CN104039349A - 用于治疗过敏反应的药物组合物 - Google Patents

用于治疗过敏反应的药物组合物 Download PDF

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Publication number
CN104039349A
CN104039349A CN201280057730.4A CN201280057730A CN104039349A CN 104039349 A CN104039349 A CN 104039349A CN 201280057730 A CN201280057730 A CN 201280057730A CN 104039349 A CN104039349 A CN 104039349A
Authority
CN
China
Prior art keywords
inhibitor
compositions
cells
mouse
allergen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280057730.4A
Other languages
English (en)
Chinese (zh)
Inventor
T.格伦瓦尔德
C.B.施密特-韦伯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Munich Helmholtz Environment And Health Research Center Co Ltd
Pls Designs Co Ltd
Original Assignee
Munich Helmholtz Environment And Health Research Center Co Ltd
Pls Designs Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Munich Helmholtz Environment And Health Research Center Co Ltd, Pls Designs Co Ltd filed Critical Munich Helmholtz Environment And Health Research Center Co Ltd
Publication of CN104039349A publication Critical patent/CN104039349A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2026—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280057730.4A 2011-11-23 2012-11-23 用于治疗过敏反应的药物组合物 Pending CN104039349A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11075261.5A EP2596802A1 (en) 2011-11-23 2011-11-23 Pharmaceutical composition for treatment of allergic reactions
EP11075261.5 2011-11-23
PCT/EP2012/004884 WO2013075846A1 (en) 2011-11-23 2012-11-23 Pharmaceutical composition for treatment of allergic reactions

Publications (1)

Publication Number Publication Date
CN104039349A true CN104039349A (zh) 2014-09-10

Family

ID=47358079

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280057730.4A Pending CN104039349A (zh) 2011-11-23 2012-11-23 用于治疗过敏反应的药物组合物

Country Status (6)

Country Link
US (2) US20140335162A1 (https=)
EP (1) EP2596802A1 (https=)
CN (1) CN104039349A (https=)
BR (1) BR112014012277A2 (https=)
IN (1) IN2014DN03429A (https=)
WO (1) WO2013075846A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105727371A (zh) * 2016-01-25 2016-07-06 北京天助畅运医疗技术股份有限公司 腹壁疝修补材料
CN116869964A (zh) * 2014-12-24 2023-10-13 耐克西缪恩有限公司 用于免疫疗法的纳米颗粒组合物和方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2813242A1 (en) * 2013-06-13 2014-12-17 PLS-Design GmbH Low molecular weight immune-modulators as adjuvants for specific immunotherapy
EP2918262B1 (en) * 2014-03-10 2023-08-09 PLS-Design GmbH Induction of antigen-specific tolerance by peripheral phagocytosis
KR102460040B1 (ko) 2016-04-27 2022-11-01 애브비 인코포레이티드 항-il-13 항체를 이용한 il-13 활성이 유해한 질환의 치료 방법
CN107669638B (zh) * 2017-10-23 2020-05-22 华南理工大学 一种peg-pcl-peg三嵌段共聚物修饰的羟基积雪草苷脂质体及其应用
BR112022021204A2 (pt) * 2020-04-22 2022-12-06 Kindred Biosciences Inc Polipeptídeos, proteínas heterodiméricas, ácido nucleico, células hospedeiras, método, composição farmacêutica e método de tratamento de uma espécie de animal de companhia, métodos para reduzir a atividade de sinalização de il13 e/ou il4 e para detectar il13 ou il4 em uma amostra

Citations (2)

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CN1299272A (zh) * 1998-03-02 2001-06-13 应用疫苗技术公司 调节免疫应答的方法及装置
WO2010086312A1 (en) * 2009-01-28 2010-08-05 Novartis Ag Galenic formulations of organic compounds

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DE4137333A1 (de) 1991-11-13 1993-05-19 W Prof Dr Sebald Therapeutische mittel, die antagonisten oder partielle agonisten des humanen interleukin 4 sind oder diese enthalten, hil-4-mutantenproteine sowie vefahren zu deren herstellung
BR9709715A (pt) 1996-06-14 1999-08-10 Bayer Ag Agonistas de interleucina-4 seletivos para células t
US6028176A (en) 1996-07-19 2000-02-22 Bayer Corporation High-affinity interleukin-4 muteins
CA2305621C (en) 1997-10-03 2009-01-20 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
IL138207A0 (en) * 1998-03-02 2001-10-31 Applied Vaccine Technologies C Methods and devices for modulating the immune response
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AU4139801A (en) * 1999-12-06 2001-06-12 Board Of Trustees Of The University Of Arkansas, The Controlled delivery of antigens
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WO2010086312A1 (en) * 2009-01-28 2010-08-05 Novartis Ag Galenic formulations of organic compounds

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SUSANNE M. GRUNEWALD ET AL.: "An Antagonistic IL-4 Mutant Prevents Type I Allergy in the Mouse: Inhibition of the IL-4/IL-13 Receptor System Completely Abrogates Humoral Immune Response to Allergen and Development of Allergic Symptoms In Vivo", 《 THE JOURNAL OF IMMUNOLOGY》, vol. 160, no. 8, 15 April 1998 (1998-04-15), XP002102659 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116869964A (zh) * 2014-12-24 2023-10-13 耐克西缪恩有限公司 用于免疫疗法的纳米颗粒组合物和方法
CN116869964B (zh) * 2014-12-24 2024-10-18 耐克西缪恩有限公司 用于免疫疗法的纳米颗粒组合物和方法
CN105727371A (zh) * 2016-01-25 2016-07-06 北京天助畅运医疗技术股份有限公司 腹壁疝修补材料
CN105727371B (zh) * 2016-01-25 2019-04-09 北京天助畅运医疗技术股份有限公司 腹壁疝修补材料

Also Published As

Publication number Publication date
US20180117143A1 (en) 2018-05-03
BR112014012277A2 (pt) 2019-09-24
EP2596802A1 (en) 2013-05-29
US20140335162A1 (en) 2014-11-13
WO2013075846A1 (en) 2013-05-30
IN2014DN03429A (https=) 2015-06-05

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Effective date of abandoning: 20170908