CN109381616A - A kind of preparation method of Tibetan Gastrodia broken wall medicine materical crude slice - Google Patents
A kind of preparation method of Tibetan Gastrodia broken wall medicine materical crude slice Download PDFInfo
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Abstract
The present invention relates to a kind of preparation methods of Tibetan Gastrodia broken wall medicine materical crude slice, belong to pharmaceutical technology field.Preparation method of the invention is the following steps are included: Tibetan Gastrodia is broken for thick slag through steam explosion technology by (1)；(2) thick slag is dry；Then ultrafine powder is broken for using superfine communication technique, determines Tibetan Gastrodia ultrafine powder sporoderm-broken rate by index characteristic cell of parenchyma cell, obtains sporoderm-broken rate ultrafine powder up to standard；(3) ultrafine powder solubilizer is pelletized, drying, whole grain, packing are to get Tibetan Gastrodia broken wall medicine materical crude slice.The Tibetan Gastrodia broken wall medicine materical crude slice sporoderm-broken rate of the method for the present invention preparation is high, gastrodia elata polysaccharide dissolution rate is high, particle leach in water rapidly, effective component dissolution rate it is fast, products obtained therefrom microbial limit easier to control can guarantee drug safety and effectively.
Description
Technical field
The present invention relates to a kind of preparation methods of Tibetan Gastrodia broken wall medicine materical crude slice, belong to pharmaceutical technology field.
Background technique
Tibetan Gastrodia, also known as solely shake sesame, close from grass, god grass, RHIZONA GASTRODIAE, Bai Long, it is orchid family Gastrodia herbaceos perennial.
Rhizomes is plump, no greenery, capsule obovate elliptic, often with stem tuber or seminal propagation.Its rhizome is used as medicine, to treat dizziness
The diseases such as dizzy, extremity numbness, child convulsion are rare medicinal herbs, share treatment headache and insomnia with Qiongzhen Ganoderma Lucidum.Tibetan Gastrodia is mostly located
It is less than Yunnan-Guizhou Rhizoma Gastrodiae in the quantity of wild state, artificial growth, is also quite harsh when acquisition, it is necessary to manpower is dug out,
Therefore it is more difficult on the market see Tibetan Gastrodia, reflect the preciousness of Tibetan Gastrodia.
Gastrodia elata polysaccharide is the important activity ingredient of Rhizoma Gastrodiae, studies have shown that gastrodia elata polysaccharide has multiple biological activities, including anti-
Function of tumor, liver protecting, adjusting cerebral ischemic, anti-oxidant, blood pressure lowering etc., are mainly used for study of tcm new drug exploitation and health care
Product exploitation；TCD MICROSCOPIC IDENTIFICATION is shown, containing a large amount of gelatinization polysaccharide in Rhizoma Gastrodiae, but is gelatinized polyoses grain and is present in thin-walled mostly
Cell interior.Therefore, it obtains gastrodia elata polysaccharide with maximum, needs for the parenchyma cell in Rhizoma Gastrodiae to be crushed, make more to be gelatinized
Polyoses grain is exposed；The utilization rate of effective component only has 10%~30% or so when common medicine materical crude slice decocts, though Tibetan medicine with
Powder type is used as medicine, due to the presence of crude drug cell wall, effective component absorptivity is also not very high, serious waste valuable ingredient of traditional Chinese medicine
Resource, while also affecting the performance of drug effect.
The patent of Publication No. CN104056074A discloses a kind of " Rhizoma Gastrodiae broken wall preparation " method, including Rhizoma Gastrodiae is crushed
At wall cell disruption powder, further pass through alcohol-water wet granulation, and the extrusion forming under certain revolving speed, drying and other steps.This method
Drying temperature is higher, the heat-sensitive ingredients such as destructible gastrodia elata polysaccharide.
The patent of Publication No. CN104189517A discloses " a kind of super-micro wall-broken Rhizoma Gastrodiae composition and preparation method thereof ",
Including raw material selection, raw material cleaning, boiling, slice, secondary boiled, dry, super-micro wall-broken, preparation.This method compares
It is cumbersome, and high temperature and pressure boiling raw material is repeatedly used for a long time, active constituent content drops in the ingredients such as destructible gastrodia elata polysaccharide
It is low, the deficiencies of reduced activity.
The patent of Publication No. CN106177515A discloses " preparation method of Rhizoma Gastrodiae broken wall medicine materical crude slice ", including medicinal material passes through
Pick the processes such as cleaning processing, the crushing of dry, broken, mesh pulverizer, intermittent sterilization, broken wall, granulation, drying.The party
Method sterilization process is cumbersome, time-consuming, and time cost is high, and after coarse powder sterilizing during subsequent operation vulnerable to bacterium, mould etc.
Microbial contamination, product content of microorganisms is up to standard after cannot ensure granulation.
The patent of Publication No. CN107802746A discloses " Rhizoma Gastrodiae broken wall medicine materical crude slice and preparation method thereof ", and this method obtains
Rhizoma Gastrodiae broken wall medicine materical crude slice extract content it is relatively low, gastrodia elata polysaccharide isoreactivity ingredient cannot be made full use of.
According to current technique, gastrodia elata polysaccharide isoreactivity ingredient is easily destroyed in the Rhizoma Gastrodiae broken wall medicine materical crude slice of preparation, is prepared
Cheng Yi microbial contamination, technique is time-consuming, and the extract contents such as gastrodia elata polysaccharide are low, and it is low to leach degree.It is more in order to improve Tibetan Gastrodia
The utilization rate of the effective components such as sugar, improves the curative effect of Tibetan Gastrodia, and applicant changes the preparation method of Tibetan Gastrodia broken wall medicine materical crude slice
Into gastrodia elata polysaccharide recovery rate is higher in the Tibetan Gastrodia broken wall medicine materical crude slice of exploitation, sporoderm-broken rate established standards are more scientific, shell-broken effect
More secure, content of microorganisms is easier to control, is leached more rapidly in product water, has more advantages.
Summary of the invention
A kind of Tibetan Gastrodia broken wall medicine materical crude slice is provided it is an object of the invention to overcome in place of above-mentioned the deficiencies in the prior art
Preparation method, the Tibetan Gastrodia broken wall medicine materical crude slice sporoderm-broken rate of the method for the present invention preparation is high, gastrodia elata polysaccharide dissolution rate is high, particle is molten in water
Dissipate rapidly, effective component dissolution rate it is fast, products obtained therefrom microbial limit easier to control, can guarantee drug safety and effectively.
To achieve the above object, the technical scheme adopted by the invention is as follows: a kind of preparation method of Tibetan Gastrodia broken wall medicine materical crude slice, packet
Include following steps:
(1) Tibetan Gastrodia is broken for thick slag through steam explosion technology；
(2) the resulting thick slag of step (1) is dry；Then ultrafine powder is broken for using superfine communication technique, with thin-walled
Cell is that index characteristic cell determines Tibetan Gastrodia ultrafine powder sporoderm-broken rate, obtains sporoderm-broken rate ultrafine powder up to standard；
(3) the resulting ultrafine powder solubilizer of step (2) is pelletized, drying, whole grain, packing are to get Tibetan Gastrodia broken wall drink
Piece.
The preferred embodiment of preparation method as Tibetan Gastrodia broken wall medicine materical crude slice of the present invention, in the step (1), hiding
Rhizoma Gastrodiae is fresh Tibetan Gastrodia medicinal material or the Tibetan Gastrodia medicinal material through dryness in the sun.
The preferred embodiment of preparation method as Tibetan Gastrodia broken wall medicine materical crude slice of the present invention, it is described through dryness in the sun
Tibetan Gastrodia medicinal material is soaked in water 6~12 hours before steam blasting.
The preferred embodiment of preparation method as Tibetan Gastrodia broken wall medicine materical crude slice of the present invention in the step (1), is steamed
The broken pressure of steam explosion is 1.2~1.8MPa, and Tibetan Gastrodia moisture content is 10~80%, and maintaining the time of pressure is 1.0~10min.
The preferred embodiment of preparation method as Tibetan Gastrodia broken wall medicine materical crude slice of the present invention, in the step (2), slightly
Moisture content after slag is dry is 5~12%.
The preferred embodiment of preparation method as Tibetan Gastrodia broken wall medicine materical crude slice of the present invention, in the step (2), with
Parenchyma cell is that index characteristic cell determines Tibetan Gastrodia ultrafine powder sporoderm-broken rate, refers to and is with parenchyma cell quantity before and after broken wall
Index calculates ultrafine powder sporoderm-broken rate >=99%.
The preferred embodiment of preparation method as Tibetan Gastrodia broken wall medicine materical crude slice of the present invention, the step (2) and step
Suddenly in (3), drying means be dried under reduced pressure, at least one of vacuum freeze drying.
The preferred embodiment of preparation method as Tibetan Gastrodia broken wall medicine materical crude slice of the present invention, the temperature being dried under reduced pressure
Degree is 5~45 DEG C, and drying time is 3~5 hours.
The preferred embodiment of preparation method as Tibetan Gastrodia broken wall medicine materical crude slice of the present invention, the vacuum freeze drying
Operation are as follows: set temperature be -35~-15 DEG C, be evacuated to system absolute pressure be 50~100Pa after, keep 1~5 hour
It is freeze-dried, is then heated to 30~45 DEG C, lyophilization 1~10 hour.
The preferred embodiment of preparation method as Tibetan Gastrodia broken wall medicine materical crude slice of the present invention, it is whole in the step (3)
Grain refers to be sieved 1~3 time with the concussion pelletizing machine of 30 mesh of upper layer, 100 mesh of lower layer, and the particle between 30~100 mesh is made.
Compared with prior art, the invention has the benefit that
(1) preparation method of Tibetan Gastrodia broken wall medicine materical crude slice of the present invention, sporoderm-broken rate is high, sporoderm-broken rate index is easily controllable, Rhizoma Gastrodiae is more
Sugared dissolution rate is high, the dissolution of particle in water is good, effective component dissolution rate is fast, products obtained therefrom microorganism limit easier to control
Degree can guarantee that drug safety with effectively, can both be used as medicine with other medicinal powder compatibilities, it is also possible to which water directly rushes in powder form
Clothes, easy to use, bioavilability is high, is saved greatly valuable medicinal resource, improves the utilization rate of rare traditional national medicine,
The sustainable use preserved the ecological environment with wild Tibetan Gastrodia resource；
(2) preparation method of the invention is simple, time-consuming short, easy to operate, at low cost, is suitble to industrial application.
Specific embodiment
Purposes, technical schemes and advantages in order to better illustrate the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
Fresh Tibetan Gastrodia 2kg is taken, is cleaned, (pressure of steam blasting is 1.2MPa to steam blasting, and Tibetan Gastrodia moisture content is
10%, maintaining the time of pressure is 1.0min) it is thick slag, thick slag (moisture after thick slag drying after 45 DEG C are dried under reduced pressure 3 hours
Content is 5%), to be broken for ultrafine powder using superfine communication technique, the microorganism feelings in conventional detection Tibetan Gastrodia ultrafine powder
Condition；Broken wall front and back parenchyma cell quantity is compared, calculating sporoderm-broken rate is respectively 99.6%；Certain density alcohol granulation is added,
Grain is after 40 DEG C are dried under reduced pressure 3 hours, and using 30 mesh of upper layer, the concussion pelletizing machine whole grain of 100 mesh of lower layer 2 times is dispensed up to hiding
Rhizoma Gastrodiae broken wall medicine materical crude slice.
Tibetan Gastrodia broken wall medicine materical crude slice manufactured in the present embodiment, bacterium, mould, saccharomycete and coliform be respectively 11,14,
10,15cfu/g meets less than 102The regulation of cfu/g；Tibetan Gastrodia broken wall medicine materical crude slice 5g is taken, 60 DEG C of warm water is added and leaches, leaches
Time is 1.8s；Extraction gastrodia elata polysaccharide is taken water as a solvent, Tibetan Gastrodia broken wall medicine materical crude slice Polyose extraction yield is 85.3%.
Embodiment 2
Fresh Tibetan Gastrodia 2.5kg is taken to be cleaned, (pressure of steam blasting is 1.8MPa, Tibetan Gastrodia moisture content to steam blasting
It is 80%, maintaining the time of pressure is 10min) it is thick slag, thick slag (water after thick slag drying after 45 DEG C are dried under reduced pressure 3 hours
Dividing content is 12%), to be broken for ultrafine powder using superfine communication technique, the microorganism feelings in conventional detection Tibetan Gastrodia Ultramicro-powder
Condition；Broken wall front and back parenchyma cell quantity is compared, calculating sporoderm-broken rate is 99.8%；Certain density alcohol granulation is added, particle exists
After 45 DEG C are dried under reduced pressure 2.5 hours, using 30 mesh of upper layer, the concussion pelletizing machine whole grain of 100 mesh of lower layer 1 time is dispensed up to hiding day
Numb broken wall medicine materical crude slice.
Tibetan Gastrodia broken wall medicine materical crude slice manufactured in the present embodiment, bacterium, mould, saccharomycete and coliform be respectively 16,12,
15,19cfu/g meets less than 102The regulation of cfu/g；Tibetan Gastrodia broken wall medicine materical crude slice 5g is taken, 60 DEG C of warm water is added and leaches, leaches
Time is 2.0s；Extraction gastrodia elata polysaccharide is taken water as a solvent, Tibetan Gastrodia broken wall medicine materical crude slice Polyose extraction yield is 83.4%.
Embodiment 3
Fresh Tibetan Gastrodia 2.5kg is taken to be cleaned, (pressure of steam blasting is 1.5MPa, Tibetan Gastrodia moisture content to steam blasting
It is 50%, maintaining the time of pressure is 5min) it is thick slag, thick slag (moisture after thick slag drying after 45 DEG C are dried under reduced pressure 3 hours
Content is 8%), to be broken for ultrafine powder using superfine communication technique, the microorganism situation in conventional detection Tibetan Gastrodia Ultramicro-powder；
Broken wall front and back parenchyma cell quantity is compared, calculating sporoderm-broken rate is 99.8%；Certain density alcohol granulation is added, particle is at 30 DEG C
After being dried under reduced pressure 3.5 hours, using 30 mesh of upper layer, the concussion pelletizing machine whole grain of 100 mesh of lower layer 3 times is dispensed broken up to Tibetan Gastrodia
Wall medicine materical crude slice.
Tibetan Gastrodia broken wall medicine materical crude slice manufactured in the present embodiment, bacterium, mould, saccharomycete and coliform be respectively 13,18,
10,10cfu/g meets less than 102The regulation of cfu/g；Tibetan Gastrodia broken wall medicine materical crude slice 5g is taken, 60 DEG C of warm water is added and leaches, leaches
Time is 2.5s；Extraction gastrodia elata polysaccharide is taken water as a solvent, Tibetan Gastrodia broken wall medicine materical crude slice Polyose extraction yield is 80.4%.
Embodiment 4
Tibetan Gastrodia dry product 2.5kg is taken to be cleaned, impregnated 6 hours, (pressure of steam blasting is 1.2MPa, hiding to steam blasting
Rhizoma Gastrodiae moisture content is 80%, and maintaining the time of pressure is 1.0min) it is thick slag, thick slag (thick slag after 45 DEG C are dried under reduced pressure 3 hours
Moisture content after drying is 12%), ultrafine powder to be broken for using superfine communication technique, in conventional detection Tibetan Gastrodia Ultramicro-powder
Microorganism situation；Broken wall front and back parenchyma cell quantity is compared, calculating sporoderm-broken rate is 100%；Certain density ethyl alcohol system is added
Grain, particle first after 30 DEG C are dried under reduced pressure 0.5 hour, is transferred to vacuum freeze drying, after being set as -35 DEG C, keep 2 hours into
Capable freeze-drying, being evacuated to system absolute pressure is 100Pa, begins to warm up and is warming up to 45 DEG C, lyophilization 1 hour, dries
30 mesh of upper layer is used afterwards, and the concussion pelletizing machine whole grain of 100 mesh of lower layer 2 times dispenses up to Tibetan Gastrodia broken wall medicine materical crude slice.
Tibetan Gastrodia broken wall medicine materical crude slice manufactured in the present embodiment, bacterium, mould, saccharomycete and coliform be respectively 12,10,
19,15cfu/g meets less than 102The regulation of cfu/g；Tibetan Gastrodia broken wall medicine materical crude slice 5g is taken, 60 DEG C of warm water is added and leaches, leaches
Time is 2.8s；Extraction gastrodia elata polysaccharide is taken water as a solvent, Tibetan Gastrodia broken wall medicine materical crude slice polysaccharide extract rate is 81.3%.
Comparative example 1
Using published prior art, first sterilize to coarse powder, then pulverized, it is quick-fried using steam with embodiment 1
Crushing, then the content of microorganisms of broken wall medicine materical crude slice obtained by the technique that is pulverized are compared.
Fresh Tibetan Gastrodia 2kg is cleaned, vacuum freeze drying to moisture is after 5% or so, is with Universalpulverizer crushing
Coarse powder, coarse powder use intermittent sterilization, and the microorganism situation in conventional detection Tibetan Gastrodia Ultramicro-powder directly takes drink until meeting
The requirement of piece microbial limit；Ultrafine powder is broken for using superfine communication technique, parenchyma cell quantity before and after comparison broken wall calculates
Sporoderm-broken rate is 99.0%；Certain density alcohol granulation is added, particle is after 40 DEG C are dried under reduced pressure 3 hours, using 30 mesh of upper layer,
The concussion pelletizing machine of 100 mesh of lower layer arranges 2 times, dispenses up to Tibetan Gastrodia broken wall medicine materical crude slice.
Tibetan Gastrodia broken wall medicine materical crude slice made from this comparative example, bacterium, mould, saccharomycete and coliform be respectively 87,88,
76,55cfu/g meets less than 102The regulation of cfu/g.The content of microorganisms of Tibetan Gastrodia broken wall medicine materical crude slice made from comparative example 1 is significant
Higher than the embodiment of the present invention 1, illustrate that preparation method of the invention can preferably control content of microorganisms.
Comparative example 2
Using published prior art, it is dried using heated-air circulation oven, it is dry using decompression low temperature with embodiment 2
The gastrodia elata polysaccharide recovery rate of dry resulting Tibetan Gastrodia broken wall medicine materical crude slice compares.
Fresh Tibetan Gastrodia 2.5kg is cleaned, (pressure of steam blasting is 1.8MPa to steam blasting, and Tibetan Gastrodia moisture content is
80%, maintaining the time of pressure is 10min) it is thick slag, thick slag (moisture after thick slag drying after 45 DEG C are dried under reduced pressure 3 hours
Content is 12%), to be broken for ultrafine powder using superfine communication technique, the microorganism feelings in conventional detection Tibetan Gastrodia Ultramicro-powder
Condition；Broken wall front and back parenchyma cell quantity is compared, calculating sporoderm-broken rate is 99.1%；Certain density alcohol granulation is added, particle exists
In 75 DEG C of heated-air circulation oven after drying 2.5 hours, using 30 mesh of upper layer, the concussion pelletizing machine of 100 mesh of lower layer is arranged 1 time,
It dispenses up to Tibetan Gastrodia broken wall medicine materical crude slice.
Extraction gastrodia elata polysaccharide is taken water as a solvent, the Polyose extraction yield of this comparative example Tibetan Gastrodia broken wall medicine materical crude slice is 73.5%.
The Polyose extraction yield of 2 Rhizoma Gastrodiae broken wall medicine materical crude slice of comparative example is substantially less than embodiment 2, illustrates that preparation method of the invention can improve day
The extraction yield of numb polysaccharide.
Comparative example 3
Using published patent technique, by picking cleaning, processing, drying, broken, mesh pulverizer crush,
The processes such as formula of having a rest sterilization, broken wall, granulation, drying are compared with the progress process time of embodiment 3.
By Rhizoma Gastrodiae picked cleaning/processing, medicinal material drying to medicinal material water content 10% hereinafter, by medicinal material with 10
The mechanical crusher of purpose sieve is broken into the little particle of 10 mesh or so；Further coarse crushing Rhizoma Gastrodiae reaches 100 mesh or so；Intermittently
Formula sterilization: go out bacterial propagule: Rhizoma Gastrodiae coarse powder is placed in an oven, and placing thickness is about 10mm, and setting temperature is 65 DEG C (practical
Temperature is 60~70 DEG C), keep drying sterilizing 8h；Hypopus growth: treated, and Rhizoma Gastrodiae coarse powder takes out from baking oven, pack,
When temperature is 25 DEG C, sealing is maintained 12 hours after water vapour is filled with into bag；Go out bacterial propagule: Rhizoma Gastrodiae coarse powder is put into baking
It in case, places with a thickness of 30mm, it is 75 DEG C that temperature, which is arranged, keeps drying sterilizing 4h；Microorganism in conventional detection Rhizoma Gastrodiae coarse powder
Situation must meet the Rhizoma Gastrodiae coarse powder for directly taking medicine materical crude slice microbial limit requirement；Broken wall: by partial size 100~120 mesh Rhizoma Gastrodiae
Coarse powder crushes in the environment of room temperature and relative humidity are 30% through broken wall, controls operating pressure in 0.6MPa, grader revolving speed
In 20r/s, broken wall is crushed to 300 mesh or more, obtains superfine powder (90% powder size is less than 45 microns)；Softwood processed: it will make
The superfine powder obtained is placed in trough type mixing machine, and suitable 50~60% ethyl alcohol is added, softwood is made；Granulation: super by what is made
Fine powder softwood, which is put into before oscillating granulator, spills a small amount of superfine powder into sieve, with 16 objective screen and granulatings, side when granulation
The ratio of the Rhizoma Gastrodiae superfine powder of side addition preparation when the superfine powder softwood made is added, softwood and superfine powder is 3:1；It will
Qualified broken wall medicine materical crude slice particle is taken to be placed in 70 DEG C~80 DEG C baking ovens dry, particle 10 mesh of upper layer after drying, 24 mesh of bottom
Concussion pelletizing machine whole grain be sieved 2 times, dispense up to Rhizoma Gastrodiae broken wall medicine materical crude slice.
Embodiment 3 is sterilized while steam blasting, is saved the time of medicinal material drying and sterilizing, is greatly improved
Prepare the efficiency of broken wall medicine materical crude slice.
Comparative example 4
Be dried using published technique using heated-air circulation oven, with embodiment 4 using decompression low temperature drying and
The time that leaches of the resulting Tibetan Gastrodia broken wall medicine materical crude slice of vacuum freeze drying compares.
Tibetan Gastrodia dry product 2.5kg is cleaned, is impregnated 6 hours, and (pressure of steam blasting is 1.2MPa to steam blasting, hides day
Numb moisture content is 80%, and maintaining the time of pressure is 1.0min) it is thick slag, (thick slag is dry after 45 DEG C are dried under reduced pressure 3 hours for thick slag
Moisture content after dry is 12%), to be broken for ultrafine powder, parenchyma cell number before and after comparison broken wall using superfine communication technique
Amount, calculating sporoderm-broken rate is 99.2%；Certain density alcohol granulation is added, particle drying 3 in 75 DEG C of heated-air circulation ovens is small
When, 30 mesh of upper layer is used after dry, the concussion pelletizing machine of 100 mesh of lower layer is arranged 2 times, dispensed up to Tibetan Gastrodia broken wall medicine materical crude slice.
Tibetan Gastrodia broken wall medicine materical crude slice 5g made from this comparative example is taken, 60 DEG C of warm water is added and leaches, leaching the time is 3.0min.
The time that leaches of 4 Rhizoma Gastrodiae broken wall medicine materical crude slice of comparative example than embodiment 4 leaches that the time is long, illustrates that preparation method of the invention can make day
Numb broken wall medicine materical crude slice leaches rapidly in water.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of preparation method of Tibetan Gastrodia broken wall medicine materical crude slice, which comprises the following steps:
(1) Tibetan Gastrodia is broken for thick slag through steam explosion technology；
(2) the resulting thick slag of step (1) is dry；Then ultrafine powder is broken for using superfine communication technique, with parenchyma cell
Tibetan Gastrodia ultrafine powder sporoderm-broken rate is determined for index characteristic cell, obtains sporoderm-broken rate ultrafine powder up to standard；
(3) the resulting ultrafine powder solubilizer of step (2) is pelletized, drying, whole grain, packing are to get Tibetan Gastrodia broken wall medicine materical crude slice.
2. the preparation method of Tibetan Gastrodia broken wall medicine materical crude slice as described in claim 1, which is characterized in that in the step (1), hide day
Fiber crops are fresh Tibetan Gastrodia medicinal material or the Tibetan Gastrodia medicinal material through dryness in the sun.
3. the preparation method of Tibetan Gastrodia broken wall medicine materical crude slice as claimed in claim 2, which is characterized in that the hiding through dryness in the sun
Rhizoma Gastrodiae is soaked in water 6~12 hours before steam blasting.
4. the preparation method of Tibetan Gastrodia broken wall medicine materical crude slice as described in claim 1, which is characterized in that in the step (1), steam
The pressure of explosion is 1.2~1.8MPa, and Tibetan Gastrodia moisture content is 10~80%, and maintaining the time of pressure is 1.0~10min.
5. the preparation method of Tibetan Gastrodia broken wall medicine materical crude slice as described in claim 1, which is characterized in that in the step (2), thick slag
Moisture content after drying is 5~12%.
6. the preparation method of Tibetan Gastrodia broken wall medicine materical crude slice as described in claim 1, which is characterized in that in the step (2), with thin
Parietal cell is that index characteristic cell determines Tibetan Gastrodia ultrafine powder sporoderm-broken rate, is referred to parenchyma cell quantity before and after broken wall for finger
Mark calculates ultrafine powder sporoderm-broken rate >=99%.
7. the preparation method of Tibetan Gastrodia broken wall medicine materical crude slice as described in claim 1, which is characterized in that the step (2) and step
(3) in, drying means be dried under reduced pressure, at least one of vacuum freeze drying.
8. the preparation method of Tibetan Gastrodia broken wall medicine materical crude slice as claimed in claim 7, which is characterized in that the temperature being dried under reduced pressure
It is 5~45 DEG C, drying time is 3~5 hours.
9. the preparation method of Tibetan Gastrodia broken wall medicine materical crude slice as claimed in claim 7, which is characterized in that the vacuum freeze drying
Operation are as follows: set temperature be -35~-15 DEG C, be evacuated to system absolute pressure be 50~100Pa after, keep 1~5 hour into
Row freeze-drying, is then heated to 30~45 DEG C, lyophilization 1~10 hour.
10. the preparation method of Tibetan Gastrodia broken wall medicine materical crude slice as described in claim 1, which is characterized in that whole in the step (3)
Grain refers to be sieved 1~3 time with the concussion pelletizing machine of 30 mesh of upper layer, 100 mesh of lower layer, and the particle between 30~100 mesh is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811520465.4A CN109381616B (en) | 2018-12-12 | 2018-12-12 | Preparation method of Tibetan gastrodia tuber wall-broken decoction pieces |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811520465.4A CN109381616B (en) | 2018-12-12 | 2018-12-12 | Preparation method of Tibetan gastrodia tuber wall-broken decoction pieces |
Publications (2)
| Publication Number | Publication Date |
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| CN109381616A true CN109381616A (en) | 2019-02-26 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111449957A (en) * | 2020-05-29 | 2020-07-28 | 浙江尖峰健康科技有限公司 | Preparation method of traditional Chinese medicine decoction pieces |
| CN112294920A (en) * | 2020-11-14 | 2021-02-02 | 重庆市中药研究院 | Secondary air explosion processing method for gastrodia elata |
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| CN104056074A (en) * | 2013-03-20 | 2014-09-24 | 中山市中智药业集团有限公司 | Wall-broken tall gastrodia tuber preparation |
| CN104585399A (en) * | 2015-01-21 | 2015-05-06 | 河南科技大学 | Method for preparing American ginseng solid instant tea |
| CN106177515A (en) * | 2016-08-08 | 2016-12-07 | 湖南盟合投资管理有限公司 | The preparation method of Rhizoma Gastrodiae breaking cellular wall decoction pieces |
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| CN104056074A (en) * | 2013-03-20 | 2014-09-24 | 中山市中智药业集团有限公司 | Wall-broken tall gastrodia tuber preparation |
| CN104585399A (en) * | 2015-01-21 | 2015-05-06 | 河南科技大学 | Method for preparing American ginseng solid instant tea |
| CN106177515A (en) * | 2016-08-08 | 2016-12-07 | 湖南盟合投资管理有限公司 | The preparation method of Rhizoma Gastrodiae breaking cellular wall decoction pieces |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111449957A (en) * | 2020-05-29 | 2020-07-28 | 浙江尖峰健康科技有限公司 | Preparation method of traditional Chinese medicine decoction pieces |
| CN111449957B (en) * | 2020-05-29 | 2022-04-08 | 浙江尖峰健康科技有限公司 | Preparation method of traditional Chinese medicine decoction pieces |
| CN112294920A (en) * | 2020-11-14 | 2021-02-02 | 重庆市中药研究院 | Secondary air explosion processing method for gastrodia elata |
| CN112294920B (en) * | 2020-11-14 | 2022-04-01 | 重庆市中药研究院 | Secondary air explosion processing method for gastrodia elata |
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