CN104055845B - A kind of composition and its preparation for treating cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity - Google Patents
A kind of composition and its preparation for treating cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity Download PDFInfo
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Abstract
The invention discloses a kind of composition for treating cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity, it is made by following raw materials according：Cervus elaphus linnaeus, maca, ginseng, ginkgo leaf, the red sage root.The invention provides one kind it is non-stimulated, have no toxic side effect, degree of safety is high, can effect a radical cure, and does not recur；Also there is the effect of strengthen immunity simultaneously, the composition of cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity, and the oral formulations as made from said composition can be effectively treated.Composition and its oral formulations that the present invention is provided, can effectively treat cardiovascular and cerebrovascular, liver and kidney disease, cure rate and efficient higher, cure rate 94.3%, effective percentage 100%.
Description
Technical field
It is more particularly to a kind of to treat cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity the invention belongs to the field of Chinese medicines
Composition and its preparation.
Technical background
The heart, brain, liver and kidney behaviour body important organ, its relevant disease seriously threaten human health.Cardiovascular and cerebrovascular disease, such as
Coronary heart disease, miocardial infarction, rhomboembolia type cerebrovascular disease are the big persistent ailments for threatening World Health crowd, and are had in recent years progressively
The trend of rising.The height of mortality of cardio and cerebral vascular disease, is to weigh country, the quality of life of resident, a health
The important indicator of public health work.Coronary heart disease is one of global death rate highest disease, and Chinese death toll occupies the second in the world；
Cerebral apoplexy, the annual death toll about 6,000,000 in the whole world, Chinese incidence of disease the first in the world；Injury of kidney disease, developed country's incidence of disease is
6.5%-10%, and the selected areas of China incidence of disease is up to 8%-12%, from 2005, the uremia of row renal replacement therapies was suffered from
Person there are about 60,000, and be increased with the speed for being more than l1% every year, as clinical common critical illness, wherein acute injury of kidney disease
Dead rate is up to 30%.There are some researches show the western medicine of the chronic cardiovascular and cerebrovascular disease such as long-term taking treatment coronary heart disease, hypertension
Medicine, can further trigger liver, the injury of kidney of patient, or can accelerate to deteriorate liver, the kidney diaseases of Patients with Cardiovascular/Cerebrovascular Diseases.Cause
This, active development it is safe and effective, with low cost and treat cardiovascular and cerebrovascular disease while can also synchronously be directed to liver, kidney diaseases,
The medicine for improving immunity is significant.Chinese patent CN1569157A discloses a kind of treat in cardiovascular and cerebrovascular disease
Medicine preparation and preparation method thereof, although have certain effect, but treatment cycle is long, long-term taking toxicity is big, and can not root
Control, easily rebound；Bioavilability is not high, is unfavorable for absorption of human body.
The content of the invention
Cardiovascular and cerebrovascular and liver and kidney disease, strengthen immunity, effect can be effectively treated simultaneously it is an object of the invention to provide one kind
Really good, instant effect, can effect a radical cure, not rebound, have no toxic side effect, bioavilability is high, beneficial to the composition of absorption of human body.
The composition for treating cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity of the present invention, by the raw material of following parts by weight
It is processed to be prepared from：Cervus elaphus linnaeus 120-280, maca 300-500, ginseng 400-900, ginkgo leaf 400-900, red sage root 500-
1500。
The composition for the treatment of cardiovascular and cerebrovascular provided by the present invention, liver and kidney disease and strengthen immunity is by traditional Chinese medicinal material raw materials system
Standby to form, said composition has good therapeutic effect to treatment cardiovascular and cerebrovascular, liver and kidney disease, no dependence, do not rebound, it is nontoxic
Side effect.
Preferably, the composition for the treatment of cardiovascular and cerebrovascular of the invention, liver and kidney disease and strengthen immunity, by following parts by weight
Raw material processed be prepared from：Cervus elaphus linnaeus 200, maca 440, ginseng 600, ginkgo leaf 600, the red sage root 1000.
The composition of the treatment cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity, can effectively treat cardiovascular and cerebrovascular, liver kidney
Disease, instant effect, has no toxic side effect；Also there is the effect of strengthen immunity simultaneously.
Composition of the present invention, only using cervus elaphus linnaeus, maca, ginseng, ginkgo leaf and red sage root five tastes raw material, it is not necessary to
Add other raw materials, it is possible to good effect is played to treatment cardiovascular and cerebrovascular, liver and kidney disease, treatment cycle is short, rapid-action, no
Bounce-back, has no toxic side effect；And this composition can also improve the immunity of patient, strengthen the constitution of patient, strengthen patient
Resistance against diseases.
Orally made as made from the composition and auxiliary material of the treatment cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity of the present invention
Agent, is tablet, capsule, oral liquid or granule.
Oral formulations are made in the composition of the treatment cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity of the present invention, it is convenient
Carry, it is to avoid patient takes interruption caused by going on business and influences therapeutic effect, improves the compliance of patient.
Orally made as made from the composition and auxiliary material of the treatment cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity of the present invention
Agent is tablet, and auxiliary material includes the sorbierite that parts by weight are 100-200, the silica that parts by weight are 50-100, parts by weight
The PVP that the magnesium stearate and parts by weight that Sodium Hydroxymethyl Stalcs that number is 10-30, parts by weight are 20-50 are 20-50
K30。
The synergy of sorbierite and silica, be conducive to improving tablet stability and active component in tablet it is molten
Out-degree, improves the bioavilability of active ingredient in tablet, increases the using effect of medicine；
The synergy of silica and magnesium stearate, can make tablet surface smooth and beautiful appearance after tabletting.
Orally made as made from the composition and auxiliary material of the treatment cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity of the present invention
Agent is capsule, and capsule includes capsule 's content；Capsule 's content includes composition and auxiliary material, and auxiliary material is including parts by weight
35-65 starch and parts by weight is 5-15 magnesium stearate.
The preparation method of the composition for treating cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity of the present invention, including it is as follows
Step：
1) ginseng is extracted in accordance with the following methods, obtains ginseng extract：
The ginseng of recipe quantity is weighed, after cleaning, ethanol solution refluxing extraction is added three times；Add the ethanol of 6 times of amounts for the first time
Solution refluxing extraction 2h；The ethanol solution refluxing extraction 2h of second plus 6 times amount；The ethanol solution backflow of third time plus 5 times of amounts
Extract 2h；Merge filtering at extract solution, 85 DEG C, filtrate and spray at the medicinal extract, 40 DEG C that relative density is 1.17 is concentrated at 70 DEG C
Powder dry, pulverize to obtain ginseng extract, and the yield of the ginseng extract is 10%, and the yield of the ginseng extract is
10%；
2) ginkgo leaf, the red sage root are extracted in accordance with the following methods respectively, obtains ginkgo biloba p.e, Salvia root P.E：
Ginkgo leaf, the red sage root of recipe quantity are weighed respectively, after cleaning, are separately added into purified water refluxing extraction three times；For the first time
Plus the 7-8 times of purified water refluxing extraction 2h measured；The purified water refluxing extraction 2h of second plus 8 times amount；Third time plus 5 times amount it is pure
Change water refluxing extraction 2h；It is 1.20 to merge filtering at No. three extract solutions, 85 DEG C, filtrate respectively to be concentrated into relative density at 70 DEG C
Medicinal extract, dusting at 40 DEG C dry, pulverize to obtain ginkgo biloba p.e, Salvia root P.E, the ginkgo biloba p.e, the red sage root are extracted
The yield of thing is 10%, and the ginkgo biloba p.e, the yield of Salvia root P.E are 10%；
3) maca is prepared into pueraria root powder in accordance with the following methods：
The smooth maca in surface is selected, is placed in clear water and soaks 12h, cleans, dries, cuts into slices, uses according to 1-2mm thickness
It is 4%-7% that special dew eye pallet is placed in the dry 24h of 60 DEG C of drying room to moisture after containing, and is ground into fine powder, uses
60Co radiation sterilizing 2h, produce pueraria root powder；
4) cervus elaphus linnaeus is cut into slices, it is in slightly yellow to section to be placed in baking 5-6h in 80-100 DEG C of drying box, and taking-up cools, powder
Powder is broken into, cervus elaphus linnaeus powder is obtained；
5) by step 1) obtained ginseng extract, step 2) obtained ginkgo biloba p.e and Salvia root P.E, step
3) pueraria root powder that obtains, step 4) obtained cervus elaphus linnaeus powder crosses 80 mesh sieves respectively, and then it is well mixed, produces treatment heart and brain blood
The composition of pipe, liver and kidney disease and strengthen immunity.
The preparation method of the oral formulations for treating cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity of the present invention, including such as
Lower step：
A) composition is prepared；
B) sorbierite of recipe quantity is crushed, crosses 80 mesh sieves, obtain fine powder standby；
C) silica, Sodium Hydroxymethyl Stalcs and magnesium stearate of recipe quantity are crossed into 80 mesh sieves respectively, obtains fine powder standby；
D) the sorbierite fine powder and the step c) of 1/3 recipe quantity that composition, the step b) obtained step a) is obtained are obtained
Fine silica, be put into mixer and mix 30min, obtain mixed powder, it is standby；
E) PVP K30 of recipe quantity is pressed into 1kg:250ml ratio is dissolved in 70% ethanol, and adds step d)
The mixed powder arrived, stir softwood processed, the granulation of 20 mesh, then 50-60 DEG C of drying, 20 mesh whole grains, obtains particle；
F) fine silica that particle, the step c) of 2/3 recipe quantity obtained step e) is obtained, Sodium Hydroxymethyl Stalcs
Fine powder and magnesium stearate fine powder are put into mixer and mix 10min, obtain mixture；
G) the mixture tabletting for obtaining step f), obtains tablet.
The preparation method of the oral formulations of cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity, bag are treated in the treatment of the present invention
Include following steps：
A) preparation of capsule 's content：
1) composition is prepared；
2) starch of recipe quantity, magnesium stearate are crossed into 80 mesh sieves respectively, obtains fine powder；
3) by step 1) obtained composition, step 2) obtained starch and magnesium stearate be put into mixer and mix
30min, obtains capsule 's content；
B) preparation of capsule：
Capsule 's content made from step a) is filled into capsule shells, capsule is made.
The treatment cardiovascular and cerebrovascular of the present invention, the composition of liver and kidney disease and strengthen immunity prepare treatment cardiovascular and cerebrovascular or
Application in the medicine of liver and kidney disease.
The composition for treating cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity of the present invention is preparing the medicine of strengthen immunity
Application in product.
Preparation technology provided by the present invention, realizes having no toxic side effect and being easy to human body suction for composition and oral formulations
Receive, it is low, simple to operate that the preparation technology realizes cost, be adapted to industrialized production；Obtained oral formulations facilitate patient to go out
Carry, improve the compliance of patient.
The source of primary raw material used is as follows in the present invention：
Cervus elaphus linnaeus (Cornu Cervi Pantotrichum)：The angle of animal in deer family red deer；
Maca (Peruvian ginseng)：The root tuber of Cruciferae Lepidium plant；
Ginseng (Panax ginseng C.A.Mey)：Araliaceae, the rhizome of Panax herbaceos perennial；
Ginkgo leaf (Ginkgo biloba)：The leaf of Ginkgoaceae Ginkgo plant Ginkgo biloba；
The red sage root (Salvia miltiorrhiza Bunge)：The root tuber of the Lamiaceae Salvia platymiscium red sage root.
Beneficial effects of the present invention are：
(1) raw material) is used for degree of safety high Chinese medicine or Chinese medical extract, treatment cardiovascular and cerebrovascular, the liver and kidney disease of preparation
With the composition of strengthen immunity it is non-stimulated, have no toxic side effect, degree of safety is high, can effect a radical cure, and does not recur, cure rate and it is efficient compared with
Height, cure rate 94.3%, effective percentage 100%；Also there is the effect of strengthen immunity simultaneously.
(2) preparation technology provided by the present invention, realizes having no toxic side effect and being easy to people for composition and oral formulations
Body absorbs, and it is low, simple to operate that the preparation technology realizes cost, is adapted to industrialized production；Obtained oral formulations facilitate patient
It is outgoing to carry, improve the compliance of patient.
Embodiment
With reference to embodiment, the invention will be further described：
The composition of embodiment 1
A kind of composition for treating cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity, by the raw material of following parts by weight through adding
Work is prepared from：
The ginseng 600 of 200 maca of cervus elaphus linnaeus 440
The red sage root 1000 of ginkgo leaf 600
Preparation method：
1) ginseng is extracted in accordance with the following methods, obtains ginseng extract：
The ginseng of recipe quantity is weighed, after cleaning, ethanol solution refluxing extraction is added three times；Add the ethanol of 6 times of amounts for the first time
Solution refluxing extraction 2h；The ethanol solution refluxing extraction 2h of second plus 6 times amount；The ethanol solution backflow of third time plus 5 times of amounts
Extract 2h；Merge filtering at extract solution, 85 DEG C, filtrate and spray at the medicinal extract, 40 DEG C that relative density is 1.17 is concentrated at 70 DEG C
Powder dry, pulverize to obtain ginseng extract, and the yield of the ginseng extract is 10%；
2) ginkgo leaf, the red sage root are extracted in accordance with the following methods respectively, obtains ginkgo biloba p.e, Salvia root P.E：
Ginkgo leaf, the red sage root of recipe quantity are weighed respectively, after cleaning, are separately added into purified water refluxing extraction three times；For the first time
Plus the 7-8 times of purified water refluxing extraction 2h measured；The purified water refluxing extraction 2h of second plus 8 times amount；Third time plus 5 times amount it is pure
Change water refluxing extraction 2h；It is 1.20 to merge filtering at No. three extract solutions, 85 DEG C, filtrate respectively to be concentrated into relative density at 70 DEG C
Medicinal extract, dusting at 40 DEG C dry, pulverize to obtain ginkgo biloba p.e, Salvia root P.E, the ginkgo biloba p.e, the red sage root are extracted
The yield of thing is 10%；
3) maca is prepared into pueraria root powder in accordance with the following methods：
The smooth maca in surface is selected, is placed in clear water and soaks 12h, cleans, dries, cuts into slices, uses according to 1-2mm thickness
It is 4%-7% that special dew eye pallet is placed in the dry 24h of 60 DEG C of drying room to moisture after containing, and is ground into fine powder, uses
60Co radiation sterilizing 2h, produce pueraria root powder；
4) cervus elaphus linnaeus is cut into slices, it is in slightly yellow to section to be placed in baking 5-6h in 80-100 DEG C of drying box, and taking-up cools, powder
Powder is broken into, cervus elaphus linnaeus powder is obtained；
5) by step 1) obtained ginseng extract, step 2) obtained ginkgo biloba p.e and Salvia root P.E, step
3) pueraria root powder that obtains, step 4) obtained cervus elaphus linnaeus powder crosses 80 mesh sieves respectively, and then it is well mixed, produces treatment heart and brain blood
The composition of pipe, liver and kidney disease and strengthen immunity.
The composition of embodiment 2
A kind of composition for treating cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity, by the raw material of following parts by weight through adding
Work is prepared from：
The ginseng 400 of 120 maca of cervus elaphus linnaeus 300
The red sage root 500 of ginkgo leaf 400
Preparation method：Composition is made according to the preparation method of embodiment 1.
The composition of embodiment 3
A kind of composition for treating cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity, by the raw material of following parts by weight through adding
Work is prepared from：
The ginseng 900 of 280 maca of cervus elaphus linnaeus 500
The red sage root 1500 of ginkgo leaf 900
Preparation method：Composition is made according to the preparation method of embodiment 1.
The tablet of embodiment 4
Prescription：
Preparation method：
A) composition is prepared；
B) sorbierite of recipe quantity is crushed, crosses 80 mesh sieves, obtain fine powder standby；
C) silica, Sodium Hydroxymethyl Stalcs and magnesium stearate of recipe quantity are crossed into 80 mesh sieves respectively, obtains fine powder standby；
D) the sorbierite fine powder and the step c) of 1/3 recipe quantity that composition, the step b) obtained step a) is obtained are obtained
Fine silica, be put into mixer and mix 30min, obtain mixed powder, it is standby；
E) PVP K30 of recipe quantity is pressed into 1kg:250ml ratio is dissolved in 70% ethanol, and adds step d)
The mixed powder arrived, stir softwood processed, the granulation of 20 mesh, then 50-60 DEG C of drying, 20 mesh whole grains, obtains particle；
F) fine silica that particle, the step c) of 2/3 recipe quantity obtained step e) is obtained, Sodium Hydroxymethyl Stalcs
Fine powder and magnesium stearate fine powder are put into mixer and mix 10min, obtain mixture；
G) the mixture tabletting for obtaining step f), obtains tablet, every 1.0g.
The tablet of embodiment 5
Prescription：
Preparation method：Tablet, every 1.0g is made according to the preparation method of embodiment 4.
The tablet of embodiment 6
Prescription：
Preparation method：Tablet, every 1.0g is made according to the preparation method of embodiment 4.
The capsule of embodiment 7
Prescription：
Capsule 's content：Composition 820g prepared by embodiment 1
Auxiliary material：Starch 50g
Magnesium stearate 10g
Preparation method：
A) preparation of capsule 's content：
1) composition is prepared；
2) starch of recipe quantity, magnesium stearate are crossed into 80 mesh sieves respectively, obtains fine powder；
3) by step 1) obtained composition, step 2) obtained starch and magnesium stearate be put into mixer and mix
30min, obtains capsule 's content；
B) preparation of capsule：
Capsule 's content made from step a) is filled into capsule shells, capsule, every 0.45g is made.
The capsule of embodiment 8
Prescription：
Capsule 's content：Composition 550g prepared by embodiment 2
Auxiliary material：Starch 35g
Magnesium stearate 15g
Preparation method：Capsule, every 0.45g is made according to the preparation method of embodiment 7.
The capsule of embodiment 9
Prescription：
Capsule 's content：Composition 1100g prepared by embodiment 2
Auxiliary material：Starch 65g
Magnesium stearate 5g
Preparation method：Capsule, every 0.45g is made according to the preparation method of embodiment 7.
Comparative examples 1
It is commercially available according to healthy and free from worry (Folium Ginkgo) (composition：Ginkgo biloba p.e), tablet is conventionally made.
The tablet of comparative examples 2
Prescription：
Preparation method：
A) composition is prepared；
B) sorbierite of recipe quantity is crushed, crosses 80 mesh sieves, obtain fine powder standby；
C) Sodium Hydroxymethyl Stalcs and magnesium stearate of recipe quantity are crossed into 80 mesh sieves respectively, obtains fine powder standby；
D) the sorbierite fine powder and the step c) of 1/3 recipe quantity that composition, the step b) obtained step a) is obtained are obtained
Fine silica, be put into mixer and mix 30min, obtain mixed powder, it is standby；
E) PVP K30 of recipe quantity is pressed into 1kg:250ml ratio is dissolved in 70% ethanol, and adds step d)
The mixed powder arrived, stir softwood processed, the granulation of 20 mesh, then 50-60 DEG C of drying, 20 mesh whole grains, obtains particle；
F) the Sodium Hydroxymethyl Stalcs fine powder and magnesium stearate fine powder that particle, the step c) obtained step e) is obtained are put into mixed
10min is mixed in conjunction machine, mixture is obtained；
G) the mixture tabletting for obtaining step f), obtains tablet, every 1.0g.
The stability test of test example 1
1. accelerated test
The tablet of the embodiment of the present invention 4, comparative examples 1 and comparative examples 2 is taken, 3 batches are randomly divided into respectively, is compiled respectively
Number be 4301,4302 and 4303, D101, D102 and D103, D201, D202 and D203, will more than 9 batches of samples at 40 DEG C ± 2
At DEG C, relative humidity be 75% ± 5% under conditions of place 6 months, 1 month during testing, 2 months, 3 months, 6 the end of month
It is separately sampled once, by the regulation in Chinese Pharmacopoeia, detect character, the content (labelled amount %) of maca ene and the dissolution of tablet
Degree, the results are shown in Table 1；
The accelerated test result of the tablet of table 1
The tablet that the embodiment of the present invention 4 is provided as can be seen from the table, after accelerated results showed that is placed 6 months,
Obvious change does not occur for the character of the tablet, the content of maca ene and dissolution rate；And comparative examples 1, control are implemented
After the tablet of example 2 is placed 6 months, tablet character is changed, and yellow is changed into from faint yellow, and is cracked, maca ene
Content is remarkably decreased, and dissolution is uneven；Show the tablet and comparative examples 1, the piece of comparative examples 2 of the embodiment of the present invention 4
Agent is compared, and stability is significantly improved, better according to healthy and free from worry stability than commercially available；In addition, after also illustrating that silica is added, with sorb
Alcohol serves synergy, improves the stability of tablet；
In addition, it is also seen that the tablet that the embodiment of the present invention 4 is provided, surface is smooth, even across acceleration examination from table
After testing placement 6 months, the still smooth flawless of tablet surface；And comparative examples 1, the tablet of comparative examples 2, surface is thick
It is rough, and after accelerated test is placed 6 months, occur crackle again；Show the tablet and comparative examples 2 of the embodiment of the present invention 4
Tablet compare, tablet surface smoothness is significantly improved, illustrate silica add after, served with magnesium stearate and cooperate with work
With making tablet surface smooth and beautiful appearance after tabletting.
2. long term test
The tablet of the embodiment of the present invention 4, comparative examples 1 and comparative examples 2 is taken, 3 batches are randomly divided into respectively, is compiled respectively
Number be 4301,4302 and 4303, D101, D102 and D103, D201, D202 and D203, will more than 9 batches of samples in 25 DEG C of temperature
At ± 2 DEG C, relative humidity be 60% ± 10% under conditions of place 12 months, every 3 months sampling once, respectively at 0 month, 3
Sample within individual month, 6 months, 9 months, 12 months, 18 months, 24 months, detect character, the content of the maca ene (sign of tablet
Measure %) and dissolution rate, it the results are shown in Table 2；
The long-term test results of the tablet of table 2
The tablet that the embodiment of the present invention 4 is provided as can be seen from the table, understands through long-term test results, places 24 months
Afterwards, obvious change does not occur for the character of the tablet, the content of maca ene and dissolution rate；Comparative examples 1, control are implemented
After the tablet of example 2 is placed 24 months, tablet character changes, and is changed into yellowish-brown again from the faint yellow yellow that is changed into, and produce
Crackle, the content of maca ene is remarkably decreased, and dissolution is uneven；Show the tablet of the embodiment of the present invention 4 and comparative examples 1, it is right
Compared according to the tablet of embodiment 2, stability is significantly improved, illustrate the tablet of the embodiment of the present invention 4 than commercially available according to healthy and free from worry stabilization
Property it is high, in addition, after also illustrating that silica is added, serving synergy with sorbierite, improving the stability of tablet；
In addition, it is also seen that the tablet that the embodiment of the present invention 4 is provided, surface is smooth, even across long-term examination from table
After testing placement 24 months, the still smooth flawless of tablet surface；And comparative examples 1, the tablet of centering embodiment 2, after for a long time
After experiment is placed 6 months, there is crackle；Show the tablet and comparative examples 1, the piece of comparative examples 2 of the embodiment of the present invention 4
Agent is compared, and tablet surface smoothness is significantly improved, and illustrates that the tablet of the embodiment of the present invention 4 is higher according to healthy and free from worry stability than commercially available,
In addition, after also illustrating that silica is added, serving synergy with magnesium stearate, making tablet surface smooth and beautiful appearance after tabletting.
The clinical test of test example 2
1. cardiovascular and cerebrovascular disease
1. case selection：Treatment group 35, age 35-75 Sui, average 50 years old, course of disease 1-20；Control group 35, age
It is 35-75 Sui, average 50 years old, course of disease 1-20.
2. administering mode：Treatment group：Use the combination of the treatment cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity of the present invention
Thing, 3 times a day, and warm water is taken after mixing it with water after meal, is within one month a course for the treatment of, continuous to use two courses for the treatment of.Control group：Orally according to healthy and free from worry
(composition：Folium Ginkgo), 3 times a day, one after each meal, and a course for the treatment of is two months, continuous to use three courses for the treatment of.
3. classical symptom：Headache, dizziness, tinnitus, palpitaition, dim eyesight, absent minded, failure of memory, numbness in hands and feet,
Fatigue and weak, easily agitation；The nutrient metabolics such as internal carbohydrate, fat, protein are abnormal；Dyslipidemia.
4. diagnostic criteria：
Recovery from illness：Clinical symptoms are wholly absent.
It is effective：Clinical symptoms disappear substantially.
Effectively：Clinical symptom relief.
It is invalid：Substantially it is unchanged.
5. result of the test：
The comparitive study for the treatment of group and control group the results are shown in Table 3；
The treatment group of table 3 and the comparitive study of control group
Treatment group and control group compare with otherness (P ＜ 0.05).
6. effect judges：The treatment cardiovascular and cerebrovascular of the present invention, the composition of liver and kidney disease and strengthen immunity and by its system
The oral formulations obtained, can effectively treat cardiovascular and cerebrovascular disease, and effective percentage 100%, cure rate 94.3%, efficient and cure rate are equal
Higher, good effect, the cycle is short, and curative effect is significantly better than control group.
2. liver and kidney disease
1. case selection：Treatment group 35, age 34-73 Sui, average 49 years old, course of disease 1-20；Control group 35, age
It is 34-73 Sui, average 50 years old, course of disease 1-20.
2. administering mode：Treatment group：Use the combination of the treatment cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity of the present invention
Thing, 3 times a day, and warm water is taken after mixing it with water after meal, is within one month a course for the treatment of, continuous to use two courses for the treatment of.Control group：Oral Shengui antler
Ball (composition：Ginseng, pilose antler (unhairing), Fructus Corni (wine is processed), glutinous rehmannia, prepared rhizome of rehmannia, the root of herbaceous peony, tortoise plastron (frying boiling hot vinegar to quench), turtle shell are (husky
Boiling hot vinegar is quenched), donkey-hide gelatin, the bark of eucommia (stir-fry charcoal), teasel root, asparagus fern, Poria cocos, spina date seed (stir-fry), amber, folium artemisiae argyi (stir-fry charcoal), dried orange peel, rhizoma alismatis,
Myrrh (vinegar is processed), frankincense (vinegar is processed), corydalis tuber (vinegar is processed), safflower, west safflower, radix achyranthis bidentatae (decaptitating), radix cyathulae (decaptitating), cockscomb
Flower, red halloysite (forging), rhizoma cyperi (vinegar is processed), radix glycyrrhizae, bark of ash, radix scutellariae, the bighead atractylodes rhizome (bran stir-fry), dried orange peel, the banksia rose, fructus amomi, agalloch eaglewood, Radix Angelicae Sinensis,
Ligusticum wallichii, Chinese cassia tree), 3 times a day, one after each meal, and a course for the treatment of is two months, continuous to use three courses for the treatment of.
3. classical symptom：Progressive oliguresis or anuria, blood urea nitrogen and creatinine rise.
4. diagnostic criteria：
Recovery from illness：Clinical symptoms are wholly absent.
It is effective：Clinical symptoms disappear substantially.
Effectively：Clinical symptom relief.
It is invalid：Substantially it is unchanged.
5. result of the test：
The comparitive study for the treatment of group and control group the results are shown in Table 4；
The treatment group of table 4 and the comparitive study of control group
Treatment group and control group compare with otherness (P ＜ 0.05).
6. effect judges：The treatment cardiovascular and cerebrovascular of the present invention, the composition of liver and kidney disease and strengthen immunity and by its system
Oral formulations, can effectively treat liver and kidney disease, effective percentage 100%, cure rate 91.4%, efficient and cure rate compared with
Height, good effect, the cycle is short, and curative effect is significantly better than control group.
3. hypoimmunity
1. case selection：Treatment group 33, age 25-70 Sui, average 50 years old, course of disease 1-20；Control group 33, age
It is 24-70 Sui, average 50 years old, course of disease 1-20.
2. administering mode：Treatment group：Use the combination of the treatment cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity of the present invention
Thing, 3 times a day, and warm water is taken after mixing it with water after meal, is within one month a course for the treatment of, continuous to use two courses for the treatment of.Control group：Virgin health piece is (main
Composition：The Radix Astragali, the bighead atractylodes rhizome, windproof, Chinese yam, oyster, dried orange peel), 3 times a day, and warm water is taken after mixing it with water after meal, and a course for the treatment of is two months, even
It is continuous to use three courses for the treatment of.
3. classical symptom：Have a delicate constitution, malnutritive, One's spirits are drooping, fatigue and weak, appetite are reduced, sleep-disorder；Chang Sheng
Disease, easy catching a cold, accompanying infection；It is sick easily repeatedly.
4. diagnostic criteria：
Recovery from illness：Clinical symptoms are wholly absent.
It is effective：Clinical symptoms disappear substantially.
Effectively：Clinical symptom relief.
It is invalid：Substantially it is unchanged.
5. result of the test：
The comparitive study for the treatment of group and control group the results are shown in Table 5；
The treatment group of table 5 and the comparitive study of control group
Treatment group and control group compare with otherness (P ＜ 0.05).
6. effect judges：The treatment cardiovascular and cerebrovascular of the present invention, the composition of liver and kidney disease and strengthen immunity and by its system
The oral formulations obtained, can effectively treat hypoimmunity, strengthen immunity, effective percentage 100%, cure rate 93.9%, effective percentage
Higher with cure rate, good effect, the cycle is short, and curative effect is significantly better than control group.
Model case 1：
Liu, female, 40 years old, headache, dizziness, tinnitus, palpitaition, dim eyesight, absent minded, failure of memory, trick fiber crops
Wood, easily fatigue and weak, agitation, are diagnosed as hypertension, the one kind belonged in cardiovascular and cerebrovascular disease.With treatment hypertension on the market
Medicine, without preferable curative effect.Treatment：Used by the course for the treatment of immune by the treatment cardiovascular and cerebrovascular of the present invention, liver and kidney disease and enhancing
Oral formulations made from the composition of power, application method, for three times a day, warm water is taken after mixing it with water after meal, one month is 1 course for the treatment of.Treatment
After 2 courses for the treatment of, there is a change for the better for patient body.2 courses for the treatment of are continuing with, patient body situation is returned to normal.Continue
Using 2 courses for the treatment of, consolidated.Follow-up investigation find 1 year after without recurrence.
Model case 2：
Mr. Wang, female, 54 years old, the nutrient metabolic such as hydrate, fat, protein was abnormal in carbon body, is diagnosed as diabetes,
The one kind belonged in cardiovascular and cerebrovascular disease.The medicine of used a variety for the treatment of diabetes, effect is undesirable.Treatment：Make by the course for the treatment of
With oral formulations, application method made from the composition of the treatment cardiovascular and cerebrovascular as the present invention, liver and kidney disease and strengthen immunity
It is within one month 1 course for the treatment of for 3 times a day, warm water is taken after mixing it with water after meal.Treat after 2 courses for the treatment of, there is a change for the better for patient body.After
Continuous to use 2 courses for the treatment of, patient body situation is returned to normal.2 courses for the treatment of are continuing with, are consolidated.Follow-up investigation is found
Without recurrence after 1 year.
Model case 3：
Lee, man, 70 years old, dyslipidemia was diagnosed as high fat of blood, the one kind belonged in cardiovascular and cerebrovascular disease.With on the market
The medicine of high fat of blood is treated, without preferable curative effect.Treatment：Used by the course for the treatment of by treatment cardiovascular and cerebrovascular of the invention, liver kidney disease
Oral formulations made from the composition of disease and strengthen immunity, application method is three times a day, warm water takes after mixing it with water after meal, is within one month
1 course for the treatment of.Treat after 2 courses for the treatment of, there is a change for the better for patient body.2 courses for the treatment of are continuing with, patient body situation is substantially extensive
It is multiple normal.2 courses for the treatment of are continuing with, are consolidated.Follow-up investigation find 1 year after without recurrence.
Model case 4：
Liu, man, 50 years old, progressive oliguresis or anuria, blood urea nitrogen and creatinine were raised, and are diagnosed as hepatorenal syndrome.With
The medicine of a variety for the treatment of liver and kidney diseases is crossed, effect is undesirable.Treatment：By the course for the treatment of use by the present invention treatment cardiovascular and cerebrovascular,
Oral formulations made from liver and kidney disease and the composition of strengthen immunity, application method is 3 times a day, warm water takes after mixing it with water after meal, and one
It is within individual month 1 course for the treatment of.Treat after 2 courses for the treatment of, there is a change for the better for patient body.It is continuing with 2 courses for the treatment of, patient body situation
Return to normal.2 courses for the treatment of are continuing with, are consolidated.Follow-up investigation find 1 year after without recurrence.
Model case 5：
Bai, man 40 years old, has a delicate constitution, malnutritive, One's spirits are drooping, fatigue and weak, appetite are reduced, sleep-disorder；Often
Sick, easy catching a cold, accompanying infection；It is sick easily repeatedly, be diagnosed as hypoimmunity.The medicine of used a variety of strengthen immunities, effect
Fruit is undesirable.Treatment：Used by the course for the treatment of by the composition of the treatment cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity of the present invention
Obtained oral formulations, application method, for 3 times a day, warm water is taken after mixing it with water after meal, one month is 1 course for the treatment of.Treat after 1 course for the treatment of,
There is a change for the better for patient body.1 course for the treatment of is continuing with, patient body situation is returned to normal.It is continuing with 2 treatments
Journey, is consolidated.Follow-up investigation find 1 year after without recurrence.
Claims (7)
1. a kind of composition for treating liver and kidney disease, it is characterised in that the composition is processed by the raw material of following parts by weight
It is prepared from：Cervus elaphus linnaeus 120-280, maca 300-500, ginseng 400-900, ginkgo leaf 400-900, red sage root 500-1500；
The preparation method of the composition comprises the following steps：
1) ginseng is extracted in accordance with the following methods, obtains ginseng extract：
The ginseng of recipe quantity is weighed, after cleaning, ethanol solution refluxing extraction is added three times；Add the ethanol solutions of 6 times of amounts for the first time
Refluxing extraction 2h；The ethanol solution refluxing extraction 2h of second plus 6 times amount；The ethanol solution refluxing extraction of third time plus 5 times of amounts
2h；Merge extract solution, at 85 DEG C filtering, filtrate be concentrated at 70 DEG C at the medicinal extract, 40 DEG C that relative density is 1.17 dust it is dry
It is dry, ginseng extract is crushed to obtain, the yield of the ginseng extract is 10%；
2) ginkgo leaf, the red sage root are extracted in accordance with the following methods respectively, obtains ginkgo biloba p.e, Salvia root P.E：
Ginkgo leaf, the red sage root of recipe quantity are weighed respectively, after cleaning, are separately added into purified water refluxing extraction three times；Add 7-8 for the first time
The purified water refluxing extraction 2h measured again；The purified water refluxing extraction 2h of second plus 8 times amount；The purified water of third time plus 5 times of amounts
Refluxing extraction 2h；Merge filtering at No. three extract solutions, 85 DEG C, filtrate respectively and the leaching that relative density is 1.20 is concentrated at 70 DEG C
Cream, dusting at 40 DEG C dry, pulverize to obtain ginkgo biloba p.e, Salvia root P.E, the ginkgo biloba p.e, Salvia root P.E
Yield is 10%；
3) maca is prepared into pueraria root powder in accordance with the following methods：
The smooth maca in surface is selected, is placed in clear water and soaks 12h, cleans, dries, is cut into slices according to 1-2mm thickness, with special
Dew eye pallet is placed in the dry 24h of 60 DEG C of drying room to moisture after containing be 4%-7%, fine powder is ground into, using 60Co spokes
According to sterilization 2h, pueraria root powder is produced；
4) cervus elaphus linnaeus is cut into slices, it is in slightly yellow to section to be placed in baking 5-6h in 80-100 DEG C of drying box, and taking-up cools, and is ground into
Powder, obtains cervus elaphus linnaeus powder；
5) by step 1) obtained ginseng extract, step 2) obtained ginkgo biloba p.e and Salvia root P.E, step 3)
To pueraria root powder, step 4) obtained cervus elaphus linnaeus powder crosses 80 mesh sieves respectively, be then well mixed, produce the group for the treatment of liver and kidney disease
Compound.
2. the composition for the treatment of liver and kidney disease according to claim 1, it is characterised in that the composition is by following weight
The raw material of part is processed to be prepared from：Cervus elaphus linnaeus 200, maca 440, ginseng 600, ginkgo leaf 600, the red sage root 1000.
3. the oral formulations as made from the composition and auxiliary material of the treatment liver and kidney disease described in claim 1, it is characterised in that institute
Oral formulations are stated for tablet, capsule, oral liquid or granule.
4. oral formulations according to claim 3, it is characterised in that the oral formulations are tablet, the auxiliary material includes
The methylol that silica that sorbierite that parts by weight are 100-200, parts by weight are 50-100, parts by weight are 10-30
The PVP K30 that the magnesium stearate and parts by weight that sodium starch, parts by weight are 20-50 are 20-50.
5. oral formulations according to claim 3, it is characterised in that the oral formulations are capsule, the capsule
Including capsule 's content；The capsule 's content includes composition and auxiliary material, and the auxiliary material includes the shallow lake that parts by weight are 35-65
Powder and the magnesium stearate that parts by weight are 5-15.
6. the preparation method of the oral formulations described in a kind of claim 4, it is characterised in that methods described comprises the following steps：
A) composition is prepared；
B) sorbierite of recipe quantity is crushed, crosses 80 mesh sieves, obtain fine powder standby；
C) silica, Sodium Hydroxymethyl Stalcs and magnesium stearate of recipe quantity are crossed into 80 mesh sieves respectively, obtains fine powder standby；
D) sorbierite fine powder and the step c) of 1/3 recipe quantity that composition, the step b) obtained step a) is obtained
Obtained fine silica, is put into mixer and mixes 30min, obtains mixed powder, standby；
E) PVP K30 of recipe quantity is pressed into 1kg:250ml ratio is dissolved in 70% ethanol, and adds what step d) was obtained
Mixed powder, stir softwood processed, the granulation of 20 mesh, then 50-60 DEG C of drying, 20 mesh whole grains, obtains particle；
F) fine silica that particle, the step c) of 2/3 recipe quantity obtained step e) is obtained, Sodium Hydroxymethyl Stalcs fine powder
It is put into magnesium stearate fine powder in mixer and mixes 10min, obtains mixture；
G) the mixture tabletting for obtaining step f), obtains tablet.
7. the preparation method of the oral formulations described in a kind of claim 5, it is characterised in that methods described comprises the following steps：
A) preparation of capsule 's content：
1) composition is prepared；
2) starch of recipe quantity, magnesium stearate are crossed into 80 mesh sieves respectively, obtains fine powder；
3) by step 1) obtained composition, step 2) obtained starch and magnesium stearate be put into mixer and mix 30min, obtain
Capsule 's content；
B) preparation of capsule：
Capsule 's content made from step a) is filled into capsule shells, capsule is made.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085024A (en) * | 2006-06-08 | 2007-12-12 | 天津天士力制药股份有限公司 | Traditional Chinese medicinal composition containing red sage root and ginkgo leaves and its preparation |
| CN101313985A (en) * | 2008-07-01 | 2008-12-03 | 王跃进 | Compound folium ginkgo capsule |
| CN102552621A (en) * | 2012-02-22 | 2012-07-11 | 成都中医药大学 | Drug combination for treating cardiovascular diseases and preparation method and application of same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101085024A (en) * | 2006-06-08 | 2007-12-12 | 天津天士力制药股份有限公司 | Traditional Chinese medicinal composition containing red sage root and ginkgo leaves and its preparation |
| CN101313985A (en) * | 2008-07-01 | 2008-12-03 | 王跃进 | Compound folium ginkgo capsule |
| CN102552621A (en) * | 2012-02-22 | 2012-07-11 | 成都中医药大学 | Drug combination for treating cardiovascular diseases and preparation method and application of same |
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