CN104080458B - 用于组织创伤的愈合的产品 - Google Patents

用于组织创伤的愈合的产品 Download PDF

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Publication number
CN104080458B
CN104080458B CN201280055665.1A CN201280055665A CN104080458B CN 104080458 B CN104080458 B CN 104080458B CN 201280055665 A CN201280055665 A CN 201280055665A CN 104080458 B CN104080458 B CN 104080458B
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unsubstituted
substituted
alkyl
group
aminoalkyl
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Chinese (zh)
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CN104080458A (zh
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卡尔·吉尼伯格
保罗·B·萨维奇
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Brigham Young University
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Brigham Young University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201280055665.1A 2011-09-13 2012-09-13 用于组织创伤的愈合的产品 Active CN104080458B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161534194P 2011-09-13 2011-09-13
US61/534,194 2011-09-13
PCT/US2012/055248 WO2013040269A1 (en) 2011-09-13 2012-09-13 Products for healing of tissue wounds

Publications (2)

Publication Number Publication Date
CN104080458A CN104080458A (zh) 2014-10-01
CN104080458B true CN104080458B (zh) 2020-06-02

Family

ID=47071446

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280055665.1A Active CN104080458B (zh) 2011-09-13 2012-09-13 用于组织创伤的愈合的产品

Country Status (12)

Country Link
US (1) US9161942B2 (OSRAM)
EP (1) EP2760454B1 (OSRAM)
JP (1) JP6038155B2 (OSRAM)
KR (1) KR101966293B1 (OSRAM)
CN (1) CN104080458B (OSRAM)
AU (2) AU2012308530B2 (OSRAM)
BR (1) BR112014005914B1 (OSRAM)
CA (1) CA2848567C (OSRAM)
IL (1) IL231509B (OSRAM)
MX (1) MX369385B (OSRAM)
RU (1) RU2652308C2 (OSRAM)
WO (2) WO2013040265A1 (OSRAM)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010036427A1 (en) 2008-06-17 2010-04-01 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
WO2013013221A1 (en) 2011-07-20 2013-01-24 Brigham Young University Hydrophobic ceragenin compounds and devices incorporating same
US8945217B2 (en) 2011-08-25 2015-02-03 Brigham Young University Medical devices incorporating ceragenin-containing composites
EP2755661A1 (en) 2011-09-13 2014-07-23 Brigham Young University Compositions for treating bone diseases and broken bones
US9694019B2 (en) 2011-09-13 2017-07-04 Brigham Young University Compositions and methods for treating bone diseases and broken bones
US9603859B2 (en) 2011-09-13 2017-03-28 Brigham Young University Methods and products for increasing the rate of healing of tissue wounds
EP2793832B1 (en) 2011-12-21 2018-05-23 Brigham Young University Oral care compositions
US9533063B1 (en) 2012-03-01 2017-01-03 Brigham Young University Aerosols incorporating ceragenin compounds and methods of use thereof
WO2013165574A2 (en) * 2012-05-02 2013-11-07 Brigham Young University Ceragenin particulate materials and methods for making same
EP2908826A1 (en) 2012-10-17 2015-08-26 Brigham Young University Treatment and prevention of mastitis
US9943529B2 (en) 2013-01-07 2018-04-17 Brigham Young University Methods for reducing cellular proliferation and treating certain diseases
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
JP6518230B2 (ja) 2013-03-15 2019-05-22 ブリガム・ヤング・ユニバーシティBrigham Young University 炎症、自己免疫疾患、および疼痛を治療する方法
US10568893B2 (en) 2013-03-15 2020-02-25 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
US9387215B2 (en) * 2013-04-22 2016-07-12 Brigham Young University Animal feed including cationic cholesterol additive and related methods
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US20150203527A1 (en) * 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
CA2844321C (en) 2014-02-27 2021-03-16 Brigham Young University Cationic steroidal antimicrobial compounds
US9867836B2 (en) 2014-03-13 2018-01-16 Brigham Young University Lavage and/or infusion using CSA compounds for increasing fertility in a mammal
US10220045B2 (en) 2014-03-13 2019-03-05 Brigham Young University Compositions and methods for forming stabilized compositions with reduced CSA agglomeration
US9931350B2 (en) 2014-03-14 2018-04-03 Brigham Young University Anti-infective and osteogenic compositions and methods of use
US9686966B2 (en) 2014-04-30 2017-06-27 Brigham Young University Methods and apparatus for cleaning or disinfecting a water delivery system
US10441595B2 (en) 2014-06-26 2019-10-15 Brigham Young University Methods for treating fungal infections
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
US10227376B2 (en) 2014-08-22 2019-03-12 Brigham Young University Radiolabeled cationic steroid antimicrobials and diagnostic methods
US10155788B2 (en) 2014-10-07 2018-12-18 Brigham Young University Cationic steroidal antimicrobial prodrug compositions and uses thereof
CA2991726C (en) * 2015-04-22 2022-07-19 Brigham Young University Cationic steroidal antimicrobial salts
CN108348484B (zh) * 2015-04-22 2021-12-17 布莱阿姆青年大学 阳离子甾体抗微生物盐
US10370403B2 (en) 2015-04-22 2019-08-06 Brigham Young University Methods for the synthesis of ceragenins
US9527883B2 (en) 2015-04-22 2016-12-27 Brigham Young University Methods for the synthesis of ceragenins
US9434759B1 (en) * 2015-05-18 2016-09-06 Brigham Young University Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds
US20170080128A1 (en) * 2015-09-21 2017-03-23 Brigham Young University Novel endotracheal tube for the reduction of intubation-related complication in neonates and babies
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue
US10959433B2 (en) 2017-03-21 2021-03-30 Brigham Young University Use of cationic steroidal antimicrobials for sporicidal activity
KR101792535B1 (ko) 2017-09-27 2017-11-02 오상자이엘 주식회사 화상 치료용 키트
US12186328B2 (en) * 2019-05-23 2025-01-07 Brigham Young University Use of CSA compounds to stimulate stem cells and hair growth

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070190066A1 (en) * 2006-02-01 2007-08-16 Savage Paul B Cationic Steroid Antimicrobial Compositions and Methods of Use

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US428800A (en) * 1890-05-27 miller
US4661341A (en) 1984-10-30 1987-04-28 The Procter & Gamble Company Oral compositions
US4842593A (en) 1987-10-09 1989-06-27 The Procter & Gamble Company Disposable absorbent articles for incontinent individuals
US4865855A (en) 1988-01-11 1989-09-12 Kimberly-Clark Corporation Antimicrobial absorbent food pad
US4990338A (en) 1988-05-09 1991-02-05 Dow Corning Corporation Antimicrobial superabsorbent compositions and methods
US5356630A (en) 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US4972848A (en) 1989-08-23 1990-11-27 Medtronic, Inc. Medical electrical lead with polymeric monolithic controlled release device and method of manufacture
GB9020075D0 (en) 1990-09-14 1990-10-24 Filler Aaron G Contrast agents for magnetic resonance imaging of axonal transport
US5286479A (en) 1991-12-10 1994-02-15 The Dow Chemical Company Oral compositions for suppressing mouth odors
WO1995024415A1 (en) * 1994-03-10 1995-09-14 Magainin Pharmaceuticals Inc. Steroid derivatives, pharmaceutical compositions containing them, and their pharmaceutical uses
AU694419B2 (en) 1993-03-12 1998-07-23 Zoetis P&U Llc Crystalline ceftiofur free acid
US6132765A (en) 1996-04-12 2000-10-17 Uroteq Inc. Drug delivery via therapeutic hydrogels
EP1506775A1 (en) * 1996-07-22 2005-02-16 Renovo Limited Use of sex steroid function modulators to treat wounds and fibrotic disorders
JP2002505292A (ja) 1998-03-06 2002-02-19 ブリガム ヤング ユニバーシティ ステロイド由来抗生物質
US6767904B2 (en) 1998-03-06 2004-07-27 Bringham Young University Steroid derived antibiotics
US6350738B1 (en) 1998-03-06 2002-02-26 Brigham Young University Steroid derived antibiotics
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
US6673771B1 (en) 1999-07-28 2004-01-06 The Trustees Of The University Of Pennsylvania Methods of inhibiting osteoclast activity
US6551608B2 (en) 2000-03-06 2003-04-22 Porex Technologies Corporation Porous plastic media with antiviral or antimicrobial properties and processes for making the same
CA2419801C (en) 2000-08-15 2010-08-10 Brigham Young University Steroid derived antibiotics
US6514556B2 (en) 2000-12-15 2003-02-04 Ecolab Inc. Method and composition for washing poultry during processing
CA2456977C (en) * 2001-08-16 2011-06-07 The Trustees Of The University Of Pennsylvania Synthesis and use of reagents for improved dna lipofection and/or slow release prodrug and drug therapies
US9056048B2 (en) 2001-08-16 2015-06-16 The Trustees Of The University Of Pennsylvania Synthesis and use of cationic steroids for anti-inflammatory drug therapy
US6939376B2 (en) 2001-11-05 2005-09-06 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
DE10218147B4 (de) 2002-04-23 2005-12-22 Stockhausen Gmbh Wasserabsorbierende, die Zersetzung von Körperflüssigkeiten verzögernde Polymerteilchen, deren Herstellung und Verwendung
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US7659061B2 (en) 2002-11-19 2010-02-09 Pharmacia & Upjohn Company Pharmaceutical compositions having a modified vehicle
US7282214B2 (en) 2002-12-19 2007-10-16 Johnson & Johnson Vision Care, Inc. Biomedical devices with antimicrobial coatings
AU2004248898B2 (en) 2003-06-23 2010-03-18 Beiersdorf Ag Antimicrobial wounddressing
GB0318901D0 (en) 2003-08-12 2003-09-17 Univ Bath Improvements in or relating to bone substitute material
US20050267051A1 (en) 2003-12-19 2005-12-01 Lee Henry J Antineoplastic and anti-HIV conjugates of steroid acid and nucleosides
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20060062774A1 (en) 2004-09-21 2006-03-23 The Procter & Gamble Company Compositions for maintaining and restoring normal urogenital flora
WO2007089906A2 (en) 2006-02-01 2007-08-09 Brigham Young University Cationic steroid antimicrobial compositions for treating or preventing herpes infections
WO2007089907A2 (en) 2006-02-01 2007-08-09 Brigham Young University Cationic steroid antimicrobial compositions and methods of use
WO2007089903A2 (en) * 2006-02-01 2007-08-09 Brigham Young University Cationic steroid microbial compositions for treating or preventing influenza infections
WO2007134176A2 (en) 2006-05-10 2007-11-22 Microban Products Company Antimicrobial food pad
US7858000B2 (en) 2006-06-08 2010-12-28 Novartis Ag Method of making silicone hydrogel contact lenses
US8685421B2 (en) 2006-07-07 2014-04-01 Surmodics, Inc. Beaded wound spacer device
KR100950204B1 (ko) 2006-09-26 2010-03-29 경북대학교 산학협력단 7α-아미노스테로이드 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로함유하는 항암용 또는 항생제 조성물
US7854941B2 (en) 2007-02-12 2010-12-21 The University Of Southern Mississippi Method of attaching drug compounds to non-reactive polymer surfaces
US20090016973A1 (en) 2007-07-09 2009-01-15 Micropure, Inc. Composition and Method for the Prevention of Oral Disease
US20090068122A1 (en) 2007-09-06 2009-03-12 Shira Pilch Dentifrice Compositions for Treating Xerostomia
US9095568B2 (en) 2007-09-26 2015-08-04 Mark Berninger Therapeutic and vaccine polyelectrolyte nanoparticle compositions
WO2010036427A1 (en) 2008-06-17 2010-04-01 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
US20090324517A1 (en) 2008-06-30 2009-12-31 Dan Kline Halitosis treatment
JP2012532889A (ja) * 2009-07-09 2012-12-20 クレッシェンド セラピューティクス、エルエルシー 創傷治療方法及び傷跡変性方法
WO2011066260A2 (en) 2009-11-25 2011-06-03 Michael Zasloff Formulations comprising aminosterols
US8529681B1 (en) * 2010-01-07 2013-09-10 Sandia Corporation Biofouling-resistant ceragenin-modified materials and structures for water treatment
WO2011109704A1 (en) 2010-03-04 2011-09-09 The Trustees Of The University Of Pennsylvania Center For Technology Transfer Antimicrobial cationic stereoids and methods of use
US8871716B2 (en) * 2010-10-08 2014-10-28 Korea Advanced Institute Of Science And Technology Use of antimicrobial peptides in regeneration of skin cells
CN103313597B (zh) 2010-11-03 2016-06-29 布莱阿姆青年大学 结合吸水性聚合物和塞拉集宁化合物的制品
CN102172356B (zh) * 2011-03-03 2013-04-03 山东农业大学 牛磺鹅去氧胆酸在制备防治骨质疏松的药物中的应用
US8810380B2 (en) 2011-07-01 2014-08-19 Gerald F. Leitz Golf scoring management system
WO2013013221A1 (en) 2011-07-20 2013-01-24 Brigham Young University Hydrophobic ceragenin compounds and devices incorporating same
US8945217B2 (en) 2011-08-25 2015-02-03 Brigham Young University Medical devices incorporating ceragenin-containing composites
WO2013029059A1 (en) 2011-08-25 2013-02-28 Brigham Young University Medical devices incorporating ceragenin-containing composites
WO2013029055A1 (en) 2011-08-25 2013-02-28 Brigham Young University Incorporation of particulate ceragenins in polymers
EP2793832B1 (en) 2011-12-21 2018-05-23 Brigham Young University Oral care compositions
WO2013131060A1 (en) 2012-03-01 2013-09-06 Brigham Young University Anti-microbial food processing compositions including ceragenin compounds and methods of use
US20130280391A1 (en) 2012-04-24 2013-10-24 Brigham Young University Anti-microbial wash compositions including ceragenin compounds and methods of use for treating non-meat food products
EP2908826A1 (en) 2012-10-17 2015-08-26 Brigham Young University Treatment and prevention of mastitis
US9943529B2 (en) 2013-01-07 2018-04-17 Brigham Young University Methods for reducing cellular proliferation and treating certain diseases
JP6518230B2 (ja) 2013-03-15 2019-05-22 ブリガム・ヤング・ユニバーシティBrigham Young University 炎症、自己免疫疾患、および疼痛を治療する方法
US9387215B2 (en) 2013-04-22 2016-07-12 Brigham Young University Animal feed including cationic cholesterol additive and related methods

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070190066A1 (en) * 2006-02-01 2007-08-16 Savage Paul B Cationic Steroid Antimicrobial Compositions and Methods of Use

Also Published As

Publication number Publication date
BR112014005914B1 (pt) 2021-11-09
BR112014005914A2 (pt) 2017-06-13
AU2012308526B2 (en) 2016-04-21
JP2014530192A (ja) 2014-11-17
RU2652308C2 (ru) 2018-04-25
AU2012308530A1 (en) 2014-04-03
CN104080458A (zh) 2014-10-01
EP2760454A1 (en) 2014-08-06
KR101966293B1 (ko) 2019-04-08
MX369385B (es) 2019-11-07
CA2848567C (en) 2020-03-24
AU2012308526A1 (en) 2014-04-03
AU2012308530B2 (en) 2016-04-21
EP2760454B1 (en) 2018-08-29
US9161942B2 (en) 2015-10-20
MX2014003020A (es) 2014-10-14
WO2013040265A1 (en) 2013-03-21
WO2013040269A1 (en) 2013-03-21
IL231509A0 (en) 2014-04-30
RU2014112784A (ru) 2015-10-20
KR20140075729A (ko) 2014-06-19
US20130243823A1 (en) 2013-09-19
JP6038155B2 (ja) 2016-12-07
IL231509B (en) 2019-02-28
CA2848567A1 (en) 2013-03-21

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