CN103945765B - 计算并呈现灰质中的脑部淀粉样物质的方法 - Google Patents

计算并呈现灰质中的脑部淀粉样物质的方法 Download PDF

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CN103945765B
CN103945765B CN201280056202.7A CN201280056202A CN103945765B CN 103945765 B CN103945765 B CN 103945765B CN 201280056202 A CN201280056202 A CN 201280056202A CN 103945765 B CN103945765 B CN 103945765B
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CN103945765A (zh
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F·O·蒂勒
F·文策尔
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Koninklijke Philips NV
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/0035Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03Computed tomography [CT]
    • A61B6/037Emission tomography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/501Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of the head, e.g. neuroimaging or craniography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5229Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
    • A61B6/5247Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/4808Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
    • G01R33/481MR combined with positron emission tomography [PET] or single photon emission computed tomography [SPECT]
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • G06T7/0014Biomedical image inspection using an image reference approach
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/46Arrangements for interfacing with the operator or the patient
    • A61B6/461Displaying means of special interest
    • A61B6/466Displaying means of special interest adapted to display 3D data
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10072Tomographic images
    • G06T2207/10088Magnetic resonance imaging [MRI]
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10072Tomographic images
    • G06T2207/10104Positron emission tomography [PET]
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30016Brain

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Optics & Photonics (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Quality & Reliability (AREA)
  • Pulmonology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Neurosurgery (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nuclear Medicine (AREA)
CN201280056202.7A 2011-11-16 2012-11-13 计算并呈现灰质中的脑部淀粉样物质的方法 Expired - Fee Related CN103945765B (zh)

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US201161560319P 2011-11-16 2011-11-16
US61/560,319 2011-11-16
PCT/IB2012/056379 WO2013072843A1 (en) 2011-11-16 2012-11-13 Method to compute and present brain amyloid in gray matter

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CN103945765B true CN103945765B (zh) 2016-10-26

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US (1) US9585567B2 (https=)
EP (1) EP2747658B1 (https=)
JP (1) JP6100792B2 (https=)
CN (1) CN103945765B (https=)
BR (1) BR112014009039A2 (https=)
IN (1) IN2014CN03661A (https=)
RU (1) RU2014113912A (https=)
WO (1) WO2013072843A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013214050A1 (de) * 2013-07-17 2015-01-22 Siemens Aktiengesellschaft Verfahren zu einem Darstellen von Bilddaten von Körperbereichen eines Patienten, wobei die Körperbereiche an einer Demenz-Erkrankung erkranken können, sowie ein medizinische Bildgebungssystem, das zu einer Ausführung des Verfahrens ausgelegt ist
CN105979872A (zh) * 2013-09-25 2016-09-28 理查德·R·布莱克 正电子发射断层摄影数据的病人特异性分析
JP5689205B1 (ja) * 2014-11-21 2015-03-25 日本メジフィジックス株式会社 頭部核医学画像の評価法
JP6775944B2 (ja) * 2015-12-14 2020-10-28 キヤノンメディカルシステムズ株式会社 画像処理装置
CN105816192A (zh) * 2016-03-03 2016-08-03 王雪原 个体化人脑多模态医学影像的三维配准及提取脑组织方法
KR20180077819A (ko) * 2016-12-29 2018-07-09 사회복지법인 삼성생명공익재단 뇌아밀로이드 혈관병증의 예후 예측방법
EP3387997B1 (en) * 2017-04-13 2020-02-26 Siemens Healthcare GmbH Medical imaging device and method controlling one or more parameters of a medical imaging device
KR102004964B1 (ko) * 2017-10-12 2019-07-29 전남대학교산학협력단 Pet 뇌 영상 아밀로이드 측정을 위한 부피 기반 정량지표 분석 방법 및 컴퓨터 프로그램
JP7313165B2 (ja) * 2019-03-18 2023-07-24 株式会社Erisa アルツハイマー病生存分析装置及びアルツハイマー病生存分析プログラム
KR102414974B1 (ko) * 2020-08-03 2022-06-30 사회복지법인 삼성생명공익재단 Pet-ct 영상을 이용하는 알츠하이머 질환의 진단 장치 및 이의 동작 방법
US20220067919A1 (en) * 2020-08-26 2022-03-03 GE Precision Healthcare LLC System and method for identifying a tumor or lesion in a probabilty map

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7270800B2 (en) * 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US6819952B2 (en) 2001-03-23 2004-11-16 The Board Of Trustees Of The Leland Stanford Junior University Magnetic resonance spectroscopic imaging method to monitor progression and treatment of neurodegenerative conditions
US8423125B2 (en) * 2004-11-09 2013-04-16 Spectrum Dynamics Llc Radioimaging
WO2007023522A1 (ja) * 2005-08-22 2007-03-01 National Center Of Neurology And Psychiatry 脳疾患の診断支援方法及び装置
US7929737B2 (en) * 2005-09-29 2011-04-19 General Electric Company Method and system for automatically generating a disease severity index
US20100135556A1 (en) * 2006-10-26 2010-06-03 Pasha Razifar Method and system for outlining a region in positron emission tomography studies
ES2414614T3 (es) 2007-01-30 2013-07-22 Ge Healthcare Limited Herramientas para ayudar en el diagnóstico de enfermedades neurodegenerativas
WO2008114801A1 (en) 2007-03-12 2008-09-25 National Institute Of Radiological Sciences Pet visualization of amyloid-associated neuroinflammation in the brain
US7887784B2 (en) * 2007-03-21 2011-02-15 University Of Montana 1-[(2′-substituted)-piperazin-1′ -yl]-isoquinolines as norepinephrine transporter inhibitor therapeutics and positron emission tomography imaging agents
DE102007018630A1 (de) * 2007-04-19 2008-10-23 Siemens Ag Multimodales Bildakquisitions-, Bildverarbeitungs-, Bildarchivierungs- und Bildvisialisierungssystem zur Koregistrierung, Fusionierung, Archivierung und grafischen Visualisierung endoluminaler CT- bzw. MRT-Bilddaten mit eingeblendeten PET-, PET-CT-, SPECT- bzw. SPECT-CT-Bilddaten
DE102007034956A1 (de) * 2007-07-26 2009-02-05 Siemens Ag Verfahren zum Detektieren einer neuropathologisch veränderten Gehirnregion
US7989630B2 (en) * 2008-04-30 2011-08-02 National Institutes Of Health Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health Radiotracers for imaging P-glycoprotein function
WO2009146388A1 (en) * 2008-05-28 2009-12-03 The Trustees Of Columbia University In The City Of New York Voxel-based methods for assessing subjects using positron emission tomography
EP2399238B1 (en) * 2009-02-17 2015-06-17 Koninklijke Philips N.V. Functional imaging
US8811708B2 (en) * 2009-04-15 2014-08-19 Koninklijke Philips N.V. Quantification of medical image data
SG2014012686A (en) * 2009-10-08 2014-06-27 Ge Healthcare Ltd Purification method
JP2013521233A (ja) 2010-02-25 2013-06-10 ヤンセン アルツハイマー イミュノセラピー Aβを標的とする免疫療法のPETモニタリング
WO2012051170A2 (en) * 2010-10-12 2012-04-19 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phingylbenzothiazole, stilbene, or biphenylalkyne derivatives
CN103415779B (zh) * 2011-03-07 2016-05-11 皇家飞利浦有限公司 利用混合式核成像/mr中的核发射数据进行mr分割的系统及方法
US9002081B2 (en) * 2011-10-18 2015-04-07 Matthew Sherman Brown Computer-aided bone scan assessment with automated lesion detection and quantitative assessment of bone disease burden changes

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US9585567B2 (en) 2017-03-07
JP2015502535A (ja) 2015-01-22
JP6100792B2 (ja) 2017-03-22
EP2747658A1 (en) 2014-07-02
WO2013072843A1 (en) 2013-05-23
RU2014113912A (ru) 2015-10-20
US20140257084A1 (en) 2014-09-11
EP2747658B1 (en) 2020-01-15
BR112014009039A2 (pt) 2017-05-09
CN103945765A (zh) 2014-07-23
IN2014CN03661A (https=) 2015-10-16

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