CN104098530A - 一种沃替西汀的制备方法 - Google Patents
一种沃替西汀的制备方法 Download PDFInfo
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- CN104098530A CN104098530A CN201410386153.4A CN201410386153A CN104098530A CN 104098530 A CN104098530 A CN 104098530A CN 201410386153 A CN201410386153 A CN 201410386153A CN 104098530 A CN104098530 A CN 104098530A
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- GLUUGHFHXGJENI-UHFFFAOYSA-N C1NCCNC1 Chemical compound C1NCCNC1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
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CN201410386153.4A CN104098530B (zh) | 2014-08-07 | 2014-08-07 | 一种沃替西汀的制备方法 |
Applications Claiming Priority (1)
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CN201410386153.4A CN104098530B (zh) | 2014-08-07 | 2014-08-07 | 一种沃替西汀的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN104098530A true CN104098530A (zh) | 2014-10-15 |
CN104098530B CN104098530B (zh) | 2016-03-09 |
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CN201410386153.4A Expired - Fee Related CN104098530B (zh) | 2014-08-07 | 2014-08-07 | 一种沃替西汀的制备方法 |
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Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104356092A (zh) * | 2014-11-27 | 2015-02-18 | 合肥创新医药技术有限公司 | 沃替西汀的制备方法 |
CN105061364A (zh) * | 2015-08-17 | 2015-11-18 | 河北国龙制药有限公司 | 氢溴酸沃替西汀的制备方法 |
CN105367516A (zh) * | 2015-11-11 | 2016-03-02 | 北京万全德众医药生物技术有限公司 | 一种沃替西汀的新制备方法 |
CN105439980A (zh) * | 2015-05-08 | 2016-03-30 | 北京北陆药业股份有限公司 | 一种氢溴酸沃替西汀一仲丁醇合物及其制备方法 |
CN105801517A (zh) * | 2014-12-30 | 2016-07-27 | 上海奥博生物医药技术有限公司 | 一种沃替西汀氢溴酸盐新晶型及其制备方法 |
CN105985301A (zh) * | 2015-02-05 | 2016-10-05 | 山东康美乐医药科技有限公司 | 一种氢溴酸沃替西汀的制备方法 |
CN106458943A (zh) * | 2014-04-07 | 2017-02-22 | 斯洛文尼亚莱柯制药股份有限公司 | 通过(2,4‑二甲基苯基)(2‑碘苯基)硫烷中间体合成沃替西汀 |
CN106556663A (zh) * | 2015-09-30 | 2017-04-05 | 成都弘达药业有限公司 | 一种1-[2-(2,4-二甲基苯基硫烷基)苯基]哌嗪或其盐的检测方法 |
CN107501209A (zh) * | 2016-06-14 | 2017-12-22 | 江苏吉贝尔药业股份有限公司 | 4‑[2‑(2‑甲基‑4‑溴‑苯巯基)‑苯基]哌嗪‑1‑羧酸叔丁酯合成方法 |
CN107513048A (zh) * | 2016-06-17 | 2017-12-26 | 江苏吉贝尔药业股份有限公司 | 一种氘代沃替西汀氢溴酸盐的合成方法 |
US10428033B2 (en) | 2017-02-15 | 2019-10-01 | Piramal Enterprises Limited | Process for the preparation of vortioxetine and salts thereof |
CN110804027A (zh) * | 2019-10-11 | 2020-02-18 | 杭州和康药业有限公司 | 一种沃替西汀杂质1-[3-(2,4-二甲基苯基硫烷基)-苯基]哌嗪及其用途 |
CN113125586A (zh) * | 2019-12-31 | 2021-07-16 | 成都百裕制药股份有限公司 | 一种1-[2-(2,4-二甲基-苯硫基)-苯基]哌嗪及其异构体的检测方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040116518A1 (en) * | 1998-12-29 | 2004-06-17 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
CN101070297A (zh) * | 2007-04-25 | 2007-11-14 | 上海大学 | 2,2,2-三氟-n-(2-芳基硫代)芳基乙酰胺衍生物及其制备方法 |
-
2014
- 2014-08-07 CN CN201410386153.4A patent/CN104098530B/zh not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040116518A1 (en) * | 1998-12-29 | 2004-06-17 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
CN101070297A (zh) * | 2007-04-25 | 2007-11-14 | 上海大学 | 2,2,2-三氟-n-(2-芳基硫代)芳基乙酰胺衍生物及其制备方法 |
Non-Patent Citations (8)
Title |
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BENNY BANG-ANDERSEN等: "Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder", 《MEDICINAL CHEMISTRY》 * |
DAWEI MA等: "Mild Method for Ullmann Coupling Reaction of Amines and Aryl Halides", 《ORGANIC LETTERS》 * |
HUI ZHANG等: "Amino Acid Promoted CuI-Catalyzed C-N Bond Formation between Aryl Halides and Amines or N-Containing Heterocycles", 《J. ORG. CHEM.》 * |
MONICA CARRIL等: "Simple and Efficient Recyclable Catalytic System for Performing Copper-Catalysed S-Arylation Reactions in the Presence of Water", 《CHEM. EUR. J.》 * |
任世言等: "沃替西汀的合成", 《药学研究》 * |
张慧等: "邻基效应促进的2-芳基硫代芳胺衍生物的简易合成", 《有机化学》 * |
许华建等: "铜催化碳杂偶联反应的新进展", 《有机化学》 * |
郑云法等: "室温离子液体中CuBr-脯氨酸催化的硫醇、硫酚与卤代芳烃的偶联反应", 《有机化学》 * |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106458943A (zh) * | 2014-04-07 | 2017-02-22 | 斯洛文尼亚莱柯制药股份有限公司 | 通过(2,4‑二甲基苯基)(2‑碘苯基)硫烷中间体合成沃替西汀 |
CN104356092A (zh) * | 2014-11-27 | 2015-02-18 | 合肥创新医药技术有限公司 | 沃替西汀的制备方法 |
CN104356092B (zh) * | 2014-11-27 | 2017-03-22 | 合肥创新医药技术有限公司 | 沃替西汀的制备方法 |
CN105801517A (zh) * | 2014-12-30 | 2016-07-27 | 上海奥博生物医药技术有限公司 | 一种沃替西汀氢溴酸盐新晶型及其制备方法 |
CN105985301A (zh) * | 2015-02-05 | 2016-10-05 | 山东康美乐医药科技有限公司 | 一种氢溴酸沃替西汀的制备方法 |
CN105439980B (zh) * | 2015-05-08 | 2017-10-24 | 北京北陆药业股份有限公司 | 一种氢溴酸沃替西汀一仲丁醇合物及其制备方法 |
CN105439980A (zh) * | 2015-05-08 | 2016-03-30 | 北京北陆药业股份有限公司 | 一种氢溴酸沃替西汀一仲丁醇合物及其制备方法 |
CN105061364A (zh) * | 2015-08-17 | 2015-11-18 | 河北国龙制药有限公司 | 氢溴酸沃替西汀的制备方法 |
CN106556663A (zh) * | 2015-09-30 | 2017-04-05 | 成都弘达药业有限公司 | 一种1-[2-(2,4-二甲基苯基硫烷基)苯基]哌嗪或其盐的检测方法 |
CN105367516A (zh) * | 2015-11-11 | 2016-03-02 | 北京万全德众医药生物技术有限公司 | 一种沃替西汀的新制备方法 |
CN107501209A (zh) * | 2016-06-14 | 2017-12-22 | 江苏吉贝尔药业股份有限公司 | 4‑[2‑(2‑甲基‑4‑溴‑苯巯基)‑苯基]哌嗪‑1‑羧酸叔丁酯合成方法 |
CN107513048A (zh) * | 2016-06-17 | 2017-12-26 | 江苏吉贝尔药业股份有限公司 | 一种氘代沃替西汀氢溴酸盐的合成方法 |
CN107513048B (zh) * | 2016-06-17 | 2020-07-14 | 江苏吉贝尔药业股份有限公司 | 一种氘代沃替西汀氢溴酸盐的合成方法 |
US10428033B2 (en) | 2017-02-15 | 2019-10-01 | Piramal Enterprises Limited | Process for the preparation of vortioxetine and salts thereof |
CN110804027A (zh) * | 2019-10-11 | 2020-02-18 | 杭州和康药业有限公司 | 一种沃替西汀杂质1-[3-(2,4-二甲基苯基硫烷基)-苯基]哌嗪及其用途 |
CN113125586A (zh) * | 2019-12-31 | 2021-07-16 | 成都百裕制药股份有限公司 | 一种1-[2-(2,4-二甲基-苯硫基)-苯基]哌嗪及其异构体的检测方法 |
CN113125586B (zh) * | 2019-12-31 | 2022-05-24 | 成都百裕制药股份有限公司 | 一种1-[2-(2,4-二甲基-苯硫基)-苯基]哌嗪及其异构体的检测方法 |
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CN104098530B (zh) | 2016-03-09 |
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C06 | Publication | ||
PB01 | Publication | ||
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SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Feng Xiuwu Inventor before: Duan Xifu |
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COR | Change of bibliographic data | ||
GR01 | Patent grant | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20160216 Address after: Liangshan County in Shandong province 272600 Jining City Road No. 80 Applicant after: Feng Xiuwu Address before: 276407, No. 100 village, forty Li Town, Yishui County, Shandong, Linyi Applicant before: Duan Xifu |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160309 Termination date: 20160807 |