CN104095973A - Externally-used traditional Chinese medicine composition for treating hyperostosis and preparation of externally-used traditional Chinese medicine composition - Google Patents
Externally-used traditional Chinese medicine composition for treating hyperostosis and preparation of externally-used traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention belongs to the field of Chinese herbal products, in particular to an externally-used traditional Chinese medicine composition for treating hyperostosis and preparation of the externally-used traditional Chinese medicine composition, and overcomes the defects that the conventional externally-used medicine for treating hyperostosis is complex in formula, high in cost and high in toxicity. The externally-used traditional Chinese medicine composition for treating hyperostosis, provided by the invention, comprises the following raw materials: 400 parts of szechuan lovage rhizome, 50-60 parts of burdock, 3-7 parts of musk, 50-60 parts of camphor, 20-30 parts of angelica sinensis and 20-30 parts of pseudo-ginseng. The externally-used traditional Chinese medicine composition for treating hyperostosis is scientific and reasonable in formula, good in curative effect, low in cost and suitable for being popularized and used.
Description
Technical field
The present invention relates to Chinese medicine product field, is a kind of external medicine composition and preparation thereof that is used for the treatment of hyperosteogeny.
Background technology
Hyperosteogeny, be called again hyperplastic osteoarthritis, osteoarthritis (OA), degenerated arthrosis, senile arthritis, hypertrophiarthritis, be due to soft tissue degeneration, degenerations such as the cartilage that forms joint, intervertebral disc, ligaments, edge, joint forms bony spur, and synovial membrane plumpness waits variation, and there is osteoclasia, cause insecondary hyperosteogeny, cause joint deformity, in the time being subject to abnormal load, cause arthralgia, a kind of disease of the symptoms such as limitation of activity.The traditional Chinese medical science claims again bony spur.Be apt to occur in lumbar vertebra and knee joint portion, except these two, along with modern age women to like the agitation wearing high heels popular, the sickness rate of women's spur in heels has been altered rapidly, suddenly becomes the hyperosteogeny disease of sickness rate the 3rd.It is many because insufficiency of vital energy and blood, caused by liver and kidney deficiency, wind-cold damp pathogen are invaded bone network that Chinese medicine thinks that primary disease occurs; Or tumbling down sprain and contusion, trauma bone network, so that stagnation of QI-blood, operation is lost smooth, long-time stimulus diaphysis tissue, so that bone table hypertrophy forms bony spur.Bone matrix hyperplasia divides two kinds of constitutional and Secondary cases.Hyperosteogeny is a kind of frequently-occurring disease, commonly encountered diseases! It is a kind of disease that causes arthralgia.
In prior art, treat hyperosteogeny and often adopt the method for excision hyperosteogeny part, but though the method take effect temporarily, but patient suffering is large, and bony spur can continued growth, relapse rate is high, can not effect a radical cure.The method that adopts Western medicine control hyperosteogeny, toxic and side effects is large, well scheme.Chinese medicine hyperosteogeny has good radical cure effect, is three points of poison of medicine, and oral Chinese medicine hyperosteogeny, the in the situation that of long-term prescription, although toxic and side effects is less, but also can have impact to health.The most of formula of medicine of the treatment hyperosteogeny of external is complicated, technique is complicated, cost is high, in the medicine using, contain noxious substance, although the traditional Chinese medical science is particular about treating the poisonous disease with poisonous drugs, but in the use procedure of extensive patients,, due to different situations, the noxious substance during some people also may absorb the drug, causes harmful effect to health.
Summary of the invention
The medicine an object of the present invention is as solving above-mentioned existing treatment hyperosteogeny has toxic and side effects, and the high problem of complicated cost of filling a prescription, provides a kind of external medicine composition that is used for the treatment of hyperosteogeny.
Another object of the present invention is to provide a kind of preparation method of the external medicine composition that is used for the treatment of hyperosteogeny.
For achieving the above object, a technical scheme of the present invention provides a kind of external medicine composition that is used for the treatment of hyperosteogeny, and said composition comprises 400 parts of Rhizoma Chuanxiongs, Fructus Arctii 50-60 part, Moschus 3-7 part, Camphora 50-60 part, Radix Angelicae Sinensis 20-30 part, Radix Notoginseng 20-30 part.
This Chinese medicine composition also comprises Radix Achyranthis Bidentatae 0-60 part, Cortex Phellodendri 0-30 part.
An optimal technical scheme of the present invention is:
Chinese medicine composition comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, 50 parts of Radix Achyranthis Bidentataes, 25 parts of Cortex Phellodendris.
This Chinese medicine composition also comprises Semen Crataegi extract 0-5 part.
An optimal technical scheme of the present invention is:
Chinese medicine composition comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, 50 parts of Radix Achyranthis Bidentataes, 25 parts of Cortex Phellodendris, 2 parts of Semen Crataegi extract.
This Chinese medicine composition also comprises Folium Eriobotryae 0-500 part; Borneolum Syntheticum 0-20 part.
An optimal technical scheme of the present invention is:
Chinese medicine composition comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, 50 parts of Radix Achyranthis Bidentataes, 25 parts of Cortex Phellodendris, 2 parts of Semen Crataegi extract, 400 parts of Folium Eriobotryaes, 10 parts of Borneolum Syntheticums.
This Chinese medicine composition also comprises water 0-500 part, Chinese liquor 0-1000 part, or Oleum sesami 0-800 part.A technical scheme of the present invention provides a kind of preparation method of the external medicine composition that is used for the treatment of hyperosteogeny, and the method is carried out in the following manner:
C. by crude drug except Folium Eriobotryae, be ground into Powderedly, the group of adding water into, is pressed into pie, spreads on affected part, or is put on Folium Eriobotryae, spreads on affected part.
Described Folium Eriobotryae is fresh Folium Eriobotryae or the Folium Eriobotryae with having one's hair waved, can be that with starting, having one's hair waved is directly used fresh Folium Eriobotryae later or dry Folium Eriobotryae maceration uses with the Folium Eriobotryae of having one's hair waved.
D. by crude drug, be ground into Powderedly, put into Chinese liquor, soak more than 7 days, preferably soak more than 90 days, dip wine liquid massage affected part, the medicinal residues after soaking are coated in to affected part.
C. crude drug is ground into except Folium Eriobotryae Powderedly, puts into Oleum sesami, the fried 30-60 minute of little fire, filters, and filtrate is continued to little fire fried, until simmer down to ointment.Ointment shape finished product is coated on Folium Eriobotryae, or Folium Eriobotryae water was decocted after 20-60 minute, by dregs filtering, filtrate continuation decocts to paste, and after Extractum Folii Eriobotryae Inspissmatum is mixed with ointment, little fire is fried, and content liquid is less than 25%.Described paste is that in system, content liquid is less than 25%.
Fructus Arctii is the whole strain of feverfew Fructus Arctii Arctium lappa Lim.Another name: Fructus Arctii, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae), burdock father-in-law dish, Fructus Arctii, cattle dish, Fructus Arctii, Fructus Arctii, packing sow ear, black radish, white muscle Radix Ginseng.Nature and flavor: cool, sweet.Function: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.
Rhizoma Chuanxiong, has another name called: Oleum Linderae, rhizome of chuanxiong Qiong, Hu Qiong, gag bit, rhizome of chuanxiong Qiong, Latin literary fame: LigusticumchuanxiongHort. Umbelliferae, Ligustrum perennial herb, high 40-60 centimetre.Rhizome prosperity, forms irregular nodositas fist shape agglomerate, and a kind of Chinese medicinal plant, is usually used in rhizome hyoscine, function activating QI to alleviate the depression, and dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain, controlling headache and revolving the diseases such as dizzy, costalgia abdomen pain, amenorrhea, difficult labour, ulcer sores.
Moschus moschiferous (she) perfume (or spice) is natural perfume material, belongs to one of animality spice, has another name called: Moschus, umbilicus perfume (or spice), Moschus moschiferous umbilicus perfume (or spice), smelly, the smelly son of four tastes, cured son, fragrant umbilicus.Moschus is the secretions of the glandular sac between umbilicus and the genitals of male Moschus moschiferous, is graininess or bulk after dry, has special fragrance, has bitterness, can make spice, also can be used as medicine.Be central nervous excitation agent, external can be eased pain, be subsided a swelling.One of raw material of manufacturing perfume, in China also by medicinal.
Camphora, another name camphor, splendid brain, brain, oily brain, tree brain, be the root of Lauraceae magaphanerophytes Camphor tree, dry, branch, the crystallization product of leaf through refining.Pungent, hot.GUIXIN, liver, spleen channel.Effect: killing parasites for relieving itching: itch for scabies skin ulcer, have dehumidifying parasite killing, antipruritic effect, joins Cortex Pseudolaricis, the Fructus Kochiae, Fructus Cnidii, sulfur, the external of steeping in wine such as Radix Sophorae Flavescentis, or join sulfur, and dried Alumen, Radix Sophorae Flavescentis, Cortex Phellodendris etc. are ground into powder, and vegetable oil dresses.Reducing swelling and alleviating pain: for the stagnant multiple pain card such as swell and ache of tumbling down damage, the stasis of blood.Available ethanol is made into tincture and wipes outward.Ward off and dirtyly have one's ideas straightened out: for fainting suddenly or coma etc.
Borneolum Syntheticum, has another name called sheet brain, Fructus Citri tangerinae sheet, Borneolum Syntheticum, MEIHUA BINGPIAN, Dipterocarpus pilosus, Flos Mume brain, Borneolum Syntheticum brain, Mei Bing etc., is the translucent seemingly crystalline solid of Flos Mume lobe bulk, lamellar.Borneolum Syntheticum is that resin and the volatile oil processed goods of Spore density Borneolum Syntheticum extracts the crystallization obtaining, and is near pure dextro Borneolum Syntheticum.Also useful chemical method is synthetic.It can be used for for excess syndrome of stroke coma, for conjunctival congestion and swelling pain, sore throat aphtha, swells and ache for skin infection, does not hold back etc. after bursting.
Radix Angelicae Sinensis meridian distribution of property and flavor: warm in nature, sweet in the mouth, pungent.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Radix Notoginseng has another name called Radix Notoginseng, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Radix Notoginseng, Herba Wedeliae Wallichii, mountain paint, field paint, is the famous special product in Guangxi, Yunnan, is araliaceae ginseng plant, perennial herb, and its subterraneous stem is made medicine.Look at the efficacy effect of Radix Notoginseng below.Seven mainly contain hemostasis, dissipating blood stasis, detumescence, effect of analgesic therapy.To controlling haematemesis, hemoptysis, have blood in stool, metrorrhagia, puerperal blood faints, retention of lochia, fall symptoms such as flutterring blood stasis, traumatic hemorrhage, carbuncle pain and have good effect.Removing stasis to stop bleeding, the analgesic therapy of invigorating blood circulation.Radix Notoginseng can be stopped blooding, again can dissipating blood stasis, and there is hemostasis and do not stay the stasis of blood, blood stasis dispelling and do not hinder feature just, is removing stasis to stop bleeding good medicine.Radix Notoginseng energy blood circulation promoting and blood stasis dispelling and subduing swelling and relieving pain are the key medicines of analgesic therapy of invigorating blood circulation.Can take orally or external application by single, or join blood-activating and qi-moving medicinal with using.
Radix Achyranthis Bidentatae is the plant of Amaranthaceae Achyranthes.Be distributed in Africa, Russia, Vietnam, India, Malaysia, Philippine, Korea and the China ground such as all parts of the country except northeast, grow in the area of 200 meters to 1,750 meter of height above sea level, be often grown in hillside sylvan life.Radix Achyranthis Bidentatae cures mainly: soreness of waist and knee joint; Flaccidity and weakness of the lower limbs; Amenorrhea due to stagnation of blood; Dysmenorrhea; Puerperal abdominal pain due to blood stasis; Lump in the abdomen; Retention of placenta; Pyretic stranguria; Stranguria with blood; Traumatic injury; Carbuncle malignant boil; Laryngopharynx swelling and pain.
Cortex Phellodendri is the dry bark of rutaceae wampee or Cortex Phellodendri.The former practises title " Cortex Phellodendri ", and the latter practises title " Cortex Phellodendri ".Can be used as medicine, nature and flavor bitter cold, cures mainly hematodiarrhoea, has loose bowels, quench one's thirst, and jaundice ， flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, also under leucorrhea, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.
Semen Crataegi extract, generally be used for doing antibacterial composition, inventor selects this composition, original idea is to issue at the environment of higher temperature the matter that changes for fear of the medicine with abundant nutrition composition, solve the infringement that life-time service external used medicine causes skin, as the appearance of the skin problems such as red and swollen ulcer, but the great many of experiments through inventor is found, in this formula, match with other composition, better play the adding of Semen Crataegi extract the effect of antiinflammatory and detumescence blood stasis dispelling, and promote better the activity of osteocyte, help to promote periosteum growth, through mouse experiment, add Semen Crataegi extract to make the performance of anti-inflammation detumescence blood stasis dispelling of the present invention improve 2-3.5%, promote the active performance that helps the growth of promotion periosteum of osteocyte to improve 0.8-1.2%.But Semen Crataegi extract is added in other formula, and its effect aspect the growth of the active promotion of promotion osteocyte periosteum is not remarkable.
The use of Folium Eriobotryae has the effect of drawing out pus by applying a plaster to the affected part and reducing internal heat, and the plaster made from the fried raw material of Oleum sesami is that in three kinds of methods, effect is best, the one that uses most convenient, the effective ingredient of medicine is dissolved in oil, is beneficial to absorption of human body, make paste through boiling again, conveniently stick; But fried like this method is thought and has been brought " fire-toxin " in the angle of the traditional Chinese medical science, Folium Eriobotryae is refrigerant to reduce internal heat, the only effect of skin ulcer of drawing out pus by applying a plaster to the affected part has effectively been alleviated the side effect that fire-toxin brings, even if take the first or second method, the effect of Folium Eriobotryae is also very remarkable, there is the refrigerant only effect of skin ulcer of reducing internal heat, draw out pus by applying a plaster to the affected part, improved the curative effect of the present invention's formula.
Part described in the present invention, ratio is weight portion, and mass percent.
Beneficial effect of the present invention is:
The present invention, by the monarch of Chinese medicine, cooperatively interacts, and plays reducing swelling and alleviating pain, hard masses softening and resolving, and blood circulation promoting and blood stasis dispelling, the effect of removing obstruction in the collateral to relieve pain, promotes periosteum growth, repairs periosteum.
The equal avirulence of medicine using in the present invention, scientific formulation is reasonable, safe and efficient, and the present invention is topical agent, and penetrance is good, and curative effect is fast, this medicine is mild.
Formula of the present invention can effectively be treated hyperosteogeny, and other bone diseases is had to good curative effect.
Detailed description of the invention
Further illustrate the present invention below in conjunction with embodiment, but not as a limitation of the invention.
Embodiment 1
Be used for the treatment of an external medicine composition for hyperosteogeny, comprise 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, crude drug is ground into Powdered, and the group of adding water into is pressed into pie, spreads on affected part.On probation through 50 routine triers: after 5 days, 24 patients think pain relief, continue on probationly, after 10 days, 36 patients think pain relief, the equal pain relief of all patients after 20 days, uses all patients after 30 days normally to take action.But it is not too convenient that this embodiment product uses, and while being application first, medicine cake is thicker, the dose needing is large, cannot absorb waste medicine away from the skin end property of medicine; Second be that after using 2 hours, medicine cake becomes dry, and after 4 hours, starts cracked scorification, is inconvenient to use.
Embodiment 2:
Chinese medicine composition comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, 50 parts of Radix Achyranthis Bidentataes, 25 parts of Cortex Phellodendris.By crude drug, be ground into Powderedly, the group of adding water into, is pressed into pie, spreads on affected part,
Embodiment 3:
Chinese medicine composition comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, 50 parts of Radix Achyranthis Bidentataes, 25 parts of Cortex Phellodendris, 2 parts of Semen Crataegi extract.Crude drug is ground into Powdered, the group of adding water into, is pressed into pie, spreads on affected part,
Embodiment 4:
Chinese medicine composition comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, 50 parts of Radix Achyranthis Bidentataes, 25 parts of Cortex Phellodendris, 2 parts of Semen Crataegi extract, 400 parts of Folium Eriobotryaes.Crude drug, except Folium Eriobotryae, is ground into Powderedly, and the group of adding water into, is pressed into pie, spreads on affected part, or is put on Folium Eriobotryae, spreads on affected part.
Described Folium Eriobotryae is that dry Folium Eriobotryae maceration uses.
On probation through 50 routine triers: after 5 days, 32 patients think pain relief, continue on probationly, after 10 days, all patients is thought pain relief, can normally take action.
Embodiment 5:
Chinese medicine composition comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, 50 parts of Radix Achyranthis Bidentataes, 25 parts of Cortex Phellodendris, 2 parts of Semen Crataegi extract, 400 parts of Folium Eriobotryaes, 800 parts of Chinese liquor.By crude drug, be ground into Powderedly, put into Chinese liquor, soak more than 7 days, preferably soak more than 90 days, dip wine liquid massage affected part, the medicinal residues after soaking are coated in to affected part.50 routine triers are on probation: after 5 days, 36 patients think pain relief, continue on probationly, and after 10 days, 41 patients think pain relief, and after 20 days, the equal pain relief of all patients can normally be taken action.
Medicated wine cannot apply for a long time, so also easy to use not as good as making plaster.
Embodiment 6:
External medicine composition, comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, crude drug is ground into Powdered, puts into Oleum sesami, the fried 30-60 minute of little fire, filters, and filtrate is continued to little fire fried, until simmer down to ointment, on probation through 50 routine triers: after 5 days, 28 patients think and continue by pain relief on probation, after 10 days, 42 patients think pain relief, and the equal pain relief of all patients after 20 days, uses all patients after 30 days normally to take action.
Embodiment 7:
Chinese medicine composition comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, 50 parts of Radix Achyranthis Bidentataes, 25 parts of Cortex Phellodendris.Crude drug is ground into Powdered, puts into Oleum sesami, the fried 30-60 minute of little fire, filters, and filtrate is continued to little fire fried, until simmer down to ointment.
After 5 days, 32 patients think pain relief, continue on probationly, and after 10 days, 46 patients think pain relief, and after 20 days, the equal pain of all patients alleviates more greatly, and patient can normally take action.
Embodiment 8:
Chinese medicine composition comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, 50 parts of Radix Achyranthis Bidentataes, 25 parts of Cortex Phellodendris, 2 parts of Semen Crataegi extract.Crude drug is ground into Powdered, puts into Oleum sesami, the fried 30-60 minute of little fire, filters, and filtrate is continued to little fire fried, until simmer down to ointment.
After 3 days, 26 patients think pain relief, continue on probationly, and after 5 days, 38 patients think that pain is greatly alleviated, and after 10 days, the equal pain of all patients is greatly alleviated, and patient can normally take action.After using 5 days continuously there is redness in user drug of topical application position, pruritus phenomenon, and within 1 hour, after drug of topical application position is dry, red and swollen pruritus phenomenon is eased removal medicine, and after 3 hours, red and swollen pruritus phenomenon disappears, and drug withdrawal can continue after 8 hours to use.
Embodiment 9:
Chinese medicine composition comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, 50 parts of Radix Achyranthis Bidentataes, 25 parts of Cortex Phellodendris, 2 parts of Semen Crataegi extract, 400 parts of Folium Eriobotryaes.600 parts of Oleum sesami.Crude drug is ground into except Folium Eriobotryae Powdered, puts into Oleum sesami, the fried 30-60 minute of little fire, filters, and filtrate is continued to little fire fried, until simmer down to ointment.Folium Eriobotryae water was decocted after 40 minutes, and by dregs filtering, filtrate continuation decocts to paste, and described paste is that in system, content liquid is less than 25%.After Extractum Folii Eriobotryae Inspissmatum is mixed with ointment, little fire is fried, stirs; Content liquid is less than 25%.50 routine triers are on probation: after 3 days, 33 patients think pain relief, continue on probationly, and after 5 days, 42 patients think pain relief, and after 10 days, all few pain of all patients, can normally take action.
After using 8 days continuously there is redness in user drug of topical application position, pruritus phenomenon, and within 1 hour, after drug of topical application position is dry, red and swollen pruritus phenomenon is eased removal medicine, and after 3 hours, red and swollen pruritus phenomenon disappears, and drug withdrawal continues after 8 hours to use without red and swollen pruritus phenomenon; According to normal use use 16h every day or every 24h drug withdrawal 3h-8h without red and swollen pruritus phenomenon.
Embodiment 4,5,9 is the embodiment of optimization formula of the present invention, and the component adopting is identical, solvent difference; From effect, the method that embodiment 9 adopts, effect is best, and, in use, can on Folium Eriobotryae or other existing carrier, be coated with thin layer, it is dry that the characteristic of plaster is difficult for oil, so the time that human body can absorb is longer, better effects if.And water is as carrier, medicine cake needs thicker, and wastage of material is more, and easily dry and cracked, uses inconvenience.Although separate out in wine as embodiment 5 medicines of carrier with Chinese liquor, medicinal residues also can stick, wine is volatile, and the continuous action time is shorter, and use neither be very convenient.
Described Semen Crataegi extract is the product that commercially available Semen Crataegi dry distilling obtains.
Zoopery will further show the effect of each embodiment:
* auricle edema method detects embodiment 6-9 antiinflammatory action and the impact on capillary permeability:
One, experimental principle
Dimethylbenzene is achromaticity and clarification liquid, is applied in behind Mice Auricle two sides, due to its stimulation, can cause the local capillary injection of Mus ear, and permeability increases, and oozes out and increases, and edema occurs, and shows the symptoms such as red, swollen, hot, pain.
Two, experiment material
1. medicine and reagent
Aspirin Enteric-coated Tablets: AstraZeneca pharmaceutical Co. Ltd, specification: 0.5g/ sheet, lot number: 343401 YUNNAN BAIYAO cream: Yunnan Baiyao Group Wuxi Medicine Co., Ltd..
100% dimethylbenzene: chemical reagent distribution center of Nanjing pharmaceuticals provides.
2. 80 of animal KM mices, male, and body weight 20 ± 2g is provided by Nanjing University of Traditional Chinese Medicine's Experimental Animal Center, laboratory animal credit number: SYXK (Soviet Union) 2011-0012.
3. before and after experiment condition administration, experiment mice is fed with full-valence pellet feed, freely drinks water.20～23 DEG C of room temperatures, humidity 51～60%.
Three, experimental procedure
1. get 80 of KM male mices, body weight 20 ± 2g, is divided into 8 groups at random: be respectively (1) blank group: NS 0.2ml/ only; (2) aspirin group: 65mg/kg; (3) embodiment is with dosage group: every day 2ml/ only;
2. 1 times/day of aspirin group administration by gavage administration, embodiment group sticks 16h/d; Administration 3 days.
3. after last 1 administration 45min, use etherization, the front and back two sided coatings dimethylbenzene 0.2ml/ of white mice auris dextra only causes inflammation, and left ear is coated with equivalent normal saline and compares, and does not process.
4. after coating, after 30min, embodiment group applies medicine 24h cervical vertebra dislocation execution animal, cuts ears 9mm card punch and lays round auricle at same position respectively, and torsion balance claims its weight.
5. every Mus auris dextra weight deducts left auricle and is heavily swelling.
Four, experimental result shows: each administration group and model group more all have significant difference (p < 0.01), the impact of xylol induced mice auricle edema: embodiment group and normal saline control group mice auricle swelling degree are carried out to statistical analysis, result shows, embodiment group and matched group comparison, its difference has highly significant meaning (P < 0.01); Embodiment 8.9 differences have extremely significantly meaning (P < 0.001).The statistic analysis result of embodiment group and matched group auricle swelling degree difference is in table 1.Impact on capillary permeability: OD value and the comparison of normal saline control group mice that embodiment group and control group mice auricle Even ' s blue dyestuff ooze out, its difference all has extremely significantly meaning (P < 0.001).The statistic analysis result of embodiment group and control group mice auricle dyestuff transudate OD value is in table 1.The suppression ratio that embodiment product thing oozes out Mice Auricle dyestuff.
Table 1: Mus ear swelling degree and the impact on capillary permeability
Suppress the result of the test of dimethylbenzene induced mice auricle edema from embodiment product thing, embodiment group mice auricle swelling degree and matched group comparison, its difference has highly significant or extremely remarkable meaning.Embodiment group mouse ear weightening finish percentage ratio and matched group comparison, have remarkable, highly significant or utmost point significant difference.And its anti-inflammatory activity all approaches positive controls medicine aspirin, illustrate that embodiment product thing has the effect of stronger inflammation-inhibiting.
Analyze the impact of embodiment product thing on mice capillary permeability, be not difficult to find out inhibitory action and matched group comparison that embodiment product thing oozes out dyestuff, all there is utmost point significant difference, and active approximate with positive control medicine aspirin.Obviously the capillary permeability increase that, due to embodiment product thing xylol, inflammation causes and dyestuff ooze out and have very strong inhibitory action.In addition, as can be seen from Table 5, the suppression ratio that embodiment product oozes out dyestuff all, more than 87%, has shown very strong anti-inflammatory activity.In a word, by the scorching model of caused by dimethylbenzene xylene, preliminary proof 3 kinds of embodiment product things there is very strong anti-inflammatory activity.
* upright rat method and the experiment of rat granuloma detect embodiment 6-9 to antiinflammatory action and the impact on rat spine:
35 clean level Wistar rats are divided into 7 groups at random, getting one group is common group, with common cage raising, all the other each establishments are found long-term upright rat model, comprise 1 matched group, 4 embodiment positive controls (being oral aspirin group), after 5 months, embodiment group rat dorsal body setae is shaved only, apply embodiment of the present invention medicine, administration every day sticks 16h and continues to raise 4 months, except common group by rat etherization, osculum is cut at back, aseptic 20mg cotton balls is implanted subcutaneous from otch, then skin suture, start administration next day in operation, continuous 7 days, got eye socket blood in the 8th day, 4 DEG C of centrifugal 10min of 3000rpm, separation of serum, survey TNF-a according to each test kit operation instructions respectively, IL-Ib and PGE
2. after getting blood, put to death rat, open former otch, connective tissue around cotton balls UNICOM is taken out together, reject fatty tissue, put into 50 DEG C, baking oven and dry 12h, claim dry weight, deduct the former weight of cotton balls, be granulomatous weight, this soaks label taking after 24h at 4% paraformaldehyde, and clear water rinses 2h, 10%EDTA decalcification 4 weeks, changes weekly decalcifying Fluid once, paraffin embedding after specimen dehydration, and 7 μ m Coronal serial section, choose L5 vertebral rim-intervertebral disc junction and compare.
1. the impact on rat Granuloma formation: with model group comparison, the embodiment of the present invention can reduce granuloma dry weight by highly significant.In table 2.
2.2. to rat blood serum TNF-a, IL-Ib and PGE
2. impact, embodiment can significantly reduce TNF-a, IL-Ib and PGE
2in table 2.
Table 2: the impact on rat granuloma and rat blood serum:
The visible embodiment of the present invention shows as potentiation to the impact of function of immune system.
Table 3: the impact on rat substrate and collagen:
Experimental result surface, embodiment 6-9 can effectively promote periosteum growth, repairs periosteum.
Embodiment 10-18:
Above-described embodiment is the preferred technical solution of the present invention, and the common variation that those skilled in the art carries out within the scope of technical solution of the present invention and replacement all should be included in protection domain of the present utility model.
Claims (9)
1. an external medicine composition that is used for the treatment of hyperosteogeny, is characterized in that, said composition comprises 400 parts of Rhizoma Chuanxiongs, Fructus Arctii 50-60 part, Moschus 3-7 part, Camphora 50-60 part, Radix Angelicae Sinensis 20-30 part, Radix Notoginseng 20-30 part.
2. the external medicine composition that is used for the treatment of according to claim 1 hyperosteogeny, is characterized in that, this is used for the treatment of the external medicine composition of hyperosteogeny, also comprises Radix Achyranthis Bidentatae 0-60 part, Cortex Phellodendri 0-30 part.
3. the external medicine composition that is used for the treatment of according to claim 2 hyperosteogeny, is characterized in that, Chinese medicine composition comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, 50 parts of Radix Achyranthis Bidentataes, 25 parts of Cortex Phellodendris.
4. according to the external medicine composition that is used for the treatment of hyperosteogeny described in claim 1 or 2, it is characterized in that, also comprise Semen Crataegi extract 0-5 part.
5. the external medicine composition that is used for the treatment of according to claim 4 hyperosteogeny, is characterized in that, Chinese medicine composition comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, 50 parts of Radix Achyranthis Bidentataes, 25 parts of Cortex Phellodendris, 2 parts of Semen Crataegi extract.
6. the external medicine composition that is used for the treatment of according to claim 4 hyperosteogeny, is characterized in that, this Chinese medicine composition also comprises Folium Eriobotryae 0-500 part, Borneolum Syntheticum 0-20 part.
7. the external medicine composition that is used for the treatment of according to claim 6 hyperosteogeny, is characterized in that, Chinese medicine composition comprises 400 parts of Rhizoma Chuanxiongs, 55 parts of Fructus Arctii, 5 parts, Moschus, 55 parts of Camphoras, 25 parts of Radix Angelicae Sinensis, 25 parts, Radix Notoginseng, 50 parts of Radix Achyranthis Bidentataes, 25 parts of Cortex Phellodendris, 2 parts of Semen Crataegi extract, 400 parts of Folium Eriobotryaes, 10 parts of Borneolum Syntheticums.
8. the external medicine composition that is used for the treatment of according to claim 7 hyperosteogeny, is characterized in that, this Chinese medicine composition also comprises water 0-500 part, or Chinese liquor 0-1000 part, or Oleum sesami 0-800 part.
9. prepare a method for external medicine composition as claimed in claim 1, it is characterized in that: be selected from following method:
A. by crude drug except Folium Eriobotryae, be ground into Powderedly, the group of adding water into, is pressed into pie, spreads on affected part, or is put on Folium Eriobotryae, spreads on affected part;
B. by crude drug, be ground into Powderedly, put into Chinese liquor, soak more than 7 days, dip wine liquid massage affected part, the medicinal residues after soaking are coated in to affected part;
C. crude drug is ground into except Folium Eriobotryae Powderedly, puts into Oleum sesami, the fried 30-60 minute of little fire, filters, and filtrate is continued to little fire fried, until simmer down to ointment; Described ointment is that in system, content liquid is less than 25%; Ointment shape finished product is coated on Folium Eriobotryae, or Folium Eriobotryae water was decocted after 20-60 minute, by dregs filtering, filtrate continuation decocts to paste, and after Extractum Folii Eriobotryae Inspissmatum is mixed with ointment, little fire is fried, and content liquid is less than 25%.
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