CN103975239B - 用于检测自身抗体的组合物和方法 - Google Patents

用于检测自身抗体的组合物和方法 Download PDF

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Publication number
CN103975239B
CN103975239B CN201180074180.2A CN201180074180A CN103975239B CN 103975239 B CN103975239 B CN 103975239B CN 201180074180 A CN201180074180 A CN 201180074180A CN 103975239 B CN103975239 B CN 103975239B
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China
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sample
tbi
tshr
chimeric
cells
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CN201180074180.2A
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English (en)
Chinese (zh)
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CN103975239A (zh
Inventor
Y·李
P·D·奥里沃
J·金
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Ortho Clinical Diagnostics Inc
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Chief Dell
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/046—Thyroid disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CN201180074180.2A 2011-09-09 2011-09-09 用于检测自身抗体的组合物和方法 Active CN103975239B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/228,705 US8986937B2 (en) 2011-09-09 2011-09-09 Compositions and methods for detecting autoantibodies
US13/228,705 2011-09-09
PCT/US2011/050976 WO2013036239A1 (en) 2011-09-09 2011-09-09 Compositions and methods for detecting autoantibodies

Publications (2)

Publication Number Publication Date
CN103975239A CN103975239A (zh) 2014-08-06
CN103975239B true CN103975239B (zh) 2016-08-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180074180.2A Active CN103975239B (zh) 2011-09-09 2011-09-09 用于检测自身抗体的组合物和方法

Country Status (9)

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US (4) US8986937B2 (enExample)
EP (1) EP2753928B1 (enExample)
JP (1) JP5908590B2 (enExample)
KR (1) KR101872060B1 (enExample)
CN (1) CN103975239B (enExample)
DK (1) DK2753928T3 (enExample)
IN (1) IN2014KN00742A (enExample)
PL (1) PL2753928T3 (enExample)
WO (1) WO2013036239A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020050208A1 (ja) * 2018-09-05 2020-03-12 ヤマサ醤油株式会社 Ｔｓｈ受容体に対する自己抗体活性の迅速測定方法及びキット
KR20220002883A (ko) * 2019-03-12 2022-01-07 퀴델 코포레이션 자가항체 검출용 조성물, 키트, 및 방법
JP7212955B2 (ja) * 2020-12-28 2023-01-26 ヤマサ醤油株式会社 甲状腺刺激ホルモン受容体阻害性自己抗体の活性測定法およびキット
CN113686841B (zh) * 2021-09-01 2023-06-30 北京利德曼生化股份有限公司 定量检测甲状腺素结合力试剂盒及其制备方法、检测方法
WO2023214183A2 (en) 2022-05-06 2023-11-09 Antibody Analytics Limited Chemically induced proximity systems

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747139B1 (en) * 1997-11-05 2004-06-08 Quest Diagnostics Investments, Inc. Nucleic acid encoding human thyrotropin receptor
CN101282995A (zh) * 2005-08-11 2008-10-08 阿皮·马托西安-罗杰斯 用于自身免疫性疾病治疗和诊断的TCR-V-β相关肽
CN101790376A (zh) * 2007-08-31 2010-07-28 欧加农股份有限公司 拮抗tsh受体的四氢喹啉化合物
US7799532B2 (en) * 2008-11-12 2010-09-21 Hemopet Detection and measurement of thyroid hormone autoantibodies

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4537573B2 (ja) 1997-09-19 2010-09-01 プロメガ・コーポレイシヨン 熱安定ルシフェラーゼと生産方法
US8293879B2 (en) 2000-03-30 2012-10-23 Diagnostic Hybrids, Inc. Methods of using chimeric receptors to identify autoimmune disease
US8563257B2 (en) * 2000-03-30 2013-10-22 Diagnostic Hybrids, Inc. Sensitive and rapid methods of using chimeric receptors to identify autoimmune disease and assess disease severity
US20080305098A1 (en) 2005-11-21 2008-12-11 Dr. Fenning Biomed Gmbh Recombinant Polypeptides and Methods for Detecting and/or Quantifying Autoantibodies Against Tsh Receptor
EP2121758B1 (en) * 2007-02-15 2014-08-06 R S R Limited Human monoclonal antibodies to the thyrotropin receptor which act as antagonists
EP2617735A3 (en) * 2008-12-24 2013-10-16 Rsr Limited Human anti tshr antibodies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747139B1 (en) * 1997-11-05 2004-06-08 Quest Diagnostics Investments, Inc. Nucleic acid encoding human thyrotropin receptor
CN101282995A (zh) * 2005-08-11 2008-10-08 阿皮·马托西安-罗杰斯 用于自身免疫性疾病治疗和诊断的TCR-V-β相关肽
CN101790376A (zh) * 2007-08-31 2010-07-28 欧加农股份有限公司 拮抗tsh受体的四氢喹啉化合物
US7799532B2 (en) * 2008-11-12 2010-09-21 Hemopet Detection and measurement of thyroid hormone autoantibodies

Also Published As

Publication number Publication date
WO2013036239A1 (en) 2013-03-14
JP2014529993A (ja) 2014-11-17
EP2753928A1 (en) 2014-07-16
US20150233914A1 (en) 2015-08-20
PL2753928T3 (pl) 2018-07-31
JP5908590B2 (ja) 2016-04-26
EP2753928B1 (en) 2018-02-07
US20240133882A1 (en) 2024-04-25
KR20140084022A (ko) 2014-07-04
US20130065252A1 (en) 2013-03-14
US20200340991A1 (en) 2020-10-29
CN103975239A (zh) 2014-08-06
DK2753928T3 (en) 2018-05-22
KR101872060B1 (ko) 2018-06-27
IN2014KN00742A (enExample) 2015-10-02
US12174185B2 (en) 2024-12-24
US8986937B2 (en) 2015-03-24
EP2753928A4 (en) 2015-05-27

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Effective date of registration: 20251021

Address after: U.S.A.

Patentee after: ORTHO-CLINICAL DIAGNOSTICS, Inc.

Country or region after: U.S.A.

Address before: California, USA

Patentee before: QUIDEL Corp.

Country or region before: U.S.A.