CN102552621A - Drug combination for treating cardiovascular diseases and preparation method and application of same - Google Patents
Drug combination for treating cardiovascular diseases and preparation method and application of same Download PDFInfo
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Abstract
The invention provides a drug combination for treating cardiovascular diseases. The drug combination comprises the following active ingredients in weight ratio: 6-18 parts of fructus hippophae, 5-15 parts of ginseng, 4-12 parts of notoginseng, 10-20 parts of radix salviae miltiorrhizae, 3-9 parts of vampire leeches, 5-15 parts of nutgrass galingale rhizome, and 3-7 parts of folium ginkgo. The invention also provides a preparation method and application of the drug combination. According to the formula, the monarch drug, the ministerial drug, the assistant drug and the guide drug in the drug combination are explicit, and perform the own functions while are in close fit, so that the drug combination is fit with the traditional Chinese theory of 'monarch, minister, assistant and guide' on compatibility of prescriptions, and is scientific and rigorous; and all the ingredients are matched precisely and appropriately, thereby greatly improving pharmacodynamic effects.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of treating cardiovascular disease.Belong to drug world.
Technical field
Human after defeating fiendish diseases such as variola, the plague, malaria, arrange first the deadly cause of disease at present and replace by coronary heart disease.The whole world has several hundred million people attacked by coronary heart disease now, and only the U.S. just has more than 100,000,000 heart to be disturbed by coronary heart disease, and coronary heart disease also has twin brothers: the sclerosis of blood vessels that hypercholesterolemia causes, so coronary heart disease still is the fuse cord of cerebrovascular sclerosis.Along with the raising of up-to-dateness and people's living standard, the quickening of rhythm of life, the change of diet structure and living habit, cardiovascular disease such as coronary heart disease also will constantly rise.At present, China has become the highest country of aging degree, and the old people is the main morbidity colony of cardiovascular disease; Simultaneously, owing to work and life stress strengthen, motion less, reason such as environmental pollution, cardiovascular disease also presents the trend of rejuvenation; With regard to hypertension, only in 6～18 years old students in middle and primary schools of China, hypertensive sickness rate just reaches 8%; Coronary heart disease myocardial infarction has appearred in a lot of youngsters, and therefore what have goes back and death.Cardiovascular disease this " human health first killer " wreak havoc and large tracts of land takes place frequently, force WHO also to set up the special tackling key problem in association center specially, good medicine seeks treatment.
Doctor trained in Western medicine adopts Drug therapys such as heart tonifying, blood vessel dilating and diuresis more to cardiovascular disease; Like nitroglycerin, sorbitrate, calcium ion antagonist class anti-anginal drug (nifedipine), the agent of selectivity coronary dilation and antiviral agents (dipyridamole), beta-blocker (Celiprolol), segondin, propranolol; These medicines all are emergency case medications; And these medicines are also with following drawback: 1. toxic and side effects: except that gastrointestinal reaction, anaphylaxis, poisoning manifestations; Nervus centralis, hepatic and renal function are also had infringement, and the medication reaction symptom reaches nausea,vomiting,diarrhea, gastrointestinal upset, inappetence, flush, cardiopalmus, tachycardia, position hypotension, headache, dizzy, tired, insomnia, skin allergy, erythra even exfoliative dermatitis, muscular spasm, myasthenia, amyostasia, cold extremities, pruritus, oligodacrya, is in a very depressed state, skin rubefaction, erythra, burning sensation, perspiration even collapse, take reactions such as can producing drug resistance for a long time.2. many crowds can not take: if any allergies person; Glaucoma; Coronary occlusion and thrombosis; Cerebral hemorrhage; Intracranial hypertension; Cardiogenic shock; II ° or III ° atrioventricular block; Severe heart failure; Sinus bradycardia; Bronchial asthma patient; Allergies are arranged; Diabetes; Congestive heart failure; Emphysema or nonallergic bronchitis; Hepatic insufficiency; Hypothyroidism; Raynaud's syndrome or other peripheral angiopathy; Renal function goes down; The digestive tract hemorrhage that activeness Peptic Ulcers or other reasons cause; Patient such as hemophilia or thrombocytopenia and anemia of pregnant woman; The lactication woman; Children etc. all prohibit clothes.Yet the patient who suffers from cardiovascular disease often needs long-term prescription, and has contained all kinds of different crowds.The good news is that the treatment by Chinese herbs cardiovascular disease has demonstrated its unique advantages, Chinese medicine determined curative effect, lasting, untoward reaction is few, especially is widely used in clinical with late result satisfaction.
Great deal of research results and clinical practice prove; Characteristics such as Chinese medicine is better with its toleration, toxic and side effects is little demonstrate its special advantages; Chinese medicine occupies extremely important position in this market; Even can be described as and be in strong position, a wherein topmost reason is that promptly Western medicine is having absolute advantages unlike antibiotics medicine that kind aspect the treatment cardiovascular disease, belongs to curative effect and not really significant kind.Chinese medicine then has evident in efficacy, reliable and stable, advantage such as have no side effect because of it, more and more receives the concern of medical investigator and extensive patients.
Clinically, the Chinese patent medicine of more existing treatment cardiovascular disease, but the kind that belongs to " emergency ", and the medicine of " emergency " all has more serious toxic and side effects, Western medicine more the most very, Chinese patent medicine is no exception, " emergency " during urgency only, and should not take for a long time.Promptly contain Olibanum, Borneolum Syntheticum, Radix Aristolochiae, Lignum Santali Albi, Styrax wet goods composition like storax pill for treating coronary heart disease; Another kind FUFANG DANSHEN PIAN also contains Borneolum Syntheticum etc.These fragrance are dispersed composition and are consumed very much the bromhidrosis blood body fluid of hurting sb.'s feelings, and clothes are unfavorable on the contrary to the state of an illness for a long time.Also have, well-known, cardiovascular disease often need be taken medicine all the life; And in " emergency " afterwards, need badly and continue to take efficacious therapy, and this continuation treatment that just must follow up afterwards in " emergency "; Be only treatment most important, that effect a permanent cure; But clinically, exactly Western medicine lacks the effective kind of this respect, and also relative deficiency of relevant Chinese patent medicine.Medicine of the present invention, then this just still insufficient clinically at present effective Chinese patent medicine kind.
Application number: 200410062488.7, denomination of invention: a kind of strengthening the body resistance, tonifying speen and tonifying kidney, mind tranquilizing and the heart calming; The compositions of activating blood circulation to dissipate blood stasis, this invention relates to a kind of compositions, has strengthening the body resistance, tonifying speen and tonifying kidney; Mind tranquilizing and the heart calming, the effect of activating blood circulation to dissipate blood stasis, the disease that treatment prostatic hyperplasia, prostatitis, sexual hypofunction, climacteric syndrome, coronary heart disease, cerebral thrombosis, chronic fatigue syndrome, neurasthenia, hypomnesis, senile dementia and immunologic hypofunction or imbalance cause; Its prescription is: (1) Radix Ginseng 0.2g～12g, Radix Astragali 2g～40g, Fructus Hippophae 0.5g～13g; Fructus Lycii 1g～24g, Herba Epimedii 0.5g～13g, Radix Notoginseng 0.2g～12g; Fructus Schisandrae Chinensis 0.2g～8g, Fructus Schisandrae Chinensis is removed in (2) on the basis of prescription (1), and (3) increase Fructus Rubi on the basis of prescription (1); (4) on the basis of prescription (1), substitute Radix Ginseng with Radix Panacis Quinquefolii, (5) substitute Radix Notoginseng with Rhizoma Chuanxiong or Radix Salviae Miltiorrhizae on the basis of prescription (1), or (6) substitute Fructus Lycii with Fructus Rubi on the basis of prescription (1).The reason and good sense Chinese medicine of touching upon is returned The theoretical analysis from science of TCM formulas side; The real kind that belongs to strengthening the body resistance, tonifying speen and tonifying kidney of this application; And related with the treatment cardiovascular disease very little (most flavour of a drug are all returned kidney channel, spleen channel and GUIXIN warp seldom, and " the Comprehensive Treatment direction " of whole prescription be not also at the kidney spleen and at the heart.In addition, the Herba Epimedii in this application invention is the drug of first choice that the Chinese medicine sexual function improving promptly helps erection, and this takes with regard to having limited the more excited crowd of sexual function.
Summary of the invention
Technical scheme of the present invention has provided a kind of pharmaceutical composition of treating cardiovascular disease, and the present invention also provides this preparation of drug combination method and purposes.
The present invention relates to a kind of pharmaceutical composition of treating cardiovascular disease, it is the medicament that is prepared from following raw materials by weight proportions:
Fructus Hippophae 6-18 part, Radix Ginseng 5-15 part, Radix Notoginseng 4-12 part, Radix Salviae Miltiorrhizae 10-20 part, Hirudo 3-9 part, Rhizoma Cyperi 5-15 part, Folium Ginkgo 3-7 part.
Further preferably, it is the medicament that is prepared from following raw materials by weight proportions:
12 parts of Fructus Hippophaes, 10 parts of Radix Ginsengs, 8 parts of Radix Notoginseng, 15 parts of Radix Salviae Miltiorrhizaes, 6 parts of Hirudo, 10 parts of Rhizoma Cyperis, 5 parts of Folium Ginkgos.
Pharmaceutical composition of the present invention is to be active component by the primary crude drug of Fructus Hippophae, Radix Ginseng, Radix Notoginseng, Radix Salviae Miltiorrhizae, Hirudo, Rhizoma Cyperi, Folium Ginkgo or water or extractive with organic solvent, adds that acceptable accessories or complementary composition are prepared into medicament pharmaceutically commonly used.
Wherein, described medicament is tablet, capsule, soft capsule, granule, pill, drop pill, oral liquid, Sublingual spray, injection.
The present invention also provides this preparation of drug combination method, and it comprises the steps:
A, take by weighing the materials of weight proportions medicine;
The protogenic medicinal powder of b, each flavour of a drug or water or extractive with organic solvent are active component, add acceptable accessories or complementary composition and are prepared into preparation pharmaceutically commonly used.
Wherein, the described extractive with organic solvent of b step is the ethanol extraction of 60-95%.
The present invention also provides the purposes of this pharmaceutical composition in the medicine of preparation treatment cardiovascular disease.
Wherein, said medicine is the medicine of treatment atherosclerosis, coronary heart disease, hypertension, arrhythmia, hyperlipidemia, heart failure, angina pectoris (after the first aid), myocardial infarction (containing the acute myocardial infarction catabasis).
The cardiovascular disease that medicine of the present invention is controlled mainly comprises atherosclerosis, coronary heart disease and hypertension, heart failure, arrhythmia, hyperlipidemia, angina pectoris (after the first aid), myocardial infarction (containing the acute myocardial infarction catabasis) etc.
The advantage of medicine of the present invention is that also its side effect is minimum; Can satisfy clinically demand to the medication of high-efficiency low-toxicity cardiovascular patient; Compare with chemicals commonly used, medicine of the present invention not only has certain guarantee on curative effect, and toxic and side effects is more much lower than chemicals commonly used; The also more similar chemicals of cost is low with Chinese patent medicine previously, so medicine of the present invention has remarkable advantages.
" medication is as using military forces " is the original theory of Chinese medicine of very science, and each medicine tight compatibility all linked with one another as arraying troops for battle in the prescription is its effective means that is superior to the Western medicine prescription.Chinese medicine prescription theory is thought; Each prescription; Not only need be according to etiology and pathogenesis; Select suitable medicine to carry out compatibility, also should meet simultaneously the basic boom of prescription, promptly the scientific composition of " monarch's (principal agent), minister (inferior principal agent), assistant (adjuvant), make (introduce the target spot medicine or be in harmonious proportion the toxicity medicine) " is theoretical.If explain with the modern medicine language; That is: tcm prescription (comprising proved recipe) is the organic proportioning that is based upon the Chinese medicine on the comprehensive judgement basis of disease pathogenesis or its effective site (being the main pharmacodynamics composition); In medical square tube cross too many levels, many target spots and integrate the biological mechanism of regulating; To disease particularly as cerebrovascular and cardiovascular disease cause of disease disease complicated, the treatment difficulty regulate and control; Often obtain than better, the more persistent treatment effect of Western medicine, and this curative effect is to be based upon on the accurate instruction of the original theory of traditional Chinese medical science tradition that prescription of the present invention is just being followed this principle.And see that from the understanding of the traditional Chinese medical science cardiovascular disease has all generally that blood stasis is detained, the fraud of venation resistance knot (certain this pathological examination is because " permanent (old or prolonged illness etc.) causes void a little less than amassing " causes).The rule of treatment according to classical Chinese medicine Plain Questions of Huangdi's Internal Classic " disease caused by accumulations of pathogen should be treated with therapy of dispersion; disease with retention of pathogen in the body should be treated by elimination therapy " and Compendium of Material Medica " disease caused by accumulations of pathogen should be treated with therapy of dispersion, the person's of staying row " is theoretical, promptly when the method blood circulation promoting and blood stasis dispelling that " looses " with " leading to "; " gaseous pulse stagnates; so must row " of being explained as " Gu Songyuan cures mirror " be not because " blood stasis goes, and then fresh blood is not given birth to " (" Compendium of medicine " and " delete mend name hospital discuss ").Generally speaking, the result who " stagnation of QI and blood may bring about pain, pain is then obstructed " even the etiology and pathology of cardiovascular disease is considered to the smooth retardance of hyperamization sering that the stasis of blood causes because of blood deficiency in motherland's traditional medicine, occur.Yet, the formation of cardiovascular disease, be not one day for the moment, but the result of long-time paathogenic factor comprehensive function, or this is old and feeble, or innate deficiency usually, or due to the long-pending void of prolonged illness.The traditional Chinese medical science has a well-known saying " prolonged illness must cause its void ", because this course of disease is permanent, dissipates, damages healthy energy (disease-resistant factor), so cause deficient.It is thus clear that " void " is only this disease " basis ", " stasis of blood " be disease it " mark " just.And according to the theory of the traditional Chinese medical science " qi being the governor of blood ", have only " gas " (physical ability) abundance after, " blood " just can give birth to, and in the side, is only " monarch drug " (Fructus Hippophae, Radix Ginseng, Radix Notoginseng---Radix Notoginseng is rich in the ginsenoside, the same Radix Ginseng in QI invigorating aspect so treat the flavour of a drug of " deficiency of vital energy "; Mongolian medicine, the big especially benefit good merchantable brand of Tibetan medicine Fructus Hippophae); The flavour of a drug of mending " blood " then are that (Radix Salviae Miltiorrhizae, Radix Notoginseng---a kind of medicine can " be taken upon oneself several posts " " ministerial drug "; Promptly both can take on " monarch drug "; Can take on " ministerial drug " or " adjuvant drug ", " messenger drug " etc. again), the flavour of a drug that blood circulation promoting and blood stasis dispelling is promoted blood circulation are only taken on the duty of " adjuvant drug " in the side (Radix Notoginseng, Hirudo, Radix Salviae Miltiorrhizae---Rhizoma Cyperi also is " adjuvant drug " [section] as follows, and this is " two assistant "; Promptly go " assisting a ruler in governing a country ", go to work in coordination with) from two aspects.Just because this type disease stasis of blood stagnates for a long time, and it is empty that consumption is hindered positive pneumatolytic, conversely just because of empty, then unable again operation QI and blood, the vicious cycle that further produces stagnation of blood stasis is so the sick deficiency and excess that belongs to is held concurrently mutually.Since be simulataneous insufficiency and excessive, treatment just should deficiency and excess take into account, benefiting QI and nourishing blood (setting upright) and blood circulation promoting and blood stasis dispelling promote blood circulation (reality of dispelling) develop simultaneously; " in leading to benefit is arranged; residence is mended in logical ", adopt and treat rule accurately, and list all can be barely satisfactory with the method curative effect of QI invigorating with the method or the list of blood circulation promoting and blood stasis dispelling.Here it is, and the famous Zhang Jiebin of doctor family of the Ming Dynasty (Jing Yue) is stressed: " that cures the disease wants, and attacks the suitable of benefit in knowledge." " blood has void and the person that stagnates, the work that should mend it." in medication; if can choose " work of benefits it " promptly can benefiting qi and nourishing blood and the promote blood circulation medicament composing prescription of effect of blood circulation promoting and blood stasis dispelling is arranged; when be the superior article of the best, and have Radix Notoginseng, Radix Salviae Miltiorrhizae, the Fructus Hippophae that benefiting qi and nourishing blood is invigorated blood circulation and acted among the present invention, just possess this " work of benefit it " function.In addition, the traditional Chinese medical science is thought " qi being the governor of blood, blood being the material foundation of QI " " the capable then blood of gas is capable, and the stagnation of QI is stasis then ", and gas, blood must mutual dependence for existencies, can influence each other between gas and the blood.Have only QI invigorating, make healthy energy vigorous, blood just can be given birth to, and just fills and not empty (use Fructus Hippophae, people to participate in Radix Notoginseng in the prescription of the present invention and also can embody this spirit as principal agent altogether); Blood is passed unimpeded and the resistance of not becoming silted up, except the gas foot, also need move gas, the capable then blood of gas is good (to be led to the stasis of blood with the circulation of qi promoting of " adjuvant drug " Rhizoma Cyperi with the promoting the circulation of blood that promotes Radix Notoginseng, Radix Salviae Miltiorrhizae, Hirudo etc. in the prescription of the present invention, has then embodied this spirit.Certainly three of blood circulation promoting and blood stasis dispelling flavor medicines have also been taken on " adjuvant drug " simultaneously, and this is " two assistant " in the science of TCM formulas, refer to go " assisting a ruler in governing a country " from two aspects, remove to assist " monarch drug ", " ministerial drug ").So motherland's traditional medicine treatment cardiovascular disease, many treatment rules of promoting blood circulation such from benefiting qi and nourishing blood, promoting flow of QI and blood, blood stasis dispelling are set about.Also have, the theory of Chinese medical science of the Chinese traditional culture of taking root has extensive " harmonious neutralization " spirit, and this is also embodied in its pharmacology of Chinese medical formulae compatibility theory.Theoretical according to the compatibility of medicines in a prescription; Circulation of qi promoting, invigorate blood circulation, the logical stasis of blood all belongs to " logical dredging dissipated "; Need to add the kind (this kind needs again to keep on disease cure function with other " monarchs drug ", " ministerial drug " etc. and transfer) that has a little a little " convergence " simply and go to be " making "; Thereby coordination, harmonious whole prescription, such compatibility is only the brilliant prescription on the Chinese medicine.Folium Ginkgo among the present invention, solicit comments have been taken on this " messenger drug " role.Folium Ginkgo had both had the property of " convergence " in the part omitted of this agrostology of Chinese medicine, can control excessively " logical dredging dissipated " of his medicine, and among the pharmacology the cardiovascular effect of protection arranged in modern times, can imitate with transferring altogether with his medicine, and real is exquisite compatibility.
The medicine of existing treatment cardiovascular disease only is absorbed in simple blood circulation promoting and blood stasis dispelling (clothes very have fraud to the patient for a long time) mostly; And seldom have take into account set upright pathogenesis with the good side who transfers all medicines; Promptly choosing can activating blood circulation to dissipate blood stasis and dredge the collateral; Take into account the flavour of a drug that benefiting QI and nourishing blood, circulation of qi promoting are held concurrently and transferred again, with the medicine listing of rigorous and scientific composition of prescription more.
To sum up visible, prescription monarch drug of the present invention, ministerial drug, adjuvant drug, messenger drug are clear and definite, and Each performs its own functions closely cooperates again, meets the compatibility of medicines in a prescription theory of motherland's traditional medicine " monarch ", and science is and rigorous, and it is precise and appropriate that each medicine cooperates, and complements each other, and greatly strengthened drug effect.Modern study also proves; The multiple medicines combination of this " arraying troops for battle " formula is used, and has very strong synergism, has demonstrated fully, brought into play the science marrow of " medication is as using military forces " theory in the Traditional Chinese medical theory; Than with the dosage list with certain flavour of a drug or lack and use flavour of a drug, improved curative effect greatly.Modern study thinks that then the action target spot of these flavour of a drug is variant, unites use, can play synergism, reaches better effect.
The specific embodiment
The preparation of embodiment 1 medicine of the present invention
Get crude drug Fructus Hippophae 12g, Radix Ginseng 10g, Radix Notoginseng 8g, Radix Salviae Miltiorrhizae 15g, Hirudo 6g, Rhizoma Cyperi 10g, Folium Ginkgo 5g, decocte with water concentrates, and adds starch and granulates, and granulate is prepared into granule.
The preparation of embodiment 2 medicines of the present invention
Get Fructus Hippophae 6g, Radix Ginseng 5g, Radix Notoginseng 4g, Radix Salviae Miltiorrhizae 10g, Hirudo 3g, Rhizoma Cyperi 5g, Folium Ginkgo 3g, add 90% ethanol lixiviate, reclaim ethanol, concentrate, add correctives, be prepared into oral liquid.
The preparation of embodiment 3 medicines of the present invention
Get crude drug Fructus Hippophae 18g, Radix Ginseng 15g, Radix Notoginseng 12g, Radix Salviae Miltiorrhizae 20g, Hirudo 9g, Rhizoma Cyperi 15g, Folium Ginkgo 7g, decocte with water concentrates, and add starch and granulate, granulate, encapsulated, get capsule.
Below prove beneficial effect of the present invention through pharmacodynamics test.
The clinical research of Test Example 1 medicine of the present invention
According to the clinical practice in more than 30 year of inventor,, obtained comparatively satisfied curative effect with cardiovascular patient 84 examples such as Drug therapy atherosclerosis, coronary heart disease and the hypertension of embodiment 1, arrhythmia, hyperlipidemia.Treatment time: difference according to the difference of concrete conditions such as each conditions of patients weight, age size, physical strength and to some extent, generally about 3～12 months.Criterion of therapeutical effect is generally for making by oneself: subjective symptoms obviously alleviates, and simultaneously test rating has to a certain degree that the improver is " evident in efficacy "; Patient's subjective symptoms and test rating only satisfy one of aforementioned, then are " curative effect is obvious ".And patient's subjective symptoms alleviates to some extent, or its index has slightly and a bit improve, and is " certain effect is arranged "; Symptom remains unchanged, and index does not have the improver and is " DeGrain (invalid) ".
Make criterion of therapeutical effect according to this by oneself, among the 84 routine patients, have 15 routine effects remarkable, 39 routine effects are obvious, and 16 examples have certain effect, 14 routine DeGrains (invalid), and total effective rate reaches 83%.
Test Example 2 medicine effect tests of the present invention: medicine of the present invention (injection) is to the influence of isolated rat heart coronary flow
Animal and material: 250 ± 20g male SD rat.The medicine of the present invention of embodiment 1 preparation is mixed with 50 μ g/ml medicinal liquids; Positive control drug isoproterenol sulfate injection.Rockwell liquid, thermometer, aortic cannulation, ultrathermostat, perfusion device (heart thermos cup, condensing tube, perfusion bottle), recording equipment (muscular tension transducer, polygraph etc.).
Experimental technique: carry out preparation animal isolated heart after the experimental assembly work such as regulating perfusion device by " herbal pharmacology research methodology " P523 methods such as document Qi Chens: hammering rat hindbrain causes dusk, and the carotid artery blood-letting is opened breast and gently carried its heart; Cut off the blood vessel that is connected with heart, take out heart and soon put into 4 ℃ of Rockwell liquid, gently extruding; Discharge Yu Xuehou; Cut an osculum at its ascending aorta highest point, insert aortic cannulation, and fixed with the line bundle.Open alligator clamp then, make Rockwell liquid flow into right atrium through cardiac muscle, flow out from caval vein, the pulmonary artery broken ends of fractured bone by arteria coronaria.Clamp its apex of the heart with frog heart clip, connect the muscular tension transducer, trace the curve of its heartbeat,, and, connect graduated cylinder down, measure its coronary flow in its heart underlying one funnel with its heart rate of stopwatch record.Reserve 10min with after treating that its heart adaptation and recovery are stable; Rubber tube injection experiments medicinal liquid 0.2ml from its aortic cannulation top; Measure after the administration its flow of every min, heartbeat amplitude and heart rate in 1～5min, find out extreme value, calculate the maximum variable value of perfusion flow after the administration; All recover after every administration to give a kind of medicine down again behind the normal discharge, every kind of medicine repeats 5 hearts.The result sees the following form:
Table: medicine of the present invention " heart is pacified again " is to the influence of isolated rat heart coronary flow, heartbeat amplitude and the rhythm of the heart
Last table contrasts its difference significance person ▲ P＜0.01 before and after respectively organizing each item self.Can know from the result; Drug group of the present invention and isoproterenol sulfate injection positive controls all can increase the isolated rat heart coronary flow; Drug group of the present invention also can reduce its heartbeat amplitude, slow down its heart rate, and positive controls then obviously increases its heartbeat amplitude, increases its heart rate.Experiment shows that medicine of the present invention not only can increase the isolated rat heart coronary flow, and does not increase its heartbeat amplitude, does not increase its heart rate; Though and the positive control drug isoproterenol sulfate has also obviously increased its coronary flow, obviously increased its myocardial contraction amplitude again simultaneously, increase its heart rate, thereby strengthened its myocardium oxygen consumption, not too be applicable to the treatment cardiovascular disease.
Claims (8)
1. pharmaceutical composition of treating cardiovascular disease, it is characterized in that: it is the medicament that is prepared from following raw materials by weight proportions:
Fructus Hippophae 6-18 part, Radix Ginseng 5-15 part, Radix Notoginseng 4-12 part, Radix Salviae Miltiorrhizae 10-20 part, Hirudo 3-9 part, Rhizoma Cyperi 5-15 part, Folium Ginkgo 3-7 part.
2. pharmaceutical composition according to claim 1 is characterized in that: it is the medicament that is prepared from following raw materials by weight proportions:
12 parts of Fructus Hippophaes, 10 parts of Radix Ginsengs, 8 parts of Radix Notoginseng, 15 parts of Radix Salviae Miltiorrhizaes, 6 parts of Hirudo, 10 parts of Rhizoma Cyperis, 5 parts of Folium Ginkgos.
3. pharmaceutical composition according to claim 1 and 2; It is characterized in that: it is to be active component by the primary crude drug of Fructus Hippophae, Radix Ginseng, Radix Notoginseng, Radix Salviae Miltiorrhizae, Hirudo, Rhizoma Cyperi, Folium Ginkgo or water or extractive with organic solvent, adds that acceptable accessories or complementary composition are prepared into medicament pharmaceutically commonly used.
4. pharmaceutical composition according to claim 3 is characterized in that: described medicament is tablet, capsule, soft capsule, granule, pill, drop pill, oral liquid, Sublingual spray, injection.
5. method for preparing any described pharmaceutical composition of claim 1-4, it comprises the steps:
A, take by weighing the materials of weight proportions medicine;
The protogenic medicinal powder of b, each flavour of a drug or water or extractive with organic solvent are active component, add acceptable accessories or complementary composition and are prepared into preparation pharmaceutically commonly used.
6. method for preparing according to claim 5 is characterized in that: the described extractive with organic solvent of b step is the ethanol extraction of 60-95%.
7. the purposes of any described pharmaceutical composition of claim 1-4 in the medicine of preparation treatment cardiovascular disease.
8. purposes according to claim 7 is characterized in that: said medicine is the medicine of treatment atherosclerosis, coronary heart disease, hypertension, arrhythmia, hyperlipidemia.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103735603A (en) * | 2014-02-11 | 2014-04-23 | 武汉市元大生物科技有限公司 | Compound lipid-decreasing soft capsule and preparation method thereof |
| CN104055845A (en) * | 2014-07-10 | 2014-09-24 | 饶长军 | Composition for treating diseases of heart and cerebral vessel, liver and kidney and boosting immunity and preparation thereof |
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2012
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Non-Patent Citations (1)
| Title |
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| 赵鹏等: "试谈高脂血症的中医辨治思路", 《辽宁中医药大学学报》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735603A (en) * | 2014-02-11 | 2014-04-23 | 武汉市元大生物科技有限公司 | Compound lipid-decreasing soft capsule and preparation method thereof |
| CN103735603B (en) * | 2014-02-11 | 2016-08-31 | 武汉市元大生物科技有限公司 | A kind of compound antihyperglycemic soft capsule and preparation method thereof |
| CN104055845A (en) * | 2014-07-10 | 2014-09-24 | 饶长军 | Composition for treating diseases of heart and cerebral vessel, liver and kidney and boosting immunity and preparation thereof |
| CN104055845B (en) * | 2014-07-10 | 2017-08-29 | 饶长军 | A kind of composition and its preparation for treating cardiovascular and cerebrovascular, liver and kidney disease and strengthen immunity |
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