CN103933115A - Motherwort granule preparation technology - Google Patents
Motherwort granule preparation technology Download PDFInfo
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- CN103933115A CN103933115A CN201410127920.XA CN201410127920A CN103933115A CN 103933115 A CN103933115 A CN 103933115A CN 201410127920 A CN201410127920 A CN 201410127920A CN 103933115 A CN103933115 A CN 103933115A
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- herba leonuri
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- motherwort
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Abstract
The invention discloses a motherwort granule preparation technology, which comprises the following steps: (1) extraction, namely putting motherwort into a pot, adding water for decocting, pumping and filtering to obtain a filtrate; (2) concentration, namely pumping the filtrate into a three-effect energy-saving concentrator for vacuum concentration, enabling the concentrated liquor to naturally settle in a jar, and performing vacuum concentration on the naturally settled supernate, to obtain motherwort cream; (3) granulation, namely evenly mixing dextrin and the smashed saccharose, and mixing together with the motherwort cream in the step (2) to prepare a soft material, sieving the soft material with a 14-mesh sieve, and granulating and drying; (4) granule finishing, namely hermetically storing the dried granules, weighing, and hanging a tag for later packaging; and (5) packaging. The motherwort granules prepared by the technology are simple in preparation process; according to the preparation technology, the motherwort can be widely utilized, the motherwort granules re conveniently conveyed, and the demands of people on the motherwort granules are met.
Description
Technical field
The invention belongs to pharmaceutical field, specifically a kind of Herba Leonuri granule preparation technology.
Background technology
herba Leonuri is the herb of labiate Herba Leonuri, is the herbal species that Chinese Pharmacopoeia records, and is the conventional Chinese medicine of gynecological clinically, has regulating menstruation, invigorates blood circulation and the effect such as blood stasis dispelling.Chinese Patent Application No. 03118656.4 discloses a kind of preparation method of fresh motherwort particle agent, and the step complexity of the method now provides a kind of new technical scheme.
Summary of the invention
The object of the present invention is to provide a kind of preparation technology of Herba Leonuri granule.
Object of the present invention can be achieved through the following technical solutions:
A kind of Herba Leonuri granule preparation technology, described technique specifically comprises the following steps:
(1) extract: Herba Leonuri is dropped in pot, add water and decoct, take out material, filter to get filtrate; (2) concentrated: by filtrate suction Three-effect energy-saving concentrator concentrating under reduced pressure, concentrated solution to be placed in to cylinder natural subsidence, by the supernatant concentrating under reduced pressure after natural subsidence, to obtain Herba Leonuri clear paste; (3) granulate: get the sucrose mixing and stirring after dextrin, pulverizing, mix soft material processed with the Herba Leonuri clear paste of step (2), soft material is crossed to 14 mesh sieves and granulate, dry; (4) granulate: by dried granule sealed storage, weigh, list, to be packaged; (5) packaging.
The addition of described step (1) water is 10 times of weight of Herba Leonuri.
It is 1.04 that described step (2) is evaporated to relative density, and it is 1.36-1.38 that supernatant is evaporated to relative density.
Described step (2) static balance time is 18-25h.
Described step (2) static balance time is 20h.
The weight ratio of described step (3) dextrin, sucrose, Herba Leonuri clear paste is 0.5-1:1-2:1-3.
Described step (3) baking temperature is 80-90 DEG C, drying time 1-2h.
Described step (5) comprises inner packing, outer package, and wherein, inner packing technique is: granule is carried out on particle packaging machine to subpackage with composite membrane, press mold sealing.
Beneficial effect of the present invention: the step that the present invention produces Herba Leonuri granule is simple, preparation technology can be utilized Herba Leonuri widely, and Herba Leonuri granule is convenient to carry, and meets the demand of people to this product.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment 1
A kind of Herba Leonuri granule preparation technology, described technique specifically comprises the following steps:
(1) extract: Herba Leonuri is dropped in pot, add water and decoct, addition is 10 times of weight of Herba Leonuri, takes out material, filters to get filtrate; (2) concentrated: by filtrate suction Three-effect energy-saving concentrator concentrating under reduced pressure, concentrated solution is placed in to cylinder natural subsidence, static balance time is 18h, by the supernatant concentrating under reduced pressure after natural subsidence, being evaporated to relative density is 1.04, it is 1.38 that supernatant is evaporated to relative density, obtains Herba Leonuri clear paste; (3) granulate: get dextrin, sucrose mixing and stirring after pulverizing, the weight ratio of dextrin, sucrose, Herba Leonuri clear paste is 0.5:1:1, mixes soft material processed with the Herba Leonuri clear paste of step (2), and soft material is crossed to 14 mesh sieves granulations, be dried 1h at 80 DEG C; (4) granulate: by dried granule sealed storage, weigh, list, to be packaged; (5) packaging, comprises inner packing, outer package, and wherein, inner packing technique is: granule is carried out on particle packaging machine to subpackage with composite membrane, press mold sealing.
Embodiment 2
A kind of Herba Leonuri granule preparation technology, described technique specifically comprises the following steps:
(1) extract: Herba Leonuri is dropped in pot, add water and decoct, the addition of water is 10 times of weight of Herba Leonuri, takes out material, filters to get filtrate; (2) concentrated: by filtrate suction Three-effect energy-saving concentrator concentrating under reduced pressure, concentrated solution is placed in to cylinder natural subsidence, static balance time 20h, by the supernatant concentrating under reduced pressure after natural subsidence, being evaporated to relative density is 1.04, it is 1.36 that supernatant is evaporated to relative density, obtains Herba Leonuri clear paste; (3) granulate: get dextrin, sucrose mixing and stirring after pulverizing, the weight ratio of dextrin, sucrose, Herba Leonuri clear paste is 1:2:3, mixes soft material processed with the Herba Leonuri clear paste of step (2), and soft material is crossed to 14 mesh sieves granulations, be dried 2h at 90 DEG C; (4) granulate: by dried granule sealed storage, weigh, list, to be packaged; (5) packaging, comprises inner packing, outer package, and wherein, inner packing technique is: granule is carried out on particle packaging machine to subpackage with composite membrane, press mold sealing.
Embodiment 3
A kind of Herba Leonuri granule preparation technology, described technique specifically comprises the following steps:
(1) extract: Herba Leonuri is dropped in pot, add water and decoct, the addition of water is 10 times of weight of Herba Leonuri, takes out material, filters to get filtrate; (2) concentrated: by filtrate suction Three-effect energy-saving concentrator concentrating under reduced pressure, concentrated solution is placed in to cylinder natural subsidence, static balance time is 25h, by the supernatant concentrating under reduced pressure after natural subsidence, being evaporated to relative density is 1.04, it is 1.38 that supernatant is evaporated to relative density, obtains Herba Leonuri clear paste; (3) granulate: get the sucrose mixing and stirring after dextrin, pulverizing, the weight ratio of dextrin, sucrose, Herba Leonuri clear paste is 1:1:2, mixes soft material processed with the Herba Leonuri clear paste of step (2), soft material is crossed to 14 mesh sieves and granulate, 90 DEG C of dry 2h; (4) granulate: by dried granule sealed storage, weigh, list, to be packaged; (5) packaging, comprises inner packing, outer package, and wherein, inner packing technique is: granule is carried out on particle packaging machine to subpackage with composite membrane, press mold sealing.
Claims (8)
1. a Herba Leonuri granule preparation technology, is characterized in that, described technique specifically comprises the following steps: extract (1): Herba Leonuri is dropped in pot, add water and decoct, take out material, filter to get filtrate; (2) concentrated: by filtrate suction Three-effect energy-saving concentrator concentrating under reduced pressure, concentrated solution to be placed in to cylinder natural subsidence, by the supernatant concentrating under reduced pressure after natural subsidence, to obtain Herba Leonuri clear paste; (3) granulate: get the sucrose mixing and stirring after dextrin, pulverizing, mix soft material processed with the Herba Leonuri clear paste of step (2), soft material is crossed to 14 mesh sieves and granulate, dry; (4) granulate: by dried granule sealed storage, weigh, list, to be packaged; (5) packaging.
2. the preparation technology of Herba Leonuri granule according to claim 1, is characterized in that, the addition of described step (1) water is 10 times of weight of Herba Leonuri.
3. the preparation technology of Herba Leonuri granule according to claim 1, is characterized in that, it is 1.04 that described step (2) is evaporated to relative density, and it is 1.36-1.38 that supernatant is evaporated to relative density.
4. the preparation technology of Herba Leonuri granule according to claim 1, is characterized in that, described step (2) static balance time is 18-25h.
5. the preparation technology of Herba Leonuri granule according to claim 4, is characterized in that, described step (2) static balance time is 20h.
6. the preparation technology of Herba Leonuri granule according to claim 1, is characterized in that, the weight ratio of described step (3) dextrin, sucrose, Herba Leonuri clear paste is 0.5-1:1-2:1-3.
7. the preparation technology of Herba Leonuri granule according to claim 1, is characterized in that, described step (3) baking temperature is 80-90 DEG C, drying time 1-2h.
8. the preparation technology of Herba Leonuri granule according to claim 1, is characterized in that, described step (5) comprises inner packing, outer package, and wherein, inner packing technique is: granule is carried out on particle packaging machine to subpackage with composite membrane, press mold sealing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410127920.XA CN103933115A (en) | 2014-04-01 | 2014-04-01 | Motherwort granule preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410127920.XA CN103933115A (en) | 2014-04-01 | 2014-04-01 | Motherwort granule preparation technology |
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| CN103933115A true CN103933115A (en) | 2014-07-23 |
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| CN201410127920.XA Pending CN103933115A (en) | 2014-04-01 | 2014-04-01 | Motherwort granule preparation technology |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769991A (en) * | 2016-05-17 | 2016-07-20 | 海南中宝制药股份有限公司 | Preparation method of motherwort herb granules |
| CN106109568A (en) * | 2016-06-17 | 2016-11-16 | 河北征宇制药有限公司 | Preventing and treating sow tire in puerperal Herba Leonuri granule producing disease and preparation method thereof |
| CN108853006A (en) * | 2018-08-15 | 2018-11-23 | 康美保宁（四川）制药有限公司 | A kind of preparation method of motherwort thick paste and the preparation method of Herba Leonuri granule |
| CN114848600A (en) * | 2022-06-14 | 2022-08-05 | 广东一方制药有限公司 | Fresh motherwort traditional Chinese medicine formula particle and preparation method thereof |
-
2014
- 2014-04-01 CN CN201410127920.XA patent/CN103933115A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 国家药典委员会编: "《中华人民共和国药典 2010年版 第二增补本》", 30 September 2013, 中国医药科技出版社 * |
| 张绪峤: "《药物制剂设备与车间工艺设计》", 31 January 2003 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769991A (en) * | 2016-05-17 | 2016-07-20 | 海南中宝制药股份有限公司 | Preparation method of motherwort herb granules |
| CN106109568A (en) * | 2016-06-17 | 2016-11-16 | 河北征宇制药有限公司 | Preventing and treating sow tire in puerperal Herba Leonuri granule producing disease and preparation method thereof |
| CN108853006A (en) * | 2018-08-15 | 2018-11-23 | 康美保宁（四川）制药有限公司 | A kind of preparation method of motherwort thick paste and the preparation method of Herba Leonuri granule |
| CN114848600A (en) * | 2022-06-14 | 2022-08-05 | 广东一方制药有限公司 | Fresh motherwort traditional Chinese medicine formula particle and preparation method thereof |
| CN114848600B (en) * | 2022-06-14 | 2023-08-29 | 广东一方制药有限公司 | Fresh motherwort traditional Chinese medicine formula granule and preparation method thereof |
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