CN104105501B - 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗 - Google Patents

异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗 Download PDF

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Publication number
CN104105501B
CN104105501B CN201280054226.9A CN201280054226A CN104105501B CN 104105501 B CN104105501 B CN 104105501B CN 201280054226 A CN201280054226 A CN 201280054226A CN 104105501 B CN104105501 B CN 104105501B
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China
Prior art keywords
cometin
purposes
seq
allodynia
pain
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CN201280054226.9A
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English (en)
Chinese (zh)
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CN104105501A (zh
Inventor
J.R.乔根森
L.U.瓦尔伯格
T.E.约翰森
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Hoba Therapeutics
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NsGene AS
NS Gene AS
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Priority to CN201710826364.9A priority Critical patent/CN107596346A/zh
Publication of CN104105501A publication Critical patent/CN104105501A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CN201280054226.9A 2011-09-05 2012-09-05 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗 Active CN104105501B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710826364.9A CN107596346A (zh) 2011-09-05 2012-09-05 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161531024P 2011-09-05 2011-09-05
US61/531,024 2011-09-05
PCT/DK2012/050330 WO2013034157A1 (en) 2011-09-05 2012-09-05 Treatment of allodynia, hyperalgsia, spontaneous pain, and phantom pain

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201710826364.9A Division CN107596346A (zh) 2011-09-05 2012-09-05 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗

Publications (2)

Publication Number Publication Date
CN104105501A CN104105501A (zh) 2014-10-15
CN104105501B true CN104105501B (zh) 2017-10-20

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CN201280054226.9A Active CN104105501B (zh) 2011-09-05 2012-09-05 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗
CN201710826364.9A Pending CN107596346A (zh) 2011-09-05 2012-09-05 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗

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CN201710826364.9A Pending CN107596346A (zh) 2011-09-05 2012-09-05 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗

Country Status (8)

Country Link
US (2) US9474786B2 (enExample)
EP (1) EP2753347B1 (enExample)
JP (1) JP6145667B2 (enExample)
KR (1) KR102075881B1 (enExample)
CN (2) CN104105501B (enExample)
AU (1) AU2012306810B2 (enExample)
CA (1) CA2846511C (enExample)
WO (1) WO2013034157A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2730710C (en) 2008-07-24 2021-06-08 Nsgene A/S Therapeutic use of a growth factor, metrnl
CA3086046C (en) * 2017-12-29 2023-02-21 Helixmith Co., Ltd. Adeno-associated virus (aav) vector having hybrid hgf gene introduced thereto
CN110004223A (zh) * 2019-05-09 2019-07-12 苏州大学附属第一医院 一种用于预测早发型子痫前期发病的检测试剂盒
CA3217602A1 (en) * 2021-05-06 2022-11-10 Kenneth Petersen Prevention and treatment of chemotherapy-induced neuropathic pain
JP2024546758A (ja) * 2021-12-10 2024-12-26 ホバ セラピューティクス エーピーエス 侵害受容性疼痛の治療

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1982454A (zh) * 2005-12-15 2007-06-20 中国医学科学院北京协和医院 一种骨质疏松相关基因及其编码蛋白和用途
CN102164611A (zh) * 2008-07-24 2011-08-24 Ns基因公司 生长因子metrnl的治疗用途

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CN102164611A (zh) * 2008-07-24 2011-08-24 Ns基因公司 生长因子metrnl的治疗用途

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Also Published As

Publication number Publication date
CA2846511C (en) 2021-07-13
US20170143794A1 (en) 2017-05-25
EP2753347A1 (en) 2014-07-16
AU2012306810B2 (en) 2017-09-28
KR20140068148A (ko) 2014-06-05
HK1199395A1 (en) 2015-07-03
US9474786B2 (en) 2016-10-25
EP2753347B1 (en) 2016-08-03
JP6145667B2 (ja) 2017-06-14
CA2846511A1 (en) 2013-03-14
KR102075881B1 (ko) 2020-02-11
CN107596346A (zh) 2018-01-19
AU2012306810A1 (en) 2014-03-13
WO2013034157A1 (en) 2013-03-14
US20150231208A1 (en) 2015-08-20
CN104105501A (zh) 2014-10-15
US9861682B2 (en) 2018-01-09
JP2014529408A (ja) 2014-11-13

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