CN102114048B - Production method of bee pollen soft capsules for treating fatty liver - Google Patents
Production method of bee pollen soft capsules for treating fatty liver Download PDFInfo
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- CN102114048B CN102114048B CN2010106073991A CN201010607399A CN102114048B CN 102114048 B CN102114048 B CN 102114048B CN 2010106073991 A CN2010106073991 A CN 2010106073991A CN 201010607399 A CN201010607399 A CN 201010607399A CN 102114048 B CN102114048 B CN 102114048B
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- fatty liver
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Abstract
The invention discloses a production method of bee pollen soft capsules for treating fatty liver and relates to the technical field of soft capsule production. The production method comprises the following steps: after impurity removal, bee pollen is subjected to airflow crushing and wall-breaking treatment, then is soaked in water at normal pressure and normal temperature, and is subjected to ultrasonic treatment and centrifugal treatment at the rotational speed of 8000-10000 turns so as to get supernatant liquid; the supernatant liquid is separated to get bee pollen water-soluble matters with the molecular weight below 2800D under the environmental temperature of minus 5-5 DEG C; the bee pollen water-soluble matters are frozen and dried by vacuum to get bee pollen freeze-dried powder with water content below 4; and the bee pollen freeze-dried powder, lecithin and cold-pressed linseed oil or the bee pollen freeze-dried powder, the lecithin and corn salad oil are uniformly mixed and then are subjected to glue melting and pelleting to get the bee pollen soft capsules for treating the fatty liver. The bee pollen soft capsule has no side effects, is simple and easy to operate, can cover poor odor and reduce irritation, is high in stability, realizes oxidation resistance, is high in bioavailability and can be absorbed fast.
Description
Technical field
The present invention relates to product soft capsule production technology, particularly treat the bee pollen soft capsule production method of fatty liver.
Background technology
Soft capsule dosage form is meant a kind of novel form that behind tablet, hard capsule, injection etc., grows up; Can oily functional materials, functional materials solution or functional materials powder quantitatively be pressed and annotate and be encapsulated in the glued membrane, form big or small, different seal capsule.Soft capsule has can cover bad smell, reduces zest, and stability is high, antioxidation, taking convenience, characteristics such as bioavailability height.The advantage of soft capsule is can directly absorb after the disintegrate, absorbs fast; Quantitatively accurately; Bioavailability is high; Taking dose is little; The functional mass good stability is difficult for the oxidation and the moisture absorption; Good airproof performance can hide the bad smell of medicine; Sense organ is good, and is welcome.In addition, soft capsule can also produce various, welcome CF according to different needs, to reach stabilization function property composition and the purpose that is easy to identification.At present, the soft capsule dosage form of domestic production be from can being divided into masticatory pattern, colon lysotype, enteric solubility, instant type, oral gastric solubility type, spacetabs type clinically, also have external rectum type and eye with, skin with type etc.
Fatty liver is meant the pathological changes of fatty overheap in the hepatocyte that causes owing to a variety of causes, and the positive serious threat compatriots' of fatty liver disease health becomes the second largest hepatopathy that is only second to viral hepatitis, has been acknowledged as the common cause of disguised liver cirrhosis.Fatty liver is a kind of common clinical picture, but not a kind of independently disease.The lighter is asymptomatic in its clinical manifestation, and weight person's state of an illness is violent.Generally speaking, fatty liver belongs to the reversibility disease, and early diagnosis and treatment in time often can recover normal.
The treatment of current fatty liver is still removing the cause of disease, Cure the Primary Disease with adhere to that the reasonable diet system is main, medicine only plays the auxiliary treatment effect.So, the research of this disease has been become the common focus and the difficult point of domestic and international research.Up to the present, Western medicine does not still have lipotropic active drug, and for well, wherein Radix Polygoni Multiflori and Fructus Crataegi are best with Chinese medicine long-time conditioning property, can blood fat reducing, prevent that cholesterol is at intrahepatic deposition.
Bee pollen is angiospermous pollen, and China utilizes and one of edible pollen country the earliest in the world.The aboundresources of China's bee pollen, but develop low, serious waste of resources.
The research of China's bee pollen at present is in the leading level in the world; External research also is in the primary research stages such as analysis of nutritional labeling; And a series of difficult problems such as China has solved well that bee pollen is fresh-keeping, breaking cellular wall and production; Realized large-scale production, and improved the alimentation rate behind the edible bee pollen greatly, for bee pollen industry leading position in the world provides powerful guarantee.However external pollen product is but more extensive on using than China, and Sweden is applied to beauty treatment with pollen food, and Japan is used as nutriment with pollen food, and France is with the function food of pollen as the growth encourage childhood development.By comparison, though the developmental research of China's bee pollen has been carried out the more than ten years, a large amount of bee pollen products has appearred; But the comprehensive processing and utilization level is also not high; The product category of existing bee pollen is single on the market, and quality is uneven, and the degree of intensive processing is not high yet; Exported product is rare especially, and the resource of valuable bee pollen is not by good use.
Summary of the invention
The object of the invention be to invent a kind of be beneficial to long preservation, and can effectively keep the production method of its active bee pollen treatment fatty liver soft capsule.
Technical scheme of the present invention is may further comprise the steps:
1) bee pollen with remove impurity is immersed in the normal pressure and temperature water after the comminution by gas stream broken wall treatment; With ultrasonic Treatment; Through rotating speed is 8000～10000 refrigerated centrifuger centrifugal treating of changeing, and gets supernatant, again with supernatant under-5～5 ℃ ambient temperature; Cross the molecular sieve below the 2800D, isolate the bee pollen hydrotrope of molecular weight less than 2800D;
2) with molecular weight less than the bee pollen hydrotrope of 2800D after lyophilisation, obtain water content and be lower than 4% Herba leucadis ciliatae lyophilized powder;
3) with said Herba leucadis ciliatae lyophilized powder, lecithin and cold pressed flax seed oil, or with said Herba leucadis ciliatae lyophilized powder, lecithin and the mixing of corn salad oil mix homogeneously, warpization glue, pelleting promptly get the bee pollen soft capsule that is used to treat fatty liver.
The present invention utilizes bee pollen water extract treatment fatty liver effect remarkable, and has no side effect, and cost, and is simple.Products characteristics of the present invention: cover bad smell, reduce zest; Packing dosage is accurate, and stability is high, antioxidation, taking convenience; Bioavailability is high, the functional mass good stability; Absorb soon, taking dose is little; Good airproof performance; Sense organ is good, is fit to long-distance transport and long preservation.
In addition, the frequency of the classification motor of comminution by gas stream broken wall treatment is 55～60Hz in the step 1) according to the invention, and bleed pressure is 0.7～1.0MPa.
Ultrasonic treatment time described in the said step 1) is 10～20 minutes.
Said step 2) during lyophilisation, temperature of charge is-40 ℃～70 ℃ when sublimation drying and desorbing, and vacuum condition is 3～7Pa.
In the step 3), the mass ratio that feeds intake of Herba leucadis ciliatae lyophilized powder, cold pressed flax seed oil and lecithin is 1 ︰, 0.5～2 ︰ 0.5～2.
In the step 3), the mass ratio that feeds intake of Herba leucadis ciliatae lyophilized powder, corn salad oil and lecithin is 1 ︰, 0.5～2 ︰ 0.5～2.
The specific embodiment
One, the preparation bee pollen is treated the lyophilized powder of fatty edema caused by disorder of the liver extract:
1, go-on-go bee pollen: remove impurity in the bee pollen at normal temperatures.
2, breaking cellular wall: is 55～60Hz with the bee pollen of remove impurity in the frequency of classification motor, broken wall treatment under bleed pressure 0.7～1.0MPa.
3, soak supersound process: the bee pollen after the broken wall treatment is immersed in the normal pressure and temperature water, with ultrasonic Treatment 10～20 minutes.
4, remove impurity:
Remove impurity: it is centrifugal 10～15 minutes of 8000～10000 refrigerated centrifugers that change that the material after the supersound process is placed rotating speed, removes solid impurity, gets supernatant.
5, ultrafiltration: supernatant under-5～5 ℃ ambient temperature, is crossed the molecular sieve below the 2800D, isolate molecular weight, be the bee pollen hydrotrope that is used to treat fatty liver less than 2800 the hydrotrope.
6, lyophilization: the bee pollen hydrotrope that will be used to treat fatty liver is-30 ℃～70 ℃ at temperature of charge, and vacuum condition is lyophilization 30～50 hours under the condition of 3～7Pa, obtains water content and is lower than 4% lyophilized powder.
Two, system soft capsule:
1, prescription:
Weight ratio when mixing with lyophilized powder, lecithin and cold pressed flax seed oil is 1 ︰, 0.5～2 ︰, 0. 5～2 weighings respectively.
Or the weight ratio when mixing with lyophilized powder, lecithin and corn salad oil is 1 ︰, 0.5～2 ︰, 0. 5～2 weighings respectively.
2, production technology:
Batching, filtration: lyophilized powder and lecithin, the cold pressed flax seed oil (or corn salad oil) of accurate weighing are put in the colloid mill, stirred, add 100 purpose screen filtrations, get the material that leaches and change liquid-supplying bucket over to, seal subsequent use at the colloid mill discharging opening.
Change glue: get material in the liquid-supplying bucket, in the placing glue jar, after being melted to gelatin particle and being completed into, add coloring agent and glycerol, stirred 20～40 minutes; Continue to heat up, the control glue temperature is 70 ℃～76 ℃, vacuum-0.07 MPa in the maintenanceization glue jar～-0.072MPa, the pumpdown time is 45～60 minutes; Put glue afterwards, filter, glue is pressed into supplies the glue bucket, set 55 ℃～65 ℃ of holding temperatures, place after 8～12 hours and use with 100～120 orders.
Pelleting: accurately get soft capsule feed liquid and the glue that supplies in the glue bucket on request, instillation oval capsule is the 0.6g/ grain, and temperature is 18 ℃～24 ℃ between the maintenance pelleting, relative humidity 30%～50%.
Dry through typing again, pick up ball, wash ball and cool ball after, process the bee pollen soft capsule that is used to treat fatty liver of 0.6g/ grain.
Three, application and curative effect:
Certain man, 55 years old, the fatty liver symptom was: blood transaminase enzyme value index is higher.
Take the bee pollen soft capsule 2-4 grain of processing every day, after 30-60 days, symptom: blood enzyme value index recovers normal continuously.
Claims (6)
1. be used to treat the production method of the bee pollen soft capsule of fatty liver, it is characterized in that may further comprise the steps:
1) bee pollen with remove impurity is immersed in the normal pressure and temperature water after the comminution by gas stream broken wall treatment; With ultrasonic Treatment; Through rotating speed is 8000～10000 refrigerated centrifuger centrifugal treating of changeing, and gets supernatant, again with supernatant under-5～5 ℃ ambient temperature; Cross the molecular sieve below the 2800D, isolate the bee pollen hydrotrope of molecular weight less than 2800D;
2) with molecular weight less than the bee pollen hydrotrope of 2800D after lyophilisation, obtain water content and be lower than 4% Herba leucadis ciliatae lyophilized powder;
3) with said Herba leucadis ciliatae lyophilized powder, lecithin and cold pressed flax seed oil, or with said Herba leucadis ciliatae lyophilized powder, lecithin and the mixing of corn salad oil mix homogeneously, warpization glue, pelleting promptly get the bee pollen soft capsule that is used to treat fatty liver.
2. according to the said production method that is used to treat the bee pollen soft capsule of fatty liver of claim 1, the frequency that it is characterized in that the classification motor of comminution by gas stream broken wall treatment in the said step 1) is 55～60Hz, and bleed pressure is 0.7～1.0MPa.
3. according to the said production method that is used to treat the bee pollen soft capsule of fatty liver of claim 1, it is characterized in that ultrasonic treatment time described in the said step 1) is 10～20 minutes.
4. according to the said production method that is used to treat the bee pollen soft capsule of fatty liver of claim 1, it is characterized in that said step 2) during lyophilisation, temperature of charge is-40 ℃～70 ℃ when sublimation drying and desorbing, vacuum condition is 3～7Pa.
5. according to the said production method that is used to treat the bee pollen soft capsule of fatty liver of claim 1, it is characterized in that in the said step 3) that the mass ratio that feeds intake of Herba leucadis ciliatae lyophilized powder, cold pressed flax seed oil and lecithin is 1 ︰, 0.5～2 ︰ 0.5～2.
6. according to the said production method that is used to treat the bee pollen soft capsule of fatty liver of claim 1, it is characterized in that in the said step 3) that the mass ratio that feeds intake of Herba leucadis ciliatae lyophilized powder, corn salad oil and lecithin is 1 ︰, 0.5～2 ︰ 0.5～2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010106073991A CN102114048B (en) | 2010-12-28 | 2010-12-28 | Production method of bee pollen soft capsules for treating fatty liver |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010106073991A CN102114048B (en) | 2010-12-28 | 2010-12-28 | Production method of bee pollen soft capsules for treating fatty liver |
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| CN102114048A CN102114048A (en) | 2011-07-06 |
| CN102114048B true CN102114048B (en) | 2012-07-04 |
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| CN2010106073991A Expired - Fee Related CN102114048B (en) | 2010-12-28 | 2010-12-28 | Production method of bee pollen soft capsules for treating fatty liver |
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| CN102940653A (en) * | 2012-11-30 | 2013-02-27 | 扬州大学 | Bee pollen water extract buccal tablet for preventing and treating alcoholic fatty liver |
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| CN100381131C (en) * | 2006-06-07 | 2008-04-16 | 中国农业科学院蜜蜂研究所 | Bee pollen soft capsule and preparation method thereof |
| CN101756088B (en) * | 2010-02-05 | 2012-11-21 | 王平 | Preparation method of novel pine pollen preparation |
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Address after: Sheyang Baoying County town Jiangsu city Yangzhou province 225814 Dashe Road No. 9 Patentee after: Zhou Bin Patentee after: Ye Manhong Address before: 225001 Jiangsu City, Yangzhou Old City Lane seven 18-3 Patentee before: Zhou Bin Patentee before: Ye Manhong |
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Address after: No. 8, Dashan Industrial Park, Gao Hong Kong, Taizhou, Jiangsu Co-patentee after: Ye Manhong Patentee after: Zhou Bin Address before: Sheyang Baoying County town Jiangsu city Yangzhou province 225814 Dashe Road No. 9 Co-patentee before: Ye Manhong Patentee before: Zhou Bin |
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Granted publication date: 20120704 Termination date: 20171228 |