CN104023700A - 含溶解的厚朴酚类似物和ppg-1-peg-9月桂二醇醚的口腔护理或清洁剂组合物 - Google Patents
含溶解的厚朴酚类似物和ppg-1-peg-9月桂二醇醚的口腔护理或清洁剂组合物 Download PDFInfo
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Abstract
一种含有溶解的厚朴酚类似物的组合物,所述组合物包含至少一种选自丙基厚朴酚、异丙基厚朴酚、丁基厚朴酚和异丁基厚朴酚的厚朴酚类似物和PPG-1-PEG-9月桂二醇醚。这些溶解的类似物可用于个人护理、口腔护理与家庭护理组合物中以提供抗菌活性并减少促炎介质表达。
Description
技术领域
本发明公开了一种溶解的厚朴酚类似物。
背景技术
已知例如丙基厚朴酚、异丙基厚朴酚、丁基厚朴酚和异丁基厚朴酚等厚朴酚类似物具有抗菌活性,它们还显示出能够降低在口腔组织中促炎介质的表达。使用这些厚朴酚类似物的问题是它们在典型的个人护理、口腔护理或家庭护理组合物中的溶解度。它们的使用受限于它们的溶解度。需要溶解这些类似物以增加它们在个人、口腔或家庭护理组合物中的用途。问题是寻找可以溶解这些类似物的材料。即便在某一类给定的材料中,也并不是该类材料中的所有成分都能有效溶解这些类似物。
发明简述
本发明提供含有溶解的厚朴酚类似物的组合物,所述组合物包含至少一种选自丙基厚朴酚、异丙基厚朴酚、丁基厚朴酚和异丁基厚朴酚的厚朴酚类似物和PPG-1-PEG-9月桂二醇醚。所述组合物可任选进一步含有椰油醇聚醚-7和PEG-40氢化篦麻油。
本发明的其他应用领域将通过下文提供的详细描述而变得显而易见。但应当理解的是,虽然详细描述和具体实施例给出了本发明的优选实施方案,但它们仅用于举例说明的目的,而非用于限制本发明的范围。
发明详述
下面描述的优选实施方案仅仅用于示例说明,而决无意于限制本发明、其应用或用途。
本发明公开了一种含有溶解的厚朴酚类似物的组合物,所述组合物包含至少一种选自丙基厚朴酚、异丙基厚朴酚、丁基厚朴酚和异丁基厚朴酚的厚朴酚类似物和PPG-1-PEG-9月桂二醇醚。
丙基厚朴酚是5,5′-二正丙基联苯-2,2′-二酚,丁基厚朴酚是5,5′-二正丁基联苯-2,2′-二酚,异丙基厚朴酚是5,5′-二异丙基联苯-2,2′-二酚,异丁基厚朴酚是5,5′-二异丁基联苯-2,2′-二酚。
PPG-1-PEG-9月桂二醇醚能溶解高达每升100克纯的丙基厚朴酚或异丙基厚朴酚,或高达每升50克丁基厚朴酚或异丁基厚朴酚。在某些实施方式中,所述组合物中PPG-1-PEG-9月桂二醇醚的量为丙基厚朴酚或异丙基厚朴酚重量的至少10倍。在某些实施方式中,所述组合物中PPG-1-PEG-9月桂二醇醚的量为丁基厚朴酚或异丁基厚朴酚重量的至少20倍。
PPG-1-PEG-9月桂二醇醚可使用Cognis公司的EumulginTM L。
PPG-1-PEG-9月桂二醇醚还可与椰油醇聚醚-7和PEG-40氢化篦麻油结合使用。这种结合可使用Cognis公司的EumulginTM HPS。当使用这种结合时,除丁基厚朴酚以外,其它能保持同样的溶解度水平。相对于单独PPG-1-PEG-9月桂二醇醚最高每升50克的溶解度,这种结合能溶解相当于100克每升丁基厚朴酚。在某些实施方式中,这种结合的量是丁基厚朴酚重量的至少10倍。
这两种物质可以溶解这些类似物是令人感到意外的。很多其它增溶剂,例如PEG-7椰油酸甘油酯,泊洛沙姆124,PPG-2羟乙基椰油酰胺,PPG-5月桂醇聚醚-5(EumulginTM ES),PEG-8/SMDI共聚物,肉豆蔻酸异丙酯,或C12-15烷基苯甲酸酯不能够溶解异丁基厚朴酚。
在所述组合物中厚朴酚类似物的量可以是任意所需的量。在某些实施方案中,厚朴酚类似物的量为组合物的0.01至5重量%。在其它实施方案中,厚朴酚类似物的量为组合物的至少0.05、至少0.1、至少0.2、至少0.3、至少0.4、至少0.5或至少1重量%,最高可达5重量%。在其它实施方案中,厚朴酚类似物的量为组合物的前述最小量至最高达4、3、2、1重量%。PPG-1-PEG-9月桂二醇(PPG-1-PEG-9lauryl glyco1)或PPG-1-PEG-9月桂二醇醚、椰油醇聚醚-7和PEG-40氢化篦麻油的结合的重量是为溶解所述类似物的量,PPG-1-PEG-9月桂二醇或PPG-1-PEG-9月桂二醇醚、椰油醇聚醚-7和PEG-40氢化篦麻油的结合的最少用量基于所述类似物在所述PPG-1-PEG-9月桂二醇或PPG-1-PEG-9月桂二醇醚、椰油醇聚醚-7和PEG-40氢化篦麻油的结合中的最大溶解度计。在某些实施方案中,厚朴酚类似物的量为0.1%重量,0.2%重量,0.3%重量,0.4%重量,或0.5%重量。
这些溶解的类似物可用于个人护理、口腔护理和家庭护理组合物中。个人护理组合物的例子包括但不限于,沐浴露/沐浴凝胶、液体洗手液、条皂、香波、调理剂、止汗剂/除臭剂和化妆品。口腔护理组合物的例子包括但不限于,洁齿剂、牙膏、牙粉、预防性糊剂、漱口液、锭剂、树胶、凝胶、涂料、糖果和假牙清洁剂。可包含所述溶解的厚朴酚类似物的口腔护理组合物的例子可参见WO2011/106492。家庭护理组合物的例子包括但不限于,洗盘洗洁精、洗盘糊剂、硬表面清洁剂、织物调理剂和洗衣剂。
在某些实施方案中,所述厚朴酚类似物可存在于沐浴露/沐浴凝胶、液体洗手液或香波中,其中这些组合物中的每一种包括表面活性剂。所述厚朴酚类似物还可包含在皂(脂肪酸皂)中,其可以是条皂的形状。
实施例
下面为可包括溶解的厚朴酚类似物的组合物的非限定性实施例。
液体清洁剂(沐浴露或洗手液)
口腔护理组合物
贯穿本发明整篇说明书和权利要求书所提及的范围用于描述在该范围内的每一个值。所述范围内的任意值可被选作该范围的端点。此外,本文引用的所有参考文献均通过全文引用结合到本文中。在本发明公开的定义和所引用的参考有冲突时,以本发明的公开为准。
除非另有说明,在本发明书中各处所表示的所有百分数和量应理解是指重量百分比。给出的量是基于物质的活性重量计。
Claims (10)
1.含有溶解的厚朴酚类似物的组合物,所述组合物包含:
至少一种选自丙基厚朴酚、异丙基厚朴酚、丁基厚朴酚和异丁基厚朴酚的厚朴酚类似物;和
PPG-1-PEG-9月桂二醇醚。
2.前述权利要求中任一项的组合物,其中所述厚朴酚类似物在所述组合物中的存在量为0.01-5%重量。
3.前述权利要求中任一项的组合物,所述组合物进一步含有椰油醇聚醚-7和PEG-40氢化篦麻油。
4.前述权利要求中任一项的组合物,其中所述PPG-1-PEG-9月桂二醇醚的存在量为丙基厚朴酚或异丙基厚朴酚重量的至少10倍,或是丁基厚朴酚或异丁基厚朴酚重量的至少20倍。
5.权利要求3的组合物,其中所述PPG-1-PEG-9月桂二醇醚、椰油醇聚醚-7和PEG-40氢化篦麻油的存在量为丙基厚朴酚,异丙基厚朴酚或丁基厚朴酚重量的至少10倍,或是异丁基厚朴酚重量的至少20倍。
6.前述权利要求中任一项的组合物,所述组合物进一步含有表面活性剂。
7.前述权利要求中任一项的组合物,所述组合物进一步含有皂。
8.权利要求7的组合物,所述组合物是皂条的形式。
9.如权利要求6所述的组合物,所述组合物是液体清洁剂的形式。
10.权利要求1-6中任一项的组合物,所述组合物是口腔护理组合物的形式。
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TWI459957B (zh) * | 2010-02-24 | 2014-11-11 | Colgate Palmolive Co | 口腔保健組成物 |
WO2011106003A1 (en) | 2010-02-25 | 2011-09-01 | Colgate-Palmolive Company | Synthesis of magnolol and its analogue compounds |
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- 2011-12-15 CA CA2857648A patent/CA2857648A1/en not_active Abandoned
- 2011-12-15 RU RU2014128793A patent/RU2014128793A/ru not_active Application Discontinuation
- 2011-12-15 MY MYPI2014701380A patent/MY194692A/en unknown
- 2011-12-15 MX MX2014007136A patent/MX337702B/es active IP Right Grant
- 2011-12-15 US US14/362,892 patent/US9155693B2/en active Active
- 2011-12-15 WO PCT/US2011/065020 patent/WO2013089718A1/en active Application Filing
- 2011-12-15 EP EP11811222.6A patent/EP2790651B1/en active Active
- 2011-12-15 AU AU2011383310A patent/AU2011383310B2/en active Active
- 2011-12-15 CN CN201180075556.1A patent/CN104023700B/zh not_active Expired - Fee Related
- 2011-12-15 KR KR1020147016044A patent/KR20140112481A/ko not_active Application Discontinuation
-
2014
- 2014-06-05 PH PH12014501267A patent/PH12014501267A1/en unknown
- 2014-06-06 ZA ZA2014/04201A patent/ZA201404201B/en unknown
Patent Citations (5)
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CN1441664A (zh) * | 2000-05-10 | 2003-09-10 | 高露洁-棕榄公司 | 协同抗牙菌斑/抗龈炎口腔组合物 |
CN101321560A (zh) * | 2005-12-02 | 2008-12-10 | Gic创新公司 | 具有快速释放的厚朴提取物的咀嚼性组合物 |
CN101321513A (zh) * | 2005-12-02 | 2008-12-10 | Gic创新公司 | 具有厚朴提取物的口腔护理用介质 |
CN101460134A (zh) * | 2006-03-29 | 2009-06-17 | Wm.雷格利Jr.公司 | 含有厚朴提取物和精油的协同组合的口气清新和口腔清洁产品 |
WO2011106492A1 (en) * | 2010-02-24 | 2011-09-01 | Colgate-Palmolive Company | Oral care compositions |
Also Published As
Publication number | Publication date |
---|---|
CN104023700B (zh) | 2015-10-07 |
ZA201404201B (en) | 2016-10-26 |
EP2790651B1 (en) | 2016-03-16 |
US20140348761A1 (en) | 2014-11-27 |
BR112014014609B1 (pt) | 2018-06-05 |
CA2857648A1 (en) | 2013-06-20 |
MY194692A (en) | 2022-12-15 |
US9155693B2 (en) | 2015-10-13 |
KR20140112481A (ko) | 2014-09-23 |
RU2014128793A (ru) | 2016-02-10 |
AU2011383310B2 (en) | 2014-08-07 |
AU2011383310A1 (en) | 2014-05-22 |
PH12014501267A1 (en) | 2014-09-08 |
MX337702B (es) | 2016-03-15 |
WO2013089718A1 (en) | 2013-06-20 |
BR112014014609A2 (pt) | 2017-06-13 |
EP2790651A1 (en) | 2014-10-22 |
MX2014007136A (es) | 2014-09-04 |
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