CN103946217B - 2‑位胺化亚甲基或2‑位酯化亚甲基丹参酮衍生物、及其制备方法和应用 - Google Patents
2‑位胺化亚甲基或2‑位酯化亚甲基丹参酮衍生物、及其制备方法和应用 Download PDFInfo
- Publication number
- CN103946217B CN103946217B CN201280056911.5A CN201280056911A CN103946217B CN 103946217 B CN103946217 B CN 103946217B CN 201280056911 A CN201280056911 A CN 201280056911A CN 103946217 B CN103946217 B CN 103946217B
- Authority
- CN
- China
- Prior art keywords
- tanshinone
- methyl
- group
- compound
- methylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 Cc1c(C**)[o]c(-c2ccc(c(C)ccc3)c3c2C2=O)c1C2=O Chemical compound Cc1c(C**)[o]c(-c2ccc(c(C)ccc3)c3c2C2=O)c1C2=O 0.000 description 2
- OOBBECVAFSNPHN-UHFFFAOYSA-N Cc1c(CCl)[o]c(-c(ccc2c3cccc2C)c3C2=O)c1C2=O Chemical compound Cc1c(CCl)[o]c(-c(ccc2c3cccc2C)c3C2=O)c1C2=O OOBBECVAFSNPHN-UHFFFAOYSA-N 0.000 description 2
- XZKIOYOHLFMCHY-UHFFFAOYSA-N Cc1c(CO)[o]c(-c2ccc(c(C)ccc3)c3c2C2=O)c1C2=O Chemical compound Cc1c(CO)[o]c(-c2ccc(c(C)ccc3)c3c2C2=O)c1C2=O XZKIOYOHLFMCHY-UHFFFAOYSA-N 0.000 description 2
- AIGAZQPHXLWMOJ-UHFFFAOYSA-N Cc1c[o]c(-c2ccc(c(C)ccc3)c3c2C2=O)c1C2=O Chemical compound Cc1c[o]c(-c2ccc(c(C)ccc3)c3c2C2=O)c1C2=O AIGAZQPHXLWMOJ-UHFFFAOYSA-N 0.000 description 2
- OEHRTGVFYMZWDB-UHFFFAOYSA-N CCN(C)Cc1c(C)c(C(C(c2c(cccc3C)c3ccc2-2)=O)=O)c-2[o]1 Chemical compound CCN(C)Cc1c(C)c(C(C(c2c(cccc3C)c3ccc2-2)=O)=O)c-2[o]1 OEHRTGVFYMZWDB-UHFFFAOYSA-N 0.000 description 1
- YWGIVHRNOUUGMI-UHFFFAOYSA-N CC[N](C)(Cc1c(C)c(C(C(c2c(cccc3C)c3ccc2-2)=O)=O)c-2[o]1)Cc(cc1Cl)ccc1F Chemical compound CC[N](C)(Cc1c(C)c(C(C(c2c(cccc3C)c3ccc2-2)=O)=O)c-2[o]1)Cc(cc1Cl)ccc1F YWGIVHRNOUUGMI-UHFFFAOYSA-N 0.000 description 1
- RIWRFSMVIUAEBX-UHFFFAOYSA-N CNCc1ccccc1 Chemical compound CNCc1ccccc1 RIWRFSMVIUAEBX-UHFFFAOYSA-N 0.000 description 1
- BLGFIJOVWVMZNC-UHFFFAOYSA-N Cc1c(CN(C)Cc2ccccc2)[o]c(-c(ccc2c(C)cccc22)c2C2=O)c1C2=O Chemical compound Cc1c(CN(C)Cc2ccccc2)[o]c(-c(ccc2c(C)cccc22)c2C2=O)c1C2=O BLGFIJOVWVMZNC-UHFFFAOYSA-N 0.000 description 1
- GGTQWWTYUKXFPP-UHFFFAOYSA-N Fc(ccc(CBr)c1)c1Cl Chemical compound Fc(ccc(CBr)c1)c1Cl GGTQWWTYUKXFPP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201280056911.5A CN103946217B (zh) | 2011-11-30 | 2012-11-30 | 2‑位胺化亚甲基或2‑位酯化亚甲基丹参酮衍生物、及其制备方法和应用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2011/083261 | 2011-11-30 | ||
| CN2011083261 | 2011-11-30 | ||
| CN201280056911.5A CN103946217B (zh) | 2011-11-30 | 2012-11-30 | 2‑位胺化亚甲基或2‑位酯化亚甲基丹参酮衍生物、及其制备方法和应用 |
| PCT/CN2012/085660 WO2013079022A1 (zh) | 2011-11-30 | 2012-11-30 | 2-位胺化亚甲基或2-位酯化亚甲基丹参酮衍生物、及其制备方法和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103946217A CN103946217A (zh) | 2014-07-23 |
| CN103946217B true CN103946217B (zh) | 2017-04-19 |
Family
ID=48534682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280056911.5A Expired - Fee Related CN103946217B (zh) | 2011-11-30 | 2012-11-30 | 2‑位胺化亚甲基或2‑位酯化亚甲基丹参酮衍生物、及其制备方法和应用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9328083B2 (enExample) |
| EP (1) | EP2786990B1 (enExample) |
| JP (1) | JP6149043B2 (enExample) |
| CN (1) | CN103946217B (enExample) |
| DK (1) | DK2786990T3 (enExample) |
| WO (1) | WO2013079022A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013079017A1 (zh) * | 2011-11-30 | 2013-06-06 | 杭州本生药业有限公司 | 2-位烷基或芳香基取代的丹参酮衍生物、及其制备方法和应用 |
| CN105884723B (zh) * | 2014-12-25 | 2019-08-02 | 上海三帆生物医药科技有限公司 | 丹参酮衍生物、其制备方法及其应用 |
| CN105884857B (zh) * | 2015-01-23 | 2018-10-12 | 上海三帆生物医药科技有限公司 | 丹参酮衍生物、其制备方法及其应用 |
| CN106810593B (zh) * | 2016-12-26 | 2018-12-04 | 郑州大学 | 一种丹参酮类化合物17位酯化衍生物及其制备工艺和应用 |
| CN106831934B (zh) * | 2016-12-26 | 2018-09-21 | 郑州大学 | 一种丹参酮类化合物15位酰胺类衍生物及其制备工艺和应用 |
| CN111000851B (zh) * | 2019-12-31 | 2021-09-07 | 扬州大学 | 丹参酮i在制备肿瘤细胞自噬诱导剂药物中的应用 |
| CN113773289B (zh) * | 2021-09-15 | 2023-05-12 | 沈阳药科大学 | 一种萘[1,2-b]杂环-4,5-二酮类化合物及其制备方法和应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1837200A (zh) * | 2006-04-26 | 2006-09-27 | 秦引林 | 丹参酮ⅰ衍生物及其在制药中的应用 |
| CN101012270A (zh) * | 2007-01-26 | 2007-08-08 | 广东工业大学 | 丹参酮衍生物及在制备醛糖还原酶抑制剂药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100387585C (zh) | 2006-04-26 | 2008-05-14 | 秦引林 | 丹参酮ⅰ衍生物及其在制药中的应用 |
| KR20080047957A (ko) * | 2006-11-27 | 2008-05-30 | 주식회사 엠디바이오알파 | 고혈압의 치료 및 예방을 위한 약제 조성물 |
| CN101274925A (zh) * | 2007-03-29 | 2008-10-01 | 中国科学院上海药物研究所 | 一类萘并呋喃邻醌化合物及其制备方法和用途 |
| US20100209513A1 (en) * | 2007-10-11 | 2010-08-19 | In Geun Jo | Pharmaceutical composition containing micronized particles of naphthoquinone-based compound |
| KR20090073381A (ko) * | 2007-12-31 | 2009-07-03 | 주식회사 머젠스 | 심장질환의 치료 및 예방을 위한 약제 조성물 |
-
2012
- 2012-11-30 EP EP12854507.6A patent/EP2786990B1/en not_active Not-in-force
- 2012-11-30 US US14/361,548 patent/US9328083B2/en not_active Expired - Fee Related
- 2012-11-30 WO PCT/CN2012/085660 patent/WO2013079022A1/zh not_active Ceased
- 2012-11-30 DK DK12854507.6T patent/DK2786990T3/en active
- 2012-11-30 CN CN201280056911.5A patent/CN103946217B/zh not_active Expired - Fee Related
- 2012-11-30 JP JP2014543762A patent/JP6149043B2/ja not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1837200A (zh) * | 2006-04-26 | 2006-09-27 | 秦引林 | 丹参酮ⅰ衍生物及其在制药中的应用 |
| CN101012270A (zh) * | 2007-01-26 | 2007-08-08 | 广东工业大学 | 丹参酮衍生物及在制备醛糖还原酶抑制剂药物中的应用 |
Non-Patent Citations (1)
| Title |
|---|
| 丹参二萜醌的结构修饰;杨东等;《中国药科大学学报》;19980830;第29卷(第4期);第256-257页及第258页左栏倒数第1段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015500801A (ja) | 2015-01-08 |
| US9328083B2 (en) | 2016-05-03 |
| US20150126552A1 (en) | 2015-05-07 |
| EP2786990B1 (en) | 2018-08-08 |
| EP2786990A1 (en) | 2014-10-08 |
| WO2013079022A1 (zh) | 2013-06-06 |
| JP6149043B2 (ja) | 2017-06-14 |
| EP2786990A4 (en) | 2015-07-15 |
| DK2786990T3 (en) | 2018-11-19 |
| CN103946217A (zh) | 2014-07-23 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170419 Termination date: 20211130 |