CN104107239A - Traditional Chinese medicine composition for treating hypertension and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating hypertension and preparation method thereof Download PDFInfo
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- CN104107239A CN104107239A CN201410233658.7A CN201410233658A CN104107239A CN 104107239 A CN104107239 A CN 104107239A CN 201410233658 A CN201410233658 A CN 201410233658A CN 104107239 A CN104107239 A CN 104107239A
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Abstract
The invention relates to a traditional Chinese medicine composition for treating hypertension and a preparation method thereof. The traditional Chinese medicine composition is prepared from decoction pieces of 15-25 parts by weight of radix astragali, 7-13 parts by weight of cherokee rose fruit, 7-13 parts by weight of ligusticum wallichii, 10-20 parts by weight of sunset abelmoschus flower, 2-8 parts by weight of rheum officinale, 7-13 parts by weight of root of kudzu vine and 10-20 parts by weight of Achyranthes aspera L. The preparation method of the oral preparation of the traditional Chinese medicine composition comprises the following steps of extracting radix astragali, ligusticum wallichii, sunset abelmoschus flower and root of kudzu vine by ethanol, collecting the extract, carrying out condensation to obtain clear extract paste having relative density of 1.08-1.15, extracting cherokee rose fruit, rheum officinale and Achyranthes aspera L. by water, collecting the extract, carrying out condensation to obtain clear extract paste having relative density of 1.08-1.15, merging the two kinds of clear extract paste, carrying out condensation to obtain thick extract paste having relative density of 1.30-1.40, and adding an accessory material into the thick extract paste to obtain a preparation suitable for clinical use. The oral preparation of the traditional Chinese medicine composition has the advantages of high active ingredient extraction efficiency, stable content, good traditional Chinese medicine effect, low taking amount and preparation molding easiness.
Description
Technical field
The present invention relates to Chinese medicine, be specifically related to a kind of hypertensive Chinese medicine composition and preparation method thereof for the treatment of.
Background technology
Hypertension is one of common and serious chronic complicating diseases.Hypertension continues 10～20 years, it is reported that the sickness rate of DN is about DN incidence rate in 40～50%, 2 type hypertension and is about 30～40% in 1 type hypertension.This has been carried out to a large amount of research both at home and abroad, but pathogenesis is illustrated not yet completely so far, be there is no effective medicine and stop it to occur and worsen.
Summary of the invention
The object of the present invention is to provide a kind of hypertensive Chinese medicine composition and Chinese medicine preparation for the treatment of, for achieving the above object, the present invention by the following technical solutions:
Treat a hypertensive Chinese medicine composition, this Chinese medicine composition is to be made by the prepared slices of Chinese crude drugs of following weight proportioning: 15～25 parts of the Radixs Astragali, 7～13 parts of Fructus Rosae Laevigatae, 7～13 parts of Rhizoma Chuanxiongs, 10～20 parts of Flos abelmoschi manihots, 2～8 parts of Radix Et Rhizoma Rhei, 7～13 parts of Radix Puerariaes, 10～20 parts of Radix achyranthis asperae (Herba Achyranthis Asperae)s.
The hypertensive Chinese medicine composition for the treatment of as above, preferably, described Chinese medicine composition is to be made by the prepared slices of Chinese crude drugs of following weight proportioning: 20 parts of the Radixs Astragali, 10 parts of Fructus Rosae Laevigatae, 10 parts of Rhizoma Chuanxiongs, 15 parts of Flos abelmoschi manihots, 5 parts of Radix Et Rhizoma Rhei, 15 parts of Radix achyranthis asperae (Herba Achyranthis Asperae)s, 10 parts of Radix Puerariaes.
A kind of preparation method for the treatment of hypertension Chinese medicine composition, the method comprises: by weight proportion as above, take the prepared slices of Chinese crude drugs, the Radix Astragali, Rhizoma Chuanxiong, Flos abelmoschi manihot, Radix Puerariae are added by weight to 50～80 volume % alcohol reflux 1～4 time of 8～14 times, each 0.5～3 hour, collecting extracting solution and being concentrated into relative density was 1.08～1.15 clear paste; Fructus Rosae Laevigatae, Radix Et Rhizoma Rhei, Radix achyranthis asperae (Herba Achyranthis Asperae) are added by weight to the water reflux, extract, 1～4 time of 8～12 times, each 0.5～2 hour, collecting extracting solution and being concentrated into relative density was 1.08～1.15 clear paste; Above two kinds of clear paste are merged, continue to be concentrated into relative density and be 1.30～1.40 thick paste.
Preparation method as above, preferably, described method comprises: by weight proportion as above, take the prepared slices of Chinese crude drugs, the Radix Astragali, Rhizoma Chuanxiong, Flos abelmoschi manihot, Radix Puerariae are added by weight to 63% alcohol reflux 2 times of 12 times, each 2.5 hours, collecting extracting solution and being concentrated into relative density was 1.1 clear paste; Fructus Rosae Laevigatae, Radix Et Rhizoma Rhei, Radix achyranthis asperae (Herba Achyranthis Asperae) are added by weight to the water reflux, extract, 3 times of 10 times, each 1.5 hours, collecting extracting solution and being concentrated into relative density was 1.1 clear paste; Above two kinds of clear paste are merged, continue to be concentrated into relative density and be 1.4 thick paste.
Chinese medicine preparation prepared by the inventive method, extracts active ingredients efficiency is high, stable content, and the herbal medicine efficacy of preparing according to the present invention is good, and dose is low, and preparation molding is easy.
The specific embodiment
Chinese medicine compound Raw medicine in the present invention adopts the Radix Astragali, Fructus Rosae Laevigatae, Rhizoma Chuanxiong, Flos abelmoschi manihot, Radix Et Rhizoma Rhei, Radix Puerariae, Radix achyranthis asperae (Herba Achyranthis Asperae).
Wherein the Radix Astragali is monarch drug, sweet, tepor; Return lung, spleen, liver, kidney channel; Benefiting QI for strengthening the superficies, inducing diuresis to remove edema, can eliminate Jishengshenqiwan albuminuria, strengthens myocardial contraction, regulates blood sugar content, treatment chronic nephritis, albuminuria, hypertension etc.
Fructus Rosae Laevigatae is ministerial drug, and sweet, micro-acid, puckery is flat; Return spleen, kidney, large intestine, urinary bladder channel; Controlling nocturnal emission with astringent drugs reducing urination, increases the effect that serum urea and creatinine clearance rate reach renal function protecting.
Rhizoma Chuanxiong is ministerial drug, pungent, temperature; Return liver, gallbladder, heart channel; Blood-activating and qi-promoting blood stasis dispelling.Radix Et Rhizoma Rhei is bitter, cold, clearing away damp-heat, removing heat from blood, blood stasis dispelling, removing toxic substances.Flos abelmoschi manihot is sweet, pungent, cool; Inducing diuresis for treating stranguria syndrome, invigorate blood circulation, hemostasis, subduing swelling and detoxicating.Two medicines are assistant, the merit of playing altogether the turbid descending.
Radix Puerariae, sweet, pungent, cool; Return spleen, stomach warp; Can be antipyretic, promote the production of body fluid, quench the thirst, also can reduce blood glucose.
Radix achyranthis asperae (Herba Achyranthis Asperae), toil, cold; Return liver, lung, urinary bladder channel; Can diuretic, invigorate blood circulation, nourishing stomach-YIN, born fluid, except deficiency-heat.
Radix Puerariae, Radix achyranthis asperae (Herba Achyranthis Asperae) both for making, auxiliary said medicine plays a role.
Embodiment 1
By following weight proportion, take Chinese crude drug, 15 parts of the Radixs Astragali, 13 parts of Fructus Rosae Laevigatae, 7 parts of Rhizoma Chuanxiongs, 15 parts of Flos abelmoschi manihots, 3 parts of Radix Et Rhizoma Rhei, 15 parts of Radix achyranthis asperae (Herba Achyranthis Asperae)s, 13 parts of Radix Puerariaes.
The Radix Astragali, Radix Puerariae, Rhizoma Chuanxiong, Flos abelmoschi manihot are added by weight to 50% alcohol reflux 1 time of 14 times, each 180 minutes, collect extracting solution, the content that adopts the method identical with embodiment 1 to measure astragaloside is that the content of 1.3074mg/g, puerarin is that the content of 39.6242mg/g, hyperin is 7.1072mg/g, is concentrated into relative density and is 1.1 clear paste; Radix Et Rhizoma Rhei, Fructus Rosae Laevigatae, Radix achyranthis asperae (Herba Achyranthis Asperae) are added by weight to the water reflux, extract, 2 times of 10 times, each 1 hour, collect extracting solution, adopting the content of the method mensuration chrysophanic acid identical with embodiment 1 is 2.7084mg/g, is concentrated into relative density and is 1.1 clear paste; Above two kinds of clear paste are merged, continue to be concentrated into relative density and be 1.4 thick paste, add following adjuvant granulation preparation.Consisting of of this granular preparation: 2.5 parts of 500 parts of above-mentioned thick pastes, 250 parts, dextrin, 250 parts, mannitol and aspartames.
Embodiment 2
By following weight proportion, take Chinese crude drug, 20 parts of the Radixs Astragali, 7 parts of Fructus Rosae Laevigatae, 10 parts of Rhizoma Chuanxiongs, 10 parts of Flos abelmoschi manihots, 3 parts of Radix Et Rhizoma Rhei, 10 parts of Radix achyranthis asperae (Herba Achyranthis Asperae)s, 7 parts of Radix Puerariaes.
The Radix Astragali, Radix Puerariae, Rhizoma Chuanxiong, Flos abelmoschi manihot are added by weight to 70% alcohol reflux 4 times of 8 times, each 30 minutes, collect extracting solution, the content that adopts the method identical with embodiment 1 to measure astragaloside is that the content of 1.2099mg/g, puerarin is that the content of 40.2475mg/g, hyperin is 7.0431mg/g, is concentrated into relative density and is 1.1 clear paste; Radix Et Rhizoma Rhei, Fructus Rosae Laevigatae, Radix achyranthis asperae (Herba Achyranthis Asperae) are added by weight to the water reflux, extract, 4 times of 8 times, each 0.5 hour, collect extracting solution, adopting the content of the method mensuration chrysophanic acid identical with embodiment 1 is 2.5489mg/g, is concentrated into relative density and is 1.1 clear paste; Above two kinds of clear paste are merged, continue to be concentrated into relative density and be 1.4 thick paste, add following adjuvant granulation preparation.Consisting of of this granular preparation: 2.5 parts of 500 parts of above-mentioned thick pastes, 250 parts, dextrin, 250 parts, mannitol and aspartames.
Embodiment 3
By following weight proportion, take Chinese crude drug, 25 parts of the Radixs Astragali, 7 parts of Fructus Rosae Laevigatae, 7 parts of Rhizoma Chuanxiongs, 20 parts of Flos abelmoschi manihots, 6 parts of Radix Et Rhizoma Rhei, 10 parts of Radix achyranthis asperae (Herba Achyranthis Asperae)s, 12 parts of Radix Puerariaes.
The Radix Astragali, Radix Puerariae, Rhizoma Chuanxiong, Flos abelmoschi manihot are added by weight to 65% alcohol reflux 3 times of 10 times, each 120 minutes, collect extracting solution, the content that adopts the method identical with embodiment 1 to measure astragaloside is that the content of 1.2017mg/g, puerarin is that the content of 41.0188mg/g, hyperin is 7.9355mg/g, is concentrated into relative density and is 1.1 clear paste; Radix Et Rhizoma Rhei, Fructus Rosae Laevigatae, Radix achyranthis asperae (Herba Achyranthis Asperae) are added by weight to the water reflux, extract, 4 times of 8 times, each 1.5 hours, collect extracting solution, adopting the content of the method mensuration chrysophanic acid identical with embodiment 1 is 3.3461mg/g, is concentrated into relative density and is 1.1 clear paste; Above two kinds of clear paste are merged, continue to be concentrated into relative density and be 1.4 thick paste, add following adjuvant granulation preparation.Consisting of of this granular preparation: 2.5 parts of 500 parts of above-mentioned thick pastes, 350 parts, dextrin, 350 parts, mannitol and aspartames.
Claims (2)
1. treat hypertensive Chinese medicine composition for one kind, it is characterized in that, this Chinese medicine composition is to be made by the prepared slices of Chinese crude drugs of following weight proportioning: 15～25 parts of the Radixs Astragali, 7～13 parts of Fructus Rosae Laevigatae, 7～13 parts of Rhizoma Chuanxiongs, 10～20 parts of Flos abelmoschi manihots, 2～8 parts of Radix Et Rhizoma Rhei, 7～13 parts of Radix Puerariaes, 10～20 parts of Radix achyranthis asperae (Herba Achyranthis Asperae)s.
2. the preparation method of a treatment hypertension Chinese medicine composition as claimed in claim, it is characterized in that, described method comprises: by weight proportion as claimed in claim 1, take the prepared slices of Chinese crude drugs, the Radix Astragali, Rhizoma Chuanxiong, Flos abelmoschi manihot, Radix Puerariae are added by weight to 50～80 volume % alcohol reflux 1～4 time of 8～14 times, each 0.5～3 hour, collecting extracting solution and being concentrated into relative density was 1.08～1.15 clear paste; Fructus Rosae Laevigatae, Radix Et Rhizoma Rhei, Radix achyranthis asperae (Herba Achyranthis Asperae) are added by weight to the water reflux, extract, 1～4 time of 8～12 times, each 0.5～2 hour, collecting extracting solution and being concentrated into relative density was 1.08～1.15 clear paste; Above two kinds of clear paste are merged, continue to be concentrated into relative density and be 1.30～1.40 thick paste.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101313942A (en) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | Chinese medicine composition for treating nephropathy |
| CN102228536A (en) * | 2011-06-09 | 2011-11-02 | 首都医科大学 | Chinese herbal extract for treating diabetic nephropathy and preparation method thereof |
| CN103566350A (en) * | 2013-11-07 | 2014-02-12 | 李涛 | Pharmaceutical composition having blood sugar reducing effect |
| CN103830380A (en) * | 2014-03-19 | 2014-06-04 | 首都医科大学 | Chinese medicinal composition for treating diabetic nephropathy and preparation method thereof |
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- 2014-05-29 CN CN201410233658.7A patent/CN104107239A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101313942A (en) * | 2007-05-30 | 2008-12-03 | 江苏正大天晴药业股份有限公司 | Chinese medicine composition for treating nephropathy |
| CN102228536A (en) * | 2011-06-09 | 2011-11-02 | 首都医科大学 | Chinese herbal extract for treating diabetic nephropathy and preparation method thereof |
| CN103566350A (en) * | 2013-11-07 | 2014-02-12 | 李涛 | Pharmaceutical composition having blood sugar reducing effect |
| CN103830380A (en) * | 2014-03-19 | 2014-06-04 | 首都医科大学 | Chinese medicinal composition for treating diabetic nephropathy and preparation method thereof |
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Application publication date: 20141022 |