CN105148069A - Medicinal and edible water-soluble pearl powder composition and preparation method and application thereof - Google Patents
Medicinal and edible water-soluble pearl powder composition and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a medicinal and edible water-soluble pearl powder composition and a preparation method and application thereof. The medicinal and edible water-soluble pearl powder composition is prepared from 10-60 parts of water-soluble pearl powder, 10-60 parts of maca, 13-55 parts of raspberries, 15-50 parts of pueraria thomsonii, 11-41 parts of oysters, 5-20 parts of peach gum, 4-17 parts of millet, 6-18 parts of semen pruni, 3-15 parts of fingered citron, 4-15 parts of female silkworm moths, 7-19 parts of camellia and 2-14 parts of chicken's gizzard-membranes. Through extracting and refining, the pearl powder composition can be applied to preparing health-care foods for improving sleep, dispelling chloasma and reducing weight or preparing medicine for treating premature ovarian failure.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of medicine-food two-purpose water-soluble pearl compound powder and its preparation method, relate to a kind of medicine-food two-purpose water-soluble pearl compound powder and be applied to and prepare improving water flood, functions of removing chloasma, the health food of fat-reducing or preparation treatment premature ovarian failure medicine.
Background technology
Along with China's rapid economic development, living standards of the people improve constantly, and living habit and diet style constantly affect health of people, and chronic disease is on the increase, and do not have enough sleep, the dim problem such as simple and unadorned of face highlights.Along with the propelling of health idea, the health of people to oneself is also more and more concerned about, progressively recognize the importance of prevention and health care, so they are constantly strong to the demand of the serious hope of health knowledge and health-oriented products, particularly involutional women, more and more stronger to the maintenance consciousness of body weight, skin, ovary, current health product are on the market of a great variety, but still lack the compositions of the medicine-food two-purposes such as water soluble Margarita ultrafine powder, Lepidinm meyenii Walp, Semen setariae at present, play and body weight, skin, ovary are kept healthy in the convenient health food of one.
Summary of the invention
The present invention is intended to solve the problem, first object is to provide a kind of by water soluble Margarita ultrafine powder, Lepidinm meyenii Walp, the medicine food compositions such as Semen setariae carry out reasonable formula, can fully effectively play and utilize effect of raw material ingredient, integrate the water-soluble pearl compound powder for the treatment of and health care, second object is the preparation method providing a kind of water-soluble pearl compound powder, 3rd object is to provide a kind of water-soluble pearl compound powder preparing improving water flood, functions of removing chloasma, apply in the health food of fat-reducing, 4th object is to provide the application of a kind of water-soluble pearl compound powder in preparation treatment premature ovarian failure medicine.Made product is rich in animals and plants small-molecular peptides effective ingredient, and bioavailability is high, the health care served and therapeutic effect.
For achieving the above object, the invention provides a kind of water-soluble pearl compound powder, said composition contains the raw material of following weight portion:
Water soluble Margarita ultrafine powder 10 ~ 60 parts, Lepidinm meyenii Walp 10 ~ 60 parts, Fructus Rubi 13 ~ 55 parts, Pachyrhizua angulatus 15 ~ 50 parts, Concha Ostreae 11 ~ 41 parts, Resina persicae 5 ~ 20 parts, Semen setariae 4 ~ 17 parts, Semen Pruni 6 ~ 18 parts, Fructus Citri Sarcodactylis 3 ~ 15 parts, female Bombycis mori 4 ~ 15 parts, Flos Camelliae Japonicae 7 ~ 19 parts, Endothelium Corneum Gigeriae Galli 2 ~ 14 parts.
The invention provides a kind of preparation method of water-soluble pearl compound powder, it is characterized in that carrying out as follows:
(1) Semen setariae 4 ~ 17 parts is taken, Resina persicae 5 ~ 20 parts, female Bombycis mori 4 ~ 15 parts, Endothelium Corneum Gigeriae Galli 2 ~ 14 parts, superfine powder is broken into the powder of 10 ~ 500um, adds 8 ~ 12 times of water, stir, be warming up to 35 ~ 70 degree, add 3 ~ 15 parts of hydrolysis compound enzymes, react 1 ~ 5 hour, filter, dry, pulverize to 60 ~ 100 order powder, for subsequent use;
(2) by above-mentioned (1) Chinese medicine slag and Lepidinm meyenii Walp 10 ~ 60 parts, Fructus Rubi 13 ~ 55 parts, Concha Ostreae 11 ~ 41 parts, Semen Pruni 6 ~ 18 parts, Pachyrhizua angulatus 15 ~ 50 parts, Fructus Citri Sarcodactylis 3 ~ 15 parts, Flos Camelliae Japonicae 7 ~ 19 parts, is ground into coarse powder, adds 10 ~ 15 times of 10% ~ 90% ethanol, extract 2 times, each 1 ~ 3 hour, filter, merging filtrate, dry, pulverize to 60 ~ 100 order powder, for subsequent use;
(3) added by water soluble Margarita ultrafine powder 10 ~ 60 parts in above-mentioned (1) and (2) gained powder, mixing, adds proper auxiliary materials, makes tablet, capsule, granule, oral liquid.Described hydrolysis compound enzyme is bromelain: papain: aspergillus oryzae: the mixture of lactobacillus=1:0.6:2.6:0.9.
The invention provides a kind of water-soluble pearl compound powder and be applied to the health food preparing improving water flood, functions of removing chloasma, fat-reducing.
The invention provides a kind of water-soluble pearl compound powder and be applied to preparation treatment premature ovarian failure medicine.
Embodiment 1
Raw material: water soluble Margarita ultrafine powder 10 parts, Lepidinm meyenii Walp 10 parts, Fructus Rubi 13 parts, Pachyrhizua angulatus 15 parts, Concha Ostreae 11 parts, Resina persicae 5 parts, Semen setariae 4 parts, Semen Pruni 6 parts, Fructus Citri Sarcodactylis 3 parts, female Bombycis mori 4 parts, Flos Camelliae Japonicae 7 parts, Endothelium Corneum Gigeriae Galli 2 parts.
Preparation method: (1) by Semen setariae, Resina persicae, female Bombycis mori, Endothelium Corneum Gigeriae Galli, superfine powder is broken into the powder of 10um, adds 8 times of water, stirs, be warming up to 35 degree, add 3 parts hydrolysis compound enzymes, reaction 1, filter, dry, pulverize to 60 order powder, for subsequent use;
(2) by above-mentioned (1) Chinese medicine slag and Lepidinm meyenii Walp, Fructus Rubi, Concha Ostreae, Semen Pruni, Pachyrhizua angulatus, Fructus Citri Sarcodactylis, Flos Camelliae Japonicae, is ground into coarse powder, adds 10 times of 10% ethanol, extracts 2 times, each 1 hour, filter, merging filtrate, dry, pulverize to 60 order powder, for subsequent use;
(3) added by water soluble Margarita ultrafine powder in above-mentioned (1) and (2) gained powder, mixing, adds proper auxiliary materials, makes tablet, to obtain final product.
Embodiment 2
Raw material: water soluble Margarita ultrafine powder 60 parts, Lepidinm meyenii Walp 60 parts, Fructus Rubi 55 parts, Pachyrhizua angulatus 50 parts, Concha Ostreae 41 parts, Resina persicae 20 parts, Semen setariae 17 parts, Semen Pruni 18 parts, Fructus Citri Sarcodactylis 15 parts, female Bombycis mori 15 parts, Flos Camelliae Japonicae 19 parts, Endothelium Corneum Gigeriae Galli 14 parts.
Preparation method: (1) by Semen setariae, Resina persicae, female Bombycis mori, Endothelium Corneum Gigeriae Galli, superfine powder is broken into the powder of 500um, add 12 times of water, stir, be warming up to 70 degree, add 15 parts of hydrolysis compound enzymes, react 5 hours, filter, dry, pulverize to 100 order powder, for subsequent use;
(2) by above-mentioned (1) Chinese medicine slag and Lepidinm meyenii Walp, Fructus Rubi, Concha Ostreae, Semen Pruni, Pachyrhizua angulatus, Fructus Citri Sarcodactylis, Flos Camelliae Japonicae, is ground into coarse powder, adds 15 times of 90% ethanol, extracts 2 times, each 3 hours, filter, merging filtrate, dry, pulverize to 100 order powder, for subsequent use;
(3) added by water soluble Margarita ultrafine powder in above-mentioned (1) and (2) gained powder, mixing, adds proper auxiliary materials, makes capsule, granule.
Embodiment 3
Raw material: water soluble Margarita ultrafine powder 38 parts, Lepidinm meyenii Walp 38 parts, Fructus Rubi 32 parts, Pachyrhizua angulatus 32 parts, Concha Ostreae 27 parts, Resina persicae 12 parts, Semen setariae 11 parts, Semen Pruni 12 parts, Fructus Citri Sarcodactylis 8 parts, female Bombycis mori 9 parts, Flos Camelliae Japonicae 12 parts, Endothelium Corneum Gigeriae Galli 8 parts.
Preparation method: (1) by Semen setariae, Resina persicae, female Bombycis mori, Endothelium Corneum Gigeriae Galli, superfine powder is broken into the powder of 300um, add 10 times of water, stir, be warming up to 50 degree, add 9 parts of hydrolysis compound enzymes, react 3 hours, filter, dry, pulverize to 80 order powder, for subsequent use;
(2) by above-mentioned (1) Chinese medicine slag and Lepidinm meyenii Walp, Fructus Rubi, Concha Ostreae, Semen Pruni, Pachyrhizua angulatus, Fructus Citri Sarcodactylis, Flos Camelliae Japonicae, is ground into coarse powder, adds 12 times of 50% ethanol, extracts 2 times, each 2 hours, filter, merging filtrate, dry, pulverize to 70 order powder, for subsequent use;
(3) water soluble Margarita ultrafine powder part added in above-mentioned (1) and (2) gained powder, mixing, adds proper auxiliary materials, makes oral liquid.
Embodiment 4
Raw material: water soluble Margarita ultrafine powder 52 parts, Lepidinm meyenii Walp 53 parts, Fructus Rubi 45 parts, Pachyrhizua angulatus 44 parts, Concha Ostreae 36 parts, Resina persicae 14 parts, Semen setariae 13 parts, Semen Pruni 15 parts, Fructus Citri Sarcodactylis 12 parts, female Bombycis mori 11 parts, Flos Camelliae Japonicae 16 parts, Endothelium Corneum Gigeriae Galli 11 parts.
Preparation method: (1) by Semen setariae, Resina persicae, female Bombycis mori, Endothelium Corneum Gigeriae Galli, superfine powder is broken into the powder of 100um, adds 9 times of water, stirs, be warming up to 45 degree, add 8 parts hydrolysis compound enzymes, react 2 hours, filtration, dry, pulverize to 60 order powder, for subsequent use;
(2) by above-mentioned (1) Chinese medicine slag and Lepidinm meyenii Walp, Fructus Rubi, Concha Ostreae, Semen Pruni, Pachyrhizua angulatus, Fructus Citri Sarcodactylis, Flos Camelliae Japonicae, is ground into coarse powder, adds 13 times of 70% ethanol, extracts 2 times, each 1.5 hours, filter, merging filtrate, dry, pulverize to 60 order powder, for subsequent use;
(3) added by water soluble Margarita ultrafine powder in above-mentioned (1) and (2) gained powder, mixing, adds proper auxiliary materials, makes granule.
Embodiment 5
Raw material: water soluble Margarita ultrafine powder 16 parts, Lepidinm meyenii Walp 15 parts, Fructus Rubi 18 parts, Pachyrhizua angulatus 19 parts, Concha Ostreae 14 parts, Resina persicae 8 parts, Semen setariae 7 parts, Semen Pruni 9 parts, Fructus Citri Sarcodactylis 5 parts, female Bombycis mori 6 parts, Flos Camelliae Japonicae 10 parts, Endothelium Corneum Gigeriae Galli 5 parts.
Preparation method: (1) by Semen setariae, Resina persicae, female Bombycis mori, Endothelium Corneum Gigeriae Galli, superfine powder is broken into the powder of 50um, adds 11 times of water, stirs, be warming up to 55 degree, add 5 parts hydrolysis compound enzymes, react 3 hours, filtration, dry, pulverize to 80 order powder, for subsequent use;
(2) by above-mentioned (1) Chinese medicine slag and Lepidinm meyenii Walp, Fructus Rubi, Concha Ostreae, Semen Pruni, Pachyrhizua angulatus, Fructus Citri Sarcodactylis, Flos Camelliae Japonicae, is ground into coarse powder, adds 11 times of 20% ethanol, extracts 2 times, each 2 hours, filter, merging filtrate, dry, pulverize to 100 order powder, for subsequent use;
(3) added by water soluble Margarita ultrafine powder in above-mentioned (1) and (2) gained powder, mixing, adds proper auxiliary materials, makes tablet.
Embodiment 6
Raw material: water soluble Margarita ultrafine powder 33 parts, Lepidinm meyenii Walp 33 parts, Fructus Rubi 30 parts, Pachyrhizua angulatus 27 parts, Concha Ostreae 22 parts, Resina persicae 11 parts, Semen setariae 10 parts, Semen Pruni 13 parts, Fructus Citri Sarcodactylis 8 parts, female Bombycis mori 9 parts, Flos Camelliae Japonicae 14 parts, Endothelium Corneum Gigeriae Galli 8 parts.
Preparation method: (1) by Semen setariae, Resina persicae, female Bombycis mori, Endothelium Corneum Gigeriae Galli, superfine powder is broken into the powder of 100um, adds 9 times of water, stirs, be warming up to 45 degree, add 8 parts hydrolysis compound enzymes, react 2 hours, filtration, dry, pulverize to 60 order powder, for subsequent use;
(2) by above-mentioned (1) Chinese medicine slag and Lepidinm meyenii Walp, Fructus Rubi, Concha Ostreae, Semen Pruni, Pachyrhizua angulatus, Fructus Citri Sarcodactylis, Flos Camelliae Japonicae, is ground into coarse powder, adds 13 times of 70% ethanol, extracts 2 times, each 1.5 hours, filter, merging filtrate, dry, pulverize to 60 order powder, for subsequent use;
(3) added by water soluble Margarita ultrafine powder in above-mentioned (1) and (2) gained powder, mixing, adds proper auxiliary materials, makes capsule.
Embodiment 7
Raw material: monarch drug: water soluble Margarita ultrafine powder 36 parts, Lepidinm meyenii Walp 34 parts, Fructus Rubi 30 parts; Ministerial drug: Pachyrhizua angulatus 28 parts, Concha Ostreae 24 parts, Resina persicae 11 parts, Semen setariae 9 parts, Semen Pruni 11 parts; Adjuvant: Fructus Citri Sarcodactylis 8 parts, female Bombycis mori 8 parts, Flos Camelliae Japonicae 13 parts, Endothelium Corneum Gigeriae Galli 9 parts.
Preparation method: (1) by Semen setariae, Resina persicae, female Bombycis mori, Endothelium Corneum Gigeriae Galli, superfine powder is broken into the powder of 80um, adds 9 times of water, stirs, be warming up to 60 degree, add 8 parts hydrolysis compound enzymes, react 2 hours, filtration, dry, pulverize to 80 order powder, for subsequent use;
(2) by above-mentioned (1) Chinese medicine slag and Lepidinm meyenii Walp, Fructus Rubi, Concha Ostreae, Semen Pruni, Pachyrhizua angulatus, Fructus Citri Sarcodactylis, Flos Camelliae Japonicae, is ground into coarse powder, adds 13 times of 80% ethanol, extracts 2 times, each 1.5 hours, filter, merging filtrate, dry, pulverize to 100 order powder, for subsequent use;
(3) added by water soluble Margarita ultrafine powder in above-mentioned (1) and (2) gained powder, mixing, adds proper auxiliary materials, makes tablet.1, acute toxicity test
Because this present composition prepared product toxicity is lower, do not measure LD50 by reagent, namely do the maximum dosage-feeding test of ig.Before ig administration, mice fasting can't help water 12 hours, after present composition prepared product is mixed with Cmax, 30 mices (♂ ♀ half and half) ig present composition prepared product respectively, observes the response situation of mice immediately after administration, and Continuous Observation 14 days, have no dead after administration.
2, long term toxicity test
Rat gives the continuous gavage of present composition prepared product 24 weeks, observes the 12nd week, 24 weeks and the toxic reaction situation of 2 weeks (26 weeks) rats after drug withdrawal.Rat is divided into 4 groups at random: namely matched group, present composition prepared product little, in, heavy dose of group (being equivalent to 25 times of quantity, 50 times, 100 times), ig administration, every day 2 times, continuous 24 weeks, when medication 12 weeks, 24 weeks and drug withdrawal recover 2 weeks, femoral artery blood-letting, execution animal, do index of correlation and detect.Result shows, and present composition prepared product Three doses continuous ig administration 24 weeks toxicity is humble, Clinical practice safety.
Its Pharmacodynamics result of study is as follows:
1, on the impact of mice hypnosis
Mice 50, is divided into 5 groups at random by body weight, matched group, stable group, the high, medium and low dosage group of prepared product of the present invention (dosage is about equivalent to 20,10,5 times of people's clinical equivalent dosage respectively).Often organize 10, after each group mice difference ig different pharmaceutical 30min, ip pentobarbital sodium 35mg/kg, with righting reflex loss 1min for sleep index, the sleep number of elements of mice in record 25min.Matched group is solvent.Result shows, the present invention more significantly increases hypnotic effect.
Table 1 is on the impact (x ± s) of mice hypnosis
2, on the impact of chloasma model mice
Get female KM mice, be divided into 6 groups respectively at random, often organize 10: normal, the high, medium and low dosage group of model control group, vitamin C matched group, prepared product of the present invention (dosage is about equivalent to 20,10,5 times of people's clinical equivalent dosage respectively).Normal group is by body weight intramuscular injection sterilizing pharmaceutical grade vegetable oil; Inject in mice hind leg muscle with Progesterone for all the other 5 groups, dosage is 20mg/kg Progesterone.Every morning once, two lower limb alternate injection, continuous 30 days.Animal every morning irradiation ultraviolet radiation 60 minutes simultaneously.Modeling starts to gavage corresponding medicine every afternoon simultaneously, continuous 30 days.After last administration, its mensuration antioxidative activities of the skin of ultraviolet radiation of learning from else's experience, Simultaneously test liver lipofuscin.Result shows, prepared product group antioxidative activities ability of the present invention is strong, and liver lipofuscin is low, is conducive to eliminating chloasma.
Table 2 is on the impact (x ± s) of chloasma model mice
* P<0.05 is compared, * * P<0.01 with model group
3, on the impact of high nutritional rabbit body weight
Select the Male New Zealand rabbits 50 of about body weight 2.0kg, be equally divided into 5 groups, normal group, model control group, the high, medium and low dosage group of prepared product of the present invention (dosage is about equivalent to 20,10,5 times of people's clinical equivalent dosage respectively).Normal group feeds normal diet, and model control group, the high, medium and low dosage component of prepared product of the present invention Wei high fat height nutrient fodders.The administration of each administration group mouse stomach, model control group gives respective amount continuous normal saline and feeds 45 days.After last administration, each group 12h on an empty stomach, claims its body weight; And measure its body long (nose is to the length of anus); Calculate the obesity index of rat.
result shows that the present invention can obviously suppress the body weight of fat rabbit to increase.
Table 3 on impact (x ± s)
* * P<0.01 is compared with blank group
4, on the impact of gonad cell apoptosis rate
Get 150 mices (separately staying 10 with batch mice as blank), with zona pellucida polypeptide for immunogen, abdomen injection, every 2 weeks 1 time, modeling.Select the close mice of body weight after modeling success and be divided into each administration group at random, often organize 20.The administration of each administration group mouse stomach, model control group gives respective amount normal saline, and successive administration 4 weeks rear normal sterile methods stay bilateral ovaries, and paraformaldehyde is fixed for subsequent use, adopts Tunnel method to detect the apoptosis number of granular cell.Result shows that the present invention can obviously suppress gonad cell apoptosis, prevents premature ovarian failure.
Table 5 is on the impact (x ± s) of gonad cell apoptosis rate
* * P<0.01 is compared, * P<0.05 with model group
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. a medicine-food two-purpose water-soluble pearl compound powder, is characterized in that being made up of the raw material of following weight portion:
Water soluble Margarita ultrafine powder 10 ~ 60 parts, Lepidinm meyenii Walp 10 ~ 60 parts, Fructus Rubi 13 ~ 55 parts, Pachyrhizua angulatus 15 ~ 50 parts, Concha Ostreae 11 ~ 41 parts, Resina persicae 5 ~ 20 parts, Semen setariae 4 ~ 17 parts, Semen Pruni 6 ~ 18 parts, Fructus Citri Sarcodactylis 3 ~ 15 parts, female Bombycis mori 4 ~ 15 parts, Flos Camelliae Japonicae 7 ~ 19 parts, Endothelium Corneum Gigeriae Galli 2 ~ 14 parts.
2. a kind of medicine-food two-purpose water-soluble pearl compound powder as claimed in claim 1, is characterized in that being made up of the raw material of following weight portion:
Water soluble Margarita ultrafine powder 16 ~ 52 parts, Lepidinm meyenii Walp 15 ~ 53 parts, Fructus Rubi 18 ~ 45 parts, Pachyrhizua angulatus 19 ~ 44 parts, Concha Ostreae 14 ~ 36 parts, Resina persicae 8 ~ 14 parts, Semen setariae 7 ~ 13 parts, Semen Pruni 9 ~ 15 parts, Fructus Citri Sarcodactylis 5 ~ 12 parts, female Bombycis mori 6 ~ 11 parts, Flos Camelliae Japonicae 10 ~ 16 parts, Endothelium Corneum Gigeriae Galli 5 ~ 11 parts.
3. a kind of medicine-food two-purpose water-soluble pearl compound powder as claimed in claim 1, is characterized in that being made up of the raw material of following weight portion:
Monarch drug: water soluble Margarita ultrafine powder 36 parts, Lepidinm meyenii Walp 34 parts, Fructus Rubi 30 parts; Ministerial drug: Pachyrhizua angulatus 28 parts, Concha Ostreae 24 parts, Resina persicae 11 parts, Semen setariae 9 parts, Semen Pruni 11 parts; Adjuvant: Fructus Citri Sarcodactylis 8 parts, female Bombycis mori 8 parts, Flos Camelliae Japonicae 13 parts, Endothelium Corneum Gigeriae Galli 9 parts.
4. the preparation method of a kind of medicine-food two-purpose water-soluble pearl compound powder as claimed in claim 1, is characterized in that comprising the steps:
(1) Semen setariae 4 ~ 17 parts is taken, Resina persicae 5 ~ 20 parts, female Bombycis mori 4 ~ 15 parts, Endothelium Corneum Gigeriae Galli 2 ~ 14 parts, superfine powder is broken into the powder of 10 ~ 500um, adds 8 ~ 12 times of water, stir, be warming up to 35 ~ 70 degree, add 3 ~ 15 parts of hydrolysis compound enzymes, react 1 ~ 5 hour, filter, dry, pulverize to 60 ~ 100 order powder, for subsequent use;
(2) by above-mentioned (1) Chinese medicine slag and Lepidinm meyenii Walp 10 ~ 60 parts, Fructus Rubi 13 ~ 55 parts, Concha Ostreae 11 ~ 41 parts, Semen Pruni 6 ~ 18 parts, Pachyrhizua angulatus 15 ~ 50 parts, Fructus Citri Sarcodactylis 3 ~ 15 parts, Flos Camelliae Japonicae 7 ~ 19 parts, is ground into coarse powder, adds 10 ~ 15 times of 10% ~ 90% ethanol, extract 2 times, each 1 ~ 3 hour, filter, merging filtrate, dry, pulverize to 60 ~ 100 order powder, for subsequent use;
(3) added by water soluble Margarita ultrafine powder 10 ~ 60 parts in above-mentioned (1) and (2) gained powder, mixing, adds proper auxiliary materials, makes tablet, capsule, granule, oral liquid.
5. be hydrolyzed compound enzyme as claimed in claim 4, it is characterized in that for bromelain: papain: aspergillus oryzae: the mixture of lactobacillus=1:0.6:2.6:0.9.
6. a kind of medicine-food two-purpose water-soluble pearl compound powder as described in claim 1-5 is applied in the health food preparing improving water flood, functions of removing chloasma, fat-reducing.
7. the application of a kind of medicine-food two-purpose water-soluble pearl compound powder as described in claim 1-5 in preparation treatment premature ovarian failure medicine.
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Application publication date: 20151216 |