CN105211089B - A kind of Multifunctional anti-fungus antiseptic - Google Patents
A kind of Multifunctional anti-fungus antiseptic Download PDFInfo
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- CN105211089B CN105211089B CN201510613143.4A CN201510613143A CN105211089B CN 105211089 B CN105211089 B CN 105211089B CN 201510613143 A CN201510613143 A CN 201510613143A CN 105211089 B CN105211089 B CN 105211089B
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Abstract
The invention discloses a kind of Multifunctional anti-fungus antiseptic, include the raw material of following parts by weight：7~18 parts of guanidine bactericides；25~37 parts of ethanol；60~80 parts of water.As an improvement, guanidine bactericides are made of polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride, the additive amount of the polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride is 4~10:3~8.The Multifunctional anti-fungus antiseptic of the present invention is safe to use, is non-toxic product, is a kind of environment-friendly type antimildew and antibacterial agent, bactericidal range is wide, has extremely strong destroying microorganisms ability, has good insect killing effect to bacterium and fungi.
Description
Technical field
The invention belongs to sterilization technology field, and in particular to a kind of Multifunctional anti-fungus antiseptic.
Background technology
In leather and fur products, textile, ready-made clothes, toy, sports equipment, electronic product, the storage of footwear, transportational process
In, the antimildew and antibacterial agent function that generally uses is single, it is troublesome, cumbersome to prepare, using effect limitation is big, toxicity is bigger than normal, imitates
Fruit is undesirable etc., and the antimildew and antibacterial agent of certain material uses the discoloration that product is caused on other materials, damage, and mould proof anti-
The problems such as significantly decrease of bacterium effect.In addition, most of medicament using the principles of chemistry can make microorganism produce drug resistance, necessarily
The antimildew and antibacterial effect failure of the medicament after the time.In addition, most of medicament poison that antimildew and antibacterial is carried out using the principles of chemistry
Property is bigger than normal, remains in product surface, there are security risk for Long Term Contact；The people operated with for directly carrying out antimildew and antibacterial agent
Member, also easily causes security risk.
The content of the invention
The purpose of the invention is to overcome drawbacks described above, there is provided a kind of more work(safe, antimildew and antibacterial effect is good
Can antimildew and antibacterial agent.
The technical proposal of the invention is realized in this way：A kind of Multifunctional anti-fungus antiseptic, includes the original of following parts by weight
Material：7~18 parts of guanidine bactericides；25~37 parts of ethanol；60~80 parts of water.
Preferably, the raw material of following parts by weight is included：18 parts of guanidine bactericides；30 parts of ethanol；80 parts of water.
Preferably, the raw material of following parts by weight is included：12 parts of guanidine bactericides；25 parts of ethanol；70 parts of water.
Preferably, 3~5 parts of the sodium pyrithione of parts by weight is further included.
Further, the guanidine bactericides are made of polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride,
The addition of the polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride is compared for 4~10:3~8.
Further, the polyhexamethylene guanide phosphate is polyhexamethylene list guanidine phosphate or poly hexamethylene biguanide
Phosphate.
Further, the poly (hexamethylene) hydrochloride is polyhexamethylene list guanidine hydrochloride or poly hexamethylene biguanide
Hydrochloride.
Further, the addition of the single or double guanidine phosphate of the polyhexamethylene and the single or double guanidine hydrochloride of polyhexamethylene
Measure as 1:1.
Further, the addition of the single or double guanidine phosphate of the polyhexamethylene and the single or double guanidine hydrochloride of polyhexamethylene
Measure as 5:4.
Further, the water is distilled water.
A kind of Multifunctional anti-fungus antiseptic of the present invention, includes the raw material of following parts by weight：7~18 parts of guanidine bactericides；
25~37 parts of ethanol；60~80 parts of water.The Multifunctional anti-fungus antiseptic of the present invention is safe to use, is non-toxic product, is a kind of ring
Guarantor's type antimildew and antibacterial agent, and there is extremely strong destroying microorganisms ability, bactericidal range is wide, has to bacterium and fungi good
Insect killing effect.
Embodiment
Below in conjunction with the embodiment of the present invention, the technical solution in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment, is only part of the embodiment of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, those of ordinary skill in the art's all other embodiments obtained without making creative work,
Belong to the scope of protection of the invention.
A kind of Multifunctional anti-fungus antiseptic of the present invention, includes the raw material of following parts by weight：7~18 parts of guanidine bactericides；
25~37 parts of ethanol；60~80 parts of water.Wherein, guanidine bactericides are by polyhexamethylene guanide phosphate and poly (hexamethylene) acid
Salt forms, and the additive amount of polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride is 4~10:3~8.Polyhexamethylene
Guanidine phosphate is polyhexamethylene list guanidine phosphate or poly hexamethylene biguanide phosphate.Poly (hexamethylene) hydrochloride is poly- six
Methylene list guanidine hydrochloride or hexamethylene.
Further include 3~5 parts of the sodium pyrithione of parts by weight.
Wherein, the activity of the guanidine radicals of guanidine bactericides institute band so that the high polymer containing multiple (- NH) amidos into electropositive,
Therefore it is usually in the absorption of the Institute of Micro-biology such as electronegative all kinds of bacteriums, virus to be easy to.The structure of amino-contained causes guanidine radicals again
Effective active is improved, and the interaction of guanidine radicals and amido in guanidine bactericides causes its fungus and mildew resistance ability to carry significantly
It is high.Aqueous solvent is distilled water.
The single or double guanidine phosphate of polyhexamethylene and the single or double guanidine hydrochloride of polyhexamethylene are water solubility, with distilled water
For carrier, use can be directly sprayed.The single or double guanidine phosphate of polyhexamethylene is low toxicity compounds, the single or double guanidine of polyhexamethylene
The true border innocuous substance of hydrochloride, small toxicity.The single or double guanidine hydrochloride of the polyhexamethylene bacterium common to process hides has well
Bactericidal bacteriostasis, have Escherichia coli, Pseudomonas aeruginosa, staphylococcus aureus and heterotroph and preferably kill effect, be
A kind of effective process hides fungicide.The single or double guanidine hydrochloride of polyhexamethylene, odorless, tasteless, wide sterilization spectrum, has long-term antibacterial
Effect, it is safe to use to the corrosion-free effect of various metal materials.
It is some phosphorous that polyhexamethylene list guanidine phosphate and polyhexamethylene list guanidine hydrochloride are adsorbed in bacterial cell surface
Compound, and bacteria cell wall reciprocation, destroys cell membrane, causes material in the cytoplasm of low molecular weight to leak outside, as potassium from
Son etc., causes film phosphide to separate, influences the aggregation of protein, causes membrane penetrating increase, potassium ion disbalance and enzyme inactivation, so that
Growth is inhibited bacteria, and causes bacterial death.Polyhexamethylene list guanidine phosphate and polyhexamethylene list guanidine hydrochloride are to utilize
Mechanical antimycotic antiseptic, unlike chemical antimycotic antiseptic principle, will not cause resistance to the action of a drug shadow to microorganisms such as bacterium, viruses
Ring, bacterium will not produce drug resistance, and drug effect will not weaken with the growth of time, effectively solve traditional antimildew and antibacterial
The shortcomings of agent dispersiveness is bad, timeliness is short and bactericidal mould proof effect is bad, can reach long-acting, safe, non-harmful environmental protection
Antimildew and antibacterial advance material requirement, can effectively carry out fungus and mildew resistance effect for a long time.In addition, conventionally used chemistry antimycotic antiseptic is former
The universal toxicity of antimildew and antibacterial agent of reason is bigger than normal, has a great influence to operating personnel and environment, there are some potential safety problems.And this agent
Used two kinds of main component materials, are low toxicity or non-toxic medicament, the solvent used are water, to operating personnel and environment
Influence very little.
Embodiment 1
100g polyhexamethylenes list guanidine phosphate and 80g polyhexamethylene list guanidine hydrochlorides are mixed and stirred for uniformly；To
Above-mentioned raw materials are added in 800mL water, are stirred well to polyhexamethylene list guanidine phosphate and polyhexamethylene list guanidinesalt acid all
Dissolving；300mL ethanol is added in above-mentioned solution, is stirred evenly.
Embodiment 2
60g polyhexamethylenes list guanidine phosphate and 60g polyhexamethylene list guanidine hydrochlorides are mixed and stirred evenly；To above-mentioned original
Material is added in 800mL water, and being sufficiently stirred makes raw material all dissolve；300mL ethanol is added in above-mentioned solution, is stirred evenly.
Embodiment 3
40g poly hexamethylene biguanides phosphate and 30g hexamethylenes are mixed, stirred evenly；By above-mentioned original
Material is added in 600mL water, and being sufficiently stirred makes raw material all dissolve；250mL ethanol is added in above-mentioned solution, is stirred evenly.
Embodiment 4
60g polyhexamethylenes list guanidine phosphate and 80g polyhexamethylene lists guanidine hydrochloride are mixed, stirred evenly；By above-mentioned original
Material is added in 700mL water, and being sufficiently stirred makes raw material all dissolve；37mL ethanol is added in above-mentioned solution, is stirred evenly.
Embodiment 5
180g polyhexamethylene list guanidines phosphate is added in 800mL distilled water, being sufficiently stirred makes raw material all dissolve；Will
300mL ethanol is added in above-mentioned solution, is stirred evenly.
Embodiment 6
120g polyhexamethylene lists guanidine hydrochloride is added in 800mL water, being sufficiently stirred makes raw material all dissolve；Will
300mL ethanol is added in above-mentioned solution, is stirred evenly.
The anti-mold effect test of the present invention
1st, inhibition zone is tested
According to《Disinfection technology standard》2002No2.1.8.2 carry out inhibition zone test.Test strain：Escherichia coli 8099,
Staphylococcus aureus 6538.
Will be spare after a diameter of 7mm filter paper dicks high-temperature sterilization, respectively by the reality of the filter paper immersion present invention after sterilizing
Apply in the Multifunctional anti-fungus antiseptic of the preparation of example 1~6 to soaking completely, low temperature drying or naturally dry as treatment group 1~6,
Filter paper after sterilizing is soaked in ethanol to soaking completely, low temperature drying or naturally dry are as blank control group.Respectively
Treatment group and blank group are placed in and is coated with 200 μ L 37 DEG C of cultures 7d, Ran Houguan in the culture dish of bacterium solution, will be placed in incubator
Examine the growing state of bacterium and test the size of inhibition zone, test result is as shown in table 2.
The fungistatic effect of 1 sample of table
As shown in table 2, the filter paper dick for the treatment of group 1~4 is in the culture dish of staphylococcus aureus 6538,37 DEG C of trainings
Support 7d after antibacterial circle diameter reach 25~30mm, the filter paper dick for the treatment of group 1~4 in the culture dish of Escherichia coli 8099,
Antibacterial circle diameter after 37 DEG C of culture 7d reaches 23~33mm.Experimental result illustrates the anti-of the Multifunctional anti-fungus antiseptic of the present invention
Bacterium effect is good, and the fungistatic effect to staphylococcus aureus 6538 and Escherichia coli 8099 for the treatment of group 1~4 is than treatment group 5
Good with treatment group 6, this may be related with polyhexamethylene list guanidine hydrochloride and the phosphatic synergistic effect of polyhexamethylene list guanidine.
The fungistatic effect of wherein treatment group 1 is best, has good bacteriostasis to two kinds of bacteriums.
2nd, Leather mildew-proof measure of merit
Grown using Japanese Industrial Specifications mildrew resistant finish product method of inspection ASTM D4576-2008 blueness claddings antifungi
Test method tested, test strain is aspergillus niger ATCC 6275.
PU leather substances are cut to the square spare of 5*5cm sizes.Under aseptic condition, embodiment 1~6 is made respectively
Standby Multifunctional anti-fungus antiseptic, which is quantitatively applied on PU leathers to dry to be placed in PDA culture dishes, is used as treatment group 1~6, will
The PU leathers for not smearing Multifunctional anti-fungus antiseptic are placed in PDA culture dishes and are used as blank control group, every group of 3 repetitions.Will
Test cultures ware observes black-koji mould growing state, according to the mould proof grade of table 2 in 90% time 28 DEG C of temperature, humidity culture 14d
Standard judges anti-mold effect, obtains the mould proof grade for the treatment of group 1~6 as shown in table 3.
The mould proof grading standard of 2 sample of table
The mould proof grade of 3 sample of table
As can be drawn from Table 3, antimildew and antibacterial agent of the invention has leather good anti-mold effect, and mould proof grade is 0
Level.
3rd, toxicological test
Multifunctional anti-fungus antiseptic prepared by the embodiment of the present invention 1~6 tests LD to small white mouse Oral toxicity50＞
5000mg/kg, it is general to eye irritation, it is non-stimulated to skin, belong to for non-toxic type product.
Multifunctional anti-fungus antiseptic of the present invention has the following advantages：It is safe to use, it is non-toxic product；Kill fungi and bacterium
Sterilization be physical sterilization, can actively kill bacterium and mould etc.；Its bactericidal range is wide, has to bacterium and fungi extremely strong
Insect killing effect；Dosage is small, only needs the usage amount of very little when in use and can have good sterilization effect.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on, should all be included in the protection scope of the present invention god.
Claims (7)
1. a kind of Multifunctional anti-fungus antiseptic, it is characterised in that include the raw material of following parts by weight：7~18 parts of guanidine bactericides；
25~37 parts of ethanol；60~80 parts of water, the guanidine bactericides are by polyhexamethylene guanide phosphate and poly (hexamethylene) acid
Salt forms, and the addition of the polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride is compared for 4~10:3~8.
2. Multifunctional anti-fungus antiseptic according to claim 1, it is characterised in that include the raw material of following parts by weight：Guanidine
18 parts of class antiseptic；30 parts of ethanol；80 parts of water.
3. Multifunctional anti-fungus antiseptic according to claim 1, it is characterised in that include the raw material of following parts by weight：Guanidine
12 parts of class antiseptic；25 parts of ethanol；70 parts of water.
4. Multifunctional anti-fungus antiseptic according to claim 1, it is characterised in that the polyhexamethylene guanide phosphate is
Polyhexamethylene list guanidine phosphate or poly hexamethylene biguanide phosphate.
5. Multifunctional anti-fungus antiseptic according to claim 1, it is characterised in that the poly (hexamethylene) hydrochloride is
Polyhexamethylene list guanidine hydrochloride or hexamethylene.
6. Multifunctional anti-fungus antiseptic according to claim 1, it is characterised in that the polyhexamethylene guanide phosphate and
The addition of poly (hexamethylene) hydrochloride is compared for 1:1.
7. Multifunctional anti-fungus antiseptic according to claim 1, it is characterised in that the polyhexamethylene guanide phosphate and
The addition of poly (hexamethylene) hydrochloride is compared for 5:4.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510613143.4A CN105211089B (en) | 2015-09-23 | 2015-09-23 | A kind of Multifunctional anti-fungus antiseptic |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510613143.4A CN105211089B (en) | 2015-09-23 | 2015-09-23 | A kind of Multifunctional anti-fungus antiseptic |
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| CN105211089A CN105211089A (en) | 2016-01-06 |
| CN105211089B true CN105211089B (en) | 2018-04-20 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108570232A (en) * | 2018-03-13 | 2018-09-25 | 天长市荣盛有机硅科技有限公司 | A kind of antibacterial and mouldproof foamed silastic material |
| CN109161369B (en) * | 2018-08-20 | 2021-04-02 | 广西横县新威林板业有限公司 | Modified urea-formaldehyde glue and preparation method thereof |
| CN115024318A (en) * | 2022-05-17 | 2022-09-09 | 佛山科普茵生物科技有限公司 | Safe long-acting high-efficiency broad-spectrum zinc ion mildew-proof antibacterial agent and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1357235A (en) * | 2000-12-08 | 2002-07-10 | 马渝强 | Polyoxy alkene guanidine disinfectant |
| CN1413464A (en) * | 2002-09-29 | 2003-04-30 | 于锋 | Refrigerater antibiotic deodovization agent with polyolefin guanidine derivative (hydrochloride) |
| CN1478397A (en) * | 2003-07-03 | 2004-03-03 | 惠州兆婷化妆品有限公司 | Formulatioin of disinfecting liquid |
| JP6262434B2 (en) * | 2013-02-12 | 2018-01-17 | 小林製薬株式会社 | Antibacterial spray composition for skin wear |
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Address after: 510000 Room A510, Fifth Floor, Block A, Hongyun Building, 37 Station West Road, Yuexiu District, Guangzhou City, Guangdong Province Patentee after: Guangzhou Jianisi Anti-mildew and Antibacterial Technology Co., Ltd. Address before: 510000 Room A510, Fifth Floor, Block A, Hongyun Building, 37 Station West Road, Yuexiu District, Guangzhou City, Guangdong Province Patentee before: GOOD NICE ANTI-MOLD CO., LTD. |