing.

[0008] 其次,本发明在复方卤素制剂中添加辅料助剂,其特征在于:干燥稳定剂无水硫酸钠能吸收主要药剂已经吸附的水分生成五个结晶水硫酸钠;分散剂氯化钠或溴化钠能使主要药剂均匀分散;助溶剂无水碳酸钠或无水碳酸氢钠偏碱性能与主要药剂成有机酸钠盐,增加溶解度;使复方卤素有机制剂I %水溶液酸碱度PH5.5-7.0,适用各种水质和场所;增效剂烷基苯磺酸钠本身就是清洁剂。 [0008] Next, the present invention is a halogen compound added adjuvant formulation auxiliaries, characterized in that: the stabilizer dried over anhydrous sodium sulfate and capable of absorbing agent have mainly adsorbed moisture generating five crystalline water sulphate; sodium chloride or dispersant sodium bromide can uniformly disperse the main drug; cosolvent anhydrous sodium carbonate or anhydrous sodium bicarbonate or organic alkaline salt and can become the primary medicament, increase solubility; the organic halogen compound so that the formulation I% aqueous solution pH PH5.5- 7.0, for a variety of water and place; synergist benzene sulfonate itself is cleaner. 本发明克服了单一成分二溴海因和单一成分三氯异氰尿酸易吸潮,稳定性差和水中溶解度小的等缺陷,充分发挥卤素有机消毒剂的药效和增加利用率,拓宽了使用范围。 The present invention overcomes the single components and a single component DBDMH TCCA hygroscopic, poor stability and low solubility in water and other defects, halo full efficacy and increase the utilization of organic disinfectants, broadens the scope of .

[0009] 进一步,本发明提出的复方卤素有机消毒剂基本配方,其特征在于: [0009] Further, the organic halogen compound disinfectant basic formulation proposed by the present invention, wherein:

[0010] ①氯化钠(或溴化钠) 2OKg [0010] ① chloride (or sodium bromide) 2OKg

[0011] ②二溴海因(或溴氯海因或二氯海因) 1O--2OKg [0011] ② DBDMH (or BCDMH or hydantoin-dichlorophenyl) 1O - 2OKg

[0012] ③三氯异氰尿酸(或二氯异氰尿酸钠) 12--35Kg [0012] ③ trichloroisocyanuric acid (or sodium dichloroisocyanurate) 12--35Kg

[0013] ④无水硫酸钠 24Kg [0013] ④ over anhydrous sodium 24Kg

[0014] ⑤无水碳酸钠(或无水碳酸氢钠) 18Kg [0014] ⑤ anhydrous sodium carbonate (anhydrous or sodium bicarbonate) 18Kg

[0015] ⑥烷基苯磺酸钠 2Kg [0015] ⑥ benzene sulfonate 2Kg

[0016] 再进一步,将上述配方中主要有效成分和助剂粉碎,充分混合均匀,并制成粉末,颗粒和片剂。 [0016] Still further, the main active ingredient in the above formulation auxiliaries and pulverized, mixed well, and made into powders, granules and tablets. 生产的剂型包括粉末(100-120目);加入必要的粘合剂制成颗粒(20-30目/30-60目);加入必要的粘合剂和赋型剂制成片剂(I克/片、2克/片,5克/片)。 Production of dosage forms include powder (100-120 mesh); adding the necessary binder into granules (20-30 mesh / 30-60 mesh); adding necessary excipients and binders and formed into tablets (I g / plate, 2 g / plate, 5 g / sheet).

[0017] 本发明的优点为:复方卤素有机化合物消毒剂具有明显稳定、广谱、低毒,几乎无二次污染等功能和特点。 Advantages [0017] of the present invention are: halogenated organic compounds disinfectant compound having apparently stable, broad spectrum, low toxicity, little secondary pollution functions and features. 本发明的复方杀菌消毒剂适用于:水产养殖、水库、澡堂;禽兽养殖、游泳池、医院;羽绒、羊绒、羊毛、污水、湖泊蓝藻和公共场所处理等。 Bactericidal disinfectant compound of the present invention is suitable for: aquaculture, reservoirs, baths; animal breeding, swimming pool, hospital; duvets, cashmere, wool, water, lakes, cyanobacteria and public spaces treatment. 复方卤素有机化合物消毒剂有效地克服了以往单一的三氯异氰尿酸制剂或单一的二溴海因制剂的局限性。 Limitations of halogenated organic compounds disinfectant compound effectively overcome the conventional single trichloroisocyanuric acid formulations or a single formulation DBDMH.

具体实施方案 Specific embodiments

[0018] 下面通过实施例对本发明作进一步说明,而不是对本发明的限制;对本发明的复方配方成分或质量配比稍作改变而生产销售,都可能被认为是对本发明的侵权。 [0018] The following examples further illustrate the invention, not limitation of the present invention; mass composition or formulation of compound of the invention production and sales ratio slightly changes, may be considered as infringement of the present invention.

[0019] 实施例一 [0019] Example a

[0020] 配方一:有效含量20-25% (水产养殖,水库,澡堂等) [0020] Formulation a: Effective content of 20-25% (aquaculture, reservoir, bath, etc.)

[0021] ①氯化钠 20Kg [0021] ① chloride 20Kg

[0022] ②二溴海因 IOKg [0022] ② DBDMH IOKg

[0023] ③三氯异氰尿酸12Kg [0023] ③ TCCA 12Kg

[0024] ④无水硫酸钠38Kg [0024] ④ over anhydrous sodium 38Kg

[0025] ⑤无水碳酸钠 18Kg [0025] ⑤ anhydrous sodium carbonate 18Kg

[0026] ⑥烷基苯磺酸钠2Kg [0026] ⑥ sodium alkylbenzenesulfonate 2Kg

[0027] 实施例二 [0027] Second Embodiment

[0028] 配方二:有效含量28-32% (禽兽养殖,游泳池,医院等) [0028] formula II: Effective content 28-32% (animal breeding, swimming pools, hospitals, etc.)

[0029] ①氯化钠 20Kg [0029] ① chloride 20Kg

[0030] ②二溴海因 12Kg [0030] ② DBDMH 12Kg

[0031] ③三氯异氰尿酸18Kg [0031] ③ TCCA 18Kg

[0032] ④无水硫酸钠30Kg [0032] ④ over anhydrous sodium 30Kg

[0033] ⑤无水碳酸钠 18Kg [0033] ⑤ anhydrous sodium carbonate 18Kg

[0034] ⑥烷基苯磺酸钠2Kg [0034] ⑥ benzene sulfonate 2Kg

[0035] 实施例三 [0035] Example three

[0036] 配方三:有效含量35-38% (羽绒、羊绒、羊毛等)[0037] ①氯化钠 20Kg [0036] Formulation III: Effective content of 35-38% (down, cashmere, wool, etc.) [0037] ① chloride 20Kg

[0038] ②二溴海因 16Kg [0038] ② DBDMH 16Kg

[0039] ③三氯异氰尿酸 20Kg [0039] ③ TCCA 20Kg

[0040] ④无水硫酸钠 24Kg [0040] ④ over anhydrous sodium 24Kg

[0041] ⑤无水碳酸钠 18Kg [0041] ⑤ anhydrous sodium carbonate 18Kg

[0042] ⑥烷基苯磺酸钠 2Kg [0042] ⑥ benzene sulfonate 2Kg

[0043] 实施例四 [0043] Fourth Embodiment

[0044] 配方四:有效含量45-55% (公共场所,卫生系统,污水处理等) [0044] formula IV: Effective content 45-55% (in public places, health systems, sewage treatment, etc.)

[0045] ①溴化钠 IOKg [0045] ① sodium bromide IOKg

[0046] ②溴氯海因 20Kg [0046] ② BCDMH 20Kg

[0047] ③二氯异氰尿酸钠30Kg [0047] ③ sodium dichloroisocyanurate 30Kg

[0048] ④无水硫酸钠 28Kg [0048] ④ over anhydrous sodium 28Kg

[0049] ⑤无水碳酸氢钠 IOKg [0050] ⑥烷基苯磺酸钠 2Kg。 [0049] ⑤ anhydrous sodium bicarbonate or IOKg [0050] ⑥ benzene sulfonate 2Kg.

Claims (4)

  1. 1.一种稳定的复方卤素有机消毒剂的制备方法。 A method for preparing stabilized organic halogen compound disinfectant. 本发明的技术方案为:一种复方稳定高效几乎无二次污染杀菌消毒剂的制备,其主要有效成分是卤素有机化合物和助剂辅料,制成粉末,颗粒和片剂三种剂型。 Aspect of the present invention is: A COMPOUND almost stable and efficient disinfectant prepared without secondary pollution, the main active ingredient is a halogenated organic compounds and auxiliary materials, a powder, granules and tablets of three formulations.
  2. 2.根据权利要求1,复方卤素消毒剂主要有效成分卤素有机化合物为:二溴海因,或二氯海因,或氯溴海因;三氯异氰尿酸,或二氯异氰尿酸钠。 According to claim 1, the main active ingredient compound of a halogen disinfectant halogenated organic compounds: DBDMH, or dichloro hydantoin, chlorine or bromine hydantoin; trichloroisocyanuric acid or sodium dichloroisocyanurate. 总有效含量20-38%或45-55%。 The total effective content of 20-38% or 45-55%. 复方卤素有机消毒剂基本配方: ①氯化钠(或溴化钠) 2OKg ②二溴海因(或溴氯海因或二氯海因) 10—20Kg ③三氯异氰尿酸(或二氯异氰尿酸钠) 12—35Kg ④无水硫酸钠 24Kg ⑤无水碳酸钠(或无水碳酸氢钠) 18Kg ⑥烷基苯磺酸钠 2Kg。 The organic halogen compound disinfectant basic recipe: ① chloride (or sodium bromide) 2OKg ② DBDMH (or BCDMH or hydantoin-dichlorophenyl) 10-20Kg ③ TCCA (or dichloroisocyanurate sodium cyanurate) 12-35Kg ④ 24Kg ⑤ over anhydrous sodium sulfate anhydrous sodium carbonate (anhydrous or sodium bicarbonate) 18Kg ⑥ sodium alkylbenzenesulfonate 2Kg.
  3. 3.根据权利要求1-2,复方卤素有机消毒剂的助剂分别是:干燥稳定剂无水硫酸钠,分散剂氯化钠或溴化钠,助溶剂无水碳酸钠或无水碳酸氢钠,增效剂烷基苯磺酸钠。 According to claim 1-2, an organic halogen compound disinfectant additives are: stabilizers dried over anhydrous sodium sulfate, sodium chloride or sodium bromide dispersants, solubilizers anhydrous sodium carbonate or anhydrous sodium bicarbonate or synergist LAS.
  4. 4.根据权利要求1-3 ,复方卤素有机消毒剂制成三种剂型;粉末(100-120目),颗粒(20-30目,30-60目)和片剂(I克/片、2克/片,5克/片)。 According to claim 1-3, an organic halogen compound disinfectant prepared three formulations; powder (100-120 mesh), granules (20-30 mesh, 30-60 mesh) and tablet (I g / piece 2 g / plate, 5 g / sheet).
CN 201210566221 2012-12-25 2012-12-25 Preparation method of stable compound halogen organic disinfectant CN103891727A (en)

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Publication number Priority date Publication date Assignee Title
CN105379719A (en) * 2015-10-08 2016-03-09 山东大明消毒科技有限公司 Preparation method of high-stability dibromohydantoin disinfection solution
CN106342819A (en) * 2016-08-30 2017-01-25 濮阳可利威化工有限公司 Fishery water quality stabilizer
CN106675797A (en) * 2016-12-26 2017-05-17 李心 Chlorine-containing compound disinfectant detergent and preparation method thereof

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EP1486541A1 (en) * 2003-06-11 2004-12-15 Hewlett-Packard Development Company, L.P. Pigment-based ink-jet systems with polyurethane binder and crashing agent
CN1836514A (en) * 2005-03-25 2006-09-27 高旭 Novel disinfection and slow-release composition containing BCDMH and its preparation method
CN101103728A (en) * 2007-08-17 2008-01-16 王安林 Agricultural sterilizing and disinfecting composition, preparation method and application thereof
CN102258018A (en) * 2011-05-30 2011-11-30 河南黑马动物药业有限公司 A COMPOUND effervescent tablet and preparation method for disinfecting

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1486541A1 (en) * 2003-06-11 2004-12-15 Hewlett-Packard Development Company, L.P. Pigment-based ink-jet systems with polyurethane binder and crashing agent
CN1836514A (en) * 2005-03-25 2006-09-27 高旭 Novel disinfection and slow-release composition containing BCDMH and its preparation method
CN101103728A (en) * 2007-08-17 2008-01-16 王安林 Agricultural sterilizing and disinfecting composition, preparation method and application thereof
CN102258018A (en) * 2011-05-30 2011-11-30 河南黑马动物药业有限公司 A COMPOUND effervescent tablet and preparation method for disinfecting

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105379719A (en) * 2015-10-08 2016-03-09 山东大明消毒科技有限公司 Preparation method of high-stability dibromohydantoin disinfection solution
CN105379719B (en) * 2015-10-08 2018-03-27 山东大明消毒科技有限公司 The method of preparing a highly stable disinfectant DBDMH
CN106342819A (en) * 2016-08-30 2017-01-25 濮阳可利威化工有限公司 Fishery water quality stabilizer
CN106675797A (en) * 2016-12-26 2017-05-17 李心 Chlorine-containing compound disinfectant detergent and preparation method thereof

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