CN103933182A - Traditional Chinese medicine composition for treating psoriasis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating psoriasis and preparation method thereof Download PDFInfo
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- 238000000034 method Methods 0.000 claims description 35
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for treating psoriasis. The composition consists of the following raw medicinal materials in parts by weight: 30-50 parts of solidago decurrens, 5-25 parts of cortex dictamni, 40-60 parts of rheum officinale, 90-110 parts of rice vinegar, 20-40 parts of szechwan chinaberry bark, 20-40 parts of leech, 20-40 parts of sulphur, 20-40 parts of eucalyptus robusta, 6-13 parts of nidus vespae, 10-30 parts of rumex japonicus root and 20-40 parts of golden cypress. The traditional Chinese medicine composition made of the raw medicinal materials has a remarkable effect on treating psoriasis, allows fast effect, and is low in cost and convenient to use.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of Chinese medicine composition that Corii Bovis seu Bubali is fresh and preparation method thereof for the treatment of.
Background technology
Psoriasis vulgaris is commonly called as psoriasis, it is a kind of common chronic inflammatory skin disease that is easy to recurrence with characteristic skin lesion, from the beginning of being the red pimple of inflammatory, about foxtail millet grain is to Semen phaseoli radiati size, expand gradually later or merge and become brownish red speckle, clear border, have inflammatory blush around, substrate infiltrates obviously, the canescence that surface coverage multilamellar is dry or silvery white squama, strike off gently surperficial squama, expose gradually the shinny semitransparent thin film of one deck pale red, claim thin film phenomenon, then strike off thin film, there is little petechia, claim petechial hemorrhage phenomenon.White squama, shinny thin film and petechial hemorrhage are the psoriatic key characters of diagnosis, are called three and levy.Psoriasis vulgaris is broadly divided into three periods from occurring to finally to disappear: carry out phase, resting stage, catagen.
Treatment psoriasis conventionally according to disease light, in, heavy degree selects the mode for the treatment of: slightly refer to skin lesion area 10%.Slight psoriasis only needs external medication, in, severe need use innerlich anwenden, medicine for external use and physiotherapy therapeutic alliance.Being used for the treatment of psoriasic external used medicine generally comprises following several: tar preparation, conventional have coal tar, pine tar, pityrol, a Pityrol etc., concentration is generally 5%, using method is conventional outer painting, package and the treatment of associating other drug, best to chronic stable psoriasis, scalp psoriasis and volar psoriasis effect, forbid in the anemia of pregnant woman of especially front 3 months of trimester of pregnancy, be also not used in the patient of the serious acne of companion and folliculitis; Dithranol, claims again anthraline, is the most effective medicine for the treatment of homeliness type stability psoriasis.Conventional anthralin Ointment and rod wax, method has conventional coating method, short contact therapy and conjoint therapy; Glucocorticoids, belongs to the most frequently used medicine for external use, and psoriasis vulgaris can be selected middle effect or potent glucocorticoid, best with ointment effect, and lotion is for poor, usage be the outer painting method of routine, intermittence flooding, rotation therapy, package therapy, conjoint therapy; Tretinoin medicine, it is applicable to homeliness type plaque psoriasis.Can cause local excitation and phenomenon of photosensitivity, if combine with glucocorticoid or UVB, can improve curative effect, reduce untoward reaction.Anemia of pregnant woman, women breast-feeding their children and have in the recent period the women forbidding of fertility hope, child avoids using.Avoid contacting with mucosa, avoid shine under sunlight more; Vitamin D 3 analogs, is used for the treatment of stable phase or plaque psoriasis very effective, and treatment psoriasis onychonosus effect is better, has calcipotriol and tacalcitol two classes, and wherein tacalcitol can be for face; Immunosuppressant, as the psoriatic first-selected medication of face, has two kinds of tacrolimus and pimecrolimus.
Summary of the invention
For this reason, the object of the present invention is to provide one to treat psoriasic Chinese medicine composition and preparation method thereof.
For solving the problems of the technologies described above, the invention provides one and treat psoriasic Chinese medicine composition, the crude drug of described compositions consists of: Herba Solidaginis 30-50 weight portion, Cortex Dictamni 5-25 weight portion, Radix Et Rhizoma Rhei 40-60 weight portion, rice vinegar 90-110 weight portion, Melia azedarach L. skin 20-40 weight portion, Hirudo 20-40 weight portion, sulfur 20-40 weight portion, Folium Eucalypti Robustae 20-40 weight portion, Nidus Vespae 6-13 weight portion, Radix Rumicis Crispi 10-30 weight portion and Cortex Phellodendri 20-40 weight portion.
The psoriasic Chinese medicine composition of described treatment, the crude drug of described compositions consists of: Herba Solidaginis 40 weight portions, Cortex Dictamni 15 weight portions, Radix Et Rhizoma Rhei 50 weight portions, rice vinegar 100 weight portions, Melia azedarach L. skin 30 weight portions, Hirudo 30 weight portions, sulfur 30 weight portions, Folium Eucalypti Robustae 30 weight portions, Nidus Vespae 8 weight portions, Radix Rumicis Crispi 20 weight portions and Cortex Phellodendri 30 weight portions.
The psoriasic Chinese medicine composition of described treatment, described Chinese medicine composition adds conventional adjuvant to make acceptable external preparation clinically according to common process.
The invention provides a kind of external preparation that adopts above-mentioned pharmaceutical composition to add conventional adjuvant to prepare according to common process.
Described external preparation comprises spray, liniment, unguentum, paste, lotion or patch.
The invention provides a kind of method of preparing the psoriasic Chinese medicine composition of described treatment, the method comprises the steps:
(a) get Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri according to selected parts by weight, be ground into respectively after mixing or mix after fine powder and be ground into fine powder, sieving for standby;
(b) get above-mentioned fine powder, add the rice vinegar of selected parts by weight, then add conventional adjuvant to make acceptable spray, liniment, unguentum, paste, lotion or patch clinically according to common process.
The invention provides a kind of method of preparing the psoriasic Chinese medicine composition of described treatment, the method comprises the steps:
(a) get Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, rice vinegar, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri according to selected parts by weight and mix, decoct with water, filter and merging filtrate, get supernatant concentration extractum;
(b) get described extractum, add conventional adjuvant to make acceptable spray, liniment, unguentum, paste, lotion or patch clinically according to common process.
The invention provides a kind of method of preparing the psoriasic Chinese medicine composition of described treatment, the method comprises the steps:
Get Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, rice vinegar, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri mixed powder according to selected parts by weight and be broken into coarse powder, add ethanol extraction and obtain alcohol extract, concentrating under reduced pressure is except after alcohol, add conventional adjuvant, make acceptable spray, liniment, unguentum, paste, lotion or patch clinically according to common process.
The present invention prepares the psoriasic Chinese medicine composition for the treatment of by above-mentioned method.
The invention provides a kind of Chinese medicine composition in the application of preparing in antipsoriatics thing.
The psoriasic Chinese medicine composition for the treatment of of the present invention, be that the Chinese medicine composition that crude drug is made has significant therapeutic effect aspect treatment psoriasis by choosing Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, rice vinegar, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri, instant effect, expense is low, easy to use, clinical cure rate is up to 98.3%.
The psoriasic clinical observation of experimental example traditional Chinese medicine composition for treating of the present invention
1, data and method
Clinical data: the present invention suffers from psoriasic patient to 120 examples and carries out clinical observation.
The evaluation criterion of clinical therapeutic efficacy is:
(1) clinical cure: original transference cure;
(2) effective: original symptom part disappears;
(3) take a turn for the better: original state of an illness alleviates to some extent;
(4) invalid: symptom and sign is unchanged.
Medication: get respectively paste prepared by spray prepared by embodiment 1 and embodiment 3 and be sprayed in right amount or be coated on patient's site of disease, every 15 days courses for the treatment of, every day 2 times.
2, therapeutic outcome
Use after the traditional Chinese medicine composition for treating prepared of the embodiment of the present invention 1 above-mentioned 60 routine sufferer 2-3 course for the treatment of, the psoriasis treatment result of observing described 60 routine patients, wherein cures 57 examples, effective 3 examples, and improvement 0 example, invalid 0 example, cure rate is 95%.
Use after the traditional Chinese medicine composition for treating prepared of the embodiment of the present invention 3 other 60 routine sufferer 2-3 course for the treatment of, the psoriasis treatment result of observing described 60 routine patients, wherein cures 59 examples, effective 1 example, and improvement 0 example, invalid 0 example, cure rate is 98.3%.
Toxic and side effects: after treatment finishes, check hematuria routine, stool, the heart, liver and the no abnormal change of renal function.After 3 months, above-mentioned case is paid a return visit, without patients with recurrent.
3, conclusion
(1) Chinese medicine composition of the present invention has significant therapeutic effect at aspects such as treatment psoriasiss, and its cure rate can reach 98.3%, short treating period, and instant effect, and have no side effect.
Detailed description of the invention
Embodiment 1 spray dosage form
The psoriasic Chinese medicine composition for the treatment of of the present embodiment, its formula is as follows:
Herba Solidaginis 30g, Cortex Dictamni 25g, Radix Et Rhizoma Rhei 40g, rice vinegar 110g, Melia azedarach L. skin 20g, Hirudo 40g, sulfur 20g, Folium Eucalypti Robustae 40g, Nidus Vespae 13g, Radix Rumicis Crispi 30g and Cortex Phellodendri 20g.
Described Chinese medicine composition is prepared into spray according to following steps:
(a) get Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri according to selected parts by weight, be ground into respectively after mixing or mix after fine powder and be ground into fine powder, cross 40 mesh sieves for subsequent use;
(b) get above-mentioned fine powder, add the rice vinegar of selected parts by weight, then add conventional adjuvant to make acceptable spray clinically according to common process.
Embodiment 2 liniment dosage forms
The psoriasic Chinese medicine composition for the treatment of of the present embodiment, its formula is as follows:
Herba Solidaginis 50g, Cortex Dictamni 5g, Radix Et Rhizoma Rhei 60g, rice vinegar 90g, Melia azedarach L. skin 40g, Hirudo 20g, sulfur 40g, Folium Eucalypti Robustae 20g, Nidus Vespae 6g, Radix Rumicis Crispi 10g and Cortex Phellodendri 40g.
Described Chinese medicine composition is prepared into liniment according to following steps:
(a) get Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri according to selected parts by weight, be ground into respectively after mixing or mix after fine powder and be ground into fine powder, cross 400 mesh sieves for subsequent use;
(b) get above-mentioned fine powder, add the rice vinegar of selected parts by weight, then add conventional adjuvant to make acceptable liniment clinically according to common process.
Embodiment 3 paste dosage forms
The psoriasic Chinese medicine composition for the treatment of of the present embodiment, its formula is as follows:
Herba Solidaginis 40g, Cortex Dictamni 15g, Radix Et Rhizoma Rhei 50g, rice vinegar 100g, Melia azedarach L. skin 30g, Hirudo 30g, sulfur 30g, Folium Eucalypti Robustae 30g, Nidus Vespae 8g, Radix Rumicis Crispi 20g and Cortex Phellodendri 30g.
Described Chinese medicine composition is prepared into paste according to following steps:
(a) get Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri according to selected parts by weight, be ground into respectively after mixing or mix after fine powder and be ground into fine powder, cross 200 mesh sieves for subsequent use;
(b) get above-mentioned fine powder, add the rice vinegar of selected parts by weight, then add conventional adjuvant to make acceptable paste clinically according to common process.
Embodiment 4 unguentum dosage forms
The psoriasic Chinese medicine composition for the treatment of of the present embodiment, its formula is as follows:
Herba Solidaginis 30g, Cortex Dictamni 5g, Radix Et Rhizoma Rhei 40g, rice vinegar 90g, Melia azedarach L. skin 20g, Hirudo 20g, sulfur 20g, Folium Eucalypti Robustae 20g, Nidus Vespae 11g, Radix Rumicis Crispi 10g and Cortex Phellodendri 20g.
Described Chinese medicine composition is prepared into unguentum according to following steps:
(a) getting Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, rice vinegar, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri according to selected parts by weight mixes, decoct with water secondary, add for the first time the water of 8 times of drug weight, decoct 2.5 hours, add for the second time 6 times of water gagings, decoct 2 hours, filter, merging filtrate, hold over night, gets the extractum that supernatant concentration to 60 DEG C relative density is 1.2-1.25;
(b) get described extractum, add conventional adjuvant to make acceptable unguentum clinically according to common process.
Embodiment 5 patch dosage forms
The psoriasic Chinese medicine composition for the treatment of of the present embodiment, its formula is as follows:
Herba Solidaginis 50g, Cortex Dictamni 25g, Radix Et Rhizoma Rhei 60g, rice vinegar 110g, Melia azedarach L. skin 40g, Hirudo 40g, sulfur 40g, Folium Eucalypti Robustae 40g, Nidus Vespae 8g, Radix Rumicis Crispi 30g and Cortex Phellodendri 40g.
Described Chinese medicine composition is prepared into patch according to following steps:
(a) getting Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, rice vinegar, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri according to selected parts by weight mixes, decoct with water secondary, add for the first time the water of 12 times of drug weight, decoct 1.5 hours, add for the second time 10 times of water gagings, decoct 1 hour, filter, merging filtrate, hold over night, gets the extractum that supernatant concentration to 60 DEG C relative density is 1.2-1.25;
(b) get described extractum, add conventional adjuvant to make acceptable patch clinically according to common process.
Embodiment 6 spray dosage forms
The psoriasic Chinese medicine composition for the treatment of of the present embodiment, its formula is as follows:
Herba Solidaginis 35g, Cortex Dictamni 20g, Radix Et Rhizoma Rhei 45g, rice vinegar 105g, Melia azedarach L. skin 25g, Hirudo 35g, sulfur 25g, Folium Eucalypti Robustae 35g, Nidus Vespae 10g, Radix Rumicis Crispi 25g and Cortex Phellodendri 25g.
Described Chinese medicine composition is prepared into spray according to following steps:
Get Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, rice vinegar, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri mixed powder according to selected parts by weight and be broken into coarse powder, add the 55-75% ethanol of 4 times of drug weight, flood after 48 hours, it is 30 DEG C～40 DEG C that medicine liquid heating is kept to fluid temperature, forced circulation 3-4 hour, filters, and obtains alcohol extract, add conventional adjuvant, make acceptable spray clinically according to common process.
Embodiment 7 lotion dosage forms
The psoriasic Chinese medicine composition for the treatment of of the present embodiment, its formula is as follows:
Herba Solidaginis 45g, Cortex Dictamni 10g, Radix Et Rhizoma Rhei 55g, rice vinegar 95g, Melia azedarach L. skin 35g, Hirudo 25g, sulfur 35g, Folium Eucalypti Robustae 25g, Nidus Vespae 9g, Radix Rumicis Crispi 15g and Cortex Phellodendri 35g.
Described Chinese medicine composition is prepared into lotion according to following steps:
Get Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, rice vinegar, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri mixed powder according to selected parts by weight and be broken into coarse powder, add the 55-75% ethanol of 12 times of drug weight, flood after 12 hours, it is 30 DEG C～40 DEG C that medicine liquid heating is kept to fluid temperature, forced circulation 3-4 hour, filters, and obtains alcohol extract, add conventional adjuvant, make acceptable lotion clinically according to common process.
Obviously, above-described embodiment is only for example is clearly described, and the not restriction to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here without also giving exhaustive to all embodiments.And the apparent variation of being extended out thus or variation are still among the protection domain in the invention.
Claims (10)
1. the psoriasic Chinese medicine composition for the treatment of, it is characterized in that, the crude drug of described compositions consists of: Herba Solidaginis 30-50 weight portion, Cortex Dictamni 5-25 weight portion, Radix Et Rhizoma Rhei 40-60 weight portion, rice vinegar 90-110 weight portion, Melia azedarach L. skin 20-40 weight portion, Hirudo 20-40 weight portion, sulfur 20-40 weight portion, Folium Eucalypti Robustae 20-40 weight portion, Nidus Vespae 6-13 weight portion, Radix Rumicis Crispi 10-30 weight portion and Cortex Phellodendri 20-40 weight portion.
2. the psoriasic Chinese medicine composition for the treatment of according to claim 1, it is characterized in that, the crude drug of described compositions consists of: Herba Solidaginis 40 weight portions, Cortex Dictamni 15 weight portions, Radix Et Rhizoma Rhei 50 weight portions, rice vinegar 100 weight portions, Melia azedarach L. skin 30 weight portions, Hirudo 30 weight portions, sulfur 30 weight portions, Folium Eucalypti Robustae 30 weight portions, Nidus Vespae 8 weight portions, Radix Rumicis Crispi 20 weight portions and Cortex Phellodendri 30 weight portions.
3. the psoriasic Chinese medicine composition for the treatment of according to claim 1 and 2, is characterized in that, described Chinese medicine composition adds conventional adjuvant to make acceptable external preparation clinically according to common process.
4. the external preparation that adopts the arbitrary described pharmaceutical composition of claim 1-3 to add conventional adjuvant to prepare according to common process.
5. external preparation according to claim 4, is characterized in that, described external preparation comprises spray, liniment, unguentum, paste, lotion or patch.
6. prepare as arbitrary in claim 1-3 as described in treatment psoriasic Chinese medicine composition a method, it is characterized in that, the method comprises the steps:
(a) get Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri according to selected parts by weight, be ground into respectively after mixing or mix after fine powder and be ground into fine powder, sieving for standby;
(b) get above-mentioned fine powder, add the rice vinegar of selected parts by weight, then add conventional adjuvant to make acceptable spray, liniment, unguentum, paste, lotion or patch clinically according to common process.
7. prepare as arbitrary in claim 1-3 as described in treatment psoriasic Chinese medicine composition a method, it is characterized in that, the method comprises the steps:
(a) get Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, rice vinegar, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri according to selected parts by weight and mix, decoct with water, filter and merging filtrate, get supernatant concentration extractum;
(b) get described extractum, add conventional adjuvant to make acceptable spray, liniment, unguentum, paste, lotion or patch clinically according to common process.
8. prepare as arbitrary in claim 1-3 as described in treatment psoriasic Chinese medicine composition a method, it is characterized in that, the method comprises the steps:
Get Herba Solidaginis, Cortex Dictamni, Radix Et Rhizoma Rhei, rice vinegar, Melia azedarach L. skin, Hirudo, sulfur, Folium Eucalypti Robustae, Nidus Vespae, Radix Rumicis Crispi and Cortex Phellodendri mixed powder according to selected parts by weight and be broken into coarse powder, add ethanol extraction and obtain alcohol extract, concentrating under reduced pressure is except after alcohol, add conventional adjuvant, make acceptable spray, liniment, unguentum, paste, lotion or patch clinically according to common process.
9. the Chinese medicine composition preparing according to the arbitrary described method of claim 6-8.
According to claim 1-3 or 9 arbitrary described Chinese medicine compositions in the application of preparing in antipsoriatics thing.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596080A (en) * | 2017-11-07 | 2018-01-19 | 王成红 | A kind of medicament for removing cattle and sheep foot and mouth disease and preparation method thereof |
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| CN1220884A (en) * | 1997-12-23 | 1999-06-30 | 杨会明 | Traditional Chinese medicine preparation for treatment of skin disease and running sore and carbuncle |
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| CN1220884A (en) * | 1997-12-23 | 1999-06-30 | 杨会明 | Traditional Chinese medicine preparation for treatment of skin disease and running sore and carbuncle |
| CN1481880A (en) * | 2003-07-10 | 2004-03-17 | 姜延德 | Ointment for curing tinea on manus and pedes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107596080A (en) * | 2017-11-07 | 2018-01-19 | 王成红 | A kind of medicament for removing cattle and sheep foot and mouth disease and preparation method thereof |
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Effective date of registration: 20240307 Address after: 130000 Old Village Department of Xinjia Village, Qianyugou East, Luxiang Township, Shuangyang District, Changchun City, Jilin Province Patentee after: Haiao Pharmaceutical (Changchun) Co.,Ltd. Country or region after: China Address before: 325619 Xiangyang Damaoling Village, Leqing City, Wenzhou City, Zhejiang Province Patentee before: Li Guoxuan Country or region before: China |