CN104027378B - A skin external preparation composition containing flos Lonicerae vinegar extract - Google Patents
A skin external preparation composition containing flos Lonicerae vinegar extract Download PDFInfo
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- CN104027378B CN104027378B CN201310217917.2A CN201310217917A CN104027378B CN 104027378 B CN104027378 B CN 104027378B CN 201310217917 A CN201310217917 A CN 201310217917A CN 104027378 B CN104027378 B CN 104027378B
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention relates to a skin external composition containing honeysuckle vinegar extract, and more particularly, to a skin external composition containing honeysuckle vinegar extract, which has excellent effects of enhancing skin elasticity, shrinking pores, reducing sebum, and improving acne.
Description
Technical Field
The present invention relates to a skin external composition containing honeysuckle vinegar extract, and more particularly, to a skin external composition containing honeysuckle vinegar extract, which has excellent effects of enhancing skin elasticity, shrinking pores, reducing sebum, and improving acne.
Background
Vinegar is a kind of seasoning having a sour taste, and since it is produced by fermentation of acetic acid, it contains acetic acid and has been used as a stored food. The vinegar can be classified into brewed vinegar and synthetic vinegar according to the preparation method. The brewed vinegar is prepared by brewing method, and can be classified into grain vinegar, fruit vinegar, etc. according to different raw materials, or pure brewed vinegar and alcohol vinegar according to different fermentation processes. The synthetic vinegar is prepared by chemical process, including pure synthetic vinegar and brewed vinegar added with synthetic vinegar.
Honeysuckle, also known as lonicera japonica, belongs to perennial vines of the family loniceraceae, and is mainly distributed in east asia, korea, etc. The stem has the functions of clearing heat, detoxifying and sweating, so that the stem is used for treating cold and the like, and is used as a therapeutic agent for infectious hepatitis, sore and furuncle and the like.
As described in the present invention, honeysuckle flower has an excellent effect on the skin when it is used as a vinegar extract by acetic fermentation.
[ Prior art documents ]
[ patent document ]
Korean patent laid-open publication No. 10-2004-21589
Disclosure of Invention
Technical problem to be solved
The present inventors have found that the honeysuckle vinegar extract has excellent effects on enhancing skin elasticity, shrinking pores, reducing sebum, and improving acne, and thus have completed the present invention.
Therefore, it is an object of the present invention to provide a composition for external use on skin, which contains a vinegar extract of honeysuckle flower and has the effects of enhancing skin elasticity, shrinking pores, regulating sebum, and improving acne.
Technical scheme
In order to accomplish the above objects, the present invention provides a skin external composition for enhancing skin elasticity, which contains honeysuckle vinegar extract.
In addition, the present invention provides a skin external composition for shrinking pores, which contains the honeysuckle vinegar extract.
In addition, the present invention provides a skin external composition for reducing sebum, which contains a honeysuckle vinegar extract.
In addition, the present invention provides a skin external composition for improving acne, which contains honeysuckle vinegar extract.
The present invention provides a skin external composition for enhancing skin elasticity, which contains a honeysuckle vinegar extract.
The invention provides a skin external agent composition for shrinking pores, which contains honeysuckle vinegar extract.
The present invention provides a skin external composition for reducing sebum, which contains a honeysuckle vinegar extract.
The present invention provides a skin external composition for ameliorating acne, which contains a honeysuckle vinegar extract.
The external skin preparation composition of the present invention contains 0.001 to 90.0 wt% of the honeysuckle vinegar extract, based on the total weight of the composition.
The present invention provides a method for enhancing skin elasticity using a skin external preparation composition containing a honeysuckle vinegar extract.
The present invention provides a method for shrinking skin pores using a skin external preparation composition containing a honeysuckle vinegar extract.
The present invention provides a method for improving acne using a skin external composition containing a honeysuckle vinegar extract.
Advantageous effects
The composition of the present invention contains the honeysuckle vinegar extract, thereby being capable of providing effects of enhancing skin elasticity, shrinking pores, reducing sebum, and improving acne, and particularly provides a skin external composition having remarkably superior effects in enhancing skin elasticity, shrinking pores, reducing sebum, and improving acne, compared to a common honeysuckle extract.
Detailed Description
The composition for external application to the skin of the present invention contains a Honeysuckle (Lonicera japonica; Honeysuckle) vinegar extract as an active ingredient.
The honeysuckle used in the present invention is also called honeysuckle, which belongs to perennial vines of the family loniceraceae, and is mainly distributed in east asia such as korea. The stem has the functions of clearing heat, detoxifying and sweating, so that the stem is used for treating cold and the like, and is used as a therapeutic agent for infectious hepatitis, sore and furuncle and the like.
The honeysuckle of the invention can use all parts of plants such as roots, stems, leaves, flowers and the like, and can also use the whole plant (whole plant). The honeysuckle vinegar extract is a substance prepared by performing acetic fermentation on honeysuckle. In addition, the honeysuckle vinegar extract can be prepared by a saccharification process, an ethanol fermentation process and an acetic acid fermentation process.
In one embodiment of the present invention, the honeysuckle vinegar extract may be contained in an amount of 0.001 wt% or more, preferably 10.0 wt% or more, based on the total weight of the composition. In another embodiment of the present invention, the honeysuckle vinegar extract may be contained in an amount of 90.0 wt% or less, preferably 70.0 wt%, based on the total weight of the composition. In another embodiment of the present invention, the honeysuckle vinegar extract may be contained in an amount of 0.001 wt% or more and 90.0 wt% or less, more preferably 10.0 wt% or more and 70.0 wt% or less, based on the total weight of the composition. When the amount is less than 0.001 wt%, the effect cannot be sufficiently exhibited, and when the amount exceeds 90.0 wt%, the pH may be low, causing irritation.
The composition of the present invention can be used as a composition for external preparation for skin for enhancing skin elasticity. The composition has excellent effect in promoting collagen synthesis of skin, improving skin elasticity, improving skin sagging and sagging, and can provide wrinkle removing effect.
The composition of the present invention can be used as a skin external composition for shrinking pores and regulating sebum, and has excellent effects in suppressing excessive sebum secretion and reducing pore size when applied to the skin.
The composition of the present invention can be used as a composition for external skin preparations for ameliorating acne, has an excellent antibacterial effect against acne pathogens, and suppresses skin allergy
The effect of (2) is excellent.
The compositions of the invention may be formulated with a cosmetically or dermatologically acceptable medium or base. The preparation may be in any form suitable for topical administration, for example, in the form of a solution, gel, solid, paste, anhydrous product, emulsion obtained by dispersing an oil phase in an aqueous phase, suspension, microemulsion, microcapsule, fine particle or ionic (liposome) and non-ionic vesicle dispersion, or may be in the form of cream, lotion, emollient cream (lotion), powder, ointment, spray or Concealer (Concealer Stick). In addition, the foam may be used in the form of foam (foam) or in the form of an aerosol composition further containing a compressed propellant. These compositions may be prepared according to methods conventional in the art.
Furthermore, the composition according to the invention may contain adjuvants commonly used in the field of cosmetics or dermatology, i.e., fatty substances, organic solvents, solubilizers, concentrating agents, gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ionic or nonionic emulsifiers, fillers, metal ion complexing agents
Chelating agent, antiseptic, vitamins, blocker, wetting agent, essential oil
Dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or any other ingredient commonly used in cosmetics, etc. The amount of the adjuvant used is an amount generally used in the field of cosmetics or skin science.
In addition, the composition of the present invention may contain a substance for promoting skin absorption in order to enhance the skin-improving effect.
Hereinafter, the structure and effects of the present invention will be described more specifically by way of test examples and dosage forms. However, these test examples and dosage forms are only for the purpose of facilitating understanding of the present invention, and the scope of the present invention is not limited to the following test examples and dosage forms.
[ PREPARATION EXAMPLE 1] preparation of honeysuckle Vinegar extract
Vinasse
Preparation step (saccharification step)
Washing 20kg brown rice, soaking in 30kg mineral water (160 m rock water) for 5 hr, draining off water, picking wild flos Lonicerae, cutting, washing, and draining off water. Mixing the soaked brown rice and 9kg of honeysuckle, cooking for 25-35 minutes at the temperature of 90-110 ℃, and cooling to 60 ℃. In said coolingAdding 2kg of malt flour into brown rice, and saccharifying for 12 hr. Then 6kg of malt was added
Saccharifying at 30 deg.C for 48 hr to obtain Aspergillus
Activating, and mixing with the obtained rice wine
Placing into jar, adding 40kg mineral water (160 m rock water), blocking air from outside at 25 deg.C, discharging carbon dioxide, and maintaining for 72 hr to obtain distiller's grains.
Step of ethanol fermentation
Washing 13kg of brown rice, soaking in 20kg of water for one hour, draining off water, and steaming the remaining brown rice and 1kg of honeysuckle for 25-35 minutes at 90-110 deg.C to obtain steamed rice
. Adding the steamed rice and 9kg of flos Lonicerae into the distiller's grains, and fermenting with ethanol at 25 deg.C for 10-15 days.
Acetic acid fermentation step
To the fermented product obtained in the above step 2, after diluting with 1kg of water, one (aerobic) acetic acid fermentation was carried out at 27 ℃ for 2 months, during which the opening of the jar was closed with a cloth, but oxygen was allowed to enter the jar, and occasionally it was stirred to supply oxygen. The acidity (pH-230 SD pH) of the obtained fermented product was measured, and after confirming that the pH was 4 or more, the supernatant was separated and subjected to secondary aging at 5 to 20 ℃ in the shade. Then, the aged liquid is filtered to obtain the honeysuckle vinegar extract. The prepared honeysuckle vinegar extract was sterilized, bottled and stored in a cold dark place, and used in the following test.
Comparative preparation example 1 preparation of honeysuckle extract
The honeysuckle extract is prepared by mixing 19g of whole honeysuckle with 10g of butanediol and 71g of purified water, and extracting for 1 hour by heating. Thereafter, the mixture was centrifuged at 8000rpm at 15 ℃ for 30 minutes, and then filtered through filters of 3.00. mu.m, 1.2. mu.m, 0.7. mu.m and 0.45. mu.m, in that order. The extracted stock solution was suspended in an automatic mixer (Auto mixer) at 800rpm for 1 hour to contain 10% of butylene glycol to obtain a honeysuckle extract.
Example 1 and comparative examples 1 to 2
Using the above preparation example 1 and comparative preparation example 1, according to the compositions shown in table 1 below, example 1 and comparative examples 1 to 2 (unit: wt%) were prepared.
[ TABLE 1]
< preparation method >
(1) The aqueous phase components (1-9) were mixed uniformly at room temperature.
(2) Heating the ethanol phase component (10-13) to 50-55 ℃, and uniformly dissolving and mixing.
(3) The above (1) was added to the above (2) with stirring and dissolved uniformly.
[ test example 1] skin elasticity-improving effect
In order to confirm the skin elasticity improving effect according to the present invention, the following test was performed using example 1 and comparative examples 1 to 2. The results of measuring the effect of improving skin elasticity using a skin elasticity measuring instrument (Cutometer SEM575, C + keletronic co., germany) after applying each of example 1, comparative example 1 and comparative example 2 to the face 2 times a day (morning and evening) for 4 weeks by dividing 80 women aged 30 to 40 into 3 groups of 20 women, are shown in table 2. The results in table 2 represent the skin viscoelasticity (viscoelasticity) properties of the skin elasticity tester.
[ TABLE 2]
| Test substance | Skin elasticity effect |
| Example 1 | 0.66±0.10 |
| Comparative example 1 | 0.30±0.09 |
| Comparative example 2 | 0.42±0.09 |
The results in table 2 show that comparative example 2 containing a general honeysuckle extract exhibits a skin elasticity-enhancing effect of about 140% as compared with comparative example 1. However, in the case of example 1 containing the honeysuckle vinegar extract, the skin elasticity-enhancing effect was about 220% as compared with comparative example 1, and it was found that the effect was remarkably excellent.
[ test example 2] collagen synthesis-promoting Effect
Human fibroblasts were cultured in a 24-well (well) plate incubator and then replaced with media containing the honeysuckle vinegar extract of preparation example 1 and the ordinary honeysuckle extract of comparative preparation example 1, respectively, at concentrations as shown in table 3. On the third day of culture, 0.5ml of DMEM medium containing 10% fetal bovine serum was added to each well, followed by addition of 10. mu. Ci of L [2,3,4,5-3H]-proline. After 24 hours, the medium and cells distributed in each well were collected, washed with Trichloroacetic acid (TCA; Trichloroacetic acid) solution, added to 2 tubes, 1 unit/. mu.l of collagenase type I was added to 1 tube, incubated at 37 ℃ for 90 minutes, and the other tube was stored at 4 ℃. Thereafter, 0.05ml of trichloroacetic acid was added to all the test tubes, and after leaving at 4 ℃ for 20 minutes, they were placed at 12,000rpm, respectivelyAfter centrifugation for 10 minutes, the counts Per Minute (CPM; Count Per Minute) of the radiation of the supernatant and the precipitate were determined by a Liquid Scintillation Counter (LSC), and the Collagen Biosynthesis ratio (RCB; Relative Collagen Biosynthesis) was measured for the control group and the experimental group according to the following equation 1, and the results are shown in Table 3.
[ mathematical formula 1]
[ TABLE 3]
As can be seen from the results of table 3, comparative example 3 treated with the general honeysuckle extract showed a collagen biosynthesis ratio of about 120% compared to the control group, while example 2 treated with the honeysuckle vinegar extract showed a collagen biosynthesis ratio of 152% compared to the control group, thereby showing significantly superior efficacy.
[ test example 3] sensory evaluation of wrinkle-removing efficacy
The degrees of wrinkle-removing effect feeling were evaluated by questionnaire according to the following evaluation criteria for 4 weeks after starting the use of 20 women aged 25 to 35 who suffered from skin sagging using the lotions of example 1 and comparative examples 1 to 2 according to the method of use of ordinary lotions, respectively.
< evaluation criteria >
+++: has very good improvement effect.
++: has appropriate improving effect.
+: has weak improvement effect.
+ -: although the effect was not improved, the effect was not deteriorated.
-: the effect is not improved, but rather worsened.
[ TABLE 4]
In the results of said table 4, example 1 containing the honeysuckle vinegar extract of the present invention shows rapid and excellent wrinkle removal efficacy, compared to comparative example 1 containing no extract at all, and comparative example 2 containing the general honeysuckle extract.
[ test example 4] pore size reduction efficacy
23 women aged 30 or older who suffered from pores were selected, example 1 was applied to the site where pores were evident every day for 2 weeks, the pore size was measured by the skin contact (manufacturing company: True system) pore analysis program at intervals of 1 week before and after the start of the experiment, and the average pore size was classified into 3 grades by the pore analysis program, and the number of people in each grade group was measured, with the results shown in table 5.
[ TABLE 5]
As can be seen from the results in table 5, the composition of the present invention can effectively reduce the size of pores.
Test example 5 sensory evaluation of pore-reducing Effect
The results of using the lotions of examples 1 and comparative examples 1 to 2 for 20 women aged 25 to 35 who suffered from large pores for 4 weeks according to the method of using the ordinary lotion, and judging the degree of skin improvement according to the following evaluation criteria according to the user's opinion are shown in table 6.
< evaluation criteria >
+++: has very good improvement effect.
++: has appropriate improving effect.
+: has weak improvement effect.
+ -: although the effect was not improved, the effect was not deteriorated.
-: the effect is not improved, but rather worsened.
[ TABLE 6]
In the results of table 6 above, example 1 containing the honeysuckle vinegar extract showed a rapid and excellent pore-reducing effect, compared to comparative example 1 containing no honeysuckle vinegar extract and comparative example 2 containing a common honeysuckle extract.
[ test example 6] confirmation of sebum-reducing efficacy of honeysuckle vinegar extract
10 male and female testers of 20-30 years old who felt abundant sebum secretion were selected, and the above example 1 was applied to the facial area with abundant sebum every day for 4 weeks. The results of measuring the amount of sebum before the start of the test, after 2 weeks and 4 weeks after the test using a skin oil analyzer (Sebumeter SM 810) are shown in table 7.
[ TABLE 7]
From the results of table 7, it was confirmed that the composition of the present invention can effectively suppress sebum.
[ test example 7] evaluation of efficacy of acne ameliorating Effect
20 women aged 19 to 26 years who had a pink tingle were treated with the lotions of examples 1 and comparative examples 1 to 2 for 4 weeks according to the usual method of use of the lotions, and the degree of skin improvement was judged according to the following evaluation criteria according to the user's opinion, and the results are shown in Table 8 below.
< evaluation criteria >
+++: has very good improvement effect.
++: has appropriate improving effect.
+: has weak improvement effect.
+ -: although the effect was not improved, the effect was not deteriorated.
-: the effect is not improved, but rather worsened.
[ TABLE 8 ]
In the results of table 8 above, example 1 containing the honeysuckle vinegar extract showed a rapid and excellent acne skin improvement effect compared to comparative example 1 containing no honeysuckle vinegar extract and comparative example 2 containing a general honeysuckle extract.
Claims (9)
1. A skin external composition for enhancing skin elasticity contains honeysuckle vinegar extract obtained by saccharification process, ethanol fermentation process and acetic acid fermentation process as effective component.
2. A skin external composition for reducing pores contains honeysuckle vinegar extract obtained by saccharification process, ethanol fermentation process and acetic acid fermentation process as effective component.
3. A skin external composition for reducing sebum contains honeysuckle vinegar extract obtained by saccharification process, ethanol fermentation process and acetic acid fermentation process as effective component.
4. A skin external composition for improving acne contains honeysuckle vinegar extract obtained by saccharification process, ethanol fermentation process and acetic acid fermentation process as effective component.
5. The composition for external application to skin as claimed in any one of claims 1 to 4, wherein the honeysuckle vinegar extract is contained in an amount of 0.001 to 90.0 wt% based on the total weight of the composition.
6. A method for enhancing skin elasticity using a skin external composition containing a honeysuckle vinegar extract prepared by a saccharification process, an ethanol fermentation process and an acetic acid fermentation process as an effective ingredient, wherein the method is for non-therapeutic use.
7. A method for shrinking skin pores using a skin external composition containing a honeysuckle vinegar extract prepared through a saccharification process, an ethanol fermentation process and an acetic acid fermentation process as an effective ingredient, wherein the method is used for non-therapeutic purposes.
8. A method for reducing sebum on skin using a composition for external use for skin comprising honeysuckle vinegar extract as an effective ingredient, which is prepared by a saccharification process, an ethanol fermentation process and an acetic acid fermentation process, wherein the method is used for non-therapeutic use.
9. A method for improving acne using a skin external composition containing honeysuckle vinegar extract prepared by saccharification process, ethanol fermentation process and acetic acid fermentation process as an effective ingredient, wherein the method is for non-therapeutic use.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020130024585A KR102070662B1 (en) | 2013-03-07 | 2013-03-07 | Skin external composition comprising Lonicera japonica vinegar extract |
| KR10-2013-24585 | 2013-03-07 |
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| CN104027378A CN104027378A (en) | 2014-09-10 |
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| JP (1) | JP6271159B2 (en) |
| KR (1) | KR102070662B1 (en) |
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| KR102031723B1 (en) * | 2017-12-07 | 2019-10-14 | 김영미 | Cosmetic composition for acne improvement comprising black vinegar and niacinamide |
| KR101930264B1 (en) | 2018-07-16 | 2018-12-18 | 주식회사 코스메카코리아 | Cosmetic composition for inhibiting secretion of sebum and for improving acne symptoms containing natural complex extract |
| KR102079310B1 (en) * | 2019-05-20 | 2020-02-19 | (주)아모레퍼시픽 | Skin external composition comprising Lonicera japonica vinegar extract |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406589A (en) * | 2011-11-19 | 2012-04-11 | 大连得达科技发展有限公司 | Bacteriocidal and bacteriostatic soaking bath cream |
| CN102499974A (en) * | 2011-12-28 | 2012-06-20 | 张步天 | Medicament for inhibiting skin fungi and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54145226A (en) * | 1978-04-28 | 1979-11-13 | Maanaa Kosumechitsukusu Kk | Cosmetics |
| JPS61254180A (en) * | 1985-05-02 | 1986-11-11 | Tomohiko Fukuda | Production of food vinegar |
| FR2715845B1 (en) * | 1994-02-04 | 1996-03-29 | Oreal | Cosmetic and / or dermatological composition containing vinegar. |
| WO2002072040A1 (en) | 2001-03-13 | 2002-09-19 | Ajinomoto Co., Inc. | Comsetics or external preparaiotns for skin |
| JP2004217584A (en) * | 2003-01-16 | 2004-08-05 | Naris Cosmetics Co Ltd | Skin care preparation for external use |
| JP2006320308A (en) * | 2005-04-19 | 2006-11-30 | Yuho:Kk | Method for producing animal/plant extract solution, animal/plant extract solution, and health drink, food, cosmetic or drug containing the animal/plant extract solution |
| US20090246153A1 (en) * | 2008-03-28 | 2009-10-01 | Nu Skin International, Inc. | Cosmetic compositions for the inhibition of reactive oxygen species |
| JP5791879B2 (en) * | 2010-06-22 | 2015-10-07 | 三省製薬株式会社 | NF-κB activation inhibitor and pore care agent |
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2013
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- 2013-06-03 JP JP2013116871A patent/JP6271159B2/en active Active
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406589A (en) * | 2011-11-19 | 2012-04-11 | 大连得达科技发展有限公司 | Bacteriocidal and bacteriostatic soaking bath cream |
| CN102499974A (en) * | 2011-12-28 | 2012-06-20 | 张步天 | Medicament for inhibiting skin fungi and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 金银花蒲公英合白酒治疗复发性皮肤疖肿;陈平虎;《新疆中医药》;20020825;第20卷(第4期);第41-42页 * |
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| JP6271159B2 (en) | 2018-01-31 |
| KR20140110375A (en) | 2014-09-17 |
| KR102070662B1 (en) | 2020-01-29 |
| CN104027378A (en) | 2014-09-10 |
| JP2014172905A (en) | 2014-09-22 |
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