CN104053992B - 确定包括细胞的体液中的靶分子的存在 - Google Patents
确定包括细胞的体液中的靶分子的存在 Download PDFInfo
- Publication number
- CN104053992B CN104053992B CN201380005531.3A CN201380005531A CN104053992B CN 104053992 B CN104053992 B CN 104053992B CN 201380005531 A CN201380005531 A CN 201380005531A CN 104053992 B CN104053992 B CN 104053992B
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- Prior art keywords
- chamber
- particle
- lysate
- body fluid
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 210000001124 body fluid Anatomy 0.000 title claims abstract description 46
- 239000010839 body fluid Substances 0.000 title claims abstract description 46
- 239000000758 substrate Substances 0.000 claims abstract description 48
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- 239000006166 lysate Substances 0.000 claims abstract description 37
- 239000002245 particle Substances 0.000 claims abstract description 31
- 238000005336 cracking Methods 0.000 claims abstract description 24
- 238000001514 detection method Methods 0.000 claims abstract description 14
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- 239000003599 detergent Substances 0.000 claims description 24
- 102000004169 proteins and genes Human genes 0.000 claims description 8
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- 150000001720 carbohydrates Chemical class 0.000 claims 1
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 28
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
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- 150000007523 nucleic acids Chemical class 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 101800000407 Brain natriuretic peptide 32 Proteins 0.000 description 1
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- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- 108010048233 Procalcitonin Proteins 0.000 description 1
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- 102000013394 Troponin I Human genes 0.000 description 1
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- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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- 239000000692 natriuretic peptide Substances 0.000 description 1
- 238000001579 optical reflectometry Methods 0.000 description 1
- 239000000199 parathyroid hormone Substances 0.000 description 1
- 229960001319 parathyroid hormone Drugs 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 108010008064 pro-brain natriuretic peptide (1-76) Proteins 0.000 description 1
- CWCXERYKLSEGEZ-KDKHKZEGSA-N procalcitonin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 CWCXERYKLSEGEZ-KDKHKZEGSA-N 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0429—Sample carriers adapted for special purposes
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261586879P | 2012-01-16 | 2012-01-16 | |
| US61/586,879 | 2012-01-16 | ||
| PCT/IB2013/050335 WO2013108168A2 (en) | 2012-01-16 | 2013-01-14 | Determining a presence of target molecules in a body fluid comprising cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104053992A CN104053992A (zh) | 2014-09-17 |
| CN104053992B true CN104053992B (zh) | 2016-12-14 |
Family
ID=47833316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380005531.3A Active CN104053992B (zh) | 2012-01-16 | 2013-01-14 | 确定包括细胞的体液中的靶分子的存在 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20150004624A1 (ru) |
| EP (1) | EP2805164B1 (ru) |
| JP (1) | JP6335792B2 (ru) |
| CN (1) | CN104053992B (ru) |
| BR (1) | BR112014017140A8 (ru) |
| RU (1) | RU2014133714A (ru) |
| WO (1) | WO2013108168A2 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016105363A1 (en) | 2014-12-23 | 2016-06-30 | Hewlett Packard Enterprise Development Lp | Detection of allergen exposure |
| CN105738615A (zh) * | 2016-04-15 | 2016-07-06 | 张红 | 基于惰性电极稳态电学状态测量的免疫检测装置及方法 |
| JP6635897B2 (ja) * | 2016-08-30 | 2020-01-29 | シスメックス株式会社 | 試料分析用カートリッジ及びその製造方法、並びにその利用 |
| EP3526587B1 (en) * | 2016-10-13 | 2024-05-01 | Instrumentation Laboratory Company | Total protein measurement using whole blood refractometry |
| CA3187872A1 (en) | 2020-08-03 | 2022-02-10 | Jeffrey R. Jasperse | Lysis devices having a piezo element and methods |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813059A (zh) * | 2003-05-02 | 2006-08-02 | 西格玛-奥尔德利希公司 | 固相细胞裂解和捕获平台 |
| CN101848765A (zh) * | 2007-07-23 | 2010-09-29 | 科隆迪亚戈有限公司 | 分析方法 |
| CN102257391A (zh) * | 2008-12-22 | 2011-11-23 | 皇家飞利浦电子股份有限公司 | 使用磁性标记进行的肌钙蛋白i测定 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5447837A (en) * | 1987-08-05 | 1995-09-05 | Calypte, Inc. | Multi-immunoassay diagnostic system for antigens or antibodies or both |
| NO890029D0 (no) * | 1989-01-04 | 1989-01-04 | Axis Research | Nye modifiserte peptider og proteiner for in vitro diagnoser (diabetes). |
| EP0637996B1 (en) * | 1992-05-01 | 1997-07-23 | The Trustees Of The University Of Pennsylvania | Microfabricated detection structures |
| US6106779A (en) * | 1997-10-02 | 2000-08-22 | Biosite Diagnostics, Inc. | Lysis chamber for use in an assay device |
| SE9904539D0 (sv) * | 1999-12-10 | 1999-12-10 | Alphahelix Ab | Method and device for the handling of samples and reagents |
| US20030017467A1 (en) * | 2000-02-18 | 2003-01-23 | Aclara Biosciences, Inc. | Multiple-site sample-handling apparatus and method |
| IL139708A0 (en) * | 2000-11-15 | 2002-02-10 | Amiel Gilad | Process of decellularizing biological matrices and acellular biological matrices useful in tissue engineering |
| JP2003066047A (ja) * | 2001-06-14 | 2003-03-05 | Matsushita Electric Ind Co Ltd | 免疫反応測定方法及びそれに用いる免疫反応測定用試薬 |
| EP1432786B1 (en) * | 2001-09-06 | 2009-07-22 | Genomic Profiling Systems, Inc. | Rapid detection of replicating cells |
| US20050208539A1 (en) * | 2003-12-31 | 2005-09-22 | Vann Charles S | Quantitative amplification and detection of small numbers of target polynucleotides |
| CA2558959C (en) * | 2004-04-30 | 2014-11-04 | Enterix Pty. Limited | Device and method for detecting the presence of hemoglobin in a biological sample |
| EP3527976A1 (en) * | 2004-07-19 | 2019-08-21 | ProteinSimple | Method and device for analyte detection |
| US20090291508A1 (en) * | 2008-05-20 | 2009-11-26 | Rapid Pathogen Screening Inc. | Nanoparticles in diagnostic tests |
| DE102005015005A1 (de) * | 2005-04-01 | 2006-10-05 | Qiagen Gmbh | Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe |
| US7938573B2 (en) * | 2005-09-02 | 2011-05-10 | Genefluidics, Inc. | Cartridge having variable volume reservoirs |
| JP4692200B2 (ja) * | 2005-10-06 | 2011-06-01 | 横河電機株式会社 | 化学処理用カートリッジおよびその使用方法 |
| JP5431732B2 (ja) * | 2005-12-29 | 2014-03-05 | ハネウェル・インターナショナル・インコーポレーテッド | マイクロ流体フォーマットにおけるアッセイ実装 |
| US20100120132A1 (en) * | 2006-03-31 | 2010-05-13 | Intel Corporation | Bioassays by direct optical detection of nanoparticles |
| EP2072133A1 (en) * | 2007-12-20 | 2009-06-24 | Koninklijke Philips Electronics N.V. | Multi-compartment device with magnetic particles |
| KR101465701B1 (ko) * | 2008-01-22 | 2014-11-28 | 삼성전자 주식회사 | 핵산 증폭 장치 |
| JP5628784B2 (ja) * | 2008-03-17 | 2014-11-19 | コーニンクレッカ フィリップス エヌ ヴェ | 磁性粒子によるアッセイ用カートリッジ |
| US8609433B2 (en) * | 2009-12-04 | 2013-12-17 | Rapid Pathogen Screening, Inc. | Multiplanar lateral flow assay with sample compressor |
| US9110058B2 (en) * | 2008-06-30 | 2015-08-18 | Sekisui Medical Co., Ltd. | Porous solid phase for binding assay, and binding assay method using the same |
| EP2313775A4 (en) * | 2008-07-15 | 2012-03-14 | Rapid Pathogen Screening Inc | LYSE IN SITU OF CELLS IN LATERAL FLOW IMMUNOLOGICAL ANALYSIS |
| EP2784508B1 (en) * | 2008-12-25 | 2017-06-14 | Universal Bio Research Co., Ltd. | Automated nucleic acid assay system |
| US9625454B2 (en) * | 2009-09-04 | 2017-04-18 | The Research Foundation For The State University Of New York | Rapid and continuous analyte processing in droplet microfluidic devices |
| WO2011036597A1 (en) * | 2009-09-23 | 2011-03-31 | Koninklijke Philips Electronics N.V. | Binding assay with multiple magnetically labelled tracer binding agents. |
| RU2564911C2 (ru) * | 2009-12-04 | 2015-10-10 | Рэпид Пэтоджен Скрининг, Инк. | Многослойный анализ с горизонтальным потоком с прессом для образцов |
-
2013
- 2013-01-14 BR BR112014017140A patent/BR112014017140A8/pt not_active IP Right Cessation
- 2013-01-14 EP EP13707917.4A patent/EP2805164B1/en active Active
- 2013-01-14 US US14/370,874 patent/US20150004624A1/en not_active Abandoned
- 2013-01-14 RU RU2014133714A patent/RU2014133714A/ru not_active Application Discontinuation
- 2013-01-14 WO PCT/IB2013/050335 patent/WO2013108168A2/en active Application Filing
- 2013-01-14 CN CN201380005531.3A patent/CN104053992B/zh active Active
- 2013-01-14 JP JP2014551718A patent/JP6335792B2/ja active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813059A (zh) * | 2003-05-02 | 2006-08-02 | 西格玛-奥尔德利希公司 | 固相细胞裂解和捕获平台 |
| CN101848765A (zh) * | 2007-07-23 | 2010-09-29 | 科隆迪亚戈有限公司 | 分析方法 |
| CN102257391A (zh) * | 2008-12-22 | 2011-11-23 | 皇家飞利浦电子股份有限公司 | 使用磁性标记进行的肌钙蛋白i测定 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014017140A2 (pt) | 2017-06-13 |
| EP2805164B1 (en) | 2017-11-08 |
| JP2015503760A (ja) | 2015-02-02 |
| JP6335792B2 (ja) | 2018-05-30 |
| CN104053992A (zh) | 2014-09-17 |
| US20150004624A1 (en) | 2015-01-01 |
| BR112014017140A8 (pt) | 2017-07-04 |
| EP2805164A2 (en) | 2014-11-26 |
| WO2013108168A3 (en) | 2013-10-31 |
| RU2014133714A (ru) | 2016-03-10 |
| WO2013108168A2 (en) | 2013-07-25 |
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