CN108853006A - A kind of preparation method of motherwort thick paste and the preparation method of Herba Leonuri granule - Google Patents
A kind of preparation method of motherwort thick paste and the preparation method of Herba Leonuri granule Download PDFInfo
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of preparation methods of motherwort thick paste, including pre-treatment step, extraction step and concentration step.The present invention also provides a kind of preparation methods of Herba Leonuri granule.The preparation method of motherwort thick paste of the invention, the preparation method passes through the setting of pre-treatment step, extraction step and concentration step design parameter and technique, it solves the problems, such as that production process motherwort receives cream amount, improve production efficiency and reduces production cost, guarantee product quality.
Description
Technical field
The present invention relates to the preparation methods and Herba Leonuri granule of field of traditional Chinese medicine preparation more particularly to a kind of motherwort thick paste
Preparation method.
Background technique
Herba Leonuri granule, Chinese patent drug name motherwort are Labiatae, mother wort plant, summer-flowering.It dries overground part
It is divided into conventional Chinese medicine, most of China area produces, and raw use or cook paste are used.1 year or biennial herb whole nation most area it is equal
It is distributed, is born in wilderness, ridge, meadow etc..It is picked in the summer riotous growth non-standard-sized sheet of flower, acrid flavour is bitter, cool, promoting blood circulation,
Dispel silt, menstruation regulating, disappear water.The effect that motherwort has inducing diuresis to remove edema, shrinks uterus effect is that ancient Chinese medicine doctor is used to treat gynaecological disease
Key medicine；Motherwort can all herbal medicine, effective component be motherwort element, motherwort contain leonurine, stachydrine, leonuridine, benefit
A variety of alkaloids and benzoic acid, potassium chloride etc. such as Brittle Falsepimpernel Herb is peaceful, motherwort formulation plays the role of excited animal uterus, after pituitary
Foline is similar, and Herba Leonuri extractum and decoction have strong and lasting excitation to uterus, can not only enhance its convergent force, while energy
Improve its tensity and shrinking percentage.Currently, Herba Leonuri granule is in process of production, loss of effective components is more, to the receipts of product
Rate has an impact.
Summary of the invention
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of preparation sides of motherwort thick paste
Method, the preparation method pass through the setting of pre-treatment step, extraction step and concentration step design parameter and technique, and solution produced
Journey motherwort receives the problem of cream amount, improves production efficiency and reduces production cost, guarantees product quality.
Second object of the present invention is to provide for a kind of preparation method of Herba Leonuri granule, which includes benefit
Brittle Falsepimpernel Herb thick paste preparation step, granulation step, whole grain step and packaging step improve the matter of product by the improvement to technique
Amount.
An object of the present invention adopts the following technical scheme that realization：
A kind of preparation method of motherwort thick paste, including,
Pre-treatment step：Motherwort is cleaned, is put into medicine-washing machine and cleans, the motherwort section of 2-3cm is cut into after cleaning；
Extraction step：It is added into motherwort section and once uses water, once boiled, once filter, obtain the first filtrate, then to
Motherwort Duan Zhongjia seconary water use, it is secondary boil, secondary filter, obtain the second filtrate, merge the first filtrate and the second filtrate, obtain
To mixed filtrate；
Concentration step：Mixed filtrate is concentrated, the thick paste that relative density is 1.21-1.25 is obtained.
Further, in extraction step, the primary weight ratio with water and motherwort section is (9-11)：1.
Further, in extraction step, after once boiling, boiling 1.5-2.5h is maintained；Primary filtering uses 120 mesh pipelines
Filtering.
Further, in extraction step, the weight ratio of seconary water use and motherwort section is (10-11)：1.
Further, in extraction step, it is secondary boil after, maintain boiling 0.5-1.5h；Secondary filter uses 120 mesh pipelines
Filtering.
Further, concentration step is specially：Mixed filtrate is subjected to an effect compression, an effect temperature is 60-90 DEG C, vacuum
Degree is 0.04-0.08Mpa, then carries out two effect compressions, and two effect temperature are 50-70 DEG C, and vacuum degree 0.05-0.09Mpa is obtained thick
Cream.
Further, in concentration step, the temperature of thick paste is 75-85 DEG C.
Realize that second object of the present invention can reach by adopting the following technical scheme that：
A kind of preparation method of Herba Leonuri granule, the preparation method including above-mentioned motherwort thick paste further include granulation step
Suddenly, whole grain step and packaging step；Granulation step is specially：It takes thick paste to mix with auxiliary material, makes softwood, softwood is sieved and is made
Grain, it is dry, obtain granule.
Further, whole grain step is specially：Granule is sealed and stored, sieving, the sieve of shaking screen are vibrated after weighing
Specification is upper 20 mesh and lower 40 mesh, collects the granule for not passing through 40 mesh by 20 mesh.
Further, packaging step is specially：After granule is dispensed, then press mold sealing packs, obtains motherwort
Grain.
The beneficial effects of the present invention are：
1, the preparation method of motherwort thick paste of the present invention, the preparation method pass through pre-treatment step, extraction step and concentration
The setting of step design parameter and technique solves the problems, such as that production process motherwort receives cream amount, improves production efficiency and drop
Low production cost guarantees product quality；
2, the preparation method of Herba Leonuri granule of the invention, the preparation method include motherwort thick paste preparation step, granulation
Step, whole grain step and packaging step improve the quality of product by the improvement to technique.
Specific embodiment
In the following, being described further in conjunction with specific embodiment to the present invention, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
A kind of preparation method of motherwort thick paste, including,
Pre-treatment step：Motherwort is cleaned, is put into medicine-washing machine and cleans, the motherwort section of 2-3cm is cut into after cleaning；
Extraction step：It is added into motherwort section and once uses water, once boiled, once filter, obtain the first filtrate, then to
Motherwort Duan Zhongjia seconary water use, it is secondary boil, secondary filter, obtain the second filtrate, merge the first filtrate and the second filtrate, obtain
To mixed filtrate；
Concentration step：Mixed filtrate is concentrated, the thick paste that relative density is 1.21-1.25 is obtained.
As further embodiment, in extraction step, the primary weight ratio with water and motherwort section is (9-11)：1.
As further embodiment, in extraction step, after once boiling, boiling 1.5-2.5h is maintained；Primary filtering
Using 120 mesh filter pipelines.
As further embodiment, in extraction step, the weight ratio of seconary water use and motherwort section is (10-11)：
1。
As further embodiment, in extraction step, it is secondary boil after, maintain boiling 0.5-1.5h；Secondary filter
Using 120 mesh filter pipelines.
As further embodiment, concentration step is specially：Mixed filtrate is subjected to an effect compression, an effect temperature is
60-90 DEG C, vacuum degree 0.04-0.08Mpa, then two effect compressions are carried out, two effect temperature are 50-70 DEG C, vacuum degree 0.05-
0.09Mpa obtains thick paste.
As further embodiment, in concentration step, the temperature of thick paste is 75-85 DEG C.
A kind of preparation method of Herba Leonuri granule, the preparation method including above-mentioned motherwort thick paste further include granulation step
Suddenly, whole grain step and packaging step；Granulation step is specially：It takes thick paste to mix with auxiliary material, makes softwood, softwood is sieved and is made
Grain, it is dry, obtain granule.
As further embodiment, whole grain step is specially：Granule is sealed and stored, sieving is vibrated after weighing,
The sieve specification of shaking screen is upper 20 mesh and lower 40 mesh, collects the granule for not passing through 40 mesh by 20 mesh.
As further embodiment, packaging step is specially：After granule is dispensed, then press mold sealing is packed,
Obtain Herba Leonuri granule.
It is specific embodiment of the present invention below, used raw material, equipment etc. remove special limit in the following embodiments
It can be obtained by buying pattern outside fixed.
Embodiment 1：
A kind of preparation method of Herba Leonuri granule, including motherwort thick paste preparation step, granulation step, whole grain step and packet
Fill step；
Granulation step：It takes thick paste to mix with auxiliary material, makes softwood, softwood is sieved and is pelletized, it is dry, obtain granule；
Whole grain step：Granule is sealed and stored, sieving is vibrated after weighing, the sieve specification of shaking screen is upper 20 mesh under
40 mesh collect the granule for not passing through 40 mesh by 20 mesh；
Packaging step：After granule is dispensed, then press mold sealing packs, obtains Herba Leonuri granule.
Wherein, the preparation step of motherwort thick paste is as follows, including,
Pre-treatment step：Motherwort is cleaned, is put into medicine-washing machine and cleans, the motherwort section of 2cm is cut into after cleaning；
Extraction step：It is added into motherwort section and once uses water, the primary weight ratio with water and motherwort section is 9：1；One
It is secondary boil after, maintain boiling 1.5h, then once filtered using 120 mesh pipelines, obtain the first filtrate；Again into motherwort section
Add seconary water use, the weight ratio of seconary water use and motherwort section is 10：1, it is secondary boil after maintain boiling 0.5h, then use 120
Mesh pipeline carries out secondary filter, obtains the second filtrate；Merge the first filtrate and the second filtrate, obtains mixed filtrate；
Concentration step：Mixed filtrate is subjected to an effect compression, an effect temperature is 60 DEG C, vacuum degree 0.04Mpa, then is carried out
Two effect compressions, two effect temperature are 50 DEG C, vacuum degree 0.05Mpa, obtain the thick paste that relative density is 1.21, temperature is 75 DEG C.
Embodiment 2：
A kind of preparation method of Herba Leonuri granule, including motherwort thick paste preparation step, granulation step, whole grain step and packet
Fill step；
Granulation step：It takes thick paste to mix with auxiliary material, makes softwood, softwood is sieved and is pelletized, it is dry, obtain granule；
Whole grain step：Granule is sealed and stored, sieving is vibrated after weighing, the sieve specification of shaking screen is upper 20 mesh under
40 mesh collect the granule for not passing through 40 mesh by 20 mesh；
Packaging step：After granule is dispensed, then press mold sealing packs, obtains Herba Leonuri granule.
Wherein, the preparation step of motherwort thick paste is as follows, including,
Pre-treatment step：Motherwort is cleaned, is put into medicine-washing machine and cleans, the motherwort section of 2cm is cut into after cleaning；
Extraction step：It is added into motherwort section and once uses water, the primary weight ratio with water and motherwort section is 10：1；One
It is secondary boil after, maintain boiling 2h, then once filtered using 120 mesh pipelines, obtain the first filtrate；Again to motherwort Duan Zhongjia
The weight ratio of seconary water use, seconary water use and motherwort section is 10：1, it is secondary boil after maintain boiling 1h, then use 120 mesh pipes
Road carries out secondary filter, obtains the second filtrate；Merge the first filtrate and the second filtrate, obtains mixed filtrate；
Concentration step：Mixed filtrate is subjected to an effect compression, an effect temperature is 70 DEG C, vacuum degree 0.06Mpa, then is carried out
Two effect compressions, two effect temperature are 60 DEG C, vacuum degree 0.07Mpa, obtain the thick paste that relative density is 1.23, temperature is 80 DEG C.
Embodiment 3：
A kind of preparation method of Herba Leonuri granule, including motherwort thick paste preparation step, granulation step, whole grain step and packet
Fill step；
Granulation step：It takes thick paste to mix with auxiliary material, makes softwood, softwood is sieved and is pelletized, it is dry, obtain granule；
Whole grain step：Granule is sealed and stored, sieving is vibrated after weighing, the sieve specification of shaking screen is upper 20 mesh under
40 mesh collect the granule for not passing through 40 mesh by 20 mesh；
Packaging step：After granule is dispensed, then press mold sealing packs, obtains Herba Leonuri granule.
Wherein, the preparation step of motherwort thick paste is as follows, including,
Pre-treatment step：Motherwort is cleaned, is put into medicine-washing machine and cleans, the motherwort section of 3cm is cut into after cleaning；
Extraction step：It is added into motherwort section and once uses water, the primary weight ratio with water and motherwort section is 11：1；One
It is secondary boil after, maintain boiling 2.5h, then once filtered using 120 mesh pipelines, obtain the first filtrate；Again into motherwort section
Add seconary water use, the weight ratio of seconary water use and motherwort section is 11：1, it is secondary boil after maintain boiling 1.5h, then use 120
Mesh pipeline carries out secondary filter, obtains the second filtrate；Merge the first filtrate and the second filtrate, obtains mixed filtrate；
Concentration step：Mixed filtrate is subjected to an effect compression, an effect temperature is 90 DEG C, vacuum degree 0.08Mpa, then is carried out
Two effect compressions, two effect temperature are 70 DEG C, vacuum degree 0.09Mpa, obtain the thick paste that relative density is 1.25, temperature is 85 DEG C.
Comparative example 1：
1 difference from Example 1 of comparative example is, net in the pre-treatment step of the preparation step of the thick paste of comparative example 1
Motherwort is selected, is put into medicine-washing machine and cleans, crushes motherwort for motherwort powder after cleaning.
Comparative example 2：
2 difference from Example 1 of comparative example is, net in the pre-treatment step of the preparation step of the thick paste of comparative example 2
Motherwort is selected, is put into medicine-washing machine and cleans, the motherwort section of 5cm is cut into after cleaning.
Comparative example 3：
3 difference from Example 1 of comparative example is, in the extraction step of the preparation step of the thick paste of comparative example 3, by one
It is secondary to replace with ethyl alcohol with water and seconary water use.
Effect assessment and performance detection
The motherwort thick paste of embodiment 1-3 and comparative example 1-3 being prepared is detected, testing result is as follows：
1 testing result of table
| Liquid volume | Medical fluid standard volume | As a result | |
| Embodiment 1 | 326g | 320g | It is qualified |
| Embodiment 2 | 330g | 320g | It is qualified |
| Embodiment 3 | 325g | 320g | It is qualified |
| Comparative example 1 | 220g | 320g | It is unqualified |
| Comparative example 2 | 201g | 320g | It is unqualified |
| Comparative example 3 | 234g | 320g | It is unqualified |
By the testing result of table 1 as it can be seen that the preparation method of the motherwort thick paste of embodiment 1-3 passes through pre-treatment step, mentions
The setting for taking step and concentration step design parameter and technique solves the problems, such as that production process motherwort receives cream amount, improves product
Production efficiency and reduction production cost, guarantee product quality.And in comparative example 1-2 by motherwort cutting it is the benefit of powder or 5cm
Brittle Falsepimpernel Herb section, effect are worse than embodiment 1-3, this illustrates the form of motherwort and the matter of thickness effect product in pre-treatment step
Water is changed to ethyl alcohol in comparative example 3 by amount, and effect is also worse than embodiment 1-3, this illustrates the selection of extracting solution in extraction step also shadow
Ring the quality of product.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (10)
1. a kind of preparation method of motherwort thick paste, which is characterized in that including,
Pre-treatment step：Motherwort is cleaned, is put into medicine-washing machine and cleans, the motherwort section of 2-3cm is cut into after cleaning；
Extraction step：It is added into motherwort section and once uses water, once boiled, once filter, obtain the first filtrate, then is female to benefit
In careless section plus seconary water use, it is secondary boil, secondary filter, obtain the second filtrate, merge the first filtrate and the second filtrate, mixed
Close filtrate；
Concentration step：Mixed filtrate is concentrated, the thick paste that relative density is 1.21-1.25 is obtained.
2. the preparation method of motherwort thick paste as described in claim 1, which is characterized in that in extraction step, once with water with
The weight ratio of motherwort section is (9-11)：1.
3. the preparation method of motherwort thick paste as described in claim 1, which is characterized in that in extraction step, after once boiling,
Maintain boiling 1.5-2.5h；Primary filtering uses 120 mesh filter pipelines.
4. the preparation method of motherwort thick paste as described in claim 1, which is characterized in that in extraction step, seconary water use with
The weight ratio of motherwort section is (10-11)：1.
5. the preparation method of motherwort thick paste as described in claim 1, which is characterized in that in extraction step, it is secondary boil after,
Maintain boiling 0.5-1.5h；Secondary filter uses 120 mesh filter pipelines.
6. the preparation method of motherwort thick paste as claimed in claim 5, which is characterized in that concentration step is specially：It will mixing
Filtrate carries out an effect compression, and an effect temperature is 60-90 DEG C, vacuum degree 0.04-0.08Mpa, then carries out two effect compressions, two effect temperature
Degree is 50-70 DEG C, and vacuum degree 0.05-0.09Mpa obtains thick paste.
7. the preparation method of motherwort thick paste as claimed in claim 6, which is characterized in that in concentration step, the temperature of thick paste
It is 75-85 DEG C.
8. a kind of preparation method of Herba Leonuri granule, it is characterised in that including such as described in any item motherworts of claim 1-7
The preparation method of thick paste further includes granulation step, whole grain step and packaging step；Granulation step is specially：Take thick paste and auxiliary material
Mixing makes softwood, and softwood is sieved and is pelletized, dry, obtains granule.
9. the preparation method of Herba Leonuri granule as claimed in claim 8, which is characterized in that whole grain step is specially：By particle
Body is sealed and stored, and sieving is vibrated after weighing, and the sieve specification of shaking screen is upper 20 mesh and lower 40 mesh, is collected and is not passed through by 20 mesh
The granule of 40 mesh.
10. the preparation method of Herba Leonuri granule as claimed in claim 8, which is characterized in that packaging step is specially：By particle
After body packing, then press mold sealing packs, obtains Herba Leonuri granule.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230434A (en) * | 2013-04-18 | 2013-08-07 | 杭州求本植物科技有限公司 | Manufacturing process of leonurus |
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| CN103933116A (en) * | 2014-04-01 | 2014-07-23 | 回音必集团安徽制药有限公司 | Preparation process of herba leonuri paste |
| CN105769991A (en) * | 2016-05-17 | 2016-07-20 | 海南中宝制药股份有限公司 | Preparation method of motherwort herb granules |
| CN106377573A (en) * | 2016-08-31 | 2017-02-08 | 宁夏多维药业有限公司 | Preparation method of motherwort herb extract |
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2018
- 2018-08-15 CN CN201810925564.4A patent/CN108853006A/en active Pending
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| CN103230434A (en) * | 2013-04-18 | 2013-08-07 | 杭州求本植物科技有限公司 | Manufacturing process of leonurus |
| CN103933115A (en) * | 2014-04-01 | 2014-07-23 | 回音必集团安徽制药有限公司 | Motherwort granule preparation technology |
| CN103933116A (en) * | 2014-04-01 | 2014-07-23 | 回音必集团安徽制药有限公司 | Preparation process of herba leonuri paste |
| CN105769991A (en) * | 2016-05-17 | 2016-07-20 | 海南中宝制药股份有限公司 | Preparation method of motherwort herb granules |
| CN106377573A (en) * | 2016-08-31 | 2017-02-08 | 宁夏多维药业有限公司 | Preparation method of motherwort herb extract |
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Application publication date: 20181123 |