CN102114052A - Production method of pine pollen soft capsule for treating fatty liver - Google Patents
Production method of pine pollen soft capsule for treating fatty liver Download PDFInfo
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- CN102114052A CN102114052A CN 201010607361 CN201010607361A CN102114052A CN 102114052 A CN102114052 A CN 102114052A CN 201010607361 CN201010607361 CN 201010607361 CN 201010607361 A CN201010607361 A CN 201010607361A CN 102114052 A CN102114052 A CN 102114052A
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Abstract
The invention discloses a production method of a pine pollen soft capsule for treating fatty liver, relating to the technical field of production of health care soft capsules. The production method comprises the following steps of: performing air stream pulverization and wall breaking on pine pollen with impurities removed; soaking in water of normal pressure and temperature; performing ultrasonic treatment; centrifuging by a refrigerated centrifuge with the rotation speed of 10000-16000rpm, taking supernatant; separating the supernatant at the ambient temperature of 1-5 DEG C to obtain water soluble matters of pine pollen of which the molecular weight is smaller than 3000D; performing vacuum freeze drying on the water soluble matters of pine pollen to form lyophilized powder of pine pollen with the moisture content below 5%; evenly mixing the lyophilized powder of pine pollen with flax seed oil and lecithin; and gelatinating and pelleting to obtain the pine pollen soft capsule for treating fatty liver. The product disclosed by the invention has no side effect, high stability, oxidation resistance and high bioavailability, can cover up unpleasant odor and reduce irritation, and is convenient to take and quick to absorb.
Description
Technical field
The present invention relates to the health care soft capsule production technical field, particularly treat the production method of the soft capsule of fatty liver.
Background technology
Soft capsule dosage form is meant a kind of novel form that grows up behind tablet, hard capsule, injection etc., can and be encapsulated in the glued membrane oily functional materials, functional materials solution or the quantitative pressure injection of functional materials powder, form big or small, different seal capsule.Soft capsule has can cover bad smell, reduces zest, and stability is high, antioxidation, taking convenience, characteristics such as bioavailability height.The advantage of soft capsule is can directly absorb after the disintegrate, absorbs fast; Quantitatively accurately; The bioavailability height; Taking dose is little; The functional mass good stability is difficult for the oxidation and the moisture absorption; Good airproof performance can hide the bad smell of medicine; Sense organ is good, and is welcome.In addition, soft capsule can also produce various, welcome CF according to different needs, to reach stabilization function composition and the purpose that is easy to identification.At present, the soft capsule dosage form of domestic production be from can being divided into masticatory pattern, colon lysotype, enteric solubility, instant type, oral gastric solubility type, spacetabs type clinically, also have external rectum type and eye with, skin with type etc.
Fatty liver is meant the pathological changes of fatty overheap in the hepatocyte that causes owing to a variety of causes, and the positive serious threat compatriots' of fatty liver disease health becomes the second largest hepatopathy that is only second to viral hepatitis, has been acknowledged as the common cause of disguised liver cirrhosis.Fatty liver is a kind of common clinical picture, but not a kind of independently disease.The lighter is asymptomatic in its clinical manifestation, weight person's state of an illness ferociousness.Generally speaking, fatty liver belongs to the reversibility disease, and early diagnosis and treatment in time often can recover normal.
The treatment of current fatty liver is still removing the cause of disease, Cure the Primary Disease and adhere to that the reasonable diet system is main, and medicine only plays the auxiliary treatment effect.So, the research of this disease has been become the common focus and the difficult point of domestic and international research.Up to the present, Western medicine does not still have lipotropic active drug, and for well, wherein Radix Polygoni Multiflori and Fructus Crataegi are best with the Chinese medicine long-time conditioning, can blood fat reducing, prevent that cholesterol is at intrahepatic deposition.
Pollen Pini is the pollen of pinasters such as gymnosperm Pinaceae Pinus Pinus massoniana Lamb and Pinus tabuliformis, and China utilizes and edible Pollen Pini country the earliest in the world.The resource major part of global Pollen Pini is distributed in China, but as the exclusive living resources of China, the pollen of Pinus massoniana Lamb and Pinus tabuliformis is not also developed fully.Whole nation Pollen Pini output is very abundant, the pollen of Pinus massoniana Lamb only, annual renewable output is just at nearly ten million ton, China also has more than 2,000 ten thousand hectares Chinese pine pollen can supply to gather in addition, because Pollen Pini is a wind pollination system, will be wasted if the resource of so many Pollen Pini can not in time be gathered and process.
The research of China's Pollen Pini at present is in the leading level in the world; external research also is in the primary research stages such as analysis of nutritional labeling; and a series of difficult problems such as China has solved well that Pollen Pini is fresh-keeping, breaking cellular wall and production; realized large-scale production; and improved alimentation rate behind the edible Pollen Pini greatly, for Pollen Pini industry leading position in the world provides powerful guarantee.However external pollen product is but more extensive on using than China, and Sweden is applied to beauty treatment with pollen food, and Japan is used as nutriment with pollen food, and France is with the function food of pollen as the growth encourage childhood development.By comparison, though the developmental research of China's Pollen Pini has been carried out the more than ten years, a large amount of Pollen Pini products has appearred, but the comprehensive processing and utilization level is also not high, the product category of existing Pollen Pini is single on the market, and quality is uneven, and the degree of intensive processing is not high yet, exported product is rare especially, and the resource of valuable Pollen Pini is not well utilized.
Summary of the invention
The object of the invention be to invent a kind of be beneficial to long preservation, and can effectively keep the production method of its active Pollen Pini treatment fatty liver soft capsule.
Technical solution of the present invention is may further comprise the steps:
1) Pollen Pini with remove impurity is immersed in the normal pressure and temperature water after the comminution by gas stream broken wall treatment, with ultrasonic Treatment, through rotating speed is 10000～16000 refrigerated centrifuger centrifugal treating of changeing, get supernatant, again with supernatant under 1～5 ℃ ambient temperature, cross the following molecular sieve of 3000D, isolate the Pollen Pini hydrotrope of molecular weight less than 3000D;
2) with molecular weight less than the Pollen Pini hydrotrope of 3000D after lyophilisation, obtain water content and be lower than 5% Flos pini lyophilized powder;
3) described Flos pini lyophilized powder, oleum lini and lecithin mix homogeneously are mixed,, promptly get the Pollen Pini soft capsule that is used to treat fatty liver through changing glue, pelleting.
The present invention utilizes pollen water extract treatment fatty liver effect remarkable, and has no side effect, and expense is cheap, and is simple.Products characteristics of the present invention: cover bad smell, reduce zest; Packing dosage is accurate, and stability is high, antioxidation, taking convenience; The bioavailability height, the functional mass good stability; Absorb soon, taking dose is little; Good airproof performance; Sense organ is good, is fit to long-distance transport and long preservation.
In addition, the frequency of the classification motor of comminution by gas stream broken wall treatment is 55～60Hz in the step 1) of the present invention, and bleed pressure is 0.7～1.0MPa.
Ultrasonic treatment time described in the described step 1) is 20～40 minutes.
Described step 2) during lyophilisation, temperature of charge is-40 ℃～60 ℃ when sublimation drying and desorbing, and vacuum condition is 3～7Pa.
In the described step 3), the mass ratio that feeds intake of Flos pini lyophilized powder, cold pressed flax seed oil and lecithin is 1 ︰, 0.5～2 ︰ 0.5～2.
The specific embodiment
One, preparation pollen is treated the lyophilized powder of fatty edema caused by disorder of the liver extract:
1, go-on-go pollen: remove impurity in the Pollen Pini at normal temperatures.
2, breaking cellular wall: is 55～60Hz with the pollen of remove impurity in the frequency of classification motor, broken wall treatment under bleed pressure 0.7～1.0MPa.
3, soak supersound process: the pollen after the broken wall treatment is immersed in the normal pressure and temperature water, with ultrasonic Treatment 20～40 minutes.
4, remove impurity:
Remove impurity: it is centrifugal 10～15 minutes of 10000～16000 refrigerated centrifugers that change that the material after the supersound process is placed rotating speed, removes solid impurity, gets supernatant.
5, ultrafiltration: supernatant under 1～5 ℃ ambient temperature, is crossed the following molecular sieve of 3000D, isolate the hydrotrope of molecular weight, be the pollen hydrotrope that is used for the treatment of fatty liver less than 3000D.
6, lyophilization: the pollen hydrotrope that will be used for the treatment of fatty liver is-30 ℃～60 ℃ at temperature of charge, and vacuum condition is lyophilization 20～48 hours under the condition of 3～7Pa, obtains water content and is lower than 5% lyophilized powder.
Two, system soft capsule:
1, prescription:
Weight ratio when mixing with lyophilized powder, lecithin and oleum lini is 1 ︰, 0.5～2 ︰, 0. 5～2 weighings respectively.
2, production technology:
Batching, filtration: lyophilized powder and lecithin, the oleum lini of accurate weighing are put in the colloid mill, stirred, add 100 purpose screen filtrations, get the material that leaches and change liquid-supplying bucket over to, seal standby at the colloid mill discharging opening.
Change glue: get material in the liquid-supplying bucket, in the placing glue jar, after being melted to gelatin particle and being completed into, add coloring agent and glycerol, stirred 20～40 minutes; Continue to heat up, the control glue temperature is 70 ℃～76 ℃, vacuum-0.07 MPa in the maintenanceization glue jar～-0.072MPa, the pumpdown time is 45～60 minutes; Put glue afterwards, filter, glue is pressed into for the glue bucket, set 55 ℃～65 ℃ of holding temperatures, place after 8～12 hours and use with 100～120 orders.
Pelleting: accurately get the soft capsule feed liquid on request and supply the interior glue of glue bucket, instillation oval capsule is the 0.5g/ grain, and temperature is 18 ℃～24 ℃ between the maintenance pelleting, relative humidity 30%～50%.
Again through the drying of finalizing the design, pick up ball, wash ball and cool ball after, make the Pollen Pini soft capsule that is used for the treatment of fatty liver of 0.5g/ grain.
Three, application and curative effect:
Certain man, 55 years old, the fatty liver symptom was: blood transaminase enzyme value index is higher.
Take 2～4 of the Pollen Pini soft capsules made every day, after 30～60 days, symptom: blood enzyme value index recovers normal continuously.
Claims (5)
1. be used for the treatment of the production method of the Pollen Pini soft capsule of fatty liver, it is characterized in that may further comprise the steps:
1) Pollen Pini with remove impurity is immersed in the normal pressure and temperature water after the comminution by gas stream broken wall treatment, with ultrasonic Treatment, through rotating speed is 10000～16000 refrigerated centrifuger centrifugal treating of changeing, get supernatant, again with supernatant under 1～5 ℃ ambient temperature, cross the following molecular sieve of 3000D, isolate the Pollen Pini hydrotrope of molecular weight less than 3000D;
2) with molecular weight less than the Pollen Pini hydrotrope of 3000D after lyophilisation, obtain water content and be lower than 5% Flos pini lyophilized powder;
3) described Flos pini lyophilized powder, cold pressed flax seed oil and lecithin mix homogeneously are mixed,, promptly get the Pollen Pini soft capsule that is used to treat fatty liver through changing glue, pelleting.
2. according to the described production method that is used for the treatment of the Pollen Pini soft capsule of fatty liver of claim 1, the frequency that it is characterized in that the classification motor of comminution by gas stream broken wall treatment in the described step 1) is 55～60Hz, and bleed pressure is 0.7～1.0MPa.
3. according to the described production method that is used for the treatment of the Pollen Pini soft capsule of fatty liver of claim 1, it is characterized in that ultrasonic treatment time described in the described step 1) is 20～40 minutes.
4. according to the described production method that is used for the treatment of the Pollen Pini soft capsule of fatty liver of claim 1, it is characterized in that described step 2) during lyophilisation, temperature of charge is-40 ℃～60 ℃ when sublimation drying and desorbing, vacuum condition is 3～7Pa.
5. according to the described production method that is used for the treatment of the Pollen Pini soft capsule of fatty liver of claim 1, it is characterized in that in the described step 3) that the mass ratio that feeds intake of Flos pini lyophilized powder, cold pressed flax seed oil and lecithin is 1 ︰, 0.5～2 ︰ 0.5～2.
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| CN 201010607361 CN102114052B (en) | 2010-12-28 | 2010-12-28 | Production method of pine pollen soft capsule for treating fatty liver |
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| CN 201010607361 CN102114052B (en) | 2010-12-28 | 2010-12-28 | Production method of pine pollen soft capsule for treating fatty liver |
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| CN102114052A true CN102114052A (en) | 2011-07-06 |
| CN102114052B CN102114052B (en) | 2012-07-04 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102308938A (en) * | 2011-08-01 | 2012-01-11 | 烟台新时代健康产业有限公司 | Production method of pine pollen medicinal granules for treating fatty liver |
| CN102940704A (en) * | 2012-11-30 | 2013-02-27 | 烟台新时代健康产业有限公司 | Pine pollen water extract buccal tablet for preventing and treating alcoholic fatty liver |
| CN103130902A (en) * | 2011-11-29 | 2013-06-05 | 烟台新时代健康产业有限公司 | Method of extracting polysaccharide from pine pollen |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1589802A (en) * | 2003-09-04 | 2005-03-09 | 中国林业科学研究院松花粉研究开发中心 | Pollen pini soft capsule and its preparation method |
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2010
- 2010-12-28 CN CN 201010607361 patent/CN102114052B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1589802A (en) * | 2003-09-04 | 2005-03-09 | 中国林业科学研究院松花粉研究开发中心 | Pollen pini soft capsule and its preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 《中国医疗前沿》 20071115 刘勇等 破壁松花粉及软胶囊抗前列腺增生作用 , 第22期 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102308938A (en) * | 2011-08-01 | 2012-01-11 | 烟台新时代健康产业有限公司 | Production method of pine pollen medicinal granules for treating fatty liver |
| CN103130902A (en) * | 2011-11-29 | 2013-06-05 | 烟台新时代健康产业有限公司 | Method of extracting polysaccharide from pine pollen |
| CN103130902B (en) * | 2011-11-29 | 2015-04-22 | 烟台新时代健康产业有限公司 | Method of extracting polysaccharide from pine pollen |
| CN102940704A (en) * | 2012-11-30 | 2013-02-27 | 烟台新时代健康产业有限公司 | Pine pollen water extract buccal tablet for preventing and treating alcoholic fatty liver |
| CN102940704B (en) * | 2012-11-30 | 2013-12-11 | 烟台新时代健康产业有限公司 | Pine pollen water extract buccal tablet for preventing and treating alcoholic fatty liver |
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| CN102114052B (en) | 2012-07-04 |
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