CN105211089A - A kind of Multifunctional anti-fungus antibacterial agent - Google Patents
A kind of Multifunctional anti-fungus antibacterial agent Download PDFInfo
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- CN105211089A CN105211089A CN201510613143.4A CN201510613143A CN105211089A CN 105211089 A CN105211089 A CN 105211089A CN 201510613143 A CN201510613143 A CN 201510613143A CN 105211089 A CN105211089 A CN 105211089A
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Abstract
The present invention discloses a kind of Multifunctional anti-fungus antibacterial agent, comprises the raw material of following weight portion: guanidine bactericides 7 ~ 18 parts; Ethanol 25 ~ 37 parts; 60 ~ 80 parts, water.As improvement, guanidine bactericides is made up of polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride, and the addition of described polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride is 4 ~ 10:3 ~ 8.Multifunctional anti-fungus antibacterial agent use safety of the present invention is non-toxic product, is a kind of environment-friendly type antimildew and antibacterial agent, and bactericidal range is wide, has extremely strong destroying microorganisms ability, all has good insect killing effect to bacterium and fungi.
Description
Technical field
The invention belongs to sterilization technology field, be specifically related to a kind of Multifunctional anti-fungus antibacterial agent.
Background technology
In the storage, transportation of leather and fur products, textile, ready-made clothes, toy, sports equipment, electronic product, footwear, the antimildew and antibacterial agent function singleness of general employing, preparation trouble, complex operation, result of use restriction are greatly, toxicity is bigger than normal, effect is undesirable, the antimildew and antibacterial agent of certain material be used in other materials causes product variable color, damage, and antimildew and antibacterial effect the problem such as significantly to weaken.In addition, major part utilizes the medicament of the principles of chemistry that microorganism can be made to produce drug resistance, and after certain hour, the antimildew and antibacterial effect of this medicament lost efficacy.In addition, it is bigger than normal that major part utilizes the principles of chemistry to carry out the reagent toxicity of antimildew and antibacterial, and remain in product surface, Long Term Contact exists potential safety hazard; For the personnel directly carrying out antimildew and antibacterial agent operation use, also easily cause potential safety hazard.
Summary of the invention
The object of the invention is, in order to overcome above-mentioned defect, to provide the Multifunctional anti-fungus antibacterial agent that a kind of safety is high, antimildew and antibacterial is effective.
Technical scheme of the present invention is achieved in that a kind of Multifunctional anti-fungus antibacterial agent, comprises the raw material of following weight portion: guanidine bactericides 7 ~ 18 parts; Ethanol 25 ~ 37 parts; 60 ~ 80 parts, water.
Preferably, the raw material of following weight portion is comprised: guanidine bactericides 18 parts; Ethanol 30 parts; 80 parts, water.
Preferably, the raw material of following weight portion is comprised: guanidine bactericides 12 parts; Ethanol 25 parts; 70 parts, water.
Preferably, the sodium pyrithione 3 ~ 5 parts of weight portion is also comprised.
Further, described guanidine bactericides is made up of polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride, and the interpolation ratio of described polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride is 4 ~ 10:3 ~ 8.
Further, described polyhexamethylene guanide phosphate is polyhexamethylene list guanidine phosphate or poly hexamethylene biguanide phosphate.
Further, described poly (hexamethylene) hydrochloride is polyhexamethylene list guanidine hydrochloride or hexamethylene.
Further, the addition of described polyhexamethylene list or biguanides phosphate and polyhexamethylene list or biguanide hydrochloride is 1:1.
Further, the addition of described polyhexamethylene list or biguanides phosphate and polyhexamethylene list or biguanide hydrochloride is 5:4.
Further, described water is distilled water.
A kind of Multifunctional anti-fungus antibacterial agent of the present invention, comprises the raw material of following weight portion: guanidine bactericides 7 ~ 18 parts; Ethanol 25 ~ 37 parts; 60 ~ 80 parts, water.Multifunctional anti-fungus antibacterial agent use safety of the present invention is non-toxic product, is a kind of environment-friendly type antimildew and antibacterial agent, and has extremely strong destroying microorganisms ability, and bactericidal range is wide, all has good insect killing effect to bacterium and fungi.
Embodiment
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
A kind of Multifunctional anti-fungus antibacterial agent of the present invention, comprises the raw material of following weight portion: guanidine bactericides 7 ~ 18 parts; Ethanol 25 ~ 37 parts; 60 ~ 80 parts, water.Wherein, guanidine bactericides is made up of polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride, and the addition of polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride is 4 ~ 10:3 ~ 8.Polyhexamethylene guanide phosphate is polyhexamethylene list guanidine phosphate or poly hexamethylene biguanide phosphate.Poly (hexamethylene) hydrochloride is polyhexamethylene list guanidine hydrochloride or hexamethylene.
Also comprise the sodium pyrithione 3 ~ 5 parts of weight portion.
Wherein, guanidine bactericides with the activity of guanidine radicals, make the high polymer containing multiple (-NH) amido become electropositive, thus be easy to by usually in electronegative each bacterioid, virus etc. Institute of Micro-biology adsorb.The structure of amino-contained makes again the effective active of guanidine radicals be improved, and the guanidine radicals in guanidine bactericides and the interaction of amido make its fungus and mildew resistance ability greatly improve.Aqueous solvent is distilled water.
Polyhexamethylene list or biguanides phosphate and polyhexamethylene list or biguanide hydrochloride are water-soluble, take distilled water as carrier, directly can spray use.Polyhexamethylene list or biguanides phosphate are low toxicity compounds, and polyhexamethylene list or biguanide hydrochloride true border innocuous substance, toxicity is little.Polyhexamethylene list or biguanide hydrochloride have good bactericidal effect to the bacterium that process hides is common, have good kill activity to Escherichia coli, Pseudomonas aeruginosa, staphylococcus aureus and heterotroph, are a kind of effective process hides bactericide.Polyhexamethylene list or biguanide hydrochloride, odorless, tasteless, fungicidal spectrum is wide, has long-term bacteriostasis, to the corrosion-free effect of various metal material, use safety.
Polyhexamethylene list guanidine phosphate and polyhexamethylene list guanidine hydrochloride are adsorbed in some phosphorus-containing compound of bacterial cell surface, with bacteria cell wall interaction, destroy cell wall, cause material in low-molecular-weight cytoplasm to leak outside, as potassium ion etc., cause film phosphide to be separated, affect the gathering of protein, cause membrane penetrating increase, potassium ion disbalance and enzyme deactivation, thus bacteria growing inhibiting, and cause bacterial death.Polyhexamethylene list guanidine phosphate and polyhexamethylene list guanidine hydrochloride utilize mechanical antimycotic antiseptic, with chemical antimycotic antiseptic principle unlike, pesticide resistance will be caused to affect on the microorganism such as bacterium, virus, bacterium can not produce drug resistance, drug effect also can not weaken along with the growth of time, effectively solve the shortcomings such as not good, the ageing short and bactericidal mould proof effect of traditional antimildew and antibacterial agent dispersiveness is not good, the antibacterial advance material requirement of long-acting, safe, non-harmful environment friendly mildew resistant can be reached, for a long time effectively can carry out fungus and mildew resistance effect.In addition, the general toxicity of antimildew and antibacterial agent of usual chemical antimycotic antiseptic principle used is bigger than normal, comparatively large to operating personnel and environmental influence, there is certain potential safety hazard.And this agent uses two kinds of main component materials, be low toxicity or non-toxic medicament, the solvent of use is water, very little on the impact of operating personnel and environment.
Embodiment 1
100g polyhexamethylene list guanidine phosphate and 80g polyhexamethylene list guanidine hydrochloride are mixed and stirs; Add in 800mL water to above-mentioned raw materials, be stirred well to polyhexamethylene list guanidine phosphate and polyhexamethylene list guanidine hydrochloric acid all dissolves; 300mL ethanol is added in above-mentioned solution, stirs evenly.
Embodiment 2
60g polyhexamethylene list guanidine phosphate and 60g polyhexamethylene list guanidine hydrochloride are mixed and stirs evenly; Add in 800mL water to above-mentioned raw materials, fully stir and raw material is all dissolved; 300mL ethanol is added in above-mentioned solution, stirs evenly.
Embodiment 3
By 40g poly hexamethylene biguanide phosphate and the mixing of 30g hexamethylene, stir evenly; Above-mentioned raw materials is added in 600mL water, fully stir and raw material is all dissolved; 250mL ethanol is added in above-mentioned solution, stirs evenly.
Embodiment 4
By 60g polyhexamethylene list guanidine phosphate and the mixing of 80g polyhexamethylene list guanidine hydrochloride, stir evenly; Above-mentioned raw materials is added in 700mL water, fully stir and raw material is all dissolved; 37mL ethanol is added in above-mentioned solution, stirs evenly.
Embodiment 5
180g polyhexamethylene list guanidine phosphate is added in 800mL distilled water, fully stirs and raw material is all dissolved; 300mL ethanol is added in above-mentioned solution, stirs evenly.
Embodiment 6
120g polyhexamethylene list guanidine hydrochloride is added in 800mL water, fully stirs and raw material is all dissolved; 300mL ethanol is added in above-mentioned solution, stirs evenly.
Anti-mold effect test of the present invention
1, inhibition zone test
Inhibition zone test is carried out according to " disinfection technology standard " 2002No2.1.8.2.Test bacterial classification: Escherichia coli 8099, staphylococcus aureus 6538.
Be for subsequent use after 7mm filter paper dick high-temperature sterilization by diameter, respectively the filter paper after sterilizing is soaked in the Multifunctional anti-fungus antibacterial agent of embodiments of the invention 1 ~ 6 preparation to soaking completely, low temperature drying or naturally dry as processed group 1 ~ 6, filter paper after sterilizing is soaked in ethanol to soaking completely, low temperature drying or naturally dry as blank group.Processed group and blank group are placed in respectively and are coated with 200 μ L by the culture dish of bacterium liquid, be placed in incubator 37 DEG C and cultivate 7d, then observe the growing state of bacterium and test the size of inhibition zone, test result is as shown in table 2.
The fungistatic effect of table 1 sample
As shown in table 2, the filter paper dick of processed group 1 ~ 4 is in the culture dish of staphylococcus aureus 6538, antibacterial circle diameter after 37 DEG C of cultivation 7d reaches 25 ~ 30mm, the filter paper dick of processed group 1 ~ 4 is in the culture dish of Escherichia coli 8099, and the antibacterial circle diameter after 37 DEG C of cultivation 7d reaches 23 ~ 33mm.Experimental result illustrates the good anti-bacterial effect of Multifunctional anti-fungus antibacterial agent of the present invention, the fungistatic effect to staphylococcus aureus 6538 and Escherichia coli 8099 of processed group 1 ~ 4 all than processed group 5 and processed group 6 good, this may be relevant with the phosphatic synergistic effect of polyhexamethylene list guanidine with polyhexamethylene list guanidine hydrochloride.Wherein the fungistatic effect of processed group 1 is best, all has good bacteriostasis to two kinds of bacteriums.
2, Leather mildew-proof measure of merit
Utilize the method for testing of the blue cladding antifungi growth of JIS mildrew resistant finish goods method of inspection ASTMD4576-2008 to test, test bacterial classification is aspergillus niger ATCC6275.
By for subsequent use for the square that PU leather substance is cut to 5*5cm size.Under aseptic condition, respectively Multifunctional anti-fungus antibacterial agent prepared by embodiment 1 ~ 6 is quantitatively spread upon PU leather dries and be placed in PDA culture dish as processed group 1 ~ 6, the PU leather not smearing Multifunctional anti-fungus antibacterial agent is placed in PDA culture dish as blank group, often organizes 3 repetitions.Test cultures ware is cultivated 14d 90% time in temperature 28 DEG C, humidity, and observe black-koji mould growing state, the mildew-resistant classification standard according to table 2 judges anti-mold effect, obtains the mildew-resistant grade of processed group 1 ~ 6 as shown in table 3.
Table 2 sample mildew-resistant grading standard
Table 3 sample mildew-resistant grade
As can be drawn from Table 3, antimildew and antibacterial agent of the present invention has good anti-mold effect to leather, and mildew-resistant grade is 0 grade.
3, toxicological test
Multifunctional anti-fungus antibacterial agent prepared by embodiments of the invention 1 ~ 6 is to small white mouse Oral toxicity test LD
50> 5000mg/kg, general to eye irritation, non-stimulated to skin, belong to for non-toxic type product.
Multifunctional anti-fungus antibacterial agent of the present invention has the following advantages: use safety, is non-toxic product; The sterilization of killing fungus and bacterium is physical sterilization, initiatively can kill bacterium and mould etc.; Its bactericidal range is wide, all has extremely strong insect killing effect to bacterium and fungi; Using dosage is little, only needs very little usage amount just can have good sterilization effect in use.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a Multifunctional anti-fungus antibacterial agent, is characterized in that, comprises the raw material of following weight portion: guanidine bactericides 7 ~ 18 parts; Ethanol 25 ~ 37 parts; 60 ~ 80 parts, water.
2. Multifunctional anti-fungus antibacterial agent according to claim 1, is characterized in that, comprises the raw material of following weight portion: guanidine bactericides 18 parts; Ethanol 30 parts; 80 parts, water.
3. Multifunctional anti-fungus antibacterial agent according to claim 1, is characterized in that, comprises the raw material of following weight portion: guanidine bactericides 12 parts; Ethanol 25 parts; 70 parts, water.
4. the Multifunctional anti-fungus antibacterial agent according to any one of claims 1 to 3, is characterized in that, also comprises the sodium pyrithione 3 ~ 5 parts of weight portion.
5. the Multifunctional anti-fungus antibacterial agent according to any one of claims 1 to 3, it is characterized in that, described guanidine bactericides is made up of polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride, and the interpolation ratio of described polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride is 4 ~ 10:3 ~ 8.
6. Multifunctional anti-fungus antibacterial agent according to claim 5, is characterized in that, described polyhexamethylene guanide phosphate is polyhexamethylene list guanidine phosphate or poly hexamethylene biguanide phosphate.
7. Multifunctional anti-fungus antibacterial agent according to claim 5, is characterized in that, described poly (hexamethylene) hydrochloride is polyhexamethylene list guanidine hydrochloride or hexamethylene.
8. Multifunctional anti-fungus antibacterial agent according to claim 5, is characterized in that, the interpolation of described polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride is than being 1:1.
9. Multifunctional anti-fungus antibacterial agent according to claim 5, is characterized in that, the interpolation of described polyhexamethylene guanide phosphate and poly (hexamethylene) hydrochloride is than being 5:4.
10. Multifunctional anti-fungus antibacterial agent according to any one of claims 1 to 3, is characterized in that, described water is distilled water.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510613143.4A CN105211089B (en) | 2015-09-23 | 2015-09-23 | A kind of Multifunctional anti-fungus antiseptic |
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| CN201510613143.4A CN105211089B (en) | 2015-09-23 | 2015-09-23 | A kind of Multifunctional anti-fungus antiseptic |
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| CN105211089A true CN105211089A (en) | 2016-01-06 |
| CN105211089B CN105211089B (en) | 2018-04-20 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108570232A (en) * | 2018-03-13 | 2018-09-25 | 天长市荣盛有机硅科技有限公司 | A kind of antibacterial and mouldproof foamed silastic material |
| CN109161369A (en) * | 2018-08-20 | 2019-01-08 | 广西横县新威林板业有限公司 | A kind of modified urea-formaldehyde glue and preparation method thereof |
| CN115024318A (en) * | 2022-05-17 | 2022-09-09 | 佛山科普茵生物科技有限公司 | Safe long-acting high-efficiency broad-spectrum zinc ion mildew-proof antibacterial agent and preparation method thereof |
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| CN1357235A (en) * | 2000-12-08 | 2002-07-10 | 马渝强 | Polyoxy alkene guanidine disinfectant |
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| CN1357235A (en) * | 2000-12-08 | 2002-07-10 | 马渝强 | Polyoxy alkene guanidine disinfectant |
| CN1413464A (en) * | 2002-09-29 | 2003-04-30 | 于锋 | Refrigerater antibiotic deodovization agent with polyolefin guanidine derivative (hydrochloride) |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108570232A (en) * | 2018-03-13 | 2018-09-25 | 天长市荣盛有机硅科技有限公司 | A kind of antibacterial and mouldproof foamed silastic material |
| CN109161369A (en) * | 2018-08-20 | 2019-01-08 | 广西横县新威林板业有限公司 | A kind of modified urea-formaldehyde glue and preparation method thereof |
| CN109161369B (en) * | 2018-08-20 | 2021-04-02 | 广西横县新威林板业有限公司 | Modified urea-formaldehyde glue and preparation method thereof |
| CN115024318A (en) * | 2022-05-17 | 2022-09-09 | 佛山科普茵生物科技有限公司 | Safe long-acting high-efficiency broad-spectrum zinc ion mildew-proof antibacterial agent and preparation method thereof |
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| CN105211089B (en) | 2018-04-20 |
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Address after: 510000 Room A510, Fifth Floor, Block A, Hongyun Building, 37 Station West Road, Yuexiu District, Guangzhou City, Guangdong Province Patentee after: Guangzhou Jianisi Anti-mildew and Antibacterial Technology Co., Ltd. Address before: 510000 Room A510, Fifth Floor, Block A, Hongyun Building, 37 Station West Road, Yuexiu District, Guangzhou City, Guangdong Province Patentee before: GOOD NICE ANTI-MOLD CO., LTD. |