CN108066383A - A kind of wine-prepared fructus corni medicine materical crude slice and preparation method thereof - Google Patents
A kind of wine-prepared fructus corni medicine materical crude slice and preparation method thereof Download PDFInfo
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- CN108066383A CN108066383A CN201711479717.9A CN201711479717A CN108066383A CN 108066383 A CN108066383 A CN 108066383A CN 201711479717 A CN201711479717 A CN 201711479717A CN 108066383 A CN108066383 A CN 108066383A
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- fructus corni
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- Natural Medicines & Medicinal Plants (AREA)
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Abstract
The invention discloses a kind of preparation method of wine-prepared fructus corni medicine materical crude slice, the preparation method includes the following steps：(1) select, stepping；(2) clean；(3) predrying；(4) demulcen；(5) steam；(6) it is dry；(7) pack.The method of the present invention replaces traditional immersion softening process, shortens the time, improves production efficiency.
Description
Technical field
The present invention relates to Technology of Processing Chinese Herbal Medicines fields, more particularly, to one kind by a series of processing procedures, prepare wine
The method of cornus medicine materical crude slice.
Background technology
Wine-prepared fructus corni function is with curing mainly：It tonifies the liver and kidney, puckery essence prevent prolapse.For dizziness and tinnitus, soreness of waist and knee joint, impotence and seminal emission, something lost
Urinate frequent micturition, under uterine bleeding band, profuse sweating collapse, Heat Diabetes etc..
Conventional method concocting method there are two types of record in《Chinese Pharmacopoeia》Version one in 2015 is respectively that " (1) takes raw mountain Zhu
Cornel stewes method according to wine, stewes to wine and exhausts, and takes out, dry to crust mucus it is slightly dry when, cut sheet or block, it is dry to get.(2) life is taken
Fructus Corni according to the method for steaming, is steamed to black profit, taken out, shine to it is about most probably dry when, it is dry to get." conventionally produced efficiency is low, yield
Low, energy consumption is big, is not suitable for large-scale industrial production.
CN103285305A discloses a kind of preparation method of wine-prepared fructus corni medicine materical crude slice, including selecting, stepping, cleaning, steam it is soft, dry
Dry, microwave drying, screening, packaging and other steps.The processing step it is more complicated, it is necessary to by after drying semi-finished product be packed into gunnysack,
1-2 meters of height are piled up into, shady place placement carries out the moist technique of stacking for 10-15 days, and not only step is various, but also processing time
Longer, efficiency is low, and needs to carry out special microwave drying, and progress microwave drying, energy consumption are needed after boiling again
Greatly, it is of high cost.
The content of the invention
In view of the above-mentioned problems existing in the prior art, the applicant provides a kind of wine-prepared fructus corni medicine materical crude slice and its preparation sides
Method.The method of the present invention is simple, efficient, energy saving.
Technical scheme is as follows：
A kind of preparation method of wine-prepared fructus corni medicine materical crude slice, the preparation method includes selecting, stepping, cleaning, demulcen, steams, does
Dry and packaging；With the step of it is as follows：
(1) select, stepping：Raw Fructus Corni is taken, impurity is removed, carries out stepping by size；
(2) clean：The Fructus Corni that stepping is completed is respectively put into medicine-washing machine and is eluriated, after washing, standing drains the water,
Sheet is cut into using turn table type slicer afterwards；
(3) predrying：Sheet Fructus Corni made from step (2) is placed in predrying in baking oven, be dried to water content for 12~
28%；
(4) demulcen：Fructus Corni leaching after predrying steeping in wine is moistened into 1~2h；
(5) steam：It will be put by the Fructus Corni of step (3) processing in digester, be passed through steam and steamed；
(6) it is dry：It will be placed in by the Fructus Corni of step (4) processing in baking oven, be dried to water content as less than 6%；
(7) pack：Dried product is vacuum-packed, is placed at aeration-drying and stores, the wine-prepared fructus corni is made
Medicine materical crude slice.
Medicine-washing machine described in step (2) is tumbling-box type medicine-washing machine.
Oven temperature is 60~80 DEG C during predrying described in step (3)；It is preferred that 65~75 DEG C, be kept at this temperature into
Row predrying can get rid of moisture under the conditions of comparatively gentle, and active ingredient is protected not generate destruction.
The time steamed described in step (5) is 8~12h；It is preferred that 9~11 it is small when.
Oven temperature is 60~80 DEG C when dry described in step (6).
Dried Fructus Corni piece is pre-processed before being vacuum-packed described in step (7), the mode of pretreatment is：It adopts
With 25~50KGy dosage 60Co gamma-ray irradiations, 2~5s.
The present invention is beneficial to be had technical effect that：
The method of the present invention replaces traditional immersion softening process, shortens the time, improves production efficiency.
Fructus Corni can be steamed to surface and section corvinus in the steaming time of the present invention, if steaming time is too short,
What is steamed is not enough, and if the overlong time steamed, some original active ingredients of Fructus Corni may be destroyed, are generated
Peculiar smell and ill effect.
The extract content of wine-prepared fructus corni medicine materical crude slice produced by the present invention can be no less than 50%, morroniside (C17H26O11) and Strychnos nux-vomica
Glycosides (C17H26O10) total amount be no less than 1.2%, moisture is not higher than 16%, and total ash is not higher than 6%, meets wine-prepared fructus corni drink
Tablet quality standard, and preparation method is simple, saves time and the energy, suitable for industrialized production.
Specific embodiment
With reference to embodiment, the present invention is specifically described.
Embodiment 1
A kind of preparation method of wine-prepared fructus corni medicine materical crude slice, the preparation method includes selecting, stepping, cleaning, demulcen, steams, does
Dry and packaging；With the step of it is as follows：
(1) select, stepping：Raw Fructus Corni is taken, impurity is removed, carries out stepping by size；
(2) clean：The Fructus Corni that stepping is completed is respectively put into tumbling-box type medicine-washing machine and is eluriated, after washing, is stood
It drains the water, sheet is cut into using turn table type slicer afterwards；
(3) predrying：Sheet Fructus Corni made from step (2) is placed in predrying in 60 DEG C of baking ovens, being dried to water content is
28%；
(4) demulcen：Fructus Corni leaching after predrying steeping in wine is moistened into 2h；
(5) steam：It will be put by the Fructus Corni of step (3) processing in digester, be passed through steam and carry out steaming 8h；
(6) it is dry：It will be placed in by the Fructus Corni of step (4) processing in 80 DEG C of baking ovens, be dried to water content as 6%；
(7) pack：Dried product is vacuum-packed, is placed at aeration-drying and stores, the wine-prepared fructus corni is made
Medicine materical crude slice.
Embodiment 2
A kind of preparation method of wine-prepared fructus corni medicine materical crude slice, the preparation method includes selecting, stepping, cleaning, demulcen, steams, does
Dry and packaging；With the step of it is as follows：
(1) select, stepping：Raw Fructus Corni is taken, impurity is removed, carries out stepping by size；
(2) clean：The Fructus Corni that stepping is completed is respectively put into tumbling-box type medicine-washing machine and is eluriated, after washing, is stood
It drains the water, sheet is cut into using turn table type slicer afterwards；
(3) predrying：Sheet Fructus Corni made from step (2) is placed in predrying in 80 DEG C of baking ovens, being dried to water content is
12%；
(4) demulcen：Fructus Corni leaching after predrying steeping in wine is moistened into 2h；
(5) steam：It will be put by the Fructus Corni of step (3) processing in digester, be passed through steam and carry out steaming 12h；
(6) it is dry：It will be placed in by the Fructus Corni of step (4) processing in 70 DEG C of baking ovens, be dried to water content as 5%；
(7) pack：Dried product is vacuum-packed, is placed at aeration-drying and stores, the wine-prepared fructus corni is made
Medicine materical crude slice.
Embodiment 3
A kind of preparation method of wine-prepared fructus corni medicine materical crude slice, the preparation method includes selecting, stepping, cleaning, demulcen, steams, does
Dry and packaging；With the step of it is as follows：
(1) select, stepping：Raw Fructus Corni is taken, impurity is removed, carries out stepping by size；
(2) clean：The Fructus Corni that stepping is completed is respectively put into tumbling-box type medicine-washing machine and is eluriated, after washing, is stood
It drains the water, sheet is cut into using turn table type slicer afterwards；
(3) predrying：Sheet Fructus Corni made from step (2) is placed in predrying in 70 DEG C of baking ovens, being dried to water content is
20%；
(4) demulcen：Fructus Corni leaching after predrying steeping in wine is moistened into 2h；
(5) steam：It will be put by the Fructus Corni of step (3) processing in digester, be passed through steam and carry out steaming 10h；
(6) it is dry：It will be placed in by the Fructus Corni of step (4) processing in 60 DEG C of baking ovens, be dried to water content as 5%；
(7) pack：Dried product is vacuum-packed, is placed at aeration-drying and stores, the wine-prepared fructus corni is made
Medicine materical crude slice.
Dried Fructus Corni piece is pre-processed before being vacuum-packed described in step (7), the mode of pretreatment is：It adopts
With 25KGy dosage 60Co gamma-ray irradiations 5s.
Embodiment 4
A kind of preparation method of wine-prepared fructus corni medicine materical crude slice, the preparation method includes selecting, stepping, cleaning, demulcen, steams, does
Dry and packaging；With the step of it is as follows：
(1) select, stepping：Raw Fructus Corni is taken, impurity is removed, carries out stepping by size；
(2) clean：The Fructus Corni that stepping is completed is respectively put into tumbling-box type medicine-washing machine and is eluriated, after washing, is stood
It drains the water, sheet is cut into using turn table type slicer afterwards；
(3) predrying：Sheet Fructus Corni made from step (2) is placed in predrying in 75 DEG C of baking ovens, being dried to water content is
15%；
(4) demulcen：Fructus Corni leaching after predrying steeping in wine is moistened into 1h；
(5) steam：It will be put by the Fructus Corni of step (3) processing in digester, be passed through steam and carry out steaming 10h；
(6) it is dry：It will be placed in by the Fructus Corni of step (4) processing in 80 DEG C of baking ovens, be dried to water content as 4%；
(7) pack：Dried product is vacuum-packed, is placed at aeration-drying and stores, the wine-prepared fructus corni is made
Medicine materical crude slice.
Dried Fructus Corni piece is pre-processed before being vacuum-packed described in step (7), the mode of pretreatment is：It adopts
With 50KGy dosage 60Co gamma-ray irradiations 2s.
Test case：
The wine-prepared fructus corni medicine materical crude slice lg that Example 1-4 is prepared respectively adds 80% methanol 50mL, is ultrasonically treated 30 minutes,
Filtration, filtrate are evaporated, and residue adds water 5mL to make dissolving, with water-saturated n-butanol shaking extraction 4 times, each 10mL, merge n-butanol
Liquid is evaporated, and residue adds methanol 2mL to make dissolving, as test solution.Acteoside reference substance separately is taken, methanol is added to be made often
Solution of the 1mL containing 1mg, as reference substance solution.
It is tested according to thin-layered chromatography, draws 5 μ L of test solution, 2 μ L of reference substance solution, put respectively thin in same silica G
On laminate, with acetate-methanol-formic acid (volume ratio 16:0.5:2) it is solvent, is unfolded, takes out, dry, with 0.1%
2,2- diphenyl -1- hardship diazanyls ethanol solutions impregnate, and dry.
In test sample chromatography, on position corresponding with reference substance chromatography, identical colored speckles are shown.Each ingredient measured
Content value it is as shown in table 1.
Table 1
| Extract content | Morroniside and loganin total amount | |
| Embodiment 1 | 56% | 1.4% |
| Embodiment 2 | 54% | 1.7% |
| Embodiment 3 | 59% | 1.6% |
| Embodiment 4 | 61% | 1.9% |
The extract content for the wine-prepared fructus corni medicine materical crude slice that the method for the present invention is prepared can be high it can be seen from the data of table 1
Up to more than 50%, the total amount of morroniside (C17H26O11) and loganin (C17H26010) is no less than 1.2%, and moisture is not higher than
16%, total ash is not higher than 6%, and quality is high, meets wine-prepared fructus corni prepared slice quality standard.
Applicant states that the present invention illustrates the method detailed of the present invention, but not office of the invention by above-described embodiment
It is limited to above-mentioned method detailed, that is, does not mean that the present invention has to rely on above-mentioned method detailed and could implement.Technical field
Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to each raw material of product of the present invention
Addition, selection of concrete mode etc., all fall within protection scope of the present invention and the open scope.
Claims (6)
1. a kind of preparation method of wine-prepared fructus corni medicine materical crude slice, it is characterised in that the preparation method include select, stepping, cleaning, demulcen,
It steams, dry and packs；With the step of it is as follows：
(1) select, stepping：Raw Fructus Corni is taken, impurity is removed, carries out stepping by size；
(2) clean：The Fructus Corni that stepping is completed is respectively put into medicine-washing machine and is eluriated, after washing, standing drains the water, afterwards
Sheet is cut into using turn table type slicer；
(3) predrying：Sheet Fructus Corni made from step (2) is placed in predrying in baking oven, is dried to water content as 12~28%；
(4) demulcen：Fructus Corni leaching after predrying steeping in wine is moistened into 1~2h；
(5) steam：It will be put by the Fructus Corni of step (3) processing in digester, be passed through steam and steamed；
(6) it is dry：It will be placed in by the Fructus Corni of step (4) processing in baking oven, be dried to water content as less than 6%；
(7) pack：Dried product is vacuum-packed, is placed at aeration-drying and stores, the wine-prepared fructus corni medicine materical crude slice is made.
2. preparation method according to claim 1, it is characterised in that medicine-washing machine described in step (2) is tumbling-box type medicine-washing
Machine.
3. preparation method according to claim 1, it is characterised in that oven temperature is 60 during predrying described in step (3)
~80 DEG C.
4. preparation method according to claim 1, it is characterised in that the time steamed described in step (5) is 8~12h.
5. preparation method according to claim 1, it is characterised in that when dry described in step (6) oven temperature for 60~
80℃。
6. preparation method according to claim 1, it is characterised in that dried before being vacuum-packed described in step (7)
Fructus Corni piece is pre-processed, and the mode of pretreatment is：Using 25~50KGy dosage 60Co gamma-ray irradiations, 2~5s.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711479717.9A CN108066383A (en) | 2017-12-29 | 2017-12-29 | A kind of wine-prepared fructus corni medicine materical crude slice and preparation method thereof |
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| CN201711479717.9A CN108066383A (en) | 2017-12-29 | 2017-12-29 | A kind of wine-prepared fructus corni medicine materical crude slice and preparation method thereof |
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| CN108066383A true CN108066383A (en) | 2018-05-25 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111467384A (en) * | 2020-05-21 | 2020-07-31 | 安徽昌顺药业有限公司 | Method for processing wine-processed cornus officinalis |
Citations (3)
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|---|---|---|---|---|
| CN1899354A (en) * | 2006-07-14 | 2007-01-24 | 河南中医学院 | Method for processing dogwood fruit wite white spirit |
| CN104940271A (en) * | 2015-06-19 | 2015-09-30 | 亳州市永刚饮片厂有限公司 | Manufacture method of cornus officinalis decoction pieces |
| CN105193897A (en) * | 2015-10-09 | 2015-12-30 | 江苏健生源中药材有限公司 | Method for preparing cornus officinalis decoction pieces |
-
2017
- 2017-12-29 CN CN201711479717.9A patent/CN108066383A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899354A (en) * | 2006-07-14 | 2007-01-24 | 河南中医学院 | Method for processing dogwood fruit wite white spirit |
| CN104940271A (en) * | 2015-06-19 | 2015-09-30 | 亳州市永刚饮片厂有限公司 | Manufacture method of cornus officinalis decoction pieces |
| CN105193897A (en) * | 2015-10-09 | 2015-12-30 | 江苏健生源中药材有限公司 | Method for preparing cornus officinalis decoction pieces |
Non-Patent Citations (1)
| Title |
|---|
| 浙江省科技情报研究所: "《食品工业资料选辑 第1辑》", 28 February 1985 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111467384A (en) * | 2020-05-21 | 2020-07-31 | 安徽昌顺药业有限公司 | Method for processing wine-processed cornus officinalis |
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