CN103998053B9 - 通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法 - Google Patents

通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法 Download PDF

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Publication number
CN103998053B9
CN103998053B9 CN201280061754.7A CN201280061754A CN103998053B9 CN 103998053 B9 CN103998053 B9 CN 103998053B9 CN 201280061754 A CN201280061754 A CN 201280061754A CN 103998053 B9 CN103998053 B9 CN 103998053B9
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China
Prior art keywords
lipocalin
use according
pharmaceutical composition
human
protein
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Expired - Fee Related
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CN201280061754.7A
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English (en)
Chinese (zh)
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CN103998053A (zh
CN103998053B (zh
Inventor
安德里亚斯·霍尔鲍姆
劳伦·奥多利
贝弗莉·科勒
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Pieris Pharmaceuticals GmbH
Bristol Myers Squibb Co
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Pieris AG
Pieris Pharmaceuticals GmbH
Bristol Myers Squibb Co
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Priority to CN201811146540.5A priority Critical patent/CN109432402B/zh
Publication of CN103998053A publication Critical patent/CN103998053A/zh
Application granted granted Critical
Publication of CN103998053B publication Critical patent/CN103998053B/zh
Publication of CN103998053B9 publication Critical patent/CN103998053B9/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201280061754.7A 2011-12-13 2012-12-12 通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法 Expired - Fee Related CN103998053B9 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811146540.5A CN109432402B (zh) 2011-12-13 2012-12-12 通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161570018P 2011-12-13 2011-12-13
US61/570,018 2011-12-13
PCT/EP2012/075146 WO2013087660A1 (en) 2011-12-13 2012-12-12 Methods for preventing or treating certain disorders by inhibiting binding of il-4 and/or il-13 to their respective receptors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811146540.5A Division CN109432402B (zh) 2011-12-13 2012-12-12 通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法

Publications (3)

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CN103998053A CN103998053A (zh) 2014-08-20
CN103998053B CN103998053B (zh) 2018-11-02
CN103998053B9 true CN103998053B9 (zh) 2020-07-21

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CN201280061754.7A Expired - Fee Related CN103998053B9 (zh) 2011-12-13 2012-12-12 通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法
CN201811146540.5A Expired - Fee Related CN109432402B (zh) 2011-12-13 2012-12-12 通过抑制il-4和/或il-13与其各自的受体结合来预防或治疗某些障碍的方法

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US (6) US9572863B2 (enExample)
EP (3) EP2790719B1 (enExample)
JP (5) JP6163162B2 (enExample)
CN (2) CN103998053B9 (enExample)
AU (1) AU2012350660B2 (enExample)
CA (1) CA2858962C (enExample)
DK (2) DK2790719T3 (enExample)
ES (2) ES2710384T3 (enExample)
HU (2) HUE042720T2 (enExample)
PL (2) PL3453400T3 (enExample)
SG (2) SG10201604566QA (enExample)
TR (1) TR201901826T4 (enExample)
WO (1) WO2013087660A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT201900297T1 (it) 2010-06-08 2019-07-11 Astrazeneca Ab Muteine di lipocalina lacrimale che si legano a il-4 r alfa
SG10201604566QA (en) * 2011-12-13 2016-07-28 Pieris Ag Methods for preventing or treating certain disorders by inhibiting binding of il-4 and/or il-13 to their respective receptors
CN113621050A (zh) * 2014-05-22 2021-11-09 皮里斯制药有限公司 新型特异性结合多肽及其用途
CN108348573A (zh) 2015-07-15 2018-07-31 皮里斯制药有限公司 Lag-3特异性的新型蛋白
CN113372446A (zh) * 2016-06-08 2021-09-10 苏州康乃德生物医药有限公司 用于结合白细胞介素4受体的抗体
MX2019008434A (es) 2017-01-18 2019-11-11 Pieris Pharmaceuticals Gmbh Muteínas de lipocalina con afinidad de unión por lag-3.
CA3059731A1 (en) 2017-04-21 2018-10-25 Kindred Biosciences, Inc. Il4/il13 receptor molecule for veterinary use
CN111518211B (zh) 2018-12-25 2022-06-21 江苏荃信生物医药股份有限公司 抗人白介素4受体α单克隆抗体的制药用途
WO2020200960A1 (en) 2019-03-29 2020-10-08 Astrazeneca Ab Lipocalin mutein for treatment of asthma
CN113939307A (zh) * 2019-03-29 2022-01-14 皮里斯制药有限公司 脂质运载蛋白突变蛋白的吸入施用
AU2021399151A1 (en) 2020-12-18 2023-07-27 Astrazeneca Ab Lipocalin mutein dry powder formulation for treatment of asthma
CN115414467B (zh) * 2022-10-14 2023-06-06 中国人民解放军陆军军医大学第二附属医院 载脂蛋白d在制备治疗脑出血药物中的用途

Citations (1)

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FR2649991B2 (fr) 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
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US5908621A (en) 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
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DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
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US6403564B1 (en) 1998-10-16 2002-06-11 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
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SMT201900297T1 (it) 2010-06-08 2019-07-11 Astrazeneca Ab Muteine di lipocalina lacrimale che si legano a il-4 r alfa
SG10201604566QA (en) 2011-12-13 2016-07-28 Pieris Ag Methods for preventing or treating certain disorders by inhibiting binding of il-4 and/or il-13 to their respective receptors

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Also Published As

Publication number Publication date
EP3842058B1 (en) 2023-08-23
CA2858962A1 (en) 2013-06-20
CN103998053A (zh) 2014-08-20
TR201901826T4 (tr) 2019-03-21
JP6889201B2 (ja) 2021-06-18
EP3842058A1 (en) 2021-06-30
US9572863B2 (en) 2017-02-21
DK2790719T3 (en) 2019-02-11
CN109432402A (zh) 2019-03-08
PL2790719T3 (pl) 2019-05-31
JP2019116499A (ja) 2019-07-18
JP6725447B2 (ja) 2020-07-15
EP3453400A1 (en) 2019-03-13
US20140357548A1 (en) 2014-12-04
US10016483B2 (en) 2018-07-10
ES2710384T3 (es) 2019-04-24
EP2790719A1 (en) 2014-10-22
AU2012350660A1 (en) 2014-07-03
HUE054342T2 (hu) 2021-08-30
US10398754B2 (en) 2019-09-03
HUE042720T2 (hu) 2019-07-29
WO2013087660A1 (en) 2013-06-20
ES2863410T3 (es) 2021-10-11
US20230021168A1 (en) 2023-01-19
US10857202B2 (en) 2020-12-08
JP2022084854A (ja) 2022-06-07
SG10201604566QA (en) 2016-07-28
AU2012350660B2 (en) 2018-01-25
JP2017149733A (ja) 2017-08-31
PL3453400T3 (pl) 2021-08-09
JP7441589B2 (ja) 2024-03-01
JP2020164532A (ja) 2020-10-08
JP2015505303A (ja) 2015-02-19
JP6163162B2 (ja) 2017-07-12
EP2790719B1 (en) 2018-11-21
DK3453400T3 (da) 2021-04-06
CN103998053B (zh) 2018-11-02
EP3453400B1 (en) 2021-01-20
US11382951B2 (en) 2022-07-12
US20200009223A1 (en) 2020-01-09
US20170112900A1 (en) 2017-04-27
CN109432402B (zh) 2022-04-29
US20190030121A1 (en) 2019-01-31
SG11201402992SA (en) 2014-07-30
US20210145934A1 (en) 2021-05-20
CA2858962C (en) 2023-09-05

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Address after: Freising, Germany - Stephen Weah

Applicant after: PIERIS PHARMACEUTICALS GmbH

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Effective date of registration: 20180402

Address after: Freising, Germany - Stephen Weah

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Applicant after: Bristol-Myers Squibb Co.

Address before: Freising, Germany - Stephen Weah

Applicant before: PIERIS PHARMACEUTICALS GmbH

GR01 Patent grant
GR01 Patent grant
CI03 Correction of invention patent

Correction item: Claims|Description

Correct: Claims 1-40 submitted on May 29, 2020|Paragraphs 1-133 of the specification submitted on May 29, 2020

False: Claims 1-40 submitted on May 24, 2018|13-1 / 2014

Number: 44-02

Page: full text

Volume: 34

CI03 Correction of invention patent
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20181102

CF01 Termination of patent right due to non-payment of annual fee