CN104027702A - Colla corii asini composition and preparing method and application thereof - Google Patents
Colla corii asini composition and preparing method and application thereof Download PDFInfo
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Abstract
The invention provides a colla corii asini composition and a preparing method and application thereof. The colla corii asini composition is composed of morning colla corii asini taken in the morning, noon colla corii asini taken at noon and evening colla corii asini taken in the evening. The morning colla corii asini taken in the morning comprises colla corii asini, mulberry, fructus alpiniae oxyphyllae, hericium erinaceus, emblic leafflower fruit, fructus perillae, sophora flower bud, fig, peach kernel and semen cassiae. The noon colla corii asini taken at noon comprises colla corii asini, hippophae rhamnosides, sealwort, fructus amomi, mair-cona, pachyrhizua angulatus, white lablab bean flower, chrysanthemum, jasmine flower and Chinese yam. The evening colla corii asini taken in the evening comprises colla corii asini, raspberry, spina date seed, semen cucurbitae, tangerine peel, dandelion, peony, endothelium corneum gigeriae galli, wheat and goat heart. The colla corii asini composition can be applied to preparing health food for lead removing promoting, sleep improving, chloasma removing and immunity improving or to preparing the medicine for treating the mastitis, the hyperplasia of mammary glands, the colon cancer and the lung cancer.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of donkey-hide gelatin composition with and preparation method thereof, relate to a kind of donkey-hide gelatin composition and be applied to preparation and promote Plumbum removing, improve the health food of sleep, functions of removing chloasma, raising immunity or for the preparation for the treatment of mastitis, cyclomastopathy, colon cancer, lung-cancer medicament.
Background technology
Colla Corii Asini begins to be loaded in Qin Han < in period < Sheng Nong's herbal classic > >, classifies as top gradely, and meaning clothes, make light of one's life by commiting suicide, QI invigorating.Ming Dynasty Li Shizhen (1518-1593 A.D.) < < Compendium of Materia Medica > > is referred to as the panacea of enriching blood.Colla Corii Asini is still with its definite curative effect the choice drug of enriching blood so far, and they are many is become by collagen and partial hydrolysate thereof, nitrogenous 16.43～16.54%, is protein substantially.Hydrolysis produces several amino acids, wherein has lysine 10%, arginine 7%, histidine 2% etc.From the aminoacid producing, Colla Corii Asini is similar to gelatin, but the former lysine is more, and containing cystine, and lack tryptophan.Containing ash 0.75～1.09%, calcium 0.079～0.118%.But at present among the people Colla Corii Asini is taken to comparatively tradition, this is unfavorable for that the utilization of Colla Corii Asini has also increased the weight of the working pressure of valuable medicinal, the object of the invention is to provide a kind of plurality of raw materials is carried out to reasonable formula, can fully effectively bring into play and utilize the effect of raw material ingredient, the donkey-hide gelatin composition that integrates treatment and health care, by different compatible combination, reduce the use amount of Colla Corii Asini, simultaneously in conjunction with different time points human body in a day need to absorption, give different donkey-hide gelatin compositions, reach health care and the effect for the treatment of.
Summary of the invention
The present invention is intended to address the above problem, the first object is to provide a kind of plurality of raw materials is carried out to reasonable formula, can fully effectively bring into play and utilize the effect of raw material ingredient, the donkey-hide gelatin composition that integrates treatment and health care, the second object is to provide a kind of preparation method of donkey-hide gelatin composition, the 3rd object is to provide a kind of donkey-hide gelatin composition to promote Plumbum removing in preparation, improve sleep, functions of removing chloasma, in the health food of raising immunity, apply, the 4th object is to provide a kind of donkey-hide gelatin composition at preparation treatment mastitis, cyclomastopathy, colon cancer, application in lung-cancer medicament.
For achieving the above object, the invention provides a kind of donkey-hide gelatin composition, in taking at Colla Corii Asini morning, the noon of taking morning, Colla Corii Asini and the late Colla Corii Asini taken evening form, the raw material that said composition contains following weight portion:
The raw material that Colla Corii Asini morning of taking morning contains following weight portion: 10～60 parts, Colla Corii Asini, 10～60 parts of Fructus Mori, 8～50 parts of Fructus Alpiniae Oxyphyllae, 8～50 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 8～50 parts of Fructus Phyllanthis, 5～30 parts of Fructus Perillaes, 5～20 parts of the Flos Sophorae Immaturus, 4～18 parts of Fructus Ficis, 8～26 parts, Semen Persicae, 10～28 parts of Semen Cassiaes;
The raw material that the middle Colla Corii Asini of taking noon contains following weight portion: 10～80 parts, Colla Corii Asini, 10～80 parts of Folium Hippophae, 10～50 parts of Rhizoma Polygonatis, 8～50 parts of Fructus Amomis, 8～50 parts of Lepidinm meyenii Walp, 4～18 parts of Pachyrhizua angulatus, 5～20 parts of Flos Semen Lablab Albums, 4～15 parts of Flos Chrysanthemis, 6～13 parts of Flos Jasmini Sambacs, 10～28 parts of Rhizoma Dioscoreaes;
The raw material that the late Colla Corii Asini of taking evening contains following weight portion: 14～100 parts, Colla Corii Asini, 14～100 parts of Fructus Rubies, 14～95 parts of Semen Ziziphi Spinosaes, 8～28 parts of Semen Cucurbitaes, 4～13 parts of Exocarpium Citri Rubrums, 6～21 parts of Herba Taraxacis, 10～28 parts of Flos Moutaies, 5～20 parts of Endothelium Corneum Gigeriae Galli, 11～40 parts of Semen Tritici aestivis, 3～23 parts of Cor Caprae seu ovis.
The invention provides a kind of preparation method of donkey-hide gelatin composition, it is characterized in that carrying out as follows:
(1) take 10～60 parts of Fructus Mori, 8～50 parts of Fructus Alpiniae Oxyphyllae, 8～50 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 8～50 parts of Fructus Phyllanthis, 5～30 parts of Fructus Perillaes, 5～20 parts of the Flos Sophorae Immaturus, 4～18 parts of Fructus Ficis, 8～26 parts, Semen Persicae, 10～28 parts of Semen Cassiaes, add 10～15 times of water, decoct each 1～3 hour 2 times, filter, add while hot 10～60 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 80～100 orders, adds proper auxiliary materials, make tablet, capsule, granule, oral liquid, obtains Colla Corii Asini morning of taking morning.
(2) take 10～80 parts of Folium Hippophae, 10～50 parts of Rhizoma Polygonatis, 8～50 parts of Fructus Amomis, 8～50 parts of Lepidinm meyenii Walp, 4～18 parts of Pachyrhizua angulatus, 5～20 parts of Flos Semen Lablab Albums, 4～15 parts of Flos Chrysanthemis, 6～13 parts of Flos Jasmini Sambacs, 10～28 parts of Rhizoma Dioscoreaes, add 10～12 times of water, decoct each 1.5～3 hours 2 times, filter, add while hot 10～80 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 80～100 orders, adds proper auxiliary materials, make tablet, capsule, granule, oral liquid, obtains the middle Colla Corii Asini of taking noon.
(3) take 14～100 parts of Fructus Rubies, 14～95 parts of Semen Ziziphi Spinosaes, 8～28 parts of Semen Cucurbitaes, 4～13 parts of Exocarpium Citri Rubrums, 6～21 parts of Herba Taraxacis, 10～28 parts of Flos Moutaies, 5～20 parts of Endothelium Corneum Gigeriae Galli, 11～40 parts of Semen Tritici aestivis, 3～23 parts of Cor Caprae seu ovis, add 10～12 times of water, decoct each 1.5～4 hours 2 times, filter, add while hot 14～100 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 80～100 orders, adds proper auxiliary materials, make tablet, capsule, granule, oral liquid, obtains the late Colla Corii Asini of taking evening.
The invention provides a kind of donkey-hide gelatin composition and be applied to the health food that preparation promotes Plumbum removing, improves sleep, functions of removing chloasma, raising immunity.
The invention provides a kind of donkey-hide gelatin composition and be applied to preparation treatment mastitis, cyclomastopathy, colon cancer, lung-cancer medicament.
Embodiment 1
Raw material:
The raw material that Colla Corii Asini morning of taking morning contains following weight portion: 60 parts, Colla Corii Asini, 60 parts of Fructus Mori, 50 parts of Fructus Alpiniae Oxyphyllae, 50 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 50 parts of Fructus Phyllanthis, 30 parts of Fructus Perillaes, 20 parts of the Flos Sophorae Immaturus, 18 parts of Fructus Ficis, 26 parts, Semen Persicae, 28 parts of Semen Cassiaes;
The raw material that the middle Colla Corii Asini of taking noon contains following weight portion: 80 parts, Colla Corii Asini, 80 parts of Folium Hippophae, 50 parts of Rhizoma Polygonatis, 50 parts of Fructus Amomis, 50 parts of Lepidinm meyenii Walp, 18 parts of Pachyrhizua angulatus, 20 parts of Flos Semen Lablab Albums, 15 parts of Flos Chrysanthemis, 13 parts of Flos Jasmini Sambacs, 28 parts of Rhizoma Dioscoreaes;
The raw material that the late Colla Corii Asini of taking evening contains following weight portion: 100 parts, Colla Corii Asini, 100 parts of Fructus Rubies, 95 parts of Semen Ziziphi Spinosaes, 28 parts of Semen Cucurbitaes, 13 parts of Exocarpium Citri Rubrums, 21 parts of Herba Taraxacis, 28 parts of Flos Moutaies, 20 parts of Endothelium Corneum Gigeriae Galli, 40 parts of Semen Tritici aestivis, 23 parts of Cor Caprae seu ovis.
Preparation method:
(1) take 60 parts of Fructus Mori, 50 parts of Fructus Alpiniae Oxyphyllae, 50 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 50 parts of Fructus Phyllanthis, 30 parts of Fructus Perillaes, 20 parts of the Flos Sophorae Immaturus, 18 parts of Fructus Ficis, 26 parts, Semen Persicae, 28 parts of Semen Cassiaes, add 15 times of water, decoct each 3 hours 2 times, filter, add while hot 60 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 100 orders, add proper auxiliary materials, be pressed into tablet, obtain Colla Corii Asini morning of taking morning.
(2) take 80 parts of Folium Hippophae, 50 parts of Rhizoma Polygonatis, 50 parts of Fructus Amomis, 50 parts of Lepidinm meyenii Walp, 18 parts of Pachyrhizua angulatus, 20 parts of Flos Semen Lablab Albums, 15 parts of Flos Chrysanthemis, 13 parts of Flos Jasmini Sambacs, 28 parts of Rhizoma Dioscoreaes, add 12 times of water, decoct each 3 hours 2 times, filter, add while hot 80 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 100 orders, add proper auxiliary materials, make capsule, obtain the middle Colla Corii Asini of taking noon.
(3) take 100 parts of Fructus Rubies, 95 parts of Semen Ziziphi Spinosaes, 28 parts of Semen Cucurbitaes, 13 parts of Exocarpium Citri Rubrums, 21 parts of Herba Taraxacis, 28 parts of Flos Moutaies, 20 parts of Endothelium Corneum Gigeriae Galli, 40 parts of Semen Tritici aestivis, 23 parts of Cor Caprae seu ovis, add 12 times of water, decoct each 4 hours 2 times, filter, add while hot 100 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 100 orders, add proper auxiliary materials, make oral liquid, obtain the late Colla Corii Asini of taking evening.
Embodiment 2
Raw material:
The raw material that Colla Corii Asini morning of taking morning contains following weight portion: 10 parts, Colla Corii Asini, 10 parts of Fructus Mori, 8 parts of Fructus Alpiniae Oxyphyllae, 8 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 8 parts of Fructus Phyllanthis, 5 parts of Fructus Perillaes, 5 parts of the Flos Sophorae Immaturus, 4 parts of Fructus Ficis, 8 parts, Semen Persicae, 10 parts of Semen Cassiaes;
The raw material that the middle Colla Corii Asini of taking noon contains following weight portion: 10 parts, Colla Corii Asini, 10 parts of Folium Hippophae, 10 parts of Rhizoma Polygonatis, 8 parts of Fructus Amomis, 8 parts of Lepidinm meyenii Walp, 4 parts of Pachyrhizua angulatus, 5 parts of Flos Semen Lablab Albums, 4 parts of Flos Chrysanthemis, 6 parts of Flos Jasmini Sambacs, 10 parts of Rhizoma Dioscoreaes;
The raw material that the late Colla Corii Asini of taking evening contains following weight portion: 14 parts, Colla Corii Asini, 14 parts of Fructus Rubies, 14 parts of Semen Ziziphi Spinosaes, 8 parts of Semen Cucurbitaes, 4 parts of Exocarpium Citri Rubrums, 6 parts of Herba Taraxacis, 10 parts of Flos Moutaies, 5 parts of Endothelium Corneum Gigeriae Galli, 11 parts of Semen Tritici aestivis, 3 parts of Cor Caprae seu ovis.
Preparation method:
(1) take 10 parts of Fructus Mori, 8 parts of Fructus Alpiniae Oxyphyllae, 8 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 8 parts of Fructus Phyllanthis, 5 parts of Fructus Perillaes, 5 parts of the Flos Sophorae Immaturus, 4 parts of Fructus Ficis, 8 parts, Semen Persicae, 10 parts of Semen Cassiaes, add 10 times of water, decoct each 1 hour 2 times, filter, add while hot 10 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 80 orders, add proper auxiliary materials, granulation agent, obtains Colla Corii Asini morning of taking morning.
(2) take 10 parts of Folium Hippophae, 10 parts of Rhizoma Polygonatis, 8 parts of Fructus Amomis, 8 parts of Lepidinm meyenii Walp, 4 parts of Pachyrhizua angulatus, 5 parts of Flos Semen Lablab Albums, 4 parts of Flos Chrysanthemis, 6 parts of Flos Jasmini Sambacs, 10 parts of Rhizoma Dioscoreaes, add 10 times of water, decoct each 1.5 hours 2 times, filter, add while hot 10 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 80 orders, add proper auxiliary materials, make oral liquid, obtain the middle Colla Corii Asini of taking noon.
(3) take 14 parts of Fructus Rubies, 14 parts of Semen Ziziphi Spinosaes, 8 parts of Semen Cucurbitaes, 4 parts of Exocarpium Citri Rubrums, 6 parts of Herba Taraxacis, 10 parts of Flos Moutaies, 5 parts of Endothelium Corneum Gigeriae Galli, 11 parts of Semen Tritici aestivis, 3 parts of Cor Caprae seu ovis, add 10 times of water, decoct each 1.5 hours 2 times, filter, add while hot 14 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 80 orders, add proper auxiliary materials, make capsule, obtain the late Colla Corii Asini of taking evening.
Embodiment 3
Raw material:
The raw material that Colla Corii Asini morning of taking morning contains following weight portion: 45 parts, Colla Corii Asini, 48 parts of Fructus Mori, 35 parts of Fructus Alpiniae Oxyphyllae, 38 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 34 parts of Fructus Phyllanthis, 16 parts of Fructus Perillaes, 11 parts of the Flos Sophorae Immaturus, 10 parts of Fructus Ficis, 18 parts, Semen Persicae, 19 parts of Semen Cassiaes;
The raw material that the middle Colla Corii Asini of taking noon contains following weight portion: 55 parts, Colla Corii Asini, 55 parts of Folium Hippophae, 33 parts of Rhizoma Polygonatis, 36 parts of Fructus Amomis, 34 parts of agates, 9 parts of Pachyrhizua angulatus, 10 parts of Flos Semen Lablab Albums, 8 parts of Flos Chrysanthemis, 9 parts of Flos Jasmini Sambacs, 18 parts of Rhizoma Dioscoreaes;
The raw material that the late Colla Corii Asini of taking evening contains following weight portion: 66 parts, Colla Corii Asini, 66 parts of Fructus Rubies, 58 parts of Semen Ziziphi Spinosaes, 16 parts of Semen Cucurbitaes, 7 parts of Exocarpium Citri Rubrums, 12 parts of Herba Taraxacis, 17 parts of Flos Moutaies, 11 parts of Endothelium Corneum Gigeriae Galli, 27 parts of Semen Tritici aestivis, 16 parts of Cor Caprae seu ovis.
Preparation method:
(1) take 48 parts of Fructus Mori, 35 parts of Fructus Alpiniae Oxyphyllae, 38 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 34 parts of Fructus Phyllanthis, 16 parts of Fructus Perillaes, 11 parts of the Flos Sophorae Immaturus, 10 parts of Fructus Ficis, 18 parts, Semen Persicae, 19 parts of Semen Cassiaes, add 12 times of water, decoct each 2 hours 2 times, filter, add while hot 45 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 90 orders, add proper auxiliary materials, make capsule, obtain Colla Corii Asini morning of taking morning.
(2) take 55 parts of Folium Hippophae, 33 parts of Rhizoma Polygonatis, 36 parts of Fructus Amomis, 34 parts of Lepidinm meyenii Walp, 9 parts of Pachyrhizua angulatus, 10 parts of Flos Semen Lablab Albums, 8 parts of Flos Chrysanthemis, 9 parts of Flos Jasmini Sambacs, 18 parts of Rhizoma Dioscoreaes, add 11 times of water, decoct each 2 hours 2 times, filter, add while hot 55 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 90 orders, add proper auxiliary materials, granulation agent, obtains the middle Colla Corii Asini of taking noon.
(3) take 66 parts of Fructus Rubies, 58 parts of Semen Ziziphi Spinosaes, 16 parts of Semen Cucurbitaes, 7 parts of Exocarpium Citri Rubrums, 12 parts of Herba Taraxacis, 17 parts of Flos Moutaies, 11 parts of Endothelium Corneum Gigeriae Galli, 27 parts of Semen Tritici aestivis, 16 parts of Cor Caprae seu ovis, add 11 times of water, decoct each 3 hours 2 times, filter, add while hot 66 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 90 orders, add proper auxiliary materials, make tablet, obtain the late Colla Corii Asini of taking evening.
Embodiment 4
The raw material that Colla Corii Asini morning of taking morning contains following weight portion: monarch drug: 10 parts, Colla Corii Asini, 10 parts of Fructus Mori, ministerial drug: 8 parts of Fructus Alpiniae Oxyphyllae, 8 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 8 parts of Fructus Phyllanthis, adjuvant: 5 parts of Fructus Perillaes, 5 parts of the Flos Sophorae Immaturus, 4 parts of Fructus Ficis, 8 parts, Semen Persicae, 10 parts of Semen Cassiaes;
The raw material that the middle Colla Corii Asini of taking noon contains following weight portion: monarch drug: 10 parts, Colla Corii Asini, 10 parts of Folium Hippophae, ministerial drug: 10 parts of Rhizoma Polygonatis, 8 parts of Fructus Amomis, 8 parts of Lepidinm meyenii Walp, adjuvant: 4 parts of Pachyrhizua angulatus, 5 parts of Flos Semen Lablab Albums, 4 parts of Flos Chrysanthemis, 6 parts of Flos Jasmini Sambacs, 10 parts of Rhizoma Dioscoreaes;
The raw material that the late Colla Corii Asini of taking evening contains following weight portion: monarch drug: 14 parts, Colla Corii Asini, 14 parts of Fructus Rubies, ministerial drug: 14 parts of Semen Ziziphi Spinosaes, 8 parts of Semen Cucurbitaes, 4 parts of Exocarpium Citri Rubrums, adjuvant: 6 parts of Herba Taraxacis, 10 parts of Flos Moutaies, 5 parts of Endothelium Corneum Gigeriae Galli, 11 parts of Semen Tritici aestivis, 3 parts of Cor Caprae seu ovis.
Embodiment 5
The raw material that Colla Corii Asini morning of taking morning contains following weight portion: monarch drug: 60 parts, Colla Corii Asini, 60 parts of Fructus Mori, ministerial drug: 50 parts of Fructus Alpiniae Oxyphyllae, 50 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 50 parts of Fructus Phyllanthis, adjuvant: 30 parts of Folium Perillaes, 20 parts of the Flos Sophorae Immaturus, 18 parts of Fructus Ficis, 26 parts, Semen Persicae, 28 parts of Semen Cassiaes;
The raw material that the middle Colla Corii Asini of taking noon contains following weight portion: monarch drug: 80 parts, Colla Corii Asini, 80 parts of Folium Hippophae, ministerial drug: 50 parts of Rhizoma Polygonatis, 50 parts of Fructus Amomis, 50 parts of Lepidinm meyenii Walp, adjuvant: 18 parts of Pachyrhizua angulatus, 20 parts of Flos Semen Lablab Albums, 15 parts of Flos Chrysanthemis, 13 parts of Flos Jasmini Sambacs, 28 parts of Rhizoma Dioscoreaes;
The raw material that the late Colla Corii Asini of taking evening contains following weight portion: monarch drug: 100 parts, Colla Corii Asini, 100 parts of Fructus Rubies, ministerial drug: 95 parts of Semen Ziziphi Spinosaes, 28 parts of Semen Cucurbitaes, 13 parts of Exocarpium Citri Rubrums, adjuvant: 21 parts of Herba Taraxacis, 28 parts of Flos Moutaies, 20 parts of Endothelium Corneum Gigeriae Galli, 40 parts of Semen Tritici aestivis, 23 parts of Cor Caprae seu ovis.
Embodiment 6
The raw material that Colla Corii Asini morning of taking morning contains following weight portion: monarch drug: 48 parts, Colla Corii Asini, 48 parts of Fructus Mori, ministerial drug: 28 parts of Fructus Alpiniae Oxyphyllae, 30 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 27 parts of Fructus Phyllanthis, adjuvant: 16 parts of Fructus Perillaes, 12 parts of the Flos Sophorae Immaturus, 11 parts of Fructus Ficis, 19 parts, Semen Persicae, 19 parts of Semen Cassiaes;
The raw material that the middle Colla Corii Asini of taking noon contains following weight portion: monarch drug: 55 parts, Colla Corii Asini, 55 parts of Folium Hippophae, ministerial drug: 34 parts of Rhizoma Polygonatis, 35 parts of Fructus Amomis, 31 parts of Lepidinm meyenii Walp, adjuvant: 11 parts of Pachyrhizua angulatus, 13 parts of Flos Semen Lablab Albums, 9 parts of Flos Chrysanthemis, 10 parts of Flos Jasmini Sambacs, 19 parts of Rhizoma Dioscoreaes;
The raw material that the late Colla Corii Asini of taking evening contains following weight portion: monarch drug: 60 parts, Colla Corii Asini, 60 parts of Fructus Rubies, ministerial drug: 45 parts of Semen Ziziphi Spinosaes, 19 parts of Semen Cucurbitaes, 9 parts of Exocarpium Citri Rubrums, adjuvant: 14 parts of Herba Taraxacis, 15 parts of Flos Moutaies, 12 parts of Endothelium Corneum Gigeriae Galli, 25 parts of Semen Tritici aestivis, 15 parts of Cor Caprae seu ovis.
1, acute toxicity test
Because this present composition prepared product toxicity is lower, be subject to reagent not measure LD50, do the maximum dosage-feeding test of ig.Before ig administration, mice fasting be can't help water 12 hours, and present composition prepared product is mixed with after Cmax, and 30 mices (♂ ♀ half and half) are ig present composition prepared product (0.58ml.10g respectively
-1), the response situation of observing immediately mice after administration, and Continuous Observation 14 days, after administration, mice obviously suppressed in 12 hours, but had no dead.
2, long term toxicity test
Rat gives the continuous gavage of present composition prepared product 24 weeks, observe the 12nd week, 24 weeks and drug withdrawal after the toxic reaction situations of 2 weeks (26 weeks) rats.Rat is divided into 4 groups at random: matched group, present composition prepared product little, in, heavy dose of group (be equivalent to quantity 25 times, 50 times, 100 times), ig administration, every day 2 times, continuous 24 weeks, when medication 12 weeks, 24 weeks and drug withdrawal recover 2 weeks, femoral artery blood-letting, execution animal, do index of correlation and detect.Result demonstration, 24 weeks toxicity of the continuous ig administration of present composition prepared product Three doses is humble, clinical use safety.
Its Pharmacodynamics result of study is as follows:
1, the impact on mice lead-expelling function
Select the qualified kunming mice of quarantine to be divided at random 5 groups, 10 every group: normal, model control group, the high, medium and low dosage group of prepared product of the present invention (dosage is approximately equivalent to respectively 20,10,5 times of people's clinical equivalent dosage).Except blank group is quoted deionized water, all drink containing the plumbous [Pb (CH of 0.2% glacial acetic acid for all the other 4 groups
3cOO) 2.H
2o] go from aqueous solution.Basic, normal, high dosage group by above-mentioned dosage setting, gives animal subject gavage respectively.Blank group and model control group gavage give equal-volume deionized water, continuously 30d.After last gavage 24h, eyeball blood sampling 1.00g, disconnected neck is put to death mice, gets liver 0.20g.Concentrated nitric acid and perchloric acid (both volume ratio 3:1) hot digestion for 1 side femur, measure blood lead, liver lead, femur lead content, continuous 6 weeks with graphite furnace atomic absorption spectrometry.Result shows, prepared product group of the present invention has promotion lead-eliminating effect.
Table 1 blood lead and organize plumbous measurement result (x ± s)
Compare * P<0.05, * * P<0.01 with model group
2, the impact on mice hypnosis
50 of mices, are divided into 5 groups at random by body weight, matched group, stable group, the high, medium and low dosage group of prepared product of the present invention (dosage is approximately equivalent to respectively 20,10,5 times of people's clinical equivalent dosage).Every group 12, each is organized after mice difference ig different pharmaceutical 30min, and ip pentobarbital sodium 35mg/kg, for the index of falling asleep, records the number of elements of falling asleep of mice in 25min with righting reflex loss 1min.Matched group is solvent.Result shows, the present invention more significantly increases hypnotic effect.
Table 2 is on the impact of mice hypnosis (x ± s)
Compare * P<0.05, * * P<0.01 with matched group
3, the impact on chloasma model mice
Get female kunming mice, be divided at random respectively 6 groups, 10 every group: normal, model control group, vitamin C matched group, the high, medium and low dosage group of prepared product of the present invention (dosage is approximately equivalent to respectively 20,10,5 times of people's clinical equivalent dosage).Normal group is by body weight intramuscular injection sterilizing pharmaceutical grade vegetable oil; All the other 5 groups with Progesterone in the intramuscular injection of mice back leg, dosage is 20mg/kg Progesterone.Every morning, once two lower limbs are injection alternately, continuous 30 days.Animal every morning irradiation ultraviolet radiation is 60 minutes simultaneously.Modeling starts to gavage corresponding medicine 20mg/kg, continuous 30 days every afternoon simultaneously.After last administration, it measures antioxidative activities the skin of the ultraviolet radiation of learning from else's experience, and measures liver lipofuscin simultaneously.Result shows, prepared product group antioxidative activities ability of the present invention is strong, and liver lipofuscin is low, is conducive to eliminating chloasma.
Table 3 is on the impact of chloasma model mice (x ± s)
Compare * P<0.05, * * P<0.01 with model group
4, the lymphopoiesis impact on lotus Lewis lung cancer mice
Get mice, the Lewis lung cancer suspension 0.10ml/ Mus (approximately 2 * 10 of the aseptic preparation of abdominal cavity subcutaneous vaccination
6individual tumor cell).Next day random packet, every group gavages corresponding medicine, blank group gives corresponding distilled water, after last administration, get mouse spleen next day under aseptic condition, with 100 eye mesh screens, make single splenocyte suspension, with the RPMI RPMI-1640 containing 10% deactivation calf serum, regulating cell concentration is 1 * 10
7individual cell/ml, adds 96 porocyte culture plates, every hole 100ul (1 * 10
6individual cells/well), then add the culture fluid 100ul containing ConA (6ug, ml), put 37 ℃, 7%CO
2condition is cultivated 72h.Gentle aspiration supernatant 100ul, adds MTT solution (6mg/ml) 20ul.Place 37 ℃, 7%CO
2condition adds Digestive system 100ul after cultivating 2h, then is placed to and surveys each hole OD value next day and with formula calculating stimulation index.Stimulation index=experimental group OD value/matched group OD value.Lymphocytic division growth ability has reflected the power of Immune Function to a certain extent, and lymphocyte transformation experiment is the test method that machines body immunity function is conventional.Result shows that the present invention can obviously promote mouse lymphocyte to breed and make Lewis lung cancer apoptosis.
The lymphopoietic impact (x ± s) of table 4 on lotus Lewis lung cancer mice
Compare * * P<0.01 with blank group
5, antiinflammatory action
Get 50 of female sd inbred rats, be divided at random 5 groups, 10 every group, i.e. model group, the anxious clever matched group of breast, the high, medium and low dosage group of prepared product of the present invention (dosage is approximately equivalent to respectively 20,10,5 times of people's clinical equivalent dosage).Ig administration, every day 1 time, continuous 20 days, the 12nd day, in the time of ig administration, prepare model,, under the shallow fiber crops of ether, in the scapular region of back subcutaneous injection 20ml of every Mus air, to form air bag, then in air bag, inject genuine turpentine oil 1ml, after 24h, extract air in capsule out.After last administration, 1h puts to death rat, and peels off wall internal granuloma, after normal saline rinsing, puts 80 ℃ of baking box baking 6h and claims dry weight.Result demonstration, the present invention can obviously suppress the rat air bag granuloma hypertrophy of Oleum Terebinthinae induction, and antiphlogistic effects is obvious.
The impact (x ± s) of table 5 on Oleum Terebinthinae induction rat air bag granulation hyperplasia model
Compare * * P<0.01, * P<0.05 with model group
6, the impact on rabbit hyperplasia of mammary gland model
Select 40 of Female rabbits, be divided at random 5 groups (matched group, model group, medicine of the present invention be high, in 2 dosage groups and breast increase clever matched group).Except matched group, each group adopts abdominal operation to extract bilateral ovaries through local anaesthesia.Within postoperative the 4th day, start E0.3mg/kg, the next day 1 time, inject altogether 15 times and cause hyperplasia of mammary gland model.The group of administration simultaneously gavages medicine of the present invention, every day 1 time, is total to administration 30d, and matched group and model group gavage ordinary water 1ml/kg.After last administration 1h, put to death and respectively organize rabbit, win a pair of mammary gland and make outward appearance observation and histology's light microscopy checking.Visible model group rabbit mammary gland body obviously increases, and color is slightly red.Under mirror, visible lobules of mammary gland number increases, and acinus number increases, and acinus is obviously expanded, and compares and is changed significantly with matched group.Model 20.0mg/kg administration group rabbit mammary gland volume obviously dwindles, and under mirror, visible lobules of mammary gland number obviously reduces, and acinus number obviously reduces, and compares with model group, has significant change.Model 40.0g/kg dosage group mammary gland volume significantly reduces, and lobules of mammary gland number, acinus number and alveolar lumen obviously reduce, and the results are shown in Table 11.Show that the present invention has the effect of obvious inhibition cyclomastopathy.
Table 6 is on the impact of rabbit hyperplasia of mammary gland model (x ± s)
Compare * P<0.05, * * P<0.01 with model group
7, on colon cancer cell line SW480 mice impact
Get mice, the colon cancer cell line SW480 suspension 0.10ml/ Mus (approximately 2 * 10 of the aseptic preparation of abdominal cavity subcutaneous vaccination
6individual tumor cell).Next day random packet, every group gavages corresponding medicine, and blank group gives corresponding distilled water, and after last administration, get mouse spleen next day under aseptic condition, with 100 eye mesh screens, make single splenocyte suspension, with the RPMI1640 culture fluid containing 10% deactivation calf serum, regulating cell concentration is 1 * 10
7individual cell/ml, adds 96 porocyte culture plates, every hole 100ul (1 * 10
6individual cells/well), then add the culture fluid 100ul containing ConA (6ug, ml), put 37 ℃, 7%CO
2condition is cultivated 72h.Gentle aspiration supernatant 100ul, adds MTT solution (6mg/ml) 20ul.Place 37 ℃, 7%CO
2condition adds Digestive system 100ul after cultivating 2h, then is placed to and surveys each hole OD value next day and with formula calculating stimulation index.Stimulation index=experimental group OD value/matched group OD value.Lymphocytic division growth ability has reflected the power of Immune Function to a certain extent, and lymphocyte transformation experiment is the test method that machines body immunity function is conventional.Result shows that the present invention can obviously promote mouse lymphocyte to breed and make colon cancer cell line SW480 withered.
Table 7 is on the impact of colon cancer cell line SW480 mice (x ± s)
Compare * * P<0.0` with blank group
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. a donkey-hide gelatin composition, is characterized in that in taking at Colla Corii Asini morning, the noon of taking morning Colla Corii Asini and the late Colla Corii Asini of taking evening form;
The raw material that Colla Corii Asini morning of taking described morning contains following weight portion: 10～60 parts, Colla Corii Asini, 10～60 parts of Fructus Mori, 8～50 parts of Fructus Alpiniae Oxyphyllae, 8～50 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 8～50 parts of Fructus Phyllanthis, 5～30 parts of Fructus Perillaes, 5～20 parts of the Flos Sophorae Immaturus, 4～18 parts of Fructus Ficis, 8～26 parts, Semen Persicae, 10～28 parts of Semen Cassiaes;
The raw material that the middle Colla Corii Asini of taking described noon contains following weight portion: 10～80 parts, Colla Corii Asini, 10～80 parts of Folium Hippophae, 10～50 parts of Rhizoma Polygonatis, 8～50 parts of Fructus Amomis, 8～50 parts of Lepidinm meyenii Walp, 4～18 parts of Pachyrhizua angulatus, 5～20 parts of Flos Semen Lablab Albums, 4～15 parts of Flos Chrysanthemis, 6～13 parts of Flos Jasmini Sambacs, 10～28 parts of Rhizoma Dioscoreaes;
The raw material that the late Colla Corii Asini of taking described evening contains following weight portion: 14～100 parts, Colla Corii Asini, 14～100 parts of Fructus Rubies, 14～95 parts of Semen Ziziphi Spinosaes, 8～28 parts of Semen Cucurbitaes, 4～13 parts of Exocarpium Citri Rubrums, 6～21 parts of Herba Taraxacis, 10～28 parts of Flos Moutaies, 5～20 parts of Endothelium Corneum Gigeriae Galli, 11～40 parts of Semen Tritici aestivis, 3～23 parts of Cor Caprae seu ovis.
2. a kind of donkey-hide gelatin composition as claimed in claim 1, is characterized in that in taking at Colla Corii Asini morning, the noon of taking morning Colla Corii Asini and the late Colla Corii Asini of taking evening form;
The raw material that Colla Corii Asini morning of taking described morning contains following weight portion: 14～50 parts, Colla Corii Asini, 14～50 parts of Fructus Mori, 10～40 parts of Fructus Alpiniae Oxyphyllae, 10～40 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 10～38 parts of Fructus Phyllanthis, 8～26 parts of Fructus Perillaes, 7～16 parts of the Flos Sophorae Immaturus, 6～15 parts of Fructus Ficis, 10～22 parts, Semen Persicae, 14～23 parts of Semen Cassiaes;
The raw material that the middle Colla Corii Asini of taking described noon contains following weight portion: 15～70 parts, Colla Corii Asini, 15～70 parts of Folium Hippophae, 13～42 parts of Rhizoma Polygonatis, 11～42 parts of Fructus Amomis, 10～40 parts of Lepidinm meyenii Walp, 6～15 parts of Pachyrhizua angulatus, 7～16 parts of Flos Semen Lablab Albums, 6～13 parts of Flos Chrysanthemis, 8～12 parts of Flos Jasmini Sambacs, 11～24 parts of Rhizoma Dioscoreaes;
The raw material that the late Colla Corii Asini of taking described evening contains following weight portion: 16～90 parts, Colla Corii Asini, 16～90 parts of Fructus Rubies, 16～88 parts of Semen Ziziphi Spinosaes, 11～23 parts of Semen Cucurbitaes, 6～11 parts of Exocarpium Citri Rubrums, 8～16 parts of Herba Taraxacis, 12～23 parts of Flos Moutaies, 8～17 parts of Endothelium Corneum Gigeriae Galli, 14～33 parts of Semen Tritici aestivis, 6～18 parts of Cor Caprae seu ovis.
3. a kind of donkey-hide gelatin composition as claimed in claim 1, is characterized in that in taking at Colla Corii Asini morning, the noon of taking morning Colla Corii Asini and the late Colla Corii Asini of taking evening form;
The raw material that Colla Corii Asini morning of taking described morning contains following weight portion: monarch drug: 10～60 parts, Colla Corii Asini, 10～60 parts of Fructus Mori, ministerial drug: 8～50 parts of Fructus Alpiniae Oxyphyllae, 8～50 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 8～50 parts of Fructus Phyllanthis, adjuvant: 5～30 parts of Fructus Perillaes, 5～20 parts of the Flos Sophorae Immaturus, 4～18 parts of Fructus Ficis, 8～26 parts, Semen Persicae, 10～28 parts of Semen Cassiaes;
The raw material that the middle Colla Corii Asini of taking described noon contains following weight portion: monarch drug: 10～80 parts, Colla Corii Asini, 10～80 parts of Folium Hippophae, ministerial drug: 10～50 parts of Rhizoma Polygonatis, 8～50 parts of Fructus Amomis, 8～50 parts of Lepidinm meyenii Walp, adjuvant: 4～18 parts of Pachyrhizua angulatus, 5～20 parts of Flos Semen Lablab Albums, 4～15 parts of Flos Chrysanthemis, 6～13 parts of Flos Jasmini Sambacs, 10～28 parts of Rhizoma Dioscoreaes;
The raw material that the late Colla Corii Asini of taking described evening contains following weight portion: monarch drug: 14～100 parts, Colla Corii Asini, 14～100 parts of Fructus Rubies, ministerial drug: 14～95 parts of Semen Ziziphi Spinosaes, 8～28 parts of Semen Cucurbitaes, 4～13 parts of Exocarpium Citri Rubrums, adjuvant: 6～21 parts of Herba Taraxacis, 10～28 parts of Flos Moutaies, 5～20 parts of Endothelium Corneum Gigeriae Galli, 11～40 parts of Semen Tritici aestivis, 3～23 parts of Cor Caprae seu ovis.
4. the preparation method of a kind of donkey-hide gelatin composition as described in claim 1-3, is characterized in that comprising the steps:
(1) take 10～60 parts of Fructus Mori, 8～50 parts of Fructus Alpiniae Oxyphyllae, 8～50 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 8～50 parts of Fructus Phyllanthis, 5～30 parts of Fructus Perillaes, 5～20 parts of the Flos Sophorae Immaturus, 4～18 parts of Fructus Ficis, 8～26 parts, Semen Persicae, 10～28 parts of Semen Cassiaes, add 10～15 times of water, decoct each 1～3 hour 2 times, filter, add while hot 10～60 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 80～100 orders, adds proper auxiliary materials, make tablet, capsule, granule, oral liquid, obtains Colla Corii Asini morning of taking morning.
(2) take 10～80 parts of Folium Hippophae, 10～50 parts of Rhizoma Polygonatis, 8～50 parts of Fructus Amomis, 8～50 parts of Lepidinm meyenii Walp, 4～18 parts of Pachyrhizua angulatus, 5～20 parts of Flos Semen Lablab Albums, 4～15 parts of Flos Chrysanthemis, 6～13 parts of Flos Jasmini Sambacs, 10～28 parts of Rhizoma Dioscoreaes, add 10～12 times of water, decoct each 1.5～3 hours 2 times, filter, add while hot 10～80 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 80～100 orders, adds proper auxiliary materials, make tablet, capsule, granule, oral liquid, obtains the middle Colla Corii Asini of taking noon.
(3) take 14～100 parts of Fructus Rubies, 14～95 parts of Semen Ziziphi Spinosaes, 8～28 parts of Semen Cucurbitaes, 4～13 parts of Exocarpium Citri Rubrums, 6～21 parts of Herba Taraxacis, 10～28 parts of Flos Moutaies, 5～20 parts of Endothelium Corneum Gigeriae Galli, 11～40 parts of Semen Tritici aestivis, 3～23 parts of Cor Caprae seu ovis, add 10～12 times of water, decoct each 1.5～4 hours 2 times, filter, add while hot 14～100 parts, Colla Corii Asini, stir, concentrating under reduced pressure, dry, the dried cream powder making is ground into 80～100 orders, adds proper auxiliary materials, make tablet, capsule, granule, oral liquid, obtains the late Colla Corii Asini of taking evening.
5. Colla Corii Asini morning of taking a kind of morning as described in claim 1-3, it is characterized in that the raw material that contains following weight portion: 10～60 parts, Colla Corii Asini, 10～60 parts of Fructus Mori, 8～50 parts of Fructus Alpiniae Oxyphyllae, 8～50 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 8～50 parts of Fructus Phyllanthis, 5～30 parts of Fructus Perillaes, 5～20 parts of the Flos Sophorae Immaturus, 4～18 parts of Fructus Ficis, 8～26 parts, Semen Persicae, 10～28 parts of Semen Cassiaes.
6. the middle Colla Corii Asini of taking a kind of noon as described in claim 1-3, it is characterized in that the raw material that contains following weight portion: 10～80 parts, Colla Corii Asini, 10～80 parts of Folium Hippophae, 10～50 parts of Rhizoma Polygonatis, 8～50 parts of Fructus Amomis, 8～50 parts of Lepidinm meyenii Walp, 4～18 parts of Pachyrhizua angulatus, 5～20 parts of Flos Semen Lablab Albums, 4～15 parts of Flos Chrysanthemis, 6～13 parts of Flos Jasmini Sambacs, 10～28 parts of Rhizoma Dioscoreaes.
7. the late Colla Corii Asini of taking a kind of evening as described in claim 1-3, it is characterized in that the raw material that contains following weight portion: 14～100 parts, Colla Corii Asini, 14～100 parts of Fructus Rubies, 14～95 parts of Semen Ziziphi Spinosaes, 8～28 parts of Semen Cucurbitaes, 4～13 parts of Exocarpium Citri Rubrums, 6～21 parts of Herba Taraxacis, 10～28 parts of Flos Moutaies, 5～20 parts of Endothelium Corneum Gigeriae Galli, 11～40 parts of Semen Tritici aestivis, 3～23 parts of Cor Caprae seu ovis.
8. the application of the late Colla Corii Asini of taking a kind of evening as claimed in claim 7 in preparation treatment mastitis, cyclomastopathy medicine.
9. a kind of donkey-hide gelatin composition as described in claim 1-4 promotes Plumbum removing in preparation, improves in the health food of sleep, functions of removing chloasma, raising immunity and apply.
10. the application of a kind of donkey-hide gelatin composition as described in claim 1-4 in preparation treatment mastitis, cyclomastopathy, colon cancer, lung-cancer medicament.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105148069A (en) * | 2015-09-27 | 2015-12-16 | 张雅萍 | Medicinal and edible water-soluble pearl powder composition and preparation method and application thereof |
| CN105495373A (en) * | 2015-12-25 | 2016-04-20 | 绍兴文理学院 | Valeriana officinalis, grape seed and donkey-hide gelatin containing cake with anti-aging and beautifying functions and preparation method of cake |
| CN109418763A (en) * | 2017-08-16 | 2019-03-05 | 上海晶橡商务咨询有限公司 | A kind of Jasmine donkey-hide gelatin and preparation method thereof |
| CN113616755A (en) * | 2021-09-02 | 2021-11-09 | 北京贡源本草生物科技有限公司 | Nerve-soothing and brain-nourishing composition and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100055638A (en) * | 2008-11-18 | 2010-05-27 | 서정희 | A pharmaceutical composition for inhibition immunity reduction comprising ginseng extracts as effective components |
| CN102423073B (en) * | 2011-11-28 | 2013-03-06 | 李超建 | Diet for dietotherapy and health preservation |
| CN103622003A (en) * | 2012-08-29 | 2014-03-12 | 浙江劲膳美生物科技有限公司 | Conditioning catering or meal replacement for calmness and peaceful sleep |
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2014
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105148069A (en) * | 2015-09-27 | 2015-12-16 | 张雅萍 | Medicinal and edible water-soluble pearl powder composition and preparation method and application thereof |
| CN105495373A (en) * | 2015-12-25 | 2016-04-20 | 绍兴文理学院 | Valeriana officinalis, grape seed and donkey-hide gelatin containing cake with anti-aging and beautifying functions and preparation method of cake |
| CN109418763A (en) * | 2017-08-16 | 2019-03-05 | 上海晶橡商务咨询有限公司 | A kind of Jasmine donkey-hide gelatin and preparation method thereof |
| CN113616755A (en) * | 2021-09-02 | 2021-11-09 | 北京贡源本草生物科技有限公司 | Nerve-soothing and brain-nourishing composition and preparation method thereof |
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