CN103999863B - A kind of bactericidal composition containing fluorine mepanipyrim - Google Patents
A kind of bactericidal composition containing fluorine mepanipyrim Download PDFInfo
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- CN103999863B CN103999863B CN201310061385.8A CN201310061385A CN103999863B CN 103999863 B CN103999863 B CN 103999863B CN 201310061385 A CN201310061385 A CN 201310061385A CN 103999863 B CN103999863 B CN 103999863B
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- fluorine mepanipyrim
- active component
- active
- mepanipyrim
- bactericidal composition
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- 229910052731 fluorine Inorganic materials 0.000 title claims abstract description 70
- 239000011737 fluorine Substances 0.000 title claims abstract description 70
- 239000005805 Mepanipyrim Substances 0.000 title claims abstract description 66
- CIFWZNRJIBNXRE-UHFFFAOYSA-N mepanipyrim Chemical compound CC#CC1=CC(C)=NC(NC=2C=CC=CC=2)=N1 CIFWZNRJIBNXRE-UHFFFAOYSA-N 0.000 title claims abstract description 66
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title claims abstract description 65
- 239000000203 mixture Substances 0.000 title claims abstract description 43
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 18
- 201000010099 disease Diseases 0.000 claims abstract description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 22
- JWUCHKBSVLQQCO-UHFFFAOYSA-N 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol Chemical compound C=1C=C(F)C=CC=1C(C=1C(=CC=CC=1)F)(O)CN1C=NC=N1 JWUCHKBSVLQQCO-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000005787 Flutriafol Substances 0.000 claims abstract description 17
- 230000000694 effects Effects 0.000 claims abstract description 11
- 239000004480 active ingredient Substances 0.000 claims abstract description 4
- 239000000375 suspending agent Substances 0.000 claims description 18
- 241000221785 Erysiphales Species 0.000 claims description 15
- 239000003094 microcapsule Substances 0.000 claims description 14
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 13
- 239000000839 emulsion Substances 0.000 claims description 12
- 206010039509 Scab Diseases 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 7
- 239000004563 wettable powder Substances 0.000 claims description 7
- 239000004530 micro-emulsion Substances 0.000 claims description 6
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 241001530056 Athelia rolfsii Species 0.000 claims description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 22
- WKBPZYKAUNRMKP-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(CCC)CN1C=NC=N1 WKBPZYKAUNRMKP-UHFFFAOYSA-N 0.000 abstract description 14
- 239000005813 Penconazole Substances 0.000 abstract description 14
- 239000005846 Triadimenol Substances 0.000 abstract description 14
- BAZVSMNPJJMILC-UHFFFAOYSA-N triadimenol Chemical compound C1=NC=NN1C(C(O)C(C)(C)C)OC1=CC=C(Cl)C=C1 BAZVSMNPJJMILC-UHFFFAOYSA-N 0.000 abstract description 14
- 150000001875 compounds Chemical class 0.000 abstract description 8
- 230000000855 fungicidal effect Effects 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 2
- 238000005406 washing Methods 0.000 abstract 1
- 238000013329 compounding Methods 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 230000003449 preventive effect Effects 0.000 description 15
- 238000012360 testing method Methods 0.000 description 15
- 239000002270 dispersing agent Substances 0.000 description 13
- 239000012071 phase Substances 0.000 description 13
- 239000013530 defoamer Substances 0.000 description 12
- 239000008367 deionised water Substances 0.000 description 12
- 229910021641 deionized water Inorganic materials 0.000 description 12
- 239000003814 drug Substances 0.000 description 12
- 239000003995 emulsifying agent Substances 0.000 description 10
- 239000000575 pesticide Substances 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 9
- 241000209140 Triticum Species 0.000 description 8
- 235000021307 Triticum Nutrition 0.000 description 8
- 230000002528 anti-freeze Effects 0.000 description 8
- 239000002562 thickening agent Substances 0.000 description 8
- 239000000080 wetting agent Substances 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 240000008067 Cucumis sativus Species 0.000 description 6
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 231100000820 toxicity test Toxicity 0.000 description 6
- 239000008346 aqueous phase Substances 0.000 description 5
- 206010011732 Cyst Diseases 0.000 description 4
- 241000209094 Oryza Species 0.000 description 4
- 235000007164 Oryza sativa Nutrition 0.000 description 4
- 240000008042 Zea mays Species 0.000 description 4
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 4
- 208000031513 cyst Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 229920002521 macromolecule Polymers 0.000 description 4
- 235000009973 maize Nutrition 0.000 description 4
- 239000003002 pH adjusting agent Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 235000009566 rice Nutrition 0.000 description 4
- 230000001018 virulence Effects 0.000 description 4
- 241000510928 Erysiphe necator Species 0.000 description 3
- 206010067482 No adverse event Diseases 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000013401 experimental design Methods 0.000 description 3
- -1 fluorine mepanipyrim compounds Chemical class 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 230000010165 autogamy Effects 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 238000000498 ball milling Methods 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000003852 triazoles Chemical class 0.000 description 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241001474928 Ustilaginoidea virens Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 150000003851 azoles Chemical class 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical compound NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000012990 dithiocarbamate Substances 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of bactericidal composition containing fluorine mepanipyrim, active ingredient is active components A and active component B, and active components A is selected from fluorine mepanipyrim, and active component B is selected from any one following compound：Penconazole, Flutriafol or Triadimenol, and active components A and active component B weight ratio are 1:80~80:1.The present composition has greater activity to the multiple diseases in various crop, and with obvious synergistic effect, expands fungicidal spectrum.And with dosage is small, resistance of rainwater washing against, the characteristics of synergy is obvious.
Description
Technical field
The invention belongs to technical field of pesticide, it is related to a kind of bactericidal composition of fluorine-containing mepanipyrim answering in crop disease
With.
Technical background
Fluorine mepanipyrim：Any fungi growth that mechanism of action fluorine mepanipyrim is formed from conidia germination to conidiophore
Phase, growth can be suppressed immediately.Its chemical constitution is different from existing bactericide, same to triazole type, dithiocarbamate,
Benzimidazole and other classes the no interactions resistance such as including antibiotic, thus its to sensitive or resistance cause of disease because there is excellent work
Property.
Penconazole, Flutriafol or Triadimenol belong to common fungicide, are widely used in the disease of crops.
In the real process of agricultural production, controlling disease is easiest to generate the problem that the drug-fast generation of germ.No
Compounded with kind composition, be to prevent and treat resistance germ very common method.Heterogeneity is compounded, and is imitated according to practical application
Really, come judge certain compounding be synergy, plus and or antagonism.In most cases, the compounding effect of agricultural chemicals is all to add
And effect, really have the compounding of synergistic effect seldom, especially synergistic effect clearly, synergy ratio very high compounding just more
It is few.Study, discovery mutually compounds fluorine mepanipyrim with effective active composition B, have within the specific limits very well by inventor
Synergistic effect, and about fluorine mepanipyrim it is related to penconazole, Flutriafol or Triadimenol compounding, at present at home and abroad there is not yet
Relevant report.
The content of the invention
There is synergistic function, the fluorine-containing mepanipyrim that use cost is low, preventive effect is good the purpose of the present invention is to propose to a kind of
Bactericidal composition.
A kind of bactericidal composition of fluorine-containing mepanipyrim, active ingredient is active components A and active component B, active components A with
Active component B weight ratio is 1:80~80:1, described active components A is selected from fluorine mepanipyrim, active component B be selected from penconazole,
One kind in Flutriafol or Triadimenol, active components A and active component B preferred weight ratio are 1:50~50:1；More preferably：
The weight ratio of fluorine mepanipyrim and penconazole is 1:20~20:1, the weight ratio of fluorine mepanipyrim and Flutriafol is 1:20~20:1, fluorine is phonetic
The weight ratio of bacterium amine and Triadimenol is 1:25~15:1；Most preferably：The weight ratio of fluorine mepanipyrim and penconazole is 1:9~9:1, fluorine
The weight ratio of mepanipyrim and Flutriafol is 1:9~9:1, the weight ratio of fluorine mepanipyrim and Triadimenol is 1:14~4:1.
The bactericidal composition of described fluorine-containing mepanipyrim, be made wettable powder, water dispersible granules, suspending agent, aqueous emulsion,
Microemulsion, microcapsule suspending agent or microcapsule suspension-suspendinagent agent, wherein fluorine mepanipyrim may also be fabricated which missible oil with penconazole.
The bactericidal composition of described fluorine-containing mepanipyrim is used for the disease for preventing and treating crops, and described crops include grain
Crop, legume crop, oil crops, fibre crops, sugar crop, melon crop, fruits crop, dry fruit crop, hobby
Crop, root crop, flower crop, medicinal crop, crop and green manure pasture crop.
Described disease includes powdery mildew, scab, white rot, head smut, false smut, leaf spot, banded sclerotial blight or rust
Disease.
The amount of application when content of active component depends on being used alone in the bactericidal composition of the present invention, also depends on one
The mixed ratio and synergistic effect degree of compound and another compound are planted, while also relevant with target disease.Usual group
The weight percentage of active component is the 1%~90% of gross weight, preferably 5%~80% in compound.According to different preparations
Type, active component content scope is different.Generally, liquid preparation contains by weight 1%~60% active material, preferably
Ground is 5%~50%；Solid pharmaceutical preparation contains by weight 5%~80% active material, preferably 10%~80%.
At least contain a kind of surfactant in the bactericidal composition of the present invention, active component is in water during in favor of applying
It is scattered.Surface-active contents are the 2%~30% of total formulation weight, and surplus is solid or liquid diluent.
Surfactant selected by the bactericidal composition of the present invention is known in those skilled in the art, by user
, through dilution or directly using its preparation, it can be prepared, will lived by processing method known in those skilled in the art using preceding
After property composition is mixed with liquid flux or solid carrier, surfactant such as dispersant, stabilizer, wetting agent, bonding are added
One or more in agent, defoamer etc..
Composition includes following component and content when wettable powder is made：Active components A 1% ~ 80%, active component B1% ~
80%th, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, filler surplus.
Composition includes following component and content when water dispersible granules are made：Active components A 1% ~ 80%, active component B1% ~
80%th, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, disintegrant 1% ~ 10%, binding agent 0 ~ 8%, filler surplus.
Composition includes following component and content when suspending agent is made：Active components A 0.5% ~ 50%, active component B1% ~
50%th, dispersant 1% ~ 10%, wetting agent 1% ~ 10%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, antifreeze 0 ~ 8%, deionized water add
To 100%.
Composition includes following component and content when suspension emulsion is made：Active components A 0.5% ~ 50%, active component B1% ~
50%th, emulsifying agent 1% ~ 10%, dispersant 1% ~ 10%, solvent 0 ~ 20%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, antifreeze 0 ~ 8%,
Stabilizer 0 ~ 3%, deionized water add to 100%.
Composition includes following component and content when aqueous emulsion is made：Active components A 0.5% ~ 50%, active component B1% ~
50%th, solvent 1% ~ 20%, emulsifying agent 1% ~ 12%, antifreeze 0 ~ 8%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, deionized water are added to
100%。
Composition includes following component and content when microemulsion is made：Active components A 0.5% ~ 50%, active component B1% ~
50%th, emulsifying agent 3% ~ 25%, solvent 1% ~ 10%, antifreeze 0 ~ 8%, stabilizer 0 ~ 3%, defoamer 0.01% ~ 2%, deionized water are added to
100%。
Composition includes following component and content when microcapsule suspending agent is made：Active components A 0.5% ~ 50%, active component
B1% ~ 50%, macromolecule cyst material 1% ~ 10%, dispersant 2% ~ 10%, solvent 1% ~ 10%, emulsifying agent 1% ~ 7%, pH adjusting agent
0.01% ~ 5%, defoamer 0.01% ~ 2%, deionized water add to 100%.
Composition includes following component and content when microcapsule suspension-suspendinagent agent is made：Active components A 0.5% ~ 50%, activity
Composition B1% ~ 50%, macromolecule cyst material 1% ~ 12%, dispersant 1%-12%, wetting agent 1%-8%, solvent 1% ~ 15%, emulsifying agent 1%
~ 8%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%.
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The suspension emulsion the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The microcapsule suspending agent the key technical indexes of the present invention：
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention：
The advantage of the invention is that：（1）The present composition has good synergy and lasting effect within the specific limits, prevents
Effect is higher than single dose；（2）Pesticide usage amount is reduced, residual quantity of the reduction agricultural chemicals on crop, mitigates environmental pollution；（3）Expand
Fungicidal spectrum, to multiple diseases such as powdery mildew, scab, white rot, head smut, false smut, leaf spot, banded sclerotial blight or rust etc.
Disease has special efficacy.
Embodiment
With reference to embodiment to further instruction of the present invention, the percentage in embodiment is weight percentage, but
The invention is not limited in this.
Application Example one
The wettable powder of embodiment 1~8
Fluorine mepanipyrim, active ingredient B, dispersant, wetting agent, filler are mixed, are well mixed in mixed cylinder, through air-flow
Pulverizer remixes uniform after crushing, you can wettable powder product of the present invention is made.Specifically it is shown in Table 1.
The each component of 1 embodiment of table 1~8 and content
The water dispersible granules of embodiment 9~16
By fluorine mepanipyrim, active component B, dispersant, wetting agent, binding agent（Can add to be not added with）, disintegrant, filler together
The particle diameter needed through air-flow crushing, obtains materials of pelletizing.Item is quantified in feeding fluidized bed granulating dryer by system
After grain and drying, water dispersible granules product of the present invention is made.Specifically it is shown in Table 2.
The each component of 2 embodiment of table 9~16 and content
The suspending agent of embodiment 17~24
By dispersant, wetting agent, defoamer, thickener（Can add to be not added with）, antifreeze（Can add to be not added with）By at a high speed
Shear-mixed is uniform, adds fluorine mepanipyrim, active component B, and surplus is supplied with deionized water, ball milling 2 ~ 3 hours in ball mill,
Make diameter of particle all below 5 μm, suspending agent product of the present invention is made.Specifically it is shown in Table 3.
The each component of 3 embodiment of table 17~24 and content
The suspension emulsion of embodiment 25~28
By dispersant, defoamer, thickener in above-mentioned formulation material（Can add to be not added with）, antifreeze（Can add to be not added with）, warp
Cross high speed shear-mixed uniform, add fluorine mepanipyrim, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all 5 μm with
Under, fluorine mepanipyrim suspending agent is made, it is then that active component B, solvent, emulsifying agent and various auxiliary agents is directly newborn with high speed agitator
Change into suspending agent, suspension emulsion product of the present invention is made.Specifically it is shown in Table 4.
The each component of 4 embodiment of table 25~28 and content
The aqueous emulsion of embodiment 29~32
Fluorine mepanipyrim, solvent, emulsifying agent are added together, make to be dissolved into homogeneous oil phase；Active component B, by deionized water,
Antifreeze（Can add to be not added with）, thickener（Can add to be not added with）, defoamer mix, into homogeneous aqueous phase.In high-speed stirred
Under, aqueous phase is added into oil phase, aqueous emulsion product of the present invention is made.Specifically it is shown in Table 5.
The each component of 5 embodiment of table 29~32 and content
Active component B penconazoles, Flutriafol or Triadimenol in table 1 ~ 5 are exchanged, novel formulation can be made.
The microemulsion of embodiment 33~35
By fluorine mepanipyrim, active component B, solvent, emulsifying agent, antifreeze（Can add to be not added with）, defoamer is sufficiently mixed into
The oil phase of homogeneous transparent, is slowly added into deionized water under agitation, forms WO emulsion, then agitated heating, is allowed to
Rapid phase inversion is cooled to room temperature and makes up to balance into oil-in-water type, and through filtering, surplus is supplied with deionized water；It can be prepared by this
The described microemulsion product of invention, is specifically shown in Table 6.
The each component of 6 embodiment of table 33~35 and parts by weight
Embodiment 36,37 microcapsule suspending agents
Fluorine mepanipyrim, active component B, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase, in shearing
Under the conditions of, oil phase is added to containing in emulsifying agent, pH adjusting agent, the aqueous phase solution of dispersant, surplus is supplied with deionized water,
Two kinds of materials react in oil-water interfaces, form high score ascus wall, the well dispersed microcapsule suspension of the present composition is made
Agent product.Specifically it is shown in Table 7.
The embodiment 36 of table 7,37 each components and parts by weight
Embodiment 38,39 microcapsule suspension-suspendinagent agents
Active component B, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase, by oil phase in shearing condition
Under be added to containing in emulsifying agent, the aqueous phase solution of pH adjusting agent, well dispersed microcapsule suspending agent is made.By dispersant, wet
Moisten agent, defoamer, thickener（Can add to be not added with）It is well mixed by high speed shear, add fluorine mepanipyrim, the ball in ball mill
Mill 2 ~ 3 hours, makes diameter of particle all below 5 μm, and suspending agent is made, suspending agent then is added into micro-capsule suspension
In aqueous phase solution, deionized water supplies surplus, and the well dispersed microcapsule suspension-suspendinagent agent product of the present composition is made, tool
Body is shown in Table 8.
The embodiment 38 of table 8,39 each components and parts by weight
The embodiment of the present invention is the method being combined using Toxicity Determination and field test.First pass through indoor virulence survey
Calmly, the synergy ratio after clear and definite two kinds of medicaments are compounded by a certain percentage（SR）, SR ＜ 0.5 are antagonism, 0.5≤SR≤1.5
For summation action, SR ＞ 1.5 are synergistic effect, on this basis, then carry out field test.
Test method:After determining the effective inhibition concentration scope of each medicament through prerun, medicament sets 5 respectively by active constituent content
Individual dosage processing, if clear water is compareed.Reference《Farm-chemical indoor determination test rule bactericide》Carry out, using mycelial growth speed
Rate method determines virulence of the medicament to crop germ.Colony diameter is measured with crossing method after 72h, the net growth of each processing is calculated
Amount, mycelial growth inhibition rate.
Net growth（mm）=measurement colony diameter -5
Mycelial growth inhibition rate is converted into probit value（y）, liquor strength（μg/mL）It is converted into logarithm value（x）, with minimum
Square law tries to achieve virulence regression equation（y=a+bx）, and thus calculate the EC50 values of every kind of medicament.Simultaneously according to Wadley methods
Calculate two medicament different ratio synergy ratios（SR）, SR ＜ 0.5 are antagonism, and 0.5≤SR≤1.5 are summation action,
SR ＞ 1.5 are synergistic effect.Calculation formula is as follows:
Wherein:A, b are respectively active components A and active component B ratio shared in combination；
A is fluorine mepanipyrim；
B is selected from one of penconazole, Flutriafol or Triadimenol and planted.
Virulence experiment part：Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
Application Example two：
For examination disease：Uncinula necator；
Experimental design：Determine that the effectively suppression of fluorine mepanipyrim and both penconazoles different ratio mixture is dense by pilot study
Spend scope.
Toxicity test result
The fluorine mepanipyrim of table 9 compounds the toxicity test analysis of results table to uncinula necator with penconazole
As shown in Table 9, fluorine mepanipyrim compounds the proportioning of preventing and treating uncinula necator 1 with penconazole:80~80:When 1, synergy
Ratio SR is all higher than 1.5, illustrates both 1:80~80:Mixture shows synergistic effect, fluorine mepanipyrim and penta bacterium in the range of 1
The proportioning of azoles is 1:20~20: 1, synergistic effect is more prominent, and synergy ratio is all higher than 2.90, fluorine mepanipyrim and penconazole weight
Than for 2:Synergy ratio is maximum when 1, and synergistic effect is the most obvious.Test and find through applicant, fluorine mepanipyrim and penconazole are matched somebody with somebody
Than for 20 ︰ 1,19 ︰ 1,18 ︰ 1,17 ︰ 1,16 ︰ 1,15 ︰ 1,14 ︰ 1,13 ︰ 1,12 ︰ 1,11 ︰ 1,10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰
1st, 4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰ 13,1 ︰ 14,1 ︰
15th, to powdery mildew, scab, white rot, head smut, false smut, leaf spot, line when 1 ︰ 16,1 ︰ 17,1 ︰ 18,1 ︰ 19,1 ︰ 20
The preventing and treating of rot or rust has obvious synergistic effect, and synergy ratio is more than 1.5.
Application Example three：
For examination disease：Wheat rust；
Experimental design：Determine that the effectively suppression of fluorine mepanipyrim and both Flutriafols different ratio mixture is dense by pilot study
Spend scope.
Toxicity test result
The fluorine mepanipyrim of table 10 compounds the toxicity test analysis of results table to wheat rust with Flutriafol
As shown in Table 10, fluorine mepanipyrim compounds the proportioning for preventing and treating wheat rust 1 with Flutriafol:80~80:When 1, synergic ratio
Value SR is all higher than 1.5, illustrates both 1:80~80:Mixture shows synergistic effect, fluorine mepanipyrim and Flutriafol in the range of 1
Proportioning 1:20~20: 1, synergistic effect is more prominent, and synergy ratio is all higher than 2.85, fluorine mepanipyrim and Flutriafol weight ratio
For 2:Synergy ratio is maximum when 3, and synergistic effect is the most obvious.Test and find through applicant, the proportioning of fluorine mepanipyrim and Flutriafol
For 20 ︰ 1,19 ︰ 1,18 ︰ 1,17 ︰ 1,16 ︰ 1,15 ︰ 1,14 ︰ 1,13 ︰ 1,12 ︰ 1,11 ︰ 1,10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰ 1,
4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰ 13,1 ︰ 14,1 ︰
15th, to powdery mildew, scab, white rot, head smut, false smut, leaf spot, line when 1 ︰ 16,1 ︰ 17,1 ︰ 18,1 ︰ 19,1 ︰ 20
The preventing and treating of rot or rust has obvious synergistic effect, and synergy ratio is more than 1.5.
Application Example four：
For examination disease：Powdery mildew of cucumber；
Experimental design：Determine that the effectively suppression of fluorine mepanipyrim and both Triadimenols different ratio mixture is dense by pilot study
Spend scope.
Toxicity test result
The fluorine mepanipyrim of table 11 compounds the toxicity test analysis of results table to powdery mildew of cucumber with Triadimenol
As shown in Table 11, fluorine mepanipyrim compounds the proportioning for preventing and treating powdery mildew of cucumber 1 with Triadimenol:80~80:When 1, synergy
Ratio SR is all higher than 1.5, illustrates both 1:80~80:Mixture shows synergistic effect, fluorine mepanipyrim and triazole in the range of 1
The proportioning of alcohol is 1:25~15: 1, synergistic effect is more prominent, and synergy ratio is all higher than 2.90, fluorine mepanipyrim and Triadimenol weight
Than for 1:Synergy ratio is maximum when 4, and synergistic effect is the most obvious.Test and find through applicant, fluorine mepanipyrim and Triadimenol are matched somebody with somebody
Than for 15 ︰ 1,14 ︰ 1,13 ︰ 1,12 ︰ 1,11 ︰ 1,10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰
3rd, 1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 11,1 ︰ 12,1 ︰ 13,1 ︰ 14,1 ︰ 15,1 ︰ 16,1 ︰ 17,1 ︰ 18,1 ︰ 19,
When 1 ︰ 20,1 ︰ 21,1 ︰ 22,1 ︰ 23,1 ︰ 24,1 ︰ 25 to powdery mildew, scab, white rot, head smut, false smut, leaf spot,
The preventing and treating of banded sclerotial blight or rust has obvious synergistic effect, and synergy ratio is more than 1.5.Effect experiment part：Investigational agent
Agent is researched and developed by Shaanxi Meibang Pesticide Co., Ltd., provided, and compares 10% fluorine mepanipyrim missible oil（Autogamy）, 10% penconazole missible oil
（Autogamy）, 12.5% Flutriafol suspending agent（It is purchased in market）, 15% Triadimenol wettable powder（It is purchased in market）.The state of an illness is investigated before medicine, in the state of an illness
The dispenser of first time at initial stage, altogether dispenser 1 time.
Application Example five：
Fluorine mepanipyrim prevents and treats the powdery mildew of cucumber test of pesticide effectiveness with active component B and its compounding, and this experimental arrangement is in Shaanxi Province
Weinan City Dali County, 2 days after dispenser, investigates disease index and calculates preventive effect for 10 days, 30 days respectively.Experimental result is as follows：
The fluorine mepanipyrim of table 12 prevents and treats the powdery mildew of cucumber test of pesticide effectiveness with active component B and its compounding
As can be seen from Table 12, fluorine mepanipyrim is prevented and treated with can effectively prevent and treat powdery mildew of cucumber after active component B and its compounding
Effect is more than 96%, and better than the preventive effect of single dose, and preventive effect phase is long, to target crop without bad shadow in experiment scope of medication
Ring.
Application Example six：
Fluorine mepanipyrim prevents and treats the wheat rust test of pesticide effectiveness with active component B and its compounding, and this experimental arrangement is in Shaanxi Province Weihe
Nanshi Pucheng County, 2 days after dispenser, investigates disease index and calculates preventive effect for 10 days, 30 days respectively.Experimental result is as follows：
The fluorine mepanipyrim of table 13 prevents and treats the wheat rust test of pesticide effectiveness with active component B and its compounding
As can be seen from Table 13, fluorine mepanipyrim is with can effectively prevent and treat wheat rust, preventing and treating effect after active component B and its compounding
Fruit is more than 95%, and better than the preventive effect of single dose, and preventive effect phase is long, and can prevent and treat wheat powdery mildew and wheat sharp eyespot,
Target crop is had no adverse effects in experiment scope of medication.
Application Example seven：
Fluorine mepanipyrim and active component B and its compounding preventing and treating rice green smut test of pesticide effectiveness, this experimental arrangement is in Shaanxi Province
Hanzhong City, 2 days after dispenser, investigates disease index and calculates preventive effect for 10 days, 30 days respectively.Experimental result is as follows：
The fluorine mepanipyrim of table 14 and active component B and its compounding preventing and treating rice green smut test of pesticide effectiveness
As can be seen from Table 14, fluorine mepanipyrim and energy preventing and controlling green smut of rice, preventing and treating after active component B and its compounding
Effect is more than 95%, and better than the preventive effect of single dose, and preventive effect phase is long, and can prevent and treat rice sheath blight disease and paddy rice powdery mildew,
Target crop is had no adverse effects in experiment scope of medication.
Application Example eight：
Fluorine mepanipyrim and active component B and its compounding preventing and treating maize head smut test of pesticide effectiveness, this experimental arrangement is in Shaanxi
Weinan City is saved, 2 days after dispenser, disease index is investigated respectively and preventive effect is calculated within 10 day, 30 days.Experimental result is as follows：
The fluorine mepanipyrim of table 15 and active component B and its compounding preventing and treating maize head smut test of pesticide effectiveness
As can be seen from Table 15, fluorine mepanipyrim is prevented with can effectively prevent and treat maize head smut after active component B and its compounding
Effect is controlled more than 97%, better than the preventive effect of single dose, and preventive effect phase is long, and maize sheath blight can be prevented and treated, in experiment medication
In the range of target crop is had no adverse effects.
The experiment by different places throughout the country is drawn afterwards, and fluorine mepanipyrim is multiple with penconazole, Flutriafol or Triadimenol
To the powdery mildew in various crop, scab, white rot, head smut, false smut, leaf spot, banded sclerotial blight or rust etc. after matching somebody with somebody
The preventive effect of Common Diseases is more than 95%, and better than single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. a kind of bactericidal composition containing fluorine mepanipyrim, active ingredient is active components A and active component B, it is characterised in that：
Active components A and active component B weight ratio are 1:80~80:1, described active components A is selected from fluorine mepanipyrim, active component B
Selected from Flutriafol.
2. the bactericidal composition according to claim 1 containing fluorine mepanipyrim, it is characterised in that：Active components A and activity
Composition B weight ratio is 1:50~50:1.
3. the bactericidal composition according to claim 2 containing fluorine mepanipyrim, it is characterised in that：
The weight ratio of fluorine mepanipyrim and Flutriafol is 1:20~20:1.
4. the bactericidal composition according to any one of claim 1 to 3 containing fluorine mepanipyrim, it is characterised in that：Combination
Thing be made wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent or microcapsule suspension-
Suspending agent.
5. the bactericidal composition according to claim 4 containing fluorine mepanipyrim is used for the purposes for preventing and treating disease on crops.
6. purposes according to claim 5, it is characterised in that：Described disease include powdery mildew, scab, white rot,
Head smut, false smut, leaf spot, banded sclerotial blight or rust.
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