CN104056071A - Medicine composition for treating infantile constipation, preparation method and application, - Google Patents
Medicine composition for treating infantile constipation, preparation method and application, Download PDFInfo
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- CN104056071A CN104056071A CN201410307120.6A CN201410307120A CN104056071A CN 104056071 A CN104056071 A CN 104056071A CN 201410307120 A CN201410307120 A CN 201410307120A CN 104056071 A CN104056071 A CN 104056071A
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- cortex magnoliae
- magnoliae officinalis
- fructus aurantii
- radix rehmanniae
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Abstract
The invention discloses a medicine composition for treating the infantile constipation. The medicine composition comprises, by weight, 20-100 parts of dried rehamnnia roots, 20-100 parts of prepared rehmannia roots, 15-90 parts of snake gourd seeds, 15-80 parts of dendrobe, 10-70 parts of mangnolia officinalis (processed with ginger juice), 10-70 parts of fructus aurantii (processed with honey), 10-60 parts of betel nuts, 10-50 parts of rhizoma anemarrhenae and 10-40 parts of honey-fried licorice roots. The medicine composition further discloses a preparation method and application of the medicine composition. The medicine composition is novel in formula, and has the advantages of being low in cost, good in curative effect, free of toxic and side effects, not prone to generating tolerance, convenient to take and carry, universally suitable for child patients with the functional constipation and the like; a new medication selection is provided for clinical treatment.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of infantile constipation and preparation method thereof.
Background technology
Infantile constipation is a kind of frequently-occurring disease, commonly encountered diseases clinically, is a kind of disease of very easily repeatedly showing effect.Due to food or the hypohydration taken in, make the chyme residue of enteral or the amount of feces also few, be not enough to stimulate due to the normal creepage of gastrointestinal functions of colon or the wriggle weakness of intestinal, the attenuating of intestinal muscle tone, clinically being hard and dry, hard, constipated obstructed, defecation time interval is (>2 days) for a long time, though or have awareness of defecation and can not arrange stool for principal character, just usually with abdominal distention, the minor symptoms such as poor appetite.At present, modern medicine for the treatment of Functional Constipation in Children to promote gastrointestinal peristalsis and catharsis as main.Conventional digestive tract power reinforcing medicine has mosapride; Conventional catharsis agent has displacement type catharsis agent lactulose, demulcent cathartics vegetable oil, irritant purgative Radix Et Rhizoma Rhei, Folium Sennae, local irritation cathartic glycerol/sodium chloride (glycerin) etc.When treatment, according to the constipation feature of infant, adopt different catharsis agent, it treats the course for the treatment of generally taking the smooth and easy discharge of defecating as degree, and obstinate type constipation case can proper extension.Life-time service cathartic easily causes normal defecation reflex weaken or disappear after abusing strong cathartic, can cause obstinate type constipation.
Traditional medicine, by this type of infantile constipation ownership constipation category, can be divided into constipation due to insufficiency, the large class of constipation of excess type two according to the deficiency and excess of its disease.Constipation of excess type can be divided into again stagnant three cards of gastrointestinal accumulated heat, depression and stagnation of QI, YIN-cold, and it treat taking eliminating evil as main, impose respectively purge heat, regulate the flow of vital energy, warm loose method, be aided with the product of intestinal stasis relieving; Constipation due to insufficiency to be just to support as first, according to the difference of yang blood and qi virtual loss, and the method for primary nourishing YIN and benefiting blood, QI invigorating warming YANG, the medicine of sweet gentle intestinal for drinking.By determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs Chinese medicine, the treatment of digestant for baby road tract disease is obtained to satisfied clinical efficacy.Chinese medicine also increases gradually to the research of infantile constipation at present, Chinese patent 200610076429.4 discloses a kind of Chinese medicine for the treatment of infantile constipation, this Chinese medicine is by the Rhizoma Atractylodis Macrocephalae 6～18, Fructus Aurantii (reality) 3～10, Semen Armeniacae Amarum 6～10, Cortex Magnoliae Officinalis 3～10, Semen Raphani 6～15, Semen Cassiae 6～12, Aloe 1～6 composition, Chinese patent 201310387211.0 discloses a kind of Chinese medicine composition for the treatment of infantile constipation, this Chinese medicine composition is by Semen Raphani 10g, Endothelium Corneum Gigeriae Galli 10g, Fructus Citri Sarcodactylis 10g, Fructus Hordei Germinatus (parched) 10g, Massa Medicata Fermentata 6g, Herba Dendrobii 15g, Semen Arecae 10g, Fructus Aurantii 10g, Radix Angelicae Sinensis 10g, Herba Cistanches 10g, Fructus Cannabis 12g, Semen Pruni 15g, Radix Astragali 9g, Radix Glycyrrhizae 5g composition.Although above-mentioned patent formulation has certain therapeutical effect to infantile constipation, its drug effect is all lasting not, and does not have the property of taking into account, and does not all have the effect that improves immunity function.
Summary of the invention
One object of the present invention is to overcome the deficiencies in the prior art, provide a kind of composition simple, the pharmaceutical composition of the novel treatment infantile constipation of filling a prescription, feature with low cost, evident in efficacy, that have no side effect that this pharmaceutical composition has, and can obviously recover gastrointestinal normal creepage of gastrointestinal functions, and then promote rehabilitation.
Another object of the present invention is to provide a kind of preparation method of pharmaceutical composition for the treatment of infantile constipation, and this preparation method is simple to operate, applicable to suitability for industrialized production.
The object of the invention is to be achieved through the following technical solutions:
A kind of pharmaceutical composition for the treatment of infantile constipation, it is made up of the raw material of following ratio of weight and number: Radix Rehmanniae 20-100 part, Radix Rehmanniae Preparata 20-100 part, Semen Trichosanthis 15-90 part, Herba Dendrobii 15-80 part, Cortex Magnoliae Officinalis 10-70 part, Fructus Aurantii 10-70 part, Semen Arecae 10-60 part, Rhizoma Anemarrhenae 10-50 part, Radix Glycyrrhizae Preparata 10-40 part.
Preferably, the ratio of weight and number of described each raw material is: Radix Rehmanniae 40-80 part, Radix Rehmanniae Preparata 40-80 part, Semen Trichosanthis 30-70 part, Herba Dendrobii 30-70 part, Cortex Magnoliae Officinalis 20-60 part, Fructus Aurantii 20-60 part, Semen Arecae 15-50 part, Rhizoma Anemarrhenae 15-40 part, Radix Glycyrrhizae Preparata 15-30 part.
Preferably, the ratio of weight and number of described each raw material is: Radix Rehmanniae 50-70 part, Radix Rehmanniae Preparata 50-70 part, Semen Trichosanthis 40-60 part, Herba Dendrobii 40-60 part, Cortex Magnoliae Officinalis 30-50 part, Fructus Aurantii 30-50 part, Semen Arecae 20-40 part, Rhizoma Anemarrhenae 20-30 part, Radix Glycyrrhizae Preparata 20-25 part.
Preferably, the ratio of weight and number of described each raw material is: Radix Rehmanniae 55-65 part, Radix Rehmanniae Preparata 55-65 part, Semen Trichosanthis 45-55 part, Herba Dendrobii 45-55 part, Cortex Magnoliae Officinalis 40-45 part, Fructus Aurantii 40-45 part, Semen Arecae 25-35 part, Rhizoma Anemarrhenae 20-25 part, Radix Glycyrrhizae Preparata 22-24 part.
Preferably, the ratio of weight and number of described each raw material is: 30 parts of Radix Rehmanniae, 30 parts of Radix Rehmanniae Preparata, 15 parts of Semen Trichosanthiss, 15 parts of Herba Dendrobiis, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Fructus Aurantiis, 10 parts of Semen Arecaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Radix Glycyrrhizae Preparatas.
A method of preparing above-mentioned any one pharmaceutical composition, is characterized in that: it comprises the following steps:
S1: take by weight Cortex Magnoliae Officinalis, take the Rhizoma Zingiberis Recens that Cortex Magnoliae Officinalis weight 1-2 doubly measures, will Rhizoma Zingiberis Recens get Rhizoma Zingiberis Recens juice after squeezing, after Rhizoma Zingiberis Recens juice is mixed with Cortex Magnoliae Officinalis, pour in 60-90 DEG C hot pot and concoct Cortex Magnoliae Officinalis, until take out after Cortex Magnoliae Officinalis fried dry, obtain Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), for subsequent use;
S2: take by weight Fructus Aurantii, after Fructus Aurantii is pulverized, add the Mel of equal weight, after Fructus Aurantii powder is mixed with Mel, pour in 60-90 DEG C hot pot and concoct Fructus Aurantii, until Mel dissolves among Fructus Aurantii powder completely, obtain processed with honey Fructus Aurantii, for subsequent use;
S3: take by weight Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Trichosanthis, Herba Dendrobii, Semen Arecae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae Preparata, add the water soaking 0.5～1 hour of 4～6 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour, filters and obtain decocting liquid, and medicinal residues are for subsequent use;
S4: the Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) that S1 step is obtained, the processed with honey Fructus Aurantii that S2 step obtains mix with the medicinal residues in S3 step, then add the decocting of 4～6 times of medical material amounts to boil 1～1.5 hour, filtering and obtain decocting liquid, medicinal residues discard;
S5: be condensed into extractum after the decocting liquid in S3 step and S4 step is merged, then extractum vacuum drying is obtained to dry cream, dried cream powder is broken, obtain dried cream powder end, in dried cream powder end, add pharmaceutically acceptable adjuvant to be prepared into pharmaceutically conventional pharmaceutical preparation.
Pharmaceutical preparation of the present invention is pill, tablet, capsule, granule, powder or oral liquid.
Pharmaceutically acceptable adjuvant of the present invention comprises starch, magnesium stearate, dextrin and microcrystalline Cellulose.
The application of arbitrary pharmaceutical composition of the present invention in preparation treatment infantile constipation medicine.
Pharmaceutical composition of the present invention can be prepared into the above dosage form of any pharmaceutics according to the conventional method of pharmaceutical field; Pharmaceutical composition can be applied to patient by modes such as oral, suction or intestinal external administrations.Dosage form on described pharmaceutics comprises: the tablet that uses when oral administration, capsule, pill, powder, granule, syrup, oral liquid etc.
For above-mentioned dosage form can be realized, need in the time of these dosage forms of preparation, add the acceptable adjuvant of pharmacy, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are determined, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc.
Radix Rehmanniae in pharmaceutical composition of the present invention, Radix Rehmanniae Preparata, Semen Trichosanthis, Herba Dendrobii, Cortex Magnoliae Officinalis (stir-frying with ginger juice), Fructus Aurantii (processed with honey), Semen Arecae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae Preparata are Chinese medicine or its processed product that 2010 editions " Chinese Pharmacopoeia " Firsts record.Radix Rehmanniae is the dried root of scrophulariaceae rehmannia glutinosa plant, and GUIXIN, liver, kidney channel have the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Radix Rehmanniae Preparata is the Preparation process product of Radix Rehmanniae, and sweet, slightly warm in nature, returns liver, kidney channel, has the effect that nourishing YIN and supplementing blood, beneficial essence are filled out marrow; Semen Trichosanthis is the dry mature seed of cucurbitaceous plant Fructus Trichosanthis or trichosanthes rosthornii Harms, sweet, micro-bitterness, and cold nature, returns lung, stomach, large intestine channel, has the effect of moistening the lung and resolving phlegm, laxation relieving constipation; Herba Dendrobii is the stem of the multiple Herba Dendrobiis such as the orchid family herbaceous plant dendrobium loddigesii Rolfe, Herba Dendrobii oculati, and sweet, cold nature, returns stomach, kidney channel, has the effect of reinforcing stomach reg fluid, nourishing YIN and clearing away heat; Cortex Magnoliae Officinalis is dry dried bark, root bark and the branch skin of Magnoliaceae, magnolia Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils., bitter, pungent, warm in nature, returns spleen, stomach, large intestine channel, has circulation of qi promoting removing food stagnancy, dampness except full effect; Fructus Aurantii is the dry immature fruit of rutaceae Citrus aurantium Linn. and variety thereof, bitter, pungent, sour, warm in nature, returns spleen, stomach warp, has regulating the flow of QI to ease the stomach, the effect of the stagnant relieving distension of row; Semen Arecae is the seed of babassu Semen Arecae, bitter, pungent, warm in nature, returns stomach, large intestine channel, has the effect of anthelmintic, removing food stagnancy, the therapeutic method to keep the adverse QI flowing downwards, Hang Shui, preventing the attack (or recurrence) of malaria; The Rhizoma Anemarrhenae is the dry rhizome of the liliaceous plant Rhizoma Anemarrhenae, bitter, sweet, cold, returns lung, stomach, kidney channel, the effect that has clearing away heat-fire, promotes the production of body fluid and moisturize; Radix Glycyrrhizae is dicotyledon pulse family Radix Glycyrrhizae, and the root and rhizome of Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. is sweet, flat, returns spleen, stomach, lung meridian, has the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The invention has the beneficial effects as follows: the formula novelty of pharmaceutical composition of the present invention, raw material is simple, there is feature with low cost, evident in efficacy, that have no side effect, prove that by experiment pharmaceutical composition of the present invention all has therapeutical effect in various degree to digestive tract various diseases, especially Functional Constipation in Children is had to good clinical efficacy, in addition, in experimentation, unexpected discovery pharmaceutical composition of the present invention can significantly improve the immunologic function of human body, particularly applicable for the infant of this type of infantile constipation companion immunologic hypofunction.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is described in further detail, but protection scope of the present invention is not limited to the following stated.
Embodiment 1:
Take raw material Radix Rehmanniae 20g, Radix Rehmanniae Preparata 20g, Semen Trichosanthis 15g, Herba Dendrobii 15g, Cortex Magnoliae Officinalis 10g, Fructus Aurantii 10g, Semen Arecae 10g, Rhizoma Anemarrhenae 10g, Radix Glycyrrhizae Preparata 10g, adds supplementary product starch 100g to granulate, magnesium stearate 10g, dextrin 60g, microcrystalline Cellulose 60g, evenly make granule, and tabletting, obtains tablet.
Embodiment 2:
Take raw material Radix Rehmanniae 100g, Radix Rehmanniae Preparata 100gg part, Semen Trichosanthis 90g, Herba Dendrobii 80g, Cortex Magnoliae Officinalis 70g, Fructus Aurantii 70g, Semen Arecae 60g, Rhizoma Anemarrhenae 50g, Radix Glycyrrhizae Preparata 40g, adds supplementary product starch 800g to granulate, magnesium stearate 80g, DEXTRIN 0g, microcrystalline Cellulose 400g, evenly make granule, and tabletting, obtains tablet.
Embodiment 3:
Take raw material Radix Rehmanniae 40g, Radix Rehmanniae Preparata 40g, Semen Trichosanthis 30g, Herba Dendrobii 30g, Cortex Magnoliae Officinalis 20g, Fructus Aurantii 20g, Semen Arecae 15g, Rhizoma Anemarrhenae 15g, Radix Glycyrrhizae Preparata 15g, adds supplementary product starch 230g to granulate, magnesium stearate 20g, dextrin 100g, microcrystalline Cellulose 100g, evenly make granule, and tabletting, obtains tablet.
Embodiment 4:
Take raw material Radix Rehmanniae 80g, Radix Rehmanniae Preparata 80g, Semen Trichosanthis 70g, Herba Dendrobii 70g, Cortex Magnoliae Officinalis 60g, Fructus Aurantii 60g, Semen Arecae 50g, Rhizoma Anemarrhenae 40g, Radix Glycyrrhizae Preparata 30g, adds supplementary product starch 620g to granulate, magnesium stearate 60g, dextrin 300g, microcrystalline Cellulose 300g, evenly make granule, and tabletting, obtains tablet.
Embodiment 5:
Take raw material Radix Rehmanniae 50g, Radix Rehmanniae Preparata 50g, Semen Trichosanthis 40g, Herba Dendrobii 40g, Cortex Magnoliae Officinalis 30g, Fructus Aurantii 30g, Semen Arecae 20g, Rhizoma Anemarrhenae 20g, Radix Glycyrrhizae Preparata 20g, adds supplementary product starch 340g to granulate, magnesium stearate 30g, dextrin 170g, microcrystalline Cellulose 170g, evenly make granule, and tabletting, obtains tablet.
Embodiment 6:
Take raw material Radix Rehmanniae 70g, Radix Rehmanniae Preparata 70g, Semen Trichosanthis 60g, Herba Dendrobii 60g, Cortex Magnoliae Officinalis 50g, Fructus Aurantii 50g, Semen Arecae 40g, Rhizoma Anemarrhenae 30g, Radix Glycyrrhizae Preparata 25g, adds supplementary product starch 500g to granulate, magnesium stearate 50g, dextrin 250g, microcrystalline Cellulose 250g, evenly make granule, and tabletting, obtains tablet.
Embodiment 7:
Take raw material Radix Rehmanniae 55g, Radix Rehmanniae Preparata 55g, Semen Trichosanthis 45g, Herba Dendrobii 45g, Cortex Magnoliae Officinalis 40g, Fructus Aurantii 40g, Semen Arecae 25g, Rhizoma Anemarrhenae 20g, Radix Glycyrrhizae Preparata 20g, add supplementary product starch 450g to granulate, magnesium stearate 40g, dextrin 200g, microcrystalline Cellulose 200g, evenly make granule, incapsulate, obtain capsule.
Embodiment 8:
Take raw material Radix Rehmanniae 65g, Radix Rehmanniae Preparata 65g, Semen Trichosanthis 55g, Herba Dendrobii 55g, Cortex Magnoliae Officinalis 45g, Fructus Aurantii 45g, Semen Arecae 35g, Rhizoma Anemarrhenae 25g, Radix Glycyrrhizae Preparata 25g, add supplementary product starch 480g to granulate, magnesium stearate 45g, dextrin 250g, microcrystalline Cellulose 230g, be prepared into powder according to common process.
Embodiment 9:
Take raw material Radix Rehmanniae 30g, Radix Rehmanniae Preparata 30g, Semen Trichosanthis 15g, Herba Dendrobii 15g, Cortex Magnoliae Officinalis 10g, Fructus Aurantii 10g, Semen Arecae 10g, Rhizoma Anemarrhenae 10g, Radix Glycyrrhizae Preparata 10g, add supplementary product starch 150g to granulate, magnesium stearate 15g, dextrin 75g, microcrystalline Cellulose 75g, be prepared into powder according to common process.
Embodiment 10:
A preparation method for infantile constipation pharmaceutical composition, this method comprises the steps: to take raw material Radix Rehmanniae 20g, Radix Rehmanniae Preparata 20g, Semen Trichosanthis 15g, Herba Dendrobii 15g, Cortex Magnoliae Officinalis 10g, Fructus Aurantii 10g, Semen Arecae 10g, Rhizoma Anemarrhenae 10g, Radix Glycyrrhizae Preparata 10g.S1: take by weight Cortex Magnoliae Officinalis, take the Rhizoma Zingiberis Recens that Cortex Magnoliae Officinalis weight 1-2 doubly measures, will Rhizoma Zingiberis Recens get Rhizoma Zingiberis Recens juice after squeezing, after Rhizoma Zingiberis Recens juice is mixed with Cortex Magnoliae Officinalis, pour in 60-90 DEG C hot pot and concoct Cortex Magnoliae Officinalis, until take out after Cortex Magnoliae Officinalis fried dry, obtain Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), for subsequent use; S2: take by weight Fructus Aurantii, after Fructus Aurantii is pulverized, add the Mel of equal weight, after Fructus Aurantii powder is mixed with Mel, pour in 60-90 DEG C hot pot and concoct Fructus Aurantii, until Mel dissolves among Fructus Aurantii powder completely, obtain processed with honey Fructus Aurantii, for subsequent use; S3: take by weight Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Trichosanthis, Herba Dendrobii, Semen Arecae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae Preparata, add the water soaking 0.5～1 hour of 4～6 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour, filters and obtain decocting liquid, and medicinal residues are for subsequent use; S4: the Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) that S1 step is obtained, the processed with honey Fructus Aurantii that S2 step obtains mix with the medicinal residues in S3 step, then add the decocting of 4～6 times of medical material amounts to boil 1～1.5 hour, filtering and obtain decocting liquid, medicinal residues discard; S5: be condensed into extractum after the decocting liquid in S3 step and S4 step is merged, then extractum vacuum drying is obtained to dry cream, dried cream powder is broken, obtain dried cream powder end, in dried cream powder end, add pharmaceutically acceptable adjuvant to be prepared into pharmaceutically conventional pharmaceutical preparation.
Embodiment 11:
Take raw material Radix Rehmanniae 100g, Radix Rehmanniae Preparata 100g part, Semen Trichosanthis 90g, Herba Dendrobii 80g, Cortex Magnoliae Officinalis 70g, Fructus Aurantii 70g, Semen Arecae 60g, Rhizoma Anemarrhenae 50g, Radix Glycyrrhizae Preparata 40g part, S1: take by weight Cortex Magnoliae Officinalis, take the Rhizoma Zingiberis Recens that Cortex Magnoliae Officinalis weight 1-2 doubly measures, will get Rhizoma Zingiberis Recens juice after Rhizoma Zingiberis Recens squeezing, after Rhizoma Zingiberis Recens juice is mixed with Cortex Magnoliae Officinalis, pour in the heat pot of 60-90 DEG C and concoct Cortex Magnoliae Officinalis, until take out after Cortex Magnoliae Officinalis fried dry, obtain Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), for subsequent use; S2: take by weight Fructus Aurantii, after Fructus Aurantii is pulverized, add the Mel of equal weight, after Fructus Aurantii powder is mixed with Mel, pour in 60-90 DEG C hot pot and concoct Fructus Aurantii, until Mel dissolves among Fructus Aurantii powder completely, obtain processed with honey Fructus Aurantii, for subsequent use; S3: take by weight Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Trichosanthis, Herba Dendrobii, Semen Arecae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae Preparata, add the water soaking 0.5～1 hour of 4～6 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour, filters and obtain decocting liquid, and medicinal residues are for subsequent use; S4: the Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) that S1 step is obtained, the processed with honey Fructus Aurantii that S2 step obtains mix with the medicinal residues in S3 step, then add the decocting of 4～6 times of medical material amounts to boil 1～1.5 hour, filtering and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, obtain dried cream powder end, in dried cream powder end, add pharmaceutically acceptable adjuvant to be prepared into pharmaceutically conventional tablet.
Embodiment 12:
Take raw material Radix Rehmanniae 40g, Radix Rehmanniae Preparata 40g, Semen Trichosanthis 30g, Herba Dendrobii 30g, Cortex Magnoliae Officinalis 20g, Fructus Aurantii 20g, Semen Arecae 15g, Rhizoma Anemarrhenae 15g, Radix Glycyrrhizae Preparata 15g, S1: take by weight Cortex Magnoliae Officinalis, take the Rhizoma Zingiberis Recens that Cortex Magnoliae Officinalis weight 1-2 doubly measures, will get Rhizoma Zingiberis Recens juice after Rhizoma Zingiberis Recens squeezing, after Rhizoma Zingiberis Recens juice is mixed with Cortex Magnoliae Officinalis, pour in the heat pot of 60-90 DEG C and concoct Cortex Magnoliae Officinalis, until take out after Cortex Magnoliae Officinalis fried dry, obtain Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), for subsequent use; S2: take by weight Fructus Aurantii, after Fructus Aurantii is pulverized, add the Mel of equal weight, after Fructus Aurantii powder is mixed with Mel, pour in 60-90 DEG C hot pot and concoct Fructus Aurantii, until Mel dissolves among Fructus Aurantii powder completely, obtain processed with honey Fructus Aurantii, for subsequent use; S3: take by weight Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Trichosanthis, Herba Dendrobii, Semen Arecae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae Preparata, add the water soaking 0.5～1 hour of 4～6 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour, filters and obtain decocting liquid, and medicinal residues are for subsequent use; S4: the Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) that S1 step is obtained, the processed with honey Fructus Aurantii that S2 step obtains mix with the medicinal residues in S3 step, then add the decocting of 4～6 times of medical material amounts to boil 1～1.5 hour, filtering and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, obtain dried cream powder end, in dried cream powder end, add pharmaceutically acceptable adjuvant to be prepared into pharmaceutically conventional pill.
Embodiment 13:
Take raw material Radix Rehmanniae 80g, Radix Rehmanniae Preparata 80g, Semen Trichosanthis 70g, Herba Dendrobii 70g, Cortex Magnoliae Officinalis 60g, Fructus Aurantii 60g, Semen Arecae 50g, Rhizoma Anemarrhenae 40g, Radix Glycyrrhizae Preparata 30g, S1: take by weight Cortex Magnoliae Officinalis, take the Rhizoma Zingiberis Recens that Cortex Magnoliae Officinalis weight 1-2 doubly measures, will get Rhizoma Zingiberis Recens juice after Rhizoma Zingiberis Recens squeezing, after Rhizoma Zingiberis Recens juice is mixed with Cortex Magnoliae Officinalis, pour in the heat pot of 60-90 DEG C and concoct Cortex Magnoliae Officinalis, until take out after Cortex Magnoliae Officinalis fried dry, obtain Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), for subsequent use; S2: take by weight Fructus Aurantii, after Fructus Aurantii is pulverized, add the Mel of equal weight, after Fructus Aurantii powder is mixed with Mel, pour in 60-90 DEG C hot pot and concoct Fructus Aurantii, until Mel dissolves among Fructus Aurantii powder completely, obtain processed with honey Fructus Aurantii, for subsequent use; S3: take by weight Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Trichosanthis, Herba Dendrobii, Semen Arecae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae Preparata, add the water soaking 0.5～1 hour of 4～6 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour, filters and obtain decocting liquid, and medicinal residues are for subsequent use; S4: the Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) that S1 step is obtained, the processed with honey Fructus Aurantii that S2 step obtains mix with the medicinal residues in S3 step, then add the decocting of 4～6 times of medical material amounts to boil 1～1.5 hour, filtering and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, obtain dried cream powder end, in dried cream powder end, add pharmaceutically acceptable adjuvant to be prepared into pharmaceutically conventional capsule.
Embodiment 14:
Take raw material Radix Rehmanniae 50g, Radix Rehmanniae Preparata 50g, Semen Trichosanthis 40g, Herba Dendrobii 40g, Cortex Magnoliae Officinalis 30g, Fructus Aurantii 30g, Semen Arecae 20g, Rhizoma Anemarrhenae 20g, Radix Glycyrrhizae Preparata 20g, S1: take by weight Cortex Magnoliae Officinalis, take the Rhizoma Zingiberis Recens that Cortex Magnoliae Officinalis weight 1-2 doubly measures, will get Rhizoma Zingiberis Recens juice after Rhizoma Zingiberis Recens squeezing, after Rhizoma Zingiberis Recens juice is mixed with Cortex Magnoliae Officinalis, pour in the heat pot of 60-90 DEG C and concoct Cortex Magnoliae Officinalis, until take out after Cortex Magnoliae Officinalis fried dry, obtain Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), for subsequent use; S2: take by weight Fructus Aurantii, after Fructus Aurantii is pulverized, add the Mel of equal weight, after Fructus Aurantii powder is mixed with Mel, pour in 60-90 DEG C hot pot and concoct Fructus Aurantii, until Mel dissolves among Fructus Aurantii powder completely, obtain processed with honey Fructus Aurantii, for subsequent use; S3: take by weight Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Trichosanthis, Herba Dendrobii, Semen Arecae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae Preparata, add the water soaking 0.5～1 hour of 4～6 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour, filters and obtain decocting liquid, and medicinal residues are for subsequent use; S4: the Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) that S1 step is obtained, the processed with honey Fructus Aurantii that S2 step obtains mix with the medicinal residues in S3 step, then add the decocting of 4～6 times of medical material amounts to boil 1～1.5 hour, filtering and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, obtain dried cream powder end, in dried cream powder end, add pharmaceutically acceptable adjuvant to be prepared into pharmaceutically conventional granule.
Embodiment 15:
Take raw material Radix Rehmanniae 70g, Radix Rehmanniae Preparata 70g, Semen Trichosanthis 60g, Herba Dendrobii 60g, Cortex Magnoliae Officinalis 50g, Fructus Aurantii 50g, Semen Arecae 40g, Rhizoma Anemarrhenae 30g, Radix Glycyrrhizae Preparata 25g, S1: take by weight Cortex Magnoliae Officinalis, take the Rhizoma Zingiberis Recens that Cortex Magnoliae Officinalis weight 1-2 doubly measures, will get Rhizoma Zingiberis Recens juice after Rhizoma Zingiberis Recens squeezing, after Rhizoma Zingiberis Recens juice is mixed with Cortex Magnoliae Officinalis, pour in the heat pot of 60-90 DEG C and concoct Cortex Magnoliae Officinalis, until take out after Cortex Magnoliae Officinalis fried dry, obtain Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), for subsequent use; S2: take by weight Fructus Aurantii, after Fructus Aurantii is pulverized, add the Mel of equal weight, after Fructus Aurantii powder is mixed with Mel, pour in 60-90 DEG C hot pot and concoct Fructus Aurantii, until Mel dissolves among Fructus Aurantii powder completely, obtain processed with honey Fructus Aurantii, for subsequent use; S3: take by weight Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Trichosanthis, Herba Dendrobii, Semen Arecae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae Preparata, add the water soaking 0.5～1 hour of 4～6 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour, filters and obtain decocting liquid, and medicinal residues are for subsequent use; S4: the Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) that S1 step is obtained, the processed with honey Fructus Aurantii that S2 step obtains mix with the medicinal residues in S3 step, then add the decocting of 4～6 times of medical material amounts to boil 1～1.5 hour, filtering and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, obtain dried cream powder end, in dried cream powder end, add pharmaceutically acceptable adjuvant to be prepared into pharmaceutically conventional powder.
Embodiment 16:
Take raw material Radix Rehmanniae 55g, Radix Rehmanniae Preparata 55g, Semen Trichosanthis 45g, Herba Dendrobii 45g, Cortex Magnoliae Officinalis 40g, Fructus Aurantii 40g, Semen Arecae 25g, Rhizoma Anemarrhenae 20g, Radix Glycyrrhizae Preparata 20g, S1: take by weight Cortex Magnoliae Officinalis, take the Rhizoma Zingiberis Recens that Cortex Magnoliae Officinalis weight 1-2 doubly measures, will get Rhizoma Zingiberis Recens juice after Rhizoma Zingiberis Recens squeezing, after Rhizoma Zingiberis Recens juice is mixed with Cortex Magnoliae Officinalis, pour in the heat pot of 60-90 DEG C and concoct Cortex Magnoliae Officinalis, until take out after Cortex Magnoliae Officinalis fried dry, obtain Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), for subsequent use; S2: take by weight Fructus Aurantii, after Fructus Aurantii is pulverized, add the Mel of equal weight, after Fructus Aurantii powder is mixed with Mel, pour in 60-90 DEG C hot pot and concoct Fructus Aurantii, until Mel dissolves among Fructus Aurantii powder completely, obtain processed with honey Fructus Aurantii, for subsequent use; S3: take by weight Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Trichosanthis, Herba Dendrobii, Semen Arecae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae Preparata, add the water soaking 0.5～1 hour of 4～6 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour, filters and obtain decocting liquid, and medicinal residues are for subsequent use; S4: the Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) that S1 step is obtained, the processed with honey Fructus Aurantii that S2 step obtains mix with the medicinal residues in S3 step, then add the decocting of 4～6 times of medical material amounts to boil 1～1.5 hour, filtering and obtain decocting liquid, medicinal residues discard; S5: after the decocting liquid in S3 step and S4 step is merged, be condensed into extractum, then extractum vacuum drying obtained to dry cream, dried cream powder is broken, obtain dried cream powder end, in dried cream powder end, add pharmaceutically acceptable adjuvant to be prepared into pharmaceutically conventional oral liquid.
Radix Rehmanniae of the present invention is the dried root of scrophulariaceae rehmannia glutinosa plant; Radix Rehmanniae Preparata is the Preparation process product of Radix Rehmanniae, and the tuber of scrophulariaceae rehmannia glutinosa plant steams solarization through processing and forms; Semen Trichosanthis is the dry mature seed of cucurbitaceous plant Fructus Trichosanthis or trichosanthes rosthornii Harms; Herba Dendrobii is the stem of the multiple Herba Dendrobiis such as the orchid family herbaceous plant dendrobium loddigesii Rolfe, Herba Dendrobii oculati; Cortex Magnoliae Officinalis is dry, root, the branch skin of Magnoliacea plant Cortex Magnoliae Officinalis, magnolia officinalis rehd.et wils.var.biloba rehd.et wils.; Fructus Aurantii is the dry immature fruit of rutaceae Citrus aurantium Linn. and variety thereof; Semen Arecae is the seed of babassu Semen Arecae; The Rhizoma Anemarrhenae is the dry rhizome of the liliaceous plant Rhizoma Anemarrhenae; The dry root and rhizome of Radix Glycyrrhizae Preparata glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..
Verify beneficial effect of the present invention below by concrete experimentation:
(1) clinical experiment of pharmaceutical composition of the present invention to infantile constipation
1 physical data
This organizes the out-patient who meets functional constipation diagnostic criteria of all case selection oneself Out-patient Departments treatment.Be divided into three experimental grouies by table of random number, treatment group A organizes 30 examples, wherein male 14 examples, female's 16 examples, 1～12 years old age, 8.54 ± 1.43 years old mean age; Treatment group B organizes 30 examples, wherein male 16 examples, female's 14 examples, 1～12 years old age, 8.91 ± 1.62 years old mean age; Matched group 30 examples, wherein male 13 examples, female's 17 examples, 1～12 years old age, 8.72 ± 1.38 years old mean age.Group infant, at equal no significant differences in aspect such as age, sex, anthropometic, feeding patterns, the course of disease, primary symptom, simultaneous phenomenons, has comparability.
2 diagnostic criterias
All cases all meet Western medicine diagnose standard: Functional Constipation in Children Rome III standard, tcm diagnosis standard: " traditional Chinese medical science disease Standardization of diagnosis and curative effect " that food stagnation card is promulgated with reference to 1994 State Administration of Traditional Chinese Medicines (referring to: State Administration of Traditional Chinese Medicine. traditional Chinese medical science disease Standardization of diagnosis and curative effect [M]. Nanjing: publishing house of Nanjing University, 1994.) primary symptom: 1. infrequent defecation time lengthening; 2. constipation with dry stool; 3. difficult defecation; 4. fecal incontinence.Inferior disease: 1. abdominal part distension; 2. do not think breast food; 3. xerostomia; 4. halitosis; 5. feverish sensation in the palms and soles; Tongue arteries and veins: red tongue, thick and greasy fur, rolling and forceful pulse.Possess in primary symptom 1,2,3 of inferior diseases and more than, with reference to tongue arteries and veins, can make the dialectical of food stagnation card.All cases are all got rid of organic disease, nerve illness, mental disorder, metabolism endocrine illness and by the patient due to whole body organic disease etc.
3 Therapeutic Method
Treatment group A group: take raw material Radix Rehmanniae 3kg, Radix Rehmanniae Preparata 3kg, Semen Trichosanthis 1.5kg, Herba Dendrobii 1.5kg, Cortex Magnoliae Officinalis 1kg, Fructus Aurantii 1kg, Semen Arecae 1kg, Rhizoma Anemarrhenae 1kg, Radix Glycyrrhizae Preparata 1kg.Concrete preparation method is: S1: take by weight Cortex Magnoliae Officinalis, take the Rhizoma Zingiberis Recens that Cortex Magnoliae Officinalis weight 1-2 doubly measures, will after Rhizoma Zingiberis Recens squeezing, get Rhizoma Zingiberis Recens juice, after Rhizoma Zingiberis Recens juice is mixed with Cortex Magnoliae Officinalis, pour in the heat pot of 60-90 DEG C and concoct Cortex Magnoliae Officinalis, until take out after Cortex Magnoliae Officinalis fried dry, obtain Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), for subsequent use; S2: take by weight Fructus Aurantii, after Fructus Aurantii is pulverized, add the Mel of equal weight, after Fructus Aurantii powder is mixed with Mel, pour in 60-90 DEG C hot pot and concoct Fructus Aurantii, until Mel dissolves among Fructus Aurantii powder completely, obtain processed with honey Fructus Aurantii, for subsequent use; S3: take by weight Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Trichosanthis, Herba Dendrobii, Semen Arecae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae Preparata, add the water soaking 0.5～1 hour of 4～6 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour, filters and obtain decocting liquid, and medicinal residues are for subsequent use; S4: the Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) that S1 step is obtained, the processed with honey Fructus Aurantii that S2 step obtains mix with the medicinal residues in S3 step, then add the decocting of 4～6 times of medical material amounts to boil 1～1.5 hour, filtering and obtain decocting liquid, medicinal residues discard; S5: be condensed into extractum after the decocting liquid in S3 step and S4 step is merged, then extractum vacuum drying is obtained to dry cream, dried cream powder is broken, obtain dried cream powder end, in dried cream powder end, in conventional pharmaceutical, acceptable adjuvant supplementary product starch, magnesium stearate, dextrin and microcrystalline Cellulose are prepared into capsule, calculate the capsule that is prepared into 0.25g/ grain according to crude drug.Each two, three times on the one, suitably adjust consumption according to age size.Be 2 weeks the course for the treatment of, after 1 course for the treatment of, evaluates curative effect.
Treatment B group: take raw material Radix Rehmanniae 30g, Radix Rehmanniae Preparata 30g, Semen Trichosanthis 15g, Herba Dendrobii 15g, Cortex Magnoliae Officinalis 10g, Fructus Aurantii 10g, Semen Arecae 10g, Rhizoma Anemarrhenae 10g, Radix Glycyrrhizae Preparata 10g.Decoct twice according to conventional decocting method, decoct 15-20min at every turn, be prepared into conventional decoction, take 1 dose every day, within 1st, take three times, 2 weeks courses for the treatment of, after 1 course for the treatment of, evaluate curative effect.
Matched group: matched group gives New Oral Gold bifid, 2mg/ (kgd), 3 times/d, be 2 weeks the course for the treatment of, observes 1 course for the treatment of.All advise three groups of infants to drink more water and eat the food that cellulose is many.
4 observation of curative effect
Parameters for observation on effect: " the new Chinese medicine guideline of clinical investigations " developed and published with reference to Ministry of Health of the People's Republic of China in 1993 (referring to: Ministry of Health of the People's Republic of China. new Chinese medicine guideline of clinical investigations: first volume [S]. Beijing: Chinese Medicine science and technology publishing house, 1993:132.) curative effect determinate standard.Clinical recovery: stool is normal or return to the front level of disease, and other symptoms all disappear; Effective: constipation obviously improves, infrequent defecation time and just matter approach normal, or the slightly dry and infrequent defecation of stool is in 72h, and other symptoms are most of to disappear; Effective: infrequent defecation time shorten 1 day, or the just dry and hard improvement of matter, other symptoms all take a favorable turn; Invalid: constipation and other symptoms are without improvement.
Safety observation index: (1) general health check-up project: blood pressure, heart rate, breathing, body temperature; (2) blood, urine, stool routine examination inspection; (3) liver, renal function, electrocardiogram, chest film inspection; (4) adverse effect is observed: if there is untoward reaction, answer the method for itemized record symptom and sign and solution.
5 statistical methods
Adopt SPSS17.0 software to process, measurement data adopts average
represent, with t inspection, the more useful X 2 test of enumeration data.P < 0.05, has statistical significance.
6 results
The comparison of 6.1 liang of group curative effects
The clinical efficacy for the treatment of A group, treatment B group is obviously better than matched group, and difference has statistical significance (P < 0.05), the results are shown in Table 1.
The comparison of three groups of patient's total effective rates of table 1
6.2 untoward reaction and safety indexes
All there is not serious untoward reaction in three groups of patients; All there is not obvious abnormal change in two groups of patients general vital sign, electrocardiogram, hepatic and renal function, three large routines before and after test.
Result shows by experiment, and pharmaceutical composition of the present invention has good clinical efficacy to infantile constipation patient, and drug safety.In addition, pharmaceutical composition of the present invention is carried out to efficacy experiment discovery the KM of immunologic hypofunction mice, pharmaceutical composition of the present invention is under the dosage condition of dosage ratio of the present invention, can improve index and spleen index and the thymus index of mice, show that pharmaceutical composition of the present invention contributes to improve the immunity of body.In experimentation, find, formula of the present invention is being prepared decoction according to conventional method, infantile constipation is had to good clinical efficacy, it always effectively reaches 86.67%, compare with matched group 73.33%, there is significant difference (P < 0.05), the pharmaceutical composition that traditional decoction prepares with the inventive method is compared, the pharmaceutical composition that the inventive method prepares, its clinical efficacy reaches 93.33%, although there was no significant difference, has notable synergistic advantage.
Claims (9)
1. treat the pharmaceutical composition of infantile constipation for one kind, it is characterized in that: it is made up of the raw material of following ratio of weight and number: Radix Rehmanniae 20-100 part, Radix Rehmanniae Preparata 20-100 part, Semen Trichosanthis 15-90 part, Herba Dendrobii 15-80 part, Cortex Magnoliae Officinalis 10-70 part, Fructus Aurantii 10-70 part, Semen Arecae 10-60 part, Rhizoma Anemarrhenae 10-50 part, Radix Glycyrrhizae Preparata 10-40 part.
2. a kind of pharmaceutical composition for the treatment of infantile constipation according to claim 1, it is characterized in that: the ratio of weight and number of described each raw material is: Radix Rehmanniae 40-80 part, Radix Rehmanniae Preparata 40-80 part, Semen Trichosanthis 30-70 part, Herba Dendrobii 30-70 part, Cortex Magnoliae Officinalis 20-60 part, Fructus Aurantii 20-60 part, Semen Arecae 15-50 part, Rhizoma Anemarrhenae 15-40 part, Radix Glycyrrhizae Preparata 15-30 part.
3. a kind of pharmaceutical composition for the treatment of infantile constipation according to claim 1, it is characterized in that: the ratio of weight and number of described each raw material is: Radix Rehmanniae 50-70 part, Radix Rehmanniae Preparata 50-70 part, Semen Trichosanthis 40-60 part, Herba Dendrobii 40-60 part, Cortex Magnoliae Officinalis 30-50 part, Fructus Aurantii 30-50 part, Semen Arecae 20-40 part, Rhizoma Anemarrhenae 20-30 part, Radix Glycyrrhizae Preparata 20-25 part.
4. a kind of pharmaceutical composition for the treatment of infantile constipation according to claim 1, it is characterized in that: the ratio of weight and number of described each raw material is: Radix Rehmanniae 55-65 part, Radix Rehmanniae Preparata 55-65 part, Semen Trichosanthis 45-55 part, Herba Dendrobii 45-55 part, Cortex Magnoliae Officinalis 40-45 part, Fructus Aurantii 40-45 part, Semen Arecae 25-35 part, Rhizoma Anemarrhenae 20-25 part, Radix Glycyrrhizae Preparata 22-24 part.
5. a kind of pharmaceutical composition for the treatment of infantile constipation according to claim 1, it is characterized in that: the ratio of weight and number of described each raw material is: 30 parts of Radix Rehmanniae, 30 parts of Radix Rehmanniae Preparata, 15 parts of Semen Trichosanthiss, 15 parts of Herba Dendrobiis, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Fructus Aurantiis, 10 parts of Semen Arecaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Radix Glycyrrhizae Preparatas.
6. a method of preparing the pharmaceutical composition of the treatment infantile constipation described in any one in claim 1～5, is characterized in that: it comprises the following steps:
S1: take by weight Cortex Magnoliae Officinalis, take the Rhizoma Zingiberis Recens that Cortex Magnoliae Officinalis weight 1-2 doubly measures, will Rhizoma Zingiberis Recens get Rhizoma Zingiberis Recens juice after squeezing, after Rhizoma Zingiberis Recens juice is mixed with Cortex Magnoliae Officinalis, pour in 60-90 DEG C hot pot and concoct Cortex Magnoliae Officinalis, until take out after Cortex Magnoliae Officinalis fried dry, obtain Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), for subsequent use;
S2: take by weight Fructus Aurantii, after Fructus Aurantii is pulverized, add the Mel of equal weight, after Fructus Aurantii powder is mixed with Mel, pour in 60-90 DEG C hot pot and concoct Fructus Aurantii, until Mel dissolves among Fructus Aurantii powder completely, obtain processed with honey Fructus Aurantii, for subsequent use;
S3: take by weight Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Trichosanthis, Herba Dendrobii, Semen Arecae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae Preparata, add the water soaking 0.5～1 hour of 4～6 times of amounts of medical material after mixing, decoct subsequently 0.5～1 hour, filters and obtain decocting liquid, and medicinal residues are for subsequent use;
S4: the Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) that S1 step is obtained, the processed with honey Fructus Aurantii that S2 step obtains mix with the medicinal residues in S3 step, then add the decocting of 4～6 times of medical material amounts to boil 1～1.5 hour, filtering and obtain decocting liquid, medicinal residues discard;
S5: be condensed into extractum after the decocting liquid in S3 step and S4 step is merged, then extractum vacuum drying is obtained to dry cream, dried cream powder is broken, obtain dried cream powder end, in dried cream powder end, add pharmaceutically acceptable adjuvant to be prepared into pharmaceutically conventional pharmaceutical preparation.
7. the preparation method of a kind of pharmaceutical composition for the treatment of infantile constipation according to claim 6, is characterized in that: described pharmaceutical preparation is pill, tablet, capsule, granule, powder or oral liquid.
8. the preparation method of a kind of pharmaceutical composition for the treatment of infantile constipation according to claim 6, is characterized in that: described pharmaceutically acceptable adjuvant comprises starch, magnesium stearate, dextrin and microcrystalline Cellulose.
9. the application of the pharmaceutical composition as described in any one claim in claim 1～5 in preparation treatment infantile constipation.
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| KR101391441B1 (en) * | 2011-10-11 | 2014-05-07 | 주식회사 글루칸 | Composition for improving constipation or intestinal function comprising fermented rice extracts |
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| CN101129552A (en) * | 2007-08-27 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating chronic functional constipation |
| KR101391441B1 (en) * | 2011-10-11 | 2014-05-07 | 주식회사 글루칸 | Composition for improving constipation or intestinal function comprising fermented rice extracts |
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Application publication date: 20140924 |