CN104013780A - Traditional Chinese medicine composition, traditional Chinese medicine preparation process and application of traditional Chinese medicine in field of veterinary medicament - Google Patents
Traditional Chinese medicine composition, traditional Chinese medicine preparation process and application of traditional Chinese medicine in field of veterinary medicament Download PDFInfo
- Publication number
- CN104013780A CN104013780A CN201410295751.0A CN201410295751A CN104013780A CN 104013780 A CN104013780 A CN 104013780A CN 201410295751 A CN201410295751 A CN 201410295751A CN 104013780 A CN104013780 A CN 104013780A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- radix
- rhizoma
- powder
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition prepared from the following raw materials in parts by weight: 1-50 parts of motherwort herb, 0.5-10 parts of rhodiola rosea, 1-50 parts of Chinese paris rhizome, 1-50 parts of prepared kusnezoff monkshood root, 3-60 parts of common yam rhizome, 0.5-10 parts of hellebore, 0.5-20 parts of psammosilene tunicoides and 0.01-5 parts of borneol. The invention also discloses a preparation process of the traditional Chinese medicine and an application of the traditional Chinese medicine in preparing veterinary medicaments mainly used for treating postpartum trauma rehabilitation of female livestock and veterinary medicaments mainly used for treating common diseases suffered by the female livestock in postpartum and suckling periods. The traditional Chinese medicine composition disclosed by the invention is a natural plant prescription medicament, and can not generate medicament-resistant strains in use, so that the traditional Chinese medicine composition can be used for partially replacing antibiotics; the popularization and application of the traditional Chinese medicine composition are beneficial for slowing down the troubles of antibiotic misuse in breeding industry of our country.
Description
Technical field
The present invention relates to technical field of animal remedy preparation, particularly a kind of Chinese medicine composition, preparation technique of traditional Chinese medicine and this Chinese medicine are in the application of field of veterinary.
Background technology
In cultivation industry, the incidence rate of female animal puerperal disease is very high, and inducement is numerous and diverse, is the important problem that restriction aquaculture develops rapidly.The adverse consequences of female animal various diseases post-partum period can threat to life, when impact is produced and causes sterile especially genitals occur damage and be inflamed, pathogenic microorganism is often invaded blood circulation city by infection focus even pyemia of bacteremia, septicemia is occurred.Yet, because the female animal premunition of post-partum period declines, come from the focus at other position, as mammary gland, hoof, reticulum wound and other wound etc., can be on the basis of focal traumatic infection, and then develop into septicemia.And the urogenital tract infection of this one-phase, as vaginal orifice inflammation, vaginitis and endometritis etc., may transfer chronic or recessive inflammation to, thereby cause the change of reproductive tract functional structure and interior environment to make female animal generation sterile later.Thereby, how to tackle in the development that female animal puerperal disease cultivates industry at home and be extremely important.
For now, the disease that often takes a disease the rehabilitation of female animal wound in puerperal and puerperal and age of sucking, solution is to treat with multiple antibacterials mostly clinically, there is no at present the clinical practice that good Chinese patent medicine provides such wound and disease.Because abuse of antibiotics causes producing drug resistance pathogen bacterial strain, the superbacteria of even evolving out, will increase treatment difficulty once humans and animals is sick, even causes humans and animals to past medical help to some diseases.Within 2006, European Union forbids antibiotic comprehensively, causes the follow-up follow-up of other countries.Due to China's cultivation industry ubiquity abuse of antibiotics, cause export trade difficulty, also domestic food is affected greatly safely.In order to export needs, also, for compatriots' health, searching safety, green, efficient antibiotic succedaneum have become the problem that China's aquaculture needs most breakthrough.
Summary of the invention
The invention provides a kind of Chinese medicine composition, its main purpose is to solve the defect that existing use antibiotic is tackled the generation drug resistance pathogen bacterial strain of female animal puerperal disease existence, and develops a kind of natural plants prescription medicine that can play the effect of substitute antibiotics and can not produce endurance strain.
For solving the problems of the technologies described above, the present invention adopts following technical scheme:
A Chinese medicine composition, its raw material by following weight portion is made: Herba Leonuri 1～50 weight portion; Radix Rhodiolae 0.5～10 weight portion; Rhizoma Paridis 1～50 weight portion; Radix Aconiti Kusnezoffii Preparata 1～50 weight portion; Rhizoma Dioscoreae 3～60 weight portions; Rhizoma et radix veratri (Radix Rhizoma Veratri) 0.5～10 weight portion; Radix Psammosilenes 0.5～20 weight portion; Borneolum Syntheticum 0.01～5 weight portion.
Chinese medicine composition of the present invention is under Chinese medical theory instructs; achievement in research in conjunction with modern Chinese medicine pharmacy to the disease that often takes a disease the rehabilitation of female animal wound in puerperal, female animal puerperal and age of sucking; in conjunction with applicant's research practice experience for many years; filter out following various crude drug; according to theory of Chinese medical science prescription, according to certain weight prescription, form.
Wherein Herba Leonuri is the fresh or dry aerial parts of labiate Herba Leonuri Leonurus japonicus Houtt..Fresh goods Seedling Stage in spring to first summer flower is tapped in earlier stage; Dry product stem and leaf in summer is luxuriant, Hua Weikai or just Kai Shicai cut open, dry, or cutting is dried.The effect of Herba Leonuri is: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.Cure mainly placenta retention, lochiorrhea, leukorrhagia, edema oliguria.
Radix Rhodiolae is Crassulaceae Rhodida plant Radix Rhodiolae Rhodiolasaera(Prain) dry rhizome of Fu, with all herbal medicine.Gather 9～October, cleans and dry.The effect of Radix Rhodiolae is: clearing away lung-heat to relieve cough, hemostasis, leukorrhagia stopping.For cough due to lung-heat, spitting of blood, leucorrhea; Traumatic injury is controlled in external, burn and scald.
Rhizoma Paridis is the dry rhizome of liliaceous plant Rhizoma Paridis Paris yunnanensis Franch. or seven leaves-branch flower.Excavate autumn, removes fibrous root, cleans, and dries.The effect of Rhizoma Paridis is: heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.Cure mainly cough due to lung-heat, laryngopharynx swelling and pain, venom, sore swollen toxin, traumatic injury, convulsion with spasms.
Radix Aconiti Kusnezoffii is the dried root of ranunculaceae plant Aconitum kusnezoffii Reichb Aconitum kusnezoffii Reichb..Excavate when stem and leaf is withered autumn, removes fibrous root and silt, dry.Radix Aconiti Kusnezoffii Preparata is exactly the Radix Aconiti Kusnezoffii through Preparation process, and toxicity is large less than Radix Aconiti Kusnezoffii.The effect of Radix Aconiti Kusnezoffii Preparata is: expelling wind and removing dampness, antalgic.Cure mainly rheumatic arthralgia, contracture pain, carbuncle is not burst, furuncle from the beginning of.
Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb., and winter, stem and leaf was excavated after withering, and cut root head, cleaned, and removed crust and fibrous root, after smoking with sulfur, dry; Also have and select fertile too straight dry Rhizoma Dioscoreae, put in clear water, be dipped into without the dry heart, vexed, smoked with sulfur after, trim two ends, with plank, be twisted into cylindricly, dry polishing, habit title " light yam ".The effect of Rhizoma Dioscoreae is: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Cure mainly weakness of the spleen and stomach, inappetence, diarrhea due to hypofunction of the spleen, asthenia cough with asthma, spermatorrhea, leukorrhagia, frequent micturition number.
Rhizoma et radix veratri (Radix Rhizoma Veratri) is Liliaceae Veratrum Rhizoma et radix veratri (Radix Rhizoma Veratri) VeratrumnigrumL., with root or whole herb with root, is used as medicine.Excavate root before taking out scape 5～6 the end of month, removes aerial parts, cleans and dry.The effect of Rhizoma et radix veratri (Radix Rhizoma Veratri) is: emetic, and the expectorant that dispels the wind, removing toxic substances, parasite killing.Cure mainly middle wind-phlegm and stop up, epilepsy, scabies.
Radix Psammosilenes is Caryophyllaceae Radix Psammosilenes platymiscium Radix Psammosilenes Psammosilene tunicoides W. C. Wu et C. Y. Wu., with root, is used as medicine.Autumn and winter uproot, and scrape off crust, dry standby.The effect of Radix Psammosilenes is: expelling wind and activating blood circulation, eliminating stasis to stop pain.Cure mainly traumatic injury, rheumatalgia, stomachache; Wound hemorrhage is controlled in external.
Borneolum Syntheticum is the natural crystallinity compound of separating out in the resin of Spore density borneo camphor tree.Borneolum Syntheticum, from the crack of Borneolum Syntheticum trunk, is taked dry resin, processes.Or cut down trunk and branch, cut into pieces, through vapor distillation distillation, after cooling crystallization.The effect of Borneolum Syntheticum is: sensible refreshment, heat-clearing and fire-dispersing, reducing swelling and alleviating pain.Cure mainly coma and faint from fear, laryngopharynx swelling and pain, heat in the heart tongue boil, conjunctival congestion cataracta, sore swollen toxin.
A preparation technology for above-mentioned Chinese medicine composition, comprises the following steps: a, selection are cleaned: Herba Leonuri, Radix Rhodiolae, Rhizoma Paridis, Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Radix Psammosilenes and Borneolum Syntheticum are chosen respectively to decontamination, clean up respectively; B, dry broken: ready medical material in step a is dried respectively, then pulverizes respectively and sieve; C, by proportioning, mix: by each medicinal powder of processing through step a and step b respectively and drawing according to combination matching mix homogeneously.
Preferably, the process of preparing Chinese medicine of described Rhizoma Paridis and processing comprise the following steps: 1, choose decontamination foreign body, clean, cut into slices; 2, under the condition that is 8-14 with lime water at pH, soak 12-48 hour, continue extremely neutral with clear water rinsing, circulation steam sterilization at least 30 minutes; 3, under the environment of 80-90 ℃, be dried, after being dried, pulverize and sieve, after sieving, can obtain Rhizoma Paridis powder.
Preferably, the process of preparing Chinese medicine and the processing of described Radix Aconiti Kusnezoffii Preparata comprise the following steps: 1, by processing the bubble Radix Aconiti Kusnezoffii slice, thin piece of processing, clean, choose decontamination, and 2, under the environment of 80-90 ℃, be dried, pulverize and sieve after dry, after sieving, can obtain Radix Aconiti Kusnezoffii Preparata powder; The process of preparing Chinese medicine and the processing of described Rhizoma et radix veratri (Radix Rhizoma Veratri) comprise the following steps: 1, choose decontamination foreign body, after removing the Rhizoma et radix veratri (Radix Rhizoma Veratri) grass fibrous root of bulb, with clear water, clean, 2, under the environment of 80-90 ℃, be dried, after being dried, pulverize and cross 100 mesh sieves, after sieving, can obtain Rhizoma et radix veratri (Radix Rhizoma Veratri) powder.
Preferably, the process of preparing Chinese medicine and the processing of described Radix Psammosilenes comprise the following steps: 1, choose decontamination foreign body, the Radix Psammosilenes except removing LU is cleaned; 2, use circulation steam sterilization at least 30 minutes; 3, under the environment of 80-90 ℃, be dried, after being dried, pulverize and sieve, after sieving, can obtain Radix Psammosilenes powder.
Preferably, the process of preparing Chinese medicine of described Rhizoma Dioscoreae and processing comprise the following steps: 1, choose decontamination foreign body; 2, under the environment of 80-90 ℃, dry to water content till below 6%; 3, after oven dry, pulverize and sieve, after sieving, can obtain Rhizoma Dioscoreae powder.
Preferably, the process of preparing Chinese medicine and the processing of described Radix Rhodiolae comprise the following steps: 1, choose decontamination foreign body, clean, sterilizing, and 2,80-90 ℃ of oven dry, 3, pulverize and cross 100 mesh sieves after drying, after sieving, can obtain Radix Rhodiolae powder; The process of preparing Chinese medicine and the processing of described Herba Leonuri comprise the following steps: 1, choose decontamination foreign body, clean, sterilizing; 2,80-90 ℃ of oven dry; 3, after oven dry, pulverize and cross 100 mesh sieves, after sieving, can obtain motherwort powder.
Preferably, the process of preparing Chinese medicine and the processing of described Borneolum Syntheticum comprise the following steps: put in mortar, be added with 90% ethanol and grind, excessively after 80 mesh sieves, can obtain borneol powder.
The application of a kind of above-mentioned Chinese medicine composition in preparing anti-inflammatory analgesic veterinary drug, hemostasia and promoting granulation veterinary drug, antiviral Antibacterial medicines.
A kind of above-mentioned Chinese medicine composition preparation cure mainly the rehabilitation of female animal wound in puerperal veterinary drug, cure mainly the application in the veterinary drug of the disease that often takes a disease female animal puerperal and age of sucking.
Preferably, cure mainly the rehabilitation of the wounds such as female animal atony of uterus in puerperal, placenta retention, hemorrhage and congestion.
Preferably, cure mainly the symptoms such as the antenatal uterus of female animal and breast puerperal infection.
Compared to the prior art, the beneficial effect that the present invention produces is:
Chinese medicine composition of the present invention is based on Chinese medical theory, with organic conception and the dialectical principle treatment female animal puerperal disease that treats, through the applicant, repeatedly grope practice, draw above-mentioned a kind of prescription being formed by pure Chinese medicine, Chinese medicine composition under this prescription is by the relation between flavour of a drug, dosage and compatibility, all medicines share, play altogether the antibacterial effect of anti-inflammatory analgesic, hemostasia and promoting granulation and antiviral, thereby can cure mainly targetedly the rehabilitation of the wounds such as female animal atony of uterus in puerperal, placenta retention, hemorrhage and congestion; Also can cure mainly targetedly the symptoms such as the antenatal uterus of female animal and breast puerperal infection.Through clinical trial, adopt Chinese medicine composition of the present invention to treat, its effect is not defeated by and is adopted antibiotic therapeutic modality, and above-mentioned Chinese medicine composition is natural plants prescription medicine, can not produce endurance strain in use, thereby can substitute antibiotics, of the present inventionly apply the predicament that is conducive to slow down abuse of antibiotics in China's aquaculture, owing to not using antibiotic, thereby can effectively solve the problem because of the cultured product export trade difficulty that forbidding antibiotic occurs comprehensively, also domestic food is produced safely to active influence simultaneously.
Accompanying drawing explanation
Without accompanying drawing.
The specific embodiment
The invention discloses a kind of Chinese medicine composition, preparation technique of traditional Chinese medicine and this Chinese medicine in the application of field of veterinary, those skilled in the art can use for reference content herein, suitably improve technological parameter and realize.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the artly, they are all deemed to be included in the present invention.Method of the present invention and application are described by preferred embodiment, related personnel obviously can change methods and applications as herein described or suitably change and combination within not departing from content of the present invention, spirit and scope, realizes and apply the technology of the present invention.
The invention provides a kind of Chinese medicine composition, its raw material by following weight portion is made: Herba Leonuri 1～50 weight portion; Radix Rhodiolae 0.5～10 weight portion; Rhizoma Paridis 1～50 weight portion; Radix Aconiti Kusnezoffii Preparata 1～50 weight portion; Rhizoma Dioscoreae 3～60 weight portions; Rhizoma et radix veratri (Radix Rhizoma Veratri) 0.5～10 weight portion; Radix Psammosilenes 0.5～20 weight portion; Borneolum Syntheticum 0.01～5 weight portion.
The present invention also provides a kind of preparation method of Chinese medicine composition, and raw material comprises: Herba Leonuri 1～50 weight portion; Radix Rhodiolae 0.5～10 weight portion; Rhizoma Paridis 1～50 weight portion; Radix Aconiti Kusnezoffii Preparata 1～50 weight portion; Rhizoma Dioscoreae 3～60 weight portions; Rhizoma et radix veratri (Radix Rhizoma Veratri) 0.5～10 weight portion; Radix Psammosilenes 0.5～20 weight portion; Borneolum Syntheticum 0.01～5 weight portion.Its step comprises: a, selection are cleaned: Herba Leonuri, Radix Rhodiolae, Rhizoma Paridis, Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Radix Psammosilenes and Borneolum Syntheticum are chosen respectively to decontamination, clean up respectively; B, dry broken: ready medical material in step a is dried respectively, then pulverizes respectively and sieve; C, by proportioning, mix: by each medicinal powder of processing through step a and step b respectively and drawing according to combination matching mix homogeneously.
Several embodiments of the invention are below provided:
Embodiment 1: take pulverous Chinese medicine material, wherein motherwort powder 1kg; Radix Rhodiolae powder 0.5kg; Rhizoma Paridis powder 1kg; Radix Aconiti Kusnezoffii Preparata powder 1kg; Rhizoma Dioscoreae powder 5kg; Rhizoma et radix veratri (Radix Rhizoma Veratri) powder 1kg; Radix Psammosilenes powder 1kg; Borneolum Syntheticum 0.02kg.
Embodiment 2: take pulverous Chinese medicine material, wherein motherwort powder 2kg; Radix Rhodiolae powder 1kg; Rhizoma Paridis powder 2kg; Radix Aconiti Kusnezoffii Preparata powder 1.5kg; Rhizoma Dioscoreae powder 3kg; Rhizoma et radix veratri (Radix Rhizoma Veratri) powder 0.5kg; Radix Psammosilenes powder 0.5kg; Borneolum Syntheticum 0.01kg.
Embodiment 3: take pulverous Chinese medicine material, wherein motherwort powder 5kg; Radix Rhodiolae powder 4kg; Rhizoma Paridis powder 4kg; Radix Aconiti Kusnezoffii Preparata powder 5kg; Rhizoma Dioscoreae powder 10kg; Rhizoma et radix veratri (Radix Rhizoma Veratri) powder 5kg; Radix Psammosilenes powder 5kg; Borneolum Syntheticum 2kg.
Embodiment 3: take pulverous Chinese medicine material, wherein motherwort powder 50kg; Radix Rhodiolae powder 10kg; Rhizoma Paridis powder 50kg; Radix Aconiti Kusnezoffii Preparata powder 50kg; Rhizoma Dioscoreae powder 60kg; Rhizoma et radix veratri (Radix Rhizoma Veratri) powder 10kg; Radix Psammosilenes powder 20kg; Borneolum Syntheticum 5kg.
Embodiment 4: take pulverous Chinese medicine material, wherein motherwort powder 10kg; Radix Rhodiolae powder 10kg; Rhizoma Paridis powder 20kg; Radix Aconiti Kusnezoffii Preparata powder 20kg; Rhizoma Dioscoreae powder 20kg; Rhizoma et radix veratri (Radix Rhizoma Veratri) powder 10kg; Radix Psammosilenes powder 20kg; Borneolum Syntheticum 5kg.
Embodiment 5: take pulverous Chinese medicine material, wherein motherwort powder 20kg; Radix Rhodiolae powder 8kg; Rhizoma Paridis powder 30kg; Radix Aconiti Kusnezoffii Preparata powder 30kg; Rhizoma Dioscoreae powder 50kg; Rhizoma et radix veratri (Radix Rhizoma Veratri) powder 8kg; Radix Psammosilenes powder 15kg; Borneolum Syntheticum 3kg.
Embodiment 6: take pulverous Chinese medicine material, wherein motherwort powder 25kg; Radix Rhodiolae powder 5kg; Rhizoma Paridis powder 25kg; Radix Aconiti Kusnezoffii Preparata powder 25kg; Rhizoma Dioscoreae powder 30kg; Rhizoma et radix veratri (Radix Rhizoma Veratri) powder 5kg; Radix Psammosilenes powder 11kg; Borneolum Syntheticum 2.5kg.
Embodiment 7: take pulverous Chinese medicine material, wherein motherwort powder 15kg; Radix Rhodiolae powder 5kg; Rhizoma Paridis powder 35kg; Radix Aconiti Kusnezoffii Preparata powder 45kg; Rhizoma Dioscoreae powder 10kg; Rhizoma et radix veratri (Radix Rhizoma Veratri) powder 2kg; Radix Psammosilenes powder 13kg; Borneolum Syntheticum 4kg.
Take pulverous Chinese medicine material, wherein motherwort powder 20kg; Radix Rhodiolae powder 5kg; Rhizoma Paridis powder 40kg; Radix Aconiti Kusnezoffii Preparata powder 10kg; Rhizoma Dioscoreae powder 30kg; Rhizoma et radix veratri (Radix Rhizoma Veratri) powder 10kg; Radix Psammosilenes powder 5kg; Borneolum Syntheticum 0.5kg.
Embodiment 8: take pulverous Chinese medicine material, wherein motherwort powder 35kg; Radix Rhodiolae powder 5kg; Rhizoma Paridis powder 15kg; Radix Aconiti Kusnezoffii Preparata powder 15kg; Rhizoma Dioscoreae powder 25kg; Rhizoma et radix veratri (Radix Rhizoma Veratri) powder 8kg; Radix Psammosilenes powder 18kg; Borneolum Syntheticum 3kg.
Embodiment 9: take pulverous Chinese medicine material, wherein motherwort powder 45kg; Radix Rhodiolae powder 0.5kg; Rhizoma Paridis powder 1kg; Radix Aconiti Kusnezoffii Preparata powder 1kg; Rhizoma Dioscoreae powder 5kg; Rhizoma et radix veratri (Radix Rhizoma Veratri) powder 5kg; Radix Psammosilenes powder 2kg; Borneolum Syntheticum 0.3kg.
Embodiment 10: take pulverous Chinese medicine material, wherein motherwort powder 30kg; Radix Rhodiolae powder 5kg; Rhizoma Paridis powder 40kg; Radix Aconiti Kusnezoffii Preparata powder 15kg; Rhizoma Dioscoreae powder 30kg; Rhizoma et radix veratri (Radix Rhizoma Veratri) powder 10kg; Radix Psammosilenes powder 5kg; Borneolum Syntheticum 0.5kg.
In above-mentioned 10 embodiment, pulverous Chinese medicine material, according to the different qualities of Chinese medicine monomer medical material, makes respectively in the following manner:
The process of preparing Chinese medicine and the processing of described Rhizoma Paridis comprise the following steps: 1, choose decontamination foreign body, clean, cut into slices; 2, under the condition that is 8-14 with lime water at pH, soak 12-48 hour, continue extremely neutral with clear water rinsing, circulation steam sterilization at least 30 minutes; 3, under the environment of 80-90 ℃, be dried, after being dried, pulverize and sieve, after sieving, can obtain Rhizoma Paridis powder.
The process of preparing Chinese medicine and the processing of described Radix Aconiti Kusnezoffii Preparata comprise the following steps: 1, by processing the bubble Radix Aconiti Kusnezoffii slice, thin piece of processing, cleans, chooses decontamination, and 2, under the environment of 80-90 ℃, be dried, pulverize and sieve after dry, after sieving, can obtain Radix Aconiti Kusnezoffii Preparata powder.
The process of preparing Chinese medicine and the processing of described Rhizoma et radix veratri (Radix Rhizoma Veratri) comprise the following steps: 1, choose decontamination foreign body, after removing the Rhizoma et radix veratri (Radix Rhizoma Veratri) grass fibrous root of bulb, with clear water, clean, 2, under the environment of 80-90 ℃, be dried, after being dried, pulverize and cross 100 mesh sieves, after sieving, can obtain Rhizoma et radix veratri (Radix Rhizoma Veratri) powder.
The process of preparing Chinese medicine and the processing of described Radix Psammosilenes comprise the following steps: 1, choose decontamination foreign body, the Radix Psammosilenes except removing LU is cleaned; 2, use circulation steam sterilization at least 30 minutes; 3, under the environment of 80-90 ℃, be dried, after being dried, pulverize and sieve, after sieving, can obtain Radix Psammosilenes powder.
The process of preparing Chinese medicine and the processing of described Rhizoma Dioscoreae comprise the following steps: 1, choose decontamination foreign body; 2, under the environment of 80-90 ℃, dry to water content till below 6%; 3, after oven dry, pulverize and sieve, after sieving, can obtain Rhizoma Dioscoreae powder.
The process of preparing Chinese medicine and the processing of described Radix Rhodiolae comprise the following steps: 1, chooses decontamination foreign body, cleans, sterilizing, and 2,80-90 ℃ of oven dry, 3, pulverize and cross 100 mesh sieves after drying, after sieving, can obtain Radix Rhodiolae powder.
The process of preparing Chinese medicine and the processing of described Herba Leonuri comprise the following steps: 1, choose decontamination foreign body, clean, sterilizing; 2,80-90 ℃ of oven dry; 3, after oven dry, pulverize and cross 100 mesh sieves, after sieving, can obtain motherwort powder.
The process of preparing Chinese medicine and the processing of described Borneolum Syntheticum comprise the following steps: put in mortar, be added with 90% ethanol and grind, excessively after 80 mesh sieves, can obtain borneol powder.
The clinical trial of doing with the embodiment of embodiment 10 below in conjunction with the applicant, describes pharmacological action of the present invention in detail.
Preliminary experiment research shows, the present embodiment can suppress the mouse writhing reaction that acetic acid causes, antagonism oxytocin brings out the pain caused reaction of hysterospasm, significantly suppresses rat writhing number of times, and prompting the party has good analgesic activity; The present embodiment can obviously reduce dysmenorrhea model Isolated Rat Uterus smooth muscle contraction frequency and intensity, reduce PGF2 alpha content in dysmenorrhea model rat uterus tissue, rising Plasma Beta-EP content, reduces the blood and plasma viscosity of Blood congestion model rat, has in addition obvious antibacterial and anti-inflammation functions.
Postpartum hemorrhage is that female animal causes dead primary factor, and uterine inertia is to cause postpartum hemorrhage and the bad main cause of the involution of uterus.The prompting of this result of study, the present embodiment can by increasing shrinkage amplitude, and impel pregnant tissue to discharge completely in the situation that not increasing early pregnancy incomplete abortion rat uterus smooth muscle contraction frequency, accelerates open blood sinus closed, shortens the vaginal hemorrhage time.
The present embodiment can suppress the mice auricle swelling rate that dimethylbenzene causes, suppress the swollen formation of rat granuloma, point out it to have antiinflammatory action, play the effect that control uterine cavity infects or residual tissue infects, and then prevent residual pregnant tissue and Uterus wall adhesion, promote endometrial reparation and stop blooding.
This research finds, the present embodiment can reduce blood stasis model rat blood and plasma viscosity, thus disclose this medicine to the mechanism of action of hemorrhage after drug abortion may with its blood circulation promoting and blood stasis dispelling, improve local microcirculation, promote that endometrial reparation is relevant.
Although comparatively rare because of the postpartum hemorrhage that coagulation disorders causes, once it occurs, should not stop blooding, and constantly can hemorrhagely cause or increase the weight of to have a delicate constitution and affect the involution of uterus, thereby make hemorrhage more serious.The present embodiment can shorten mice clotting time and bleeding time, illustrates that this medicine can improve the coagulation function of body, promotes hemostasis.
In sum, the present embodiment has obvious therapeutical effect to postpartum hemorrhage, and its mechanism of action may be relevant with fine hair or decidua tissue discharge, shortening clotting time and bleeding time and inflammation-inhibiting generation that raising endogenous pain control material β-EP content, the intensity of uterine contraction that alleviates blood stasis symptom, raising aborting rat, promotion remain in uterine cavity with PGF2 alpha content in reduction uterine cancer cell.
The clinical trial of doing with the embodiment of embodiment 10 below in conjunction with the applicant, describes toxicological effect of the present invention in detail.
The present embodiment is (basic, normal, high dosage group under 1.6g crude drug/kgBW, 1.0g crude drug/kgBW and 0.6g crude drug/kgBW dosage, 80,50 and 30 times of the clinical daily maximum dose level of suitable female animal respectively), the continuous gastric infusion of rat 6 months and drug withdrawal are after 4 weeks, all there is not the death relevant with drug toxicity in all dosage treated animals, medicine all affects without overt toxicity the general status of animal, activity, behavior etc.Each dosage treated animal body weight all increases, and wherein body weight gain situation has more slowly appearred in male rat high dose group over a period to come, and the reduction of indivedual dosage group food rations appears in male and female rats once in a while, but after drug withdrawal, all recovers normal.
The continuous gastric infusion of above-mentioned three dosage treated animals drug withdrawal in 12 weeks, 26 weeks 4 weeks, hematological indices and serum electrolyte content, coagulation time test result and negative control group comparison, be showed no the marked difference in toxicology meaning.The demonstration of serological biochemical markers testing result, the present embodiment successive administration 26 weeks, can cause TP and the CHO reduction in various degree of male rat, drug withdrawal can recover after 4 weeks.Organ weights, organ coefficient testing result also show, the present embodiment successive administration 26 weeks, can cause the reduction of high dose group male rat liver weight and liver coefficient, have highly significant meaning (P<0.01) with negative control group comparison difference, drug withdrawal can recover after 4 weeks.
Histopathological examination result shows, the observation of administration high dose group Rats Organs and Tissues tissue and negative control group
Result is basically identical, has no the significantly pathological change relevant with tested material.
For the purpose of clinical drug safety, the present embodiment Capsules on Rats continuous oral administration 26 weeks, its highest non-toxic is decided to be clinical 50 times of drafting daily maximum dose level of the suitable female animal of 1.0g crude drug/kgBW().
The clinical tests of embodiment 11 Chinese medicine composition of the present invention to sow atony of uterus in puerperal wound
Select 60 of the sows that suffers from atony of uterus wound in puerperal that body weight is substantially suitable, identical raising condition in same pig house
Be divided at random down following 3 groups:
Blank group: establish 20 of sows, raise not administration by daily feeding manner.
Positive controls: establish 20 of sows, by 2% concentration spice, feeding for sow with gentamycin (every 1 gram is equivalent to crude drug in whole 1g), be used in conjunction 7 days.
Test group: establish 20 of sows, by 2% concentration spice, feeding for sow with the Chinese medicine composition (every 1 gram is equivalent to crude drug in whole 1g) of embodiment 10 preparations, be used in conjunction 7 days.After 7 days, observe sow spirit appetite situation and make statistics, calculating cure rate, obvious effective rate, effective percentage and inefficiency, curative effect determinate standard is as shown in table 1.
Table 1 curative effect determinate standard
The clinical tests result of table 2 Chinese medicine composition to sow atony of uterus in puerperal wound
As seen from the above table, with the Chinese medicine composition of embodiment 10 preparations, there is the effect that substitute antibiotics is treated sow atony of uterus in puerperal wound.
The clinical tests of embodiment 12 Chinese medicine composition of the present invention to sow placenta retention in puerperal wound
Select 45 of the sows that suffers from placenta retention wound in puerperal that body weight is substantially suitable, identical raising condition in same pig house
Be divided at random down following 3 groups:
Blank group: establish 15 of sows, raise not administration by daily feeding manner.
Positive controls: establish 15 of sows, by 2% concentration spice, feeding for sow with penicillin (every 1 gram is equivalent to crude drug in whole 1g), be used in conjunction 7 days.
Test group: establish 15 of sows, by 2% concentration spice, feeding for sow with the Chinese medicine composition (every 1 gram is equivalent to crude drug in whole 1g) of embodiment 10 preparations, be used in conjunction 7 days.After 7 days, observe sow spirit appetite situation and make statistics, calculating cure rate, obvious effective rate, effective percentage and inefficiency, curative effect determinate standard is as shown in table 3.
Table 3 curative effect determinate standard
| therapeutic effect | judge index |
| recovery from illness | after 7 days, it is normal that spiritual appetite is recovered, clinical symptom disappearance. |
| effective | after 7 days, spiritual appetite takes a turn for the better, clinical symptom disappearance or alleviate. |
| invalid | after 7 days, symptom is not improved. |
The clinical tests result of table 4 Chinese medicine composition sow placenta retention in puerperal wound
As seen from the above table, with the Chinese medicine composition of embodiment 10 preparations, there is the effect that substitute antibiotics is treated sow placenta retention in puerperal wound.
The clinical tests of embodiment 12 Chinese medicine composition of the present invention to sow postpartum hemorrhage and congestion wound
Select 65 of the sows that suffers from postpartum hemorrhage and congestion wound that body weight is substantially suitable, identical raising condition in same pig house
Be divided at random down following 3 groups:
Blank group: establish sow 20, raise not administration by daily feeding manner.
Positive controls: establish 20 of sows, by 2% concentration spice, feeding for sow with chloromycetin (every 1 gram is equivalent to crude drug in whole 1g), be used in conjunction 7 days.
Test group: establish 25 of sows, by 2% concentration spice, feeding for sow with the Chinese medicine composition (every 1 gram is equivalent to crude drug in whole 1g) of embodiment 1 preparation, be used in conjunction 7 days.After 7 days, observe sow spirit appetite situation and make statistics, calculating cure rate, obvious effective rate, effective percentage and inefficiency, curative effect determinate standard is as shown in table 5.
Table 5 curative effect determinate standard
| therapeutic effect | judge index |
| recovery from illness | after 7 days, it is normal that spiritual appetite is recovered, clinical symptom disappearance. |
| effective | after 7 days, spiritual appetite takes a turn for the better, clinical symptom disappearance or alleviate. |
| invalid | after 7 days, symptom is not improved. |
The clinical tests result of table 6 Chinese medicine composition sow postpartum hemorrhage and congestion wound
As seen from the above table, with the Chinese medicine composition of embodiment 10 preparations, there is the effect that substitute antibiotics is treated sow postpartum hemorrhage and congestion wound.
The clinical tests of embodiment 13 Chinese medicine composition of the present invention to the antenatal uterus of sow or breast puerperal infection
Select 100 of the sows that suffers from antenatal uterus or breast puerperal infection that body weight is substantially suitable, in same pig house, under identical raising condition, be divided at random following 3 groups:
Blank group: establish 30 of sows, raise not administration by daily feeding manner.
Positive controls: establish 35 of sows, by 2% concentration spice, feeding for sow with gentamycin (every 1 gram is equivalent to crude drug in whole 1g), be used in conjunction 7 days.
Test group: establish 35 of sows, by 2% concentration spice, feeding for sow with the Chinese medicine composition (every 1 gram is equivalent to crude drug in whole 1g) of embodiment 1 preparation, be used in conjunction 7 days.After 7 days, observe sow spirit appetite situation and make statistics, calculating cure rate, obvious effective rate, effective percentage and inefficiency, curative effect determinate standard is as shown in table 4.
Table 7 curative effect determinate standard
| therapeutic effect | judge index |
| recovery from illness | after 7 days, it is normal that spiritual appetite is recovered, clinical symptom disappearance. |
| effective | after 7 days, spiritual appetite takes a turn for the better, clinical symptom disappearance or alleviate. |
| invalid | after 7 days, symptom is not improved. |
The clinical tests result of the antenatal uterus of table 8 Chinese medicine composition sow or breast puerperal infection
As seen from the above table, with the Chinese medicine composition of embodiment 10 preparation, there is to certain curative effect in antenatal uterus or breast puerperal infection, thereby can part substitute antibiotics treats the disease of sow antenatal uterus in puerperal or breast puerperal infection.
Above are only the specific embodiment of the present invention, but design concept of the present invention is not limited to this, allly utilizes this design to carry out the change of unsubstantiality to the present invention, all should belong to the behavior of invading protection domain of the present invention.
Claims (10)
1. a Chinese medicine composition, is characterized in that, its raw material by following weight portion is made: Herba Leonuri 1～50 weight portion; Radix Rhodiolae 0.5～10 weight portion; Rhizoma Paridis 1～50 weight portion; Radix Aconiti Kusnezoffii Preparata 1～50 weight portion; Rhizoma Dioscoreae 3～60 weight portions; Rhizoma et radix veratri (Radix Rhizoma Veratri) 0.5～10 weight portion; Radix Psammosilenes 0.5～20 weight portion; Borneolum Syntheticum 0.01～5 weight portion.
2. the preparation technology of a Chinese medicine composition as claimed in claim 1, it is characterized in that, comprise the following steps: a, selection are cleaned: Herba Leonuri, Radix Rhodiolae, Rhizoma Paridis, Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Radix Psammosilenes and Borneolum Syntheticum are chosen respectively to decontamination, clean up respectively; B, dry broken: ready medical material in step a is dried respectively, then pulverizes respectively and sieve; C, by proportioning, mix: by each medicinal powder of processing through step a and step b respectively and drawing according to combination matching mix homogeneously.
3. the preparation technology of Chinese medicine composition as claimed in claim 2, is characterized in that, the process of preparing Chinese medicine and the processing of described Rhizoma Paridis comprise the following steps: 1, choose decontamination foreign body, clean, cut into slices; 2, under the condition that is 8-14 with lime water at pH, soak 12-48 hour, continue extremely neutral with clear water rinsing, circulation steam sterilization at least 30 minutes; 3, under the environment of 80-90 ℃, be dried, after being dried, pulverize and sieve, after sieving, can obtain Rhizoma Paridis powder.
4. the preparation technology of Chinese medicine composition as claimed in claim 2, it is characterized in that, the process of preparing Chinese medicine and the processing of described Radix Aconiti Kusnezoffii Preparata comprise the following steps: 1, by processing the bubble Radix Aconiti Kusnezoffii slice, thin piece of processing, clean, choose decontamination, 2, under the environment of 80-90 ℃, be dried, after dry, pulverize and sieve, after sieving, can obtain Radix Aconiti Kusnezoffii Preparata powder; The process of preparing Chinese medicine and the processing of described Rhizoma et radix veratri (Radix Rhizoma Veratri) comprise the following steps: 1, choose decontamination foreign body, after removing the Rhizoma et radix veratri (Radix Rhizoma Veratri) grass fibrous root of bulb, with clear water, clean, 2, under the environment of 80-90 ℃, be dried, after being dried, pulverize and cross 100 mesh sieves, after sieving, can obtain Rhizoma et radix veratri (Radix Rhizoma Veratri) powder.
5. the preparation technology of Chinese medicine composition as claimed in claim 2, is characterized in that, the process of preparing Chinese medicine and the processing of described Radix Psammosilenes comprise the following steps: 1, choose decontamination foreign body, the Radix Psammosilenes except removing LU is cleaned; 2, use circulation steam sterilization at least 30 minutes; 3, under the environment of 80-90 ℃, be dried, after being dried, pulverize and sieve, after sieving, can obtain Radix Psammosilenes powder.
6. the preparation technology of Chinese medicine composition as claimed in claim 2, is characterized in that, the process of preparing Chinese medicine and the processing of described Rhizoma Dioscoreae comprise the following steps: 1, choose decontamination foreign body; 2, under the environment of 80-90 ℃, dry to water content till below 6%; 3, after oven dry, pulverize and sieve, after sieving, can obtain Rhizoma Dioscoreae powder.
7. the preparation technology of Chinese medicine composition as claimed in claim 2, it is characterized in that, the process of preparing Chinese medicine and the processing of described Radix Rhodiolae comprise the following steps: 1, choose decontamination foreign body, clean, sterilizing, 2,80-90 ℃ of oven dry, 3, after oven dry, pulverize and cross 100 mesh sieves, after sieving, can obtain Radix Rhodiolae powder; The process of preparing Chinese medicine and the processing of described Herba Leonuri comprise the following steps: 1, choose decontamination foreign body, clean, sterilizing; 2,80-90 ℃ of oven dry; 3, after oven dry, pulverize and cross 100 mesh sieves, after sieving, can obtain motherwort powder.
8. the preparation technology of Chinese medicine composition as claimed in claim 2, is characterized in that, the process of preparing Chinese medicine and the processing of described Borneolum Syntheticum comprise the following steps: put in mortar, be added with 90% ethanol and grind, excessively after 80 mesh sieves, can obtain borneol powder.
9. the application of a kind of Chinese medicine composition as claimed in claim 1 in preparing anti-inflammatory analgesic veterinary drug, hemostasia and promoting granulation veterinary drug, antiviral Antibacterial medicines.
A kind of Chinese medicine composition as claimed in claim 1 preparation cure mainly the rehabilitation of female animal wound in puerperal veterinary drug, cure mainly the application in the veterinary drug of the disease that often takes a disease female animal puerperal and age of sucking.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410295751.0A CN104013780B (en) | 2014-06-27 | 2014-06-27 | The application of Chinese medicine composition, preparation technique of traditional Chinese medicine and the Chinese medicine in field of veterinary |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410295751.0A CN104013780B (en) | 2014-06-27 | 2014-06-27 | The application of Chinese medicine composition, preparation technique of traditional Chinese medicine and the Chinese medicine in field of veterinary |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104013780A true CN104013780A (en) | 2014-09-03 |
| CN104013780B CN104013780B (en) | 2017-08-01 |
Family
ID=51430963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410295751.0A Active CN104013780B (en) | 2014-06-27 | 2014-06-27 | The application of Chinese medicine composition, preparation technique of traditional Chinese medicine and the Chinese medicine in field of veterinary |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104013780B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1478536A (en) * | 2003-07-21 | 2004-03-03 | 桂林三金集团股份有限公司 | Proprietury Chinese medicine for stopping blood, analgesia, removing blood stasis and engender new and its preparation method |
| WO2005110431A1 (en) * | 2004-05-19 | 2005-11-24 | University Of Manitoba | Herbal product containing glucosamine |
| CN103070944A (en) * | 2013-01-22 | 2013-05-01 | 无锡正大畜禽有限公司 | Chinese medicinal composition for preventing and treating dam postpartum syndrome and preparation method thereof |
| CN103316312B (en) * | 2013-05-04 | 2015-12-23 | 内蒙古瑞普大地生物药业有限责任公司 | A kind of tonification clearing heat in the pericardium mixture and preparation technology thereof |
-
2014
- 2014-06-27 CN CN201410295751.0A patent/CN104013780B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1478536A (en) * | 2003-07-21 | 2004-03-03 | 桂林三金集团股份有限公司 | Proprietury Chinese medicine for stopping blood, analgesia, removing blood stasis and engender new and its preparation method |
| WO2005110431A1 (en) * | 2004-05-19 | 2005-11-24 | University Of Manitoba | Herbal product containing glucosamine |
| CN103070944A (en) * | 2013-01-22 | 2013-05-01 | 无锡正大畜禽有限公司 | Chinese medicinal composition for preventing and treating dam postpartum syndrome and preparation method thereof |
| CN103316312B (en) * | 2013-05-04 | 2015-12-23 | 内蒙古瑞普大地生物药业有限责任公司 | A kind of tonification clearing heat in the pericardium mixture and preparation technology thereof |
Non-Patent Citations (1)
| Title |
|---|
| 叶玉兰: "胶质重楼炮制初探", 《中药材》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104013780B (en) | 2017-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107456509B (en) | A kind of external application biological agent and preparation method for vagina prevention, health care and treatment gynaecology genital inflammation | |
| CN102552769B (en) | Medicine for treating vaginitis and preparation method thereof | |
| CN102488848A (en) | Traditional Chinese medicine composition used for treating high-pathogenicity porcine reproductive and respiratory syndrome, preparation method thereof, and application thereof | |
| CN103735965A (en) | Traditional Chinese medicinal prescription for preventing and treating trichomonad of pigeon, as well as preparation method and application thereof | |
| CN103920069A (en) | Scourge-clearing toxin-vanquishing oral solution and method for preventing and treating livestock virus and respiratory tract infection | |
| CN103301271B (en) | Tibetan medicine for treating pharyngitis and preparation method thereof | |
| CN101007075A (en) | Antivirus medicine for birds and its preparation method | |
| CN103212054A (en) | Chinese medicine composition for treating infertility of women and preparation method thereof | |
| CN105497723A (en) | Traditional Chinese medicine preparation for treating bacterial pneumonia and preparation method thereof | |
| CN104547186A (en) | Compound fermented type traditional Chinese medicine for preventing and treating fowl cholera and preparation method of compound fermented type traditional Chinese medicine | |
| CN104013780A (en) | Traditional Chinese medicine composition, traditional Chinese medicine preparation process and application of traditional Chinese medicine in field of veterinary medicament | |
| CN106236959A (en) | A kind of external-applied ointment treating hemorrhoid | |
| CN109248244A (en) | A kind of Chinese medicine and preparation method thereof for treating gynaecological imflammation | |
| CN103830679B (en) | A kind of medicine and application thereof for the treatment of irritable bowel syndrome | |
| CN112891415B (en) | Traditional Chinese medicine composition for preventing and treating salpingitis disease of laying hens as well as preparation method and application thereof | |
| CN116942745B (en) | Traditional Chinese medicine composition for treating salpingitis of laying hens and preparation method thereof | |
| CN101618118B (en) | Application of Chinese medicinal composition in preparing medicament for treating cystitis | |
| CN105265786A (en) | Compound feed for cows and preparation method thereof | |
| CN105126091A (en) | Swine high fever prevention and treatment method | |
| CN105998542A (en) | Traditional Chinese medicine spray for treating acute laryngopharyngitis and preparation method of traditional Chinese medicine spray | |
| CN104971210A (en) | External lotion for treating tinea pedis and preparation method thereof | |
| CN116173111A (en) | Chinese herbal compound preparation for preventing and treating pullorum disease and preparation method thereof | |
| CN104435864A (en) | Compound fermentation type traditional Chinese medicine for chicken protozoal disease and preparation method thereof | |
| CN105412695A (en) | Medicine for treating cow endometritis and preparation method thereof | |
| CN100528219C (en) | Pharmaceutical composition for treating gynecological disease, its preparation and uses |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |