CN101912583A - Medicament for treating chronic hepatitis and early-phase hepatocirrhosis and preparation method thereof - Google Patents
Medicament for treating chronic hepatitis and early-phase hepatocirrhosis and preparation method thereof Download PDFInfo
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- CN101912583A CN101912583A CN2010102612714A CN201010261271A CN101912583A CN 101912583 A CN101912583 A CN 101912583A CN 2010102612714 A CN2010102612714 A CN 2010102612714A CN 201010261271 A CN201010261271 A CN 201010261271A CN 101912583 A CN101912583 A CN 101912583A
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Abstract
The invention relates to a medicament for treating chronic hepatitis and early-phase hepatocirrhosis and a preparation method thereof. The medicament is characterized by consisting of largehead atractylodes rhizome (fried), nutgrass galingale rhizome (processed), white paeony root, zedoary, common burreed rhizome, Chinese angelica, papaya, rhubarb, safflower, turtle shell (roasted), peach seed, turmeric root-tuber, virgate wormwood herb, seaweed, kelp, figwort root, rehmannia root, prepared rehmannia root, giant knotweed, ground beetle, bupleurum, tuber fleeceflower root (processed), Chinese trumpetcreeper flower, dung beetle, trogopterus dung, black bean and Chinese lobelia herb. The method comprises the following steps of: smashing raw materials according to the composition and weight ratio; continuously refluxing and extracting; concentrating the extract; and drying and smashing the condensate to obtain the medicament. The medicament has the remarkable advantages of improving liver fat metabolism and the organization structure of a pathologic liver, protecting the liver, remarkably saving water and steam by over 50 percent, reducing drying time, keeping the functions of the raw materials, contributing to absorbing, along with high bioavailability, high active ingredient content, low energy consumption, easy operation and the like.
Description
Technical field
The present invention relates to the preparation method of medicine, specifically a kind of medicine and preparation method for the treatment of chronic hepatitis and early stage liver cirrhosis.
Background technology
As everyone knows, hepatitis and liver cirrhosis have become a big hidden danger that threatens human life's health, and existing on the market to be used for the treatment of the hardened medicament categories of chronic hepatitis regulating liver-QI a lot, but curative effect is scarcely stable, and the healing improvement rate is lower.The traditional Chinese medical science is our quintessence of Chinese culture, tcm therapy has significant curative effect in the treatment of hepatopathy, traditional Chinese medical science field decocts 2 times the general Chinese crude drug water of the therapeutic scheme of hepatitis and liver cirrhosis, decocting time was respectively 1.5 hours, but because its operating process exists water consumption big, shortcoming such as decocting time is long, and energy consumption is big, medicine exists extractum viscosity big simultaneously, be difficult for pulverizing and the easy moisture absorption, deficiencies such as poor stability make troubles for the treatment of hepatopathy.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, the treatment chronic hepatitis that propose that a kind of therapeutic effect is good, energy consumption is low, stability is high, taking convenience, therapeutic effect is good and the medicine and the preparation method of early stage liver cirrhosis.
The present invention can reach by following measure.
A kind of medicine for the treatment of chronic hepatitis and early stage liver cirrhosis, it is characterized in that by the Rhizoma Atractylodis Macrocephalae (stir-fry), Rhizoma Cyperi (system), the Radix Paeoniae Alba, Rhizoma Curcumae, rhizoma sparganic, Radix Angelicae Sinensis, Fructus Chaenomelis, Radix Et Rhizoma Rhei, Flos Carthami, Carapax Trionycis (processing), Semen Persicae, Radix Curcumae, Herba Artemisiae Scopariae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Radix Scrophulariae, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Polygoni Cuspidati, Eupolyphaga Seu Steleophaga, Radix Bupleuri, Radix Polygoni Multiflori (system), Flos Campsis, Catharsii molossi, Oletum Trogopterori, Semen sojae atricolor, Herba Lobeliae Chinensis is formed, and each component by following weight proportion is: the Rhizoma Atractylodis Macrocephalae (stir-fry) 1-4 part, Rhizoma Cyperi (system) 4-7 part, Radix Paeoniae Alba 2-5 part, Rhizoma Curcumae 2-5 part, rhizoma sparganic 1-4 part, Radix Angelicae Sinensis 1-4 part, Fructus Chaenomelis 1-2 part, Radix Et Rhizoma Rhei 1-2 part, Flos Carthami 1-3 part, Carapax Trionycis (processing) 1-2 part, Semen Persicae 1-2 part, Radix Curcumae 1-2 part, Herba Artemisiae Scopariae 1-4 part, Sargassum 1-4 part, Thallus Laminariae (Thallus Eckloniae) 2-5 part, Radix Scrophulariae 1-4 part, Radix Rehmanniae 4-7 part, Radix Rehmanniae Preparata 2-5 part, Rhizoma Polygoni Cuspidati 4-7 part, Eupolyphaga Seu Steleophaga 4-7 part, Radix Bupleuri 1-3 part, Radix Polygoni Multiflori (system) 4-7 part, Flos Campsis 1-2 part, Catharsii molossi 1-2 part, Oletum Trogopterori 1-4 part, Semen sojae atricolor 4-7 part, Herba Lobeliae Chinensis 1-4 part.
Function of gallbladder promoting blood stasis dispelling of the present invention, dampness removing heat clearing away, QI invigorating are set upright and are the rule of treatment, through long-term clinical observation, the total effective rate that the present invention treats chronic hepatitis and early stage liver cirrhosis is 88% ideal effect, experiment confirm by Shandong Prov. Inst. of Traditional Chinese Medicine's work, the present invention obviously improves liver function, improves the organizational structure of pathologic liver and the effect of liver-protecting and blood fat-reducing, and the swollen degree that rises of hepatic tissue is alleviated.
The present invention does overtesting to mice, can cause the serum TC of pathological changes mice, the decline of T and the rising of HDL-C, thereby improves the component ratio of lipoprotein.
The present invention experimental results show that mice four carbonoxide acute liver damages, ALT in the blood plasma of mice is descended, the liver index obviously reduces, the hepatocellular degeneration degree of necrosis is alleviated, improve the organizational structure of pathologic liver, further confirmed that from the histology the present invention is to the hardened therapeutical effect of hepatitis regulating liver-QI.
In the acute toxicity testing of the present invention, when giving the disposable filling stomach of mice with clinical identical route of administration, fail to obtain fatal dose of the present invention, irritate stomach three times through Cmax, maximum volume (being equivalent to 21.44/k/ day) a day, the maximum tolerated dose multiple of obtaining mice 238.3 times of clinical usual amounts of behaving, illustrate that oral toxicity of the present invention is minimum, safe.
A kind of process for preparing medicine for the treatment of chronic hepatitis and early stage liver cirrhosis is characterized in that comprising the steps.
Steps A: prepare raw material, each component of raw material is taken by following weight proportion: the Rhizoma Atractylodis Macrocephalae (stir-fry) 1-4 part, Rhizoma Cyperi (system) 4-7 part, Radix Paeoniae Alba 2-5 part, Rhizoma Curcumae 2-5 part, rhizoma sparganic 1-4 part, Radix Angelicae Sinensis 1-4 part, Fructus Chaenomelis 1-2 part, Radix Et Rhizoma Rhei 1-2 part, Flos Carthami 1-3 part, Carapax Trionycis (processing) 1-2 part, Semen Persicae 1-2 part, Radix Curcumae 1-2 part, Herba Artemisiae Scopariae 1-4 part, Sargassum 1-4 part, Thallus Laminariae (Thallus Eckloniae) 2-5 part, Radix Scrophulariae 1-4 part, Radix Rehmanniae 4-7 part, Radix Rehmanniae Preparata 2-5 part, Rhizoma Polygoni Cuspidati 4-7 part, Eupolyphaga Seu Steleophaga 4-7 part, Radix Bupleuri 1-3 part, Radix Polygoni Multiflori (system) 4-7 part, Flos Campsis 1-2 part, Catharsii molossi 1-2 part, Oletum Trogopterori 1-4 part, Semen sojae atricolor 4-7 part, Herba Lobeliae Chinensis 1-4 part
Step B: pulverization process, the proportioning among the A is taken the Rhizoma Atractylodis Macrocephalae (stir-fry), Radix Angelicae Sinensis, Rhizoma Cyperi (system), the Radix Paeoniae Alba, Rhizoma Curcumae, rhizoma sparganic, Fructus Chaenomelis set by step, drops in the reducing mechanism and pulverizes, and makes standby medicated powder, and the medicated powder fineness is not more than 100 orders,
Step C: the proportioning among the A is taken Radix Et Rhizoma Rhei set by step, Flos Carthami, Carapax Trionycis, Semen Persicae, Radix Curcumae, Herba Artemisiae Scopariae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Radix Scrophulariae, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Polygoni Cuspidati, Eupolyphaga Seu Steleophaga, Radix Bupleuri, Radix Polygoni Multiflori (system), Flos Campsis, Catharsii molossi, Oletum Trogopterori, Semen sojae atricolor, Herba Lobeliae Chinensis, mix the back and in medicine, add water 10-12 doubly, put into extraction pot and heating, to be extracted jar of inner liquid medicine boiling, heating will be continued in the medicinal liquid suction concentration tank, evaporating solvent is back in the extraction pot, so circulation is carried out continuously, reflux, extract, 3-5 hour, obtain medicinal liquid
Step D: concentrate, step C gained medicinal liquid is carried out concentration, make thick paste, the relative density of thick paste is 1.25-1.30,
Step e: dry, pulverize, with step D gained thick paste and step B gained medicated powder mix homogeneously, and after mixture carried out the microwave vacuum drying processing, its pulverizing is obtained fine powder,
Step F: use the medicated powder that makes in the step e to make preparation.
The preparation of alleged preparation can make forms such as tablet, capsule, granule in the step F of the present invention, and convenient different patients use.
The present invention has that the blood stasis dispelling of medicine function of gallbladder promoting, dampness removing heat clearing away, QI invigorating are set upright, toxicity is minimum, safe, preparation method of the present invention can be saved the consumption of water and steam more than 50% significantly, drying time is short, the function that the medicine that makes can keep original medicine cures mainly, and be more conducive to absorb, biotic component height in the herbal raw material, the active constituent content height has significant advantages such as energy consumption is low, easy operating.
The specific embodiment:
A kind of medicine for the treatment of chronic hepatitis and early stage liver cirrhosis, it is characterized in that by the Rhizoma Atractylodis Macrocephalae (stir-fry), Rhizoma Cyperi (system), the Radix Paeoniae Alba, Rhizoma Curcumae, rhizoma sparganic, Radix Angelicae Sinensis, Fructus Chaenomelis, Radix Et Rhizoma Rhei, Flos Carthami, Carapax Trionycis (processing), Semen Persicae, Radix Curcumae, Herba Artemisiae Scopariae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Radix Scrophulariae, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Polygoni Cuspidati, Eupolyphaga Seu Steleophaga, Radix Bupleuri, Radix Polygoni Multiflori (system), Flos Campsis, Catharsii molossi, Oletum Trogopterori, Semen sojae atricolor, Herba Lobeliae Chinensis is formed, and each component by following weight proportion is: the Rhizoma Atractylodis Macrocephalae (stir-fry) 1-4 part, Rhizoma Cyperi (system) 4-7 part, Radix Paeoniae Alba 2-5 part, Rhizoma Curcumae 2-5 part, rhizoma sparganic 1-4 part, Radix Angelicae Sinensis 1-4 part, Fructus Chaenomelis 1-2 part, Radix Et Rhizoma Rhei 1-2 part, Flos Carthami 1-3 part, Carapax Trionycis (processing) 1-2 part, Semen Persicae 1-2 part, Radix Curcumae 1-2 part, Herba Artemisiae Scopariae 1-4 part, Sargassum 1-4 part, Thallus Laminariae (Thallus Eckloniae) 2-5 part, Radix Scrophulariae 1-4 part, Radix Rehmanniae 4-7 part, Radix Rehmanniae Preparata 2-5 part, Rhizoma Polygoni Cuspidati 4-7 part, Eupolyphaga Seu Steleophaga 4-7 part, Radix Bupleuri 1-3 part, Radix Polygoni Multiflori (system) 4-7 part, Flos Campsis 1-2 part, Catharsii molossi 1-2 part, Oletum Trogopterori 1-4 part, Semen sojae atricolor 4-7 part, Herba Lobeliae Chinensis 1-4 part.
Function of gallbladder promoting blood stasis dispelling of the present invention, dampness removing heat clearing away, QI invigorating are set upright and are the rule of treatment, through long-term clinical observation, total effective rate is 88% ideal effect, experiment confirm by Shandong Prov. Inst. of Traditional Chinese Medicine's work, the present invention have treatment hepatitis, liver cirrhosis, obviously improve the liver fat metabolism, improve the organizational structure of pathologic liver, have the effect of hepatoprotective.
The present invention does overtesting to mice, can cause the serum TC of pathological changes mice, the decline of T and the rising of HDL-C, thereby improves the component ratio of lipoprotein.
The present invention experimental results show that mice four carbonoxide acute liver damages, ALT in the blood plasma of mice is descended, the hepatocellular degeneration degree of necrosis is alleviated, improves the organizational structure of pathologic liver, especially to treatment hepatic disease, hepatic necrosis to alleviate effect more remarkable.
In the acute toxicity testing of the present invention, when giving the disposable filling stomach of mice with clinical identical route of administration, fail to obtain fatal dose of the present invention, irritate stomach three times through Cmax, maximum volume (being equivalent to 21.44/k/ day) a day, the maximum tolerated dose multiple of obtaining mice 238.3 times of clinical usual amounts of behaving, illustrate that oral toxicity of the present invention is minimum, safe.
A kind of process for preparing medicine for the treatment of chronic hepatitis and early stage liver cirrhosis is characterized in that comprising the steps:
Steps A: prepare raw material, each component of raw material is taken by following weight proportion: the Rhizoma Atractylodis Macrocephalae (stir-fry) 1-4 part, Rhizoma Cyperi (system) 4-7 part, Radix Paeoniae Alba 2-5 part, Rhizoma Curcumae 2-5 part, rhizoma sparganic 1-4 part, Radix Angelicae Sinensis 1-4 part, Fructus Chaenomelis 1-2 part, Radix Et Rhizoma Rhei 1-2 part, Flos Carthami 1-3 part, Carapax Trionycis (processing) 1-2 part, Semen Persicae 1-2 part, Radix Curcumae 1-2 part, Herba Artemisiae Scopariae 1-4 part, Sargassum 1-4 part, Thallus Laminariae (Thallus Eckloniae) 2-5 part, Radix Scrophulariae 1-4 part, Radix Rehmanniae 4-7 part, Radix Rehmanniae Preparata 2-5 part, Rhizoma Polygoni Cuspidati 4-7 part, Eupolyphaga Seu Steleophaga 4-7 part, Radix Bupleuri 1-3 part, Radix Polygoni Multiflori (system) 4-7 part, Flos Campsis 1-2 part, Catharsii molossi 1-2 part, Oletum Trogopterori 1-4 part, Semen sojae atricolor 4-7 part, Herba Lobeliae Chinensis 1-4 part
Step B: pulverization process, the proportioning among the A is taken the Rhizoma Atractylodis Macrocephalae (stir-fry), Radix Angelicae Sinensis, Rhizoma Cyperi (system), the Radix Paeoniae Alba, Rhizoma Curcumae, rhizoma sparganic, Fructus Chaenomelis set by step, drops in the reducing mechanism and pulverizes, and makes standby medicated powder, and the medicated powder fineness is not more than 100 orders,
Step C: the proportioning among the A is taken Radix Et Rhizoma Rhei set by step, Flos Carthami, Carapax Trionycis, Semen Persicae, Radix Curcumae, Herba Artemisiae Scopariae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Radix Scrophulariae, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Polygoni Cuspidati, Eupolyphaga Seu Steleophaga, Radix Bupleuri, Radix Polygoni Multiflori (system), Flos Campsis, Catharsii molossi, Oletum Trogopterori, Semen sojae atricolor, Herba Lobeliae Chinensis, mix the back and in medicine, add water 10-12 doubly, put into extraction pot and heating, to be extracted jar of inner liquid medicine boiling, with medicinal liquid suction concentration tank internal heating, evaporating solvent is back in the extraction pot, so circulation was carried out reflux, extract, 3-5 hour continuously, obtain medicinal liquid
Step D: concentrate, step C gained medicinal liquid is carried out concentration, make thick paste, the relative density of thick paste is 1.25-1.30,
Step e: dry, pulverize, with step D gained thick paste and step B gained medicated powder mix homogeneously, and after mixture carried out the microwave vacuum drying processing, its pulverizing is obtained fine powder,
Step F: use the medicated powder that makes in the step e to make preparation.
The preparation of alleged preparation can make forms such as tablet, capsule, granule in the step F of the present invention, convenient different patients use, wherein same as the prior art for the preparation method of tablet and granule, this does not give unnecessary details, preparation for capsule, be meant that fine powder with gained in the step e by in a certain amount of the incapsulating, makes capsule.
The present invention compared with prior art, can save significantly the consumption of water and steam more than 50%, drying time is short, the function that the medicine that makes can keep original medicine cures mainly, and be more conducive to absorb, the bioavilability height, the active constituent content height has the significant advantages such as energy consumption is low, easy operating.
Claims (3)
1. medicine for the treatment of chronic hepatitis and early stage liver cirrhosis, it is characterized in that by the Rhizoma Atractylodis Macrocephalae (stir-fry), Rhizoma Cyperi (system), the Radix Paeoniae Alba, Rhizoma Curcumae, rhizoma sparganic, Radix Angelicae Sinensis, Fructus Chaenomelis, Radix Et Rhizoma Rhei, Flos Carthami, Carapax Trionycis (processing), Semen Persicae, Radix Curcumae, Herba Artemisiae Scopariae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Radix Scrophulariae, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Polygoni Cuspidati, Eupolyphaga Seu Steleophaga, Radix Bupleuri, Radix Polygoni Multiflori (system), Flos Campsis, Catharsii molossi, Oletum Trogopterori, Semen sojae atricolor, Herba Lobeliae Chinensis is formed, and each component by following weight proportion is: the Rhizoma Atractylodis Macrocephalae (stir-fry) 1-4 part, Rhizoma Cyperi (system) 4-7 part, Radix Paeoniae Alba 2-5 part, Rhizoma Curcumae 2-5 part, rhizoma sparganic 1-4 part, Radix Angelicae Sinensis 1-4 part, Fructus Chaenomelis 1-2 part, Radix Et Rhizoma Rhei 1-2 part, Flos Carthami 1-3 part, Carapax Trionycis (processing) 1-2 part, Semen Persicae 1-2 part, Radix Curcumae 1-2 part, Herba Artemisiae Scopariae 1-4 part, Sargassum 1-4 part, Thallus Laminariae (Thallus Eckloniae) 2-5 part, Radix Scrophulariae 1-4 part, Radix Rehmanniae 4-7 part, Radix Rehmanniae Preparata 2-5 part, Rhizoma Polygoni Cuspidati 4-7 part, Eupolyphaga Seu Steleophaga 4-7 part, Radix Bupleuri 1-3 part, Radix Polygoni Multiflori (system) 4-7 part, Flos Campsis 1-2 part, Catharsii molossi 1-2 part, Oletum Trogopterori 1-4 part, Semen sojae atricolor 4-7 part, Herba Lobeliae Chinensis 1-4 part.
2. a process for preparing medicine for the treatment of chronic hepatitis and early stage liver cirrhosis is characterized in that comprising the steps:
Steps A: prepare raw material, wherein each component of raw material is taken by following weight proportion: the Rhizoma Atractylodis Macrocephalae (stir-fry) 1-4 part, Rhizoma Cyperi (system) 4-7 part, Radix Paeoniae Alba 2-5 part, Rhizoma Curcumae 2-5 part, rhizoma sparganic 1-4 part, Radix Angelicae Sinensis 1-4 part, Fructus Chaenomelis 1-2 part, Radix Et Rhizoma Rhei 1-2 part, Flos Carthami 1-3 part, Carapax Trionycis (processing) 1-2 part, Semen Persicae 1-2 part, Radix Curcumae 1-2 part, Herba Artemisiae Scopariae 1-4 part, Sargassum 1-4 part, Thallus Laminariae (Thallus Eckloniae) 2-5 part, Radix Scrophulariae 1-4 part, Radix Rehmanniae 4-7 part, Radix Rehmanniae Preparata 2-5 part, Rhizoma Polygoni Cuspidati 4-7 part, Eupolyphaga Seu Steleophaga 4-7 part, Radix Bupleuri 1-3 part, Radix Polygoni Multiflori (system) 4-7 part, Flos Campsis 1-2 part, Catharsii molossi 1-2 part, Oletum Trogopterori 1-4 part, Semen sojae atricolor 4-7 part, Herba Lobeliae Chinensis 1-4 part
Step B: pulverization process, the proportioning among the A is taken the Rhizoma Atractylodis Macrocephalae (stir-fry), Radix Angelicae Sinensis, Rhizoma Cyperi (system), the Radix Paeoniae Alba, Rhizoma Curcumae, rhizoma sparganic, Fructus Chaenomelis set by step, drops in the reducing mechanism and pulverizes, and makes standby medicated powder, and the medicated powder fineness is not more than 100 orders,
Step C: the weight proportion among the A is taken Radix Et Rhizoma Rhei set by step, Flos Carthami, Carapax Trionycis, Semen Persicae, Radix Curcumae, Herba Artemisiae Scopariae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Radix Scrophulariae, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Polygoni Cuspidati, Eupolyphaga Seu Steleophaga, Radix Bupleuri, Radix Polygoni Multiflori (system), Flos Campsis, Catharsii molossi, Oletum Trogopterori, Semen sojae atricolor, Herba Lobeliae Chinensis, mix the back and in medicine, add water 10-12 doubly, put into extraction pot and heating, to be extracted jar of inner liquid medicine boiling, with medicinal liquid suction concentration tank internal heating, evaporating solvent is back in the extraction pot, so circulation was carried out reflux, extract, 3-5 hour continuously, obtain medicinal liquid
Step D: concentrate, step C gained medicinal liquid is carried out concentration, make thick paste, the relative density of thick paste is 1.25-1.30,
Step e: dry, pulverize, with step D gained thick paste and step B gained medicated powder mix homogeneously, and after mixture carried out the microwave vacuum drying processing, its pulverizing is obtained fine powder,
Step F: use the medicated powder that makes in the step e to make preparation.
3. a kind of preparation method for the treatment of the medicine of chronic hepatitis and early stage liver cirrhosis according to claim 1 is characterized in that the preparation of alleged preparation is meant during the gained fine powder incapsulates in the step e in the step F, makes capsule.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688463A (en) * | 2012-05-08 | 2012-09-26 | 安徽智远生物科技有限公司 | Traditional Chinese medicine for treating repeated vomiting and preparation method thereof |
| CN103127330A (en) * | 2013-02-19 | 2013-06-05 | 青岛正大海尔制药有限公司 | Pharmaceutical composition for treating hepatitis |
| CN103479835A (en) * | 2013-09-29 | 2014-01-01 | 秦福玉 | Traditional Chinese medicine for treating liver cirrhosis |
-
2010
- 2010-08-24 CN CN2010102612714A patent/CN101912583A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688463A (en) * | 2012-05-08 | 2012-09-26 | 安徽智远生物科技有限公司 | Traditional Chinese medicine for treating repeated vomiting and preparation method thereof |
| CN102688463B (en) * | 2012-05-08 | 2014-05-21 | 安徽智远生物科技有限公司 | Traditional Chinese medicine for treating repeated vomiting and preparation method thereof |
| CN103127330A (en) * | 2013-02-19 | 2013-06-05 | 青岛正大海尔制药有限公司 | Pharmaceutical composition for treating hepatitis |
| CN103127330B (en) * | 2013-02-19 | 2014-11-12 | 青岛正大海尔制药有限公司 | Pharmaceutical composition for treating hepatitis |
| CN103479835A (en) * | 2013-09-29 | 2014-01-01 | 秦福玉 | Traditional Chinese medicine for treating liver cirrhosis |
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Application publication date: 20101215 |