CN109381616B - Preparation method of Tibetan gastrodia tuber wall-broken decoction pieces - Google Patents
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Abstract
The invention relates to a preparation method of Tibetan gastrodia tuber wall-broken decoction pieces, belonging to the technical field of medicines. The preparation method comprises the following steps: (1) crushing Tibetan gastrodia elata into coarse slag by a steam explosion technology; (2) drying the coarse slag; then crushing the mixture into superfine powder by adopting a superfine crushing technology, and determining the wall breaking rate of the Tibetan gastrodia ultra-fine powder by taking thin-walled cells as index characteristic cells to obtain the superfine powder with the wall breaking rate reaching the standard; (3) and (3) adding a solvent into the superfine powder, granulating, drying, grading and subpackaging to obtain the wall-broken Tibetan gastrodia elata decoction pieces. The wall-broken rate of the Tibetan gastrodia tuber wall-broken decoction pieces prepared by the method is high, the dissolution rate of gastrodia tuber polysaccharide is high, the granules are quickly dissolved in water, the dissolution rate of active ingredients is high, the microbial limit of the obtained product is easier to control, and the safety and the effectiveness of medication can be ensured.
Description
Technical Field
The invention relates to a preparation method of Tibetan gastrodia tuber wall-broken decoction pieces, belonging to the technical field of medicines.
Background
Tibetan Gastrodia elata, also known as Duyao, Heleya amabilis, Shencao, Ming Tian Ma and Bailong, is a perennial herb of Gastrodia of Orchidaceae. The rhizome is thick and has no green leaf, and the capsule is oval and is usually propagated as tuber or seed. The rhizome of the Chinese medicinal composition is used as a medicament for treating dizziness, numbness of limbs, infantile convulsion and other symptoms, is a rare medicinal material, and is used together with Qiongzhen lucid ganoderma for treating headache and insomnia. The stored gastrodia elata is mostly in a wild state, the number of artificially planted gastrodia elata is smaller than that of the Gastrodia elata, the gastrodia elata is very harsh during collection, and the gastrodia elata needs to be dug out by hands, so that the stored gastrodia elata is difficult to see in the market and is rare enough to see in the market.
The gastrodia elata polysaccharide is an important active ingredient of gastrodia elata, researches show that the gastrodia elata polysaccharide has various biological activities including an anti-tumor effect, a liver protection effect, cerebral ischemia regulation effect, antioxidation, blood pressure reduction and the like, and is mainly used for research and development of new traditional Chinese medicines and development of health care products; microscopic identification of the traditional Chinese medicine shows that the gastrodia elata contains a large amount of gelatinized polysaccharide, but most of gelatinized polysaccharide particles exist in parenchyma cells. Therefore, to obtain the gastrodia elata polysaccharide to the maximum, the parenchyma cells in the gastrodia elata need to be broken, and more gelatinized polysaccharide particles are exposed; the utilization rate of active ingredients is only about 10-30% when common decoction pieces are decocted, even if Tibetan medicines are taken as powder, the absorption rate of the active ingredients is not very high due to cell walls of the medicinal materials, precious medicinal material resources are seriously wasted, and the exertion of the medicinal effect is influenced.
Patent publication No. CN104056074A discloses a method for preparing wall-broken rhizoma Gastrodiae preparation, which comprises pulverizing rhizoma Gastrodiae into wall-broken powder, granulating by ethanol-water wet method, extruding at certain rotation speed, and drying. The method has high drying temperature, and is easy to destroy thermosensitive components such as rhizoma Gastrodiae polysaccharide.
Patent publication No. CN104189517A discloses an ultramicro wall-broken rhizoma Gastrodiae composition and its preparation method, which comprises the steps of selecting raw materials, cleaning raw materials, steaming, slicing, steaming for the second time, drying, ultramicro wall-breaking, and preparing into preparation. The method is complicated, and the raw materials are steamed at high temperature and high pressure for a long time, which easily destroys the components such as rhizoma Gastrodiae polysaccharide, reduces the content of effective components, and reduces the activity.
The patent with publication number CN106177515A discloses a method for preparing wall-broken decoction pieces of rhizoma Gastrodiae, which comprises selecting, cleaning, processing, drying, crushing, pulverizing with a pulverizer of mesh sieve, sterilizing intermittently, breaking wall, granulating, and drying. The method has the advantages of complex sterilization process, time consumption and high time cost, and the coarse powder is easily polluted by bacteria, mould and other microorganisms in the subsequent operation process after being sterilized, so that the microorganism content of the granulated product can not be ensured to reach the standard.
The patent with publication number CN107802746A discloses a rhizoma gastrodiae wall-breaking decoction piece and a preparation method thereof, the extract content of the rhizoma gastrodiae wall-breaking decoction piece obtained by the method is low, and active ingredients such as rhizoma gastrodiae polysaccharide and the like cannot be fully utilized.
According to the prior art, active ingredients such as gastrodia elata polysaccharide and the like in the prepared gastrodia elata wall-broken decoction pieces are easy to damage, the preparation process is easy to pollute by microorganisms, the process is time-consuming, the content of extracts such as gastrodia elata polysaccharide and the like is low, and the dissolving degree is low. In order to improve the utilization rate of effective components such as the polysaccharide of the Tibetan gastrodia elata and improve the curative effect of the Tibetan gastrodia elata, the applicant improves the preparation method of the Tibetan gastrodia elata wall-breaking decoction pieces, the extraction rate of the polysaccharide of the Tibetan gastrodia elata in the developed Tibetan gastrodia elata wall-breaking decoction pieces is higher, the wall-breaking rate setting standard is more scientific, the wall-breaking effect is more guaranteed, the content of microorganisms is easier to control, the product is more quickly dissolved in water, and more advantages are achieved.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides the preparation method of the wall-broken Tibetan gastrodia elata decoction pieces.
In order to achieve the purpose, the invention adopts the technical scheme that: a preparation method of Tibetan gastrodia tuber wall-broken decoction pieces comprises the following steps:
(1) crushing Tibetan gastrodia elata into coarse slag by a steam explosion technology;
(2) drying the coarse slag obtained in the step (1); then crushing the mixture into superfine powder by adopting a superfine crushing technology, and determining the wall breaking rate of the Tibetan gastrodia ultra-fine powder by taking thin-walled cells as index characteristic cells to obtain the superfine powder with the wall breaking rate reaching the standard;
(3) and (3) adding a solvent into the superfine powder obtained in the step (2) for granulation, drying, grading and subpackaging to obtain the wall-broken Tibetan gastrodia elata decoction pieces.
As a preferred embodiment of the preparation method of the Tibetan gastrodia elata wall-breaking decoction pieces, in the step (1), the Tibetan gastrodia elata is a fresh Tibetan gastrodia elata medicinal material or a Tibetan gastrodia elata medicinal material which is dried in the sun.
As a preferred embodiment of the preparation method of the Tibetan gastrodia elata wall-breaking decoction pieces, the aired and dried Tibetan gastrodia elata medicinal material is soaked in water for 6-12 hours before steam explosion.
As a preferred embodiment of the preparation method of the Tibetan gastrodia tuber wall-broken decoction pieces, in the step (1), the pressure of steam explosion is 1.2-1.8 MPa, the water content of the Tibetan gastrodia tuber is 10-80%, and the pressure maintaining time is 1.0-10 min.
As a preferred embodiment of the preparation method of the wall-broken Tibetan gastrodia elata decoction pieces, in the step (2), the moisture content of the dried coarse residue is 5-12%.
As a preferred embodiment of the preparation method of the wall-broken decoction pieces of Tibetan gastrodia elata, in the step (2), the wall-breaking rate of the Tibetan gastrodia elata ultra-micro powder is determined by taking the parenchyma cells as index characteristic cells, and the wall-breaking rate of the ultra-micro powder is calculated by taking the number of the parenchyma cells before and after wall breaking as an index and is more than or equal to 99%.
As a preferred embodiment of the preparation method of the wall-broken decoction pieces of Tibetan gastrodia elata, in the step (2) and the step (3), the drying method is at least one of reduced pressure drying and vacuum freeze drying.
As the preferable embodiment of the preparation method of the Tibetan gastrodia wall-broken decoction pieces, the temperature for reduced pressure drying is 5-45 ℃, and the drying time is 3-5 hours.
As a preferred embodiment of the preparation method of the wall-broken Tibetan gastrodia elata decoction pieces, the vacuum freeze drying operation comprises the following steps: setting the temperature to be-35 to-15 ℃, vacuumizing until the absolute pressure of the system is 50 to 100Pa, keeping for 1 to 5 hours for freeze drying, heating to 30 to 45 ℃, and carrying out sublimation drying for 1 to 10 hours.
In a preferred embodiment of the method for preparing the wall-broken decoction pieces of Tibetan gastrodia elata, in the step (3), the granulation is performed by sieving the components for 1 to 3 times by using a shaking granulator with an upper layer of 30 meshes and a lower layer of 100 meshes to prepare granules with 30 to 100 meshes.
Compared with the prior art, the invention has the beneficial effects that:
(1) the preparation method of the wall-broken Tibetan gastrodia tuber decoction pieces has the advantages of high wall-broken rate, easily controlled wall-broken rate index, high gastrodia tuber polysaccharide dissolution rate, good dissolubility of particles in water, high dissolution rate of medicinal components, easiness in controlling microbial limit of the obtained product, capability of ensuring safety and effectiveness of medication, capability of being used as medicine by being matched with other medicinal material powder in a powder form, capability of being directly taken by water, convenience in use, high bioavailability, great saving of valuable medicinal material resources, improvement of the utilization rate of rare traditional national medicines, and protection of ecological environment and sustainable utilization of wild Tibetan gastrodia tuber resources;
(2) the preparation method is simple, short in time consumption, easy to operate, low in cost and suitable for industrial application.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1
Taking 2kg of fresh Tibetan gastrodia elata, cleaning, performing steam explosion (the pressure of the steam explosion is 1.2MPa, the water content of the Tibetan gastrodia elata is 10%, and the time for maintaining the pressure is 1.0min) to obtain coarse residues, performing reduced pressure drying on the coarse residues at 45 ℃ for 3 hours (the water content of the dried coarse residues is 5%), crushing the coarse residues into superfine powder by adopting a superfine crushing technology, and conventionally detecting the microbial condition in the superfine powder of the Tibetan gastrodia elata; comparing the number of parenchyma cells before and after wall breaking, and calculating the wall breaking rate to be 99.6 percent respectively; adding ethanol with certain concentration, granulating, drying the granules at 40 deg.C under reduced pressure for 3 hr, grading for 2 times by using shaking and granulating machine with upper layer of 30 mesh and lower layer of 100 mesh, and packaging to obtain wall-broken decoction pieces of Tibetan rhizoma Gastrodiae.
The wall-broken decoction pieces of Tibetan gastrodia elata prepared in the embodiment have the bacteria, the mould, the yeast and the coliform group of 11, 14, 10 and 15cfu/g respectively, and are less than 102Specification of cfu/g; taking 5g of wall-broken Tibetan rhizoma gastrodiae decoction pieces, and adding warm water at 60 ℃ for dissolving for 1.8 s; the extraction yield of the polysaccharide of the wall-broken decoction pieces of the Tibetan gastrodia elata is 85.3 percent.
Example 2
Taking 2.5kg of fresh Tibetan gastrodia elata, cleaning, performing steam explosion (the pressure of the steam explosion is 1.8MPa, the water content of the Tibetan gastrodia elata is 80%, and the time for maintaining the pressure is 10min) to obtain coarse residues, performing reduced pressure drying on the coarse residues at 45 ℃ for 3 hours (the water content of the dried coarse residues is 12%), crushing the coarse residues into superfine powder by adopting a superfine crushing technology, and conventionally detecting the microbial condition in the superfine powder of the Tibetan gastrodia elata; comparing the number of parenchyma cells before and after wall breaking, and calculating the wall breaking rate to be 99.8%; adding ethanol with certain concentration, granulating, drying the granules at 45 deg.C under reduced pressure for 2.5 hr, grading with a shaking granulator with upper layer of 30 mesh and lower layer of 100 mesh for 1 time, and packaging to obtain wall-broken decoction pieces of Tibetan rhizoma Gastrodiae.
The wall-broken decoction pieces of Tibetan gastrodia elata prepared in the embodiment have the bacteria, mould, yeast and coliform groups of 16, 12, 15 and 19cfu/g respectively, and the coincidence is less than 102Specification of cfu/g; taking 5g of wall-broken Tibetan rhizoma gastrodiae decoction pieces, and adding warm water at 60 ℃ for dissolving for 2.0 s; the extraction yield of the polysaccharide of the wall-broken decoction pieces of the Tibetan gastrodia elata is 83.4 percent.
Example 3
Taking 2.5kg of fresh Tibetan gastrodia elata, cleaning, performing steam explosion (the pressure of the steam explosion is 1.5MPa, the water content of the Tibetan gastrodia elata is 50%, and the time for maintaining the pressure is 5min) to obtain coarse residues, performing reduced pressure drying on the coarse residues at 45 ℃ for 3 hours (the water content of the dried coarse residues is 8%), crushing the coarse residues into superfine powder by adopting an ultramicro crushing technology, and conventionally detecting the microbial condition in the superfine powder of the Tibetan gastrodia elata; comparing the number of parenchyma cells before and after wall breaking, and calculating the wall breaking rate to be 99.8%; adding ethanol with certain concentration, granulating, drying the granules at 30 deg.C under reduced pressure for 3.5 hr, grading for 3 times by using shaking granulator with upper layer of 30 mesh and lower layer of 100 mesh, and packaging to obtain wall-broken decoction pieces of Tibetan rhizoma Gastrodiae.
The wall-broken decoction pieces of Tibetan gastrodia elata prepared in the embodiment have the bacteria, mould, yeast and coliform groups of 13, 18, 10 and 10cfu/g respectively, and the concentration is less than 102Specification of cfu/g; taking 5g of wall-broken decoction pieces of Tibetan rhizoma Gastrodiae, adding 60 deg.C warm water, and dissolving for 2.5 s; the extraction yield of the polysaccharide of the wall-broken decoction pieces of the Tibetan gastrodia elata is 80.4 percent.
Example 4
Cleaning and soaking 2.5kg of dried Tibetan gastrodia elata for 6 hours, performing steam explosion (the pressure of the steam explosion is 1.2MPa, the water content of the Tibetan gastrodia elata is 80%, and the time for maintaining the pressure is 1.0min) to obtain coarse residues, performing reduced pressure drying on the coarse residues at 45 ℃ for 3 hours (the water content of the dried coarse residues is 12%), crushing the coarse residues into superfine powder by adopting an ultramicro crushing technology, and conventionally detecting the microbial condition in the superfine powder of the Tibetan gastrodia elata; comparing the number of parenchyma cells before and after wall breaking, and calculating the wall breaking rate to be 100%; adding ethanol with a certain concentration for granulation, drying the granules at 30 ℃ under reduced pressure for 0.5 hour, transferring to vacuum freeze drying, setting to-35 ℃, keeping for 2 hours for freeze drying, vacuumizing until the absolute pressure of the system is 100Pa, starting heating to 45 ℃, carrying out sublimation drying for 1 hour, carrying out drying, grading for 2 times by using a shaking granulator with an upper layer of 30 meshes and a lower layer of 100 meshes, and subpackaging to obtain the wall-broken decoction pieces of Tibetan gastrodia elata.
The wall-broken decoction pieces of Tibetan gastrodia elata prepared in the embodiment have the bacteria, the mould, the yeast and the coliform group of 12, 10, 19 and 15cfu/g respectively, and the concentration is less than 102Specification of cfu/g; taking 5g of wall-broken Tibetan rhizoma gastrodiae decoction pieces, and adding warm water at 60 ℃ for dissolving for 2.8 s; the water is used as a solvent to extract the gastrodia elata polysaccharide, and the extraction rate of the polysaccharide in the Tibetan gastrodia elata wall-breaking decoction pieces is 81.3%.
Comparative example 1
The crude powder is sterilized and then subjected to superfine grinding by adopting the disclosed prior process, and the microbial content of the wall-broken decoction pieces obtained by adopting the process of steam explosion grinding and then superfine grinding in the example 1 is compared.
Cleaning 2kg of fresh Tibetan gastrodia elata, carrying out vacuum freeze drying until the water content is about 5%, then crushing into coarse powder by using a universal crusher, carrying out intermittent sterilization on the coarse powder, and conventionally detecting the microbial condition in the Tibetan gastrodia elata superfine powder until the microbial limit requirement of directly taking decoction pieces is met; crushing the mixture into superfine powder by adopting an ultramicro crushing technology, comparing the number of parenchyma cells before and after wall breaking, and calculating the wall breaking rate to be 99.0%; adding ethanol with certain concentration for granulating, drying the granules at 40 deg.C under reduced pressure for 3 hr, sorting with 30 mesh upper layer and 100 mesh lower layer shaking granulator for 2 times, and packaging to obtain wall-broken decoction pieces of Tibetan rhizoma Gastrodiae.
The wall-broken decoction pieces of Tibetan gastrodia elata prepared in the comparative example have the bacteria, mould, yeast and coliform groups of 87, 88, 76 and 55cfu/g respectively, and are less than 102Specification of cfu/g. The microbial content of the Tibetan gastrodia tuber wall-broken decoction pieces prepared in the comparative example 1 is obviously higher than that of the Tibetan gastrodia tuber wall-broken decoction pieces prepared in the embodiment 1, which shows that the preparation method can better control the microbial content.
Comparative example 2
The prior art is adopted, a hot air circulation oven is used for drying, and the extraction rate of the gastrodia elata polysaccharide of the wall-broken decoction pieces of the Tibetan gastrodia elata obtained by adopting reduced-pressure low-temperature drying in example 2 is compared.
Cleaning 2.5kg of fresh Tibetan gastrodia elata, performing steam explosion (the pressure of the steam explosion is 1.8MPa, the water content of the Tibetan gastrodia elata is 80%, and the time for maintaining the pressure is 10min) to obtain coarse residues, performing reduced pressure drying on the coarse residues at 45 ℃ for 3 hours (the water content of the dried coarse residues is 12%), crushing the coarse residues into superfine powder by adopting an ultramicro crushing technology, and conventionally detecting the microbial condition in the superfine powder of the Tibetan gastrodia elata; comparing the number of parenchyma cells before and after wall breaking, and calculating the wall breaking rate to be 99.1%; adding ethanol with a certain concentration for granulating, drying the granules in a hot air circulation oven at 75 deg.C for 2.5 hr, sorting with a shaking granulator with upper layer of 30 meshes and lower layer of 100 meshes for 1 time, and packaging to obtain wall-broken decoction pieces of Tibetan rhizoma Gastrodiae.
The water is used as a solvent to extract the gastrodia elata polysaccharide, and the polysaccharide extraction yield of the Tibetan gastrodia elata wall-broken decoction pieces in the comparative example is 73.5%. Comparative example 2 the polysaccharide extraction yield of the rhizoma gastrodiae wall-broken decoction pieces is significantly lower than that of example 2, which shows that the preparation method of the invention can improve the extraction yield of the rhizoma gastrodiae polysaccharide.
Comparative example 3
The published patent process is adopted, and the processes of picking, cleaning, processing, drying, crushing by a pulverizer with a mesh screen, intermittent sterilization, wall breaking, granulation, drying and the like are carried out, and the process time is compared with that of the process time in the example 3.
Selecting and cleaning/processing rhizoma Gastrodiae, drying until water content is below 10%, and crushing with 10 mesh mechanical crusher into 10 mesh small granules; further coarsely pulverizing rhizoma Gastrodiae to about 100 mesh; intermittent sterilization: and (3) killing bacteria propagules: placing the coarse gastrodia elata powder in an oven, wherein the thickness of the coarse gastrodia elata powder is about 10mm, the set temperature is 65 ℃ (the actual temperature is 60-70 ℃), and drying and sterilizing are kept for 8 hours; and (3) growth of the dormant body: taking the treated coarse powder of the gastrodia elata from the oven, bagging, filling water vapor into the bag at the temperature of 25 ℃, sealing and maintaining for 12 hours; and (3) killing bacteria propagules: placing coarse powder of rhizoma Gastrodiae in oven, standing at 75 deg.C with thickness of 30mm, and drying and sterilizing for 4 hr; conventionally detecting the microbial condition in the coarse gastrodia tuber powder to obtain coarse gastrodia tuber powder meeting the microbial limit requirement of directly taking the decoction pieces; wall breaking: breaking wall of coarse powder of rhizoma Gastrodiae with particle size of 100-120 meshes at room temperature and relative humidity of 30%, pulverizing, controlling working pressure at 0.6MPa and rotational speed of classifier at 20r/s, breaking wall, and pulverizing to 300 meshes above to obtain superfine powder (90% powder particle size is less than 45 μm); preparing a soft material: placing the prepared superfine powder into a groove-shaped mixing machine, and adding a proper amount of 50-60% ethanol to prepare a soft material; and (3) granulating: placing the prepared superfine powder soft material into a swing type granulator, spraying a small amount of superfine powder into a screen mesh, granulating by using a 16-mesh screen mesh, adding the prepared superfine powder of the gastrodia elata while adding the prepared superfine powder soft material during granulation, wherein the ratio of the soft material to the superfine powder is 3: 1; drying qualified wall-broken decoction pieces granules in an oven at 70-80 deg.C, grading and sieving the dried granules with a shaking granulator with upper layer of 10 mesh and bottom layer of 24 mesh for 2 times, and subpackaging to obtain rhizoma Gastrodiae wall-broken decoction pieces.
In the embodiment 3, the sterilization is carried out while the steam explosion is carried out, so that the time for drying and sterilizing the medicinal materials is saved, and the efficiency for preparing the wall-broken decoction pieces is greatly improved.
Comparative example 4
Drying by using a hot air circulation oven by adopting the disclosed process, and comparing with the dissolving time of the wall-broken decoction pieces of the Tibetan gastrodia elata obtained in the example 4 by adopting reduced-pressure low-temperature drying and vacuum freeze drying.
Cleaning and soaking 2.5kg of dry Tibetan gastrodia elata for 6 hours, wherein steam explosion (the pressure of the steam explosion is 1.2MPa, the water content of the Tibetan gastrodia elata is 80 percent, and the time for maintaining the pressure is 1.0min) is used as coarse slag, the coarse slag is subjected to reduced pressure drying at 45 ℃ for 3 hours (the water content of the dried coarse slag is 12 percent), the coarse slag is crushed into superfine powder by adopting an ultramicro crushing technology, and the wall breaking rate is 99.2 percent according to the number of thin-wall cells before and after wall breaking; adding ethanol with a certain concentration for granulating, drying the granules in a hot air circulation oven at 75 deg.C for 3 hr, sorting with a shaking granulator with upper layer of 30 meshes and lower layer of 100 meshes for 2 times, and packaging to obtain wall-broken decoction pieces of Tibetan rhizoma Gastrodiae.
5g of Tibetan gastrodia elata wall-broken decoction pieces prepared in the comparative example are taken and added with warm water of 60 ℃ for dissolution, and the dissolution time is 3.0 min. Comparative example 4 the dissolution time of the rhizoma gastrodiae wall-broken decoction pieces is longer than that of example 4, which shows that the preparation method of the invention can rapidly dissolve the rhizoma gastrodiae wall-broken decoction pieces in water.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (6)
1. The preparation method of the Tibetan gastrodia tuber wall-broken decoction pieces is characterized by comprising the following steps of:
(1) crushing Tibetan gastrodia elata into coarse slag by a steam explosion technology;
(2) drying the coarse slag obtained in the step (1); then crushing the mixture into superfine powder by adopting a superfine crushing technology, and determining the wall breaking rate of the Tibetan gastrodia ultra-fine powder by taking thin-walled cells as index characteristic cells to obtain the superfine powder with the wall breaking rate reaching the standard;
(3) adding a solvent into the superfine powder obtained in the step (2) for granulation, drying, grading and subpackaging to obtain Tibetan gastrodia wall-broken decoction pieces;
in the step (1), the pressure of steam explosion is 1.2-1.8 MPa, the water content of the Tibetan gastrodia elata is 10-80%, and the pressure maintaining time is 1.0-10 min;
in the step (2) and the step (3), the drying method is at least one of reduced pressure drying and vacuum freeze drying;
the temperature of the reduced pressure drying is 5-45 ℃, and the drying time is 3-5 hours;
the operation of vacuum freeze drying is as follows: setting the temperature to be-35 to-15 ℃, vacuumizing until the absolute pressure of the system is 50 to 100Pa, keeping for 1 to 5 hours for freeze drying, heating to 30 to 45 ℃, and carrying out sublimation drying for 1 to 10 hours.
2. The method for preparing wall-broken decoction pieces of Tibetan gastrodia elata as claimed in claim 1, wherein in the step (1), the Tibetan gastrodia elata is a fresh Tibetan gastrodia elata medicinal material or a Tibetan gastrodia elata medicinal material which is dried in the sun.
3. The method for preparing wall-broken Tibetan gastrodia elata decoction pieces as claimed in claim 2, wherein the sun-dried Tibetan gastrodia elata medicinal material is soaked in water for 6-12 hours before steam explosion.
4. The preparation method of the Tibetan gastrodia tuber wall-broken decoction pieces as claimed in claim 1, wherein in the step (2), the moisture content of the dried coarse residue is 5-12%.
5. The method for preparing wall-broken decoction pieces of Tibetan gastrodia elata as claimed in claim 1, wherein in step (2), the wall-breaking rate of the superfine Tibetan gastrodia elata powder is determined by using parenchyma cells as index characteristic cells, which means that the wall-breaking rate of the superfine powder is not less than 99% by using the number of parenchyma cells before and after wall breaking as an index.
6. The method for preparing wall-broken Tibetan gastrodia elata decoction pieces as claimed in claim 1, wherein in the step (3), the step of granulating is to sieve the Tibetan gastrodia elata decoction pieces for 1-3 times by using a shaking granulator with an upper layer of 30 meshes and a lower layer of 100 meshes to prepare granules of 30-100 meshes.
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| CN104056074A (en) * | 2013-03-20 | 2014-09-24 | 中山市中智药业集团有限公司 | Wall-broken tall gastrodia tuber preparation |
| CN104585399A (en) * | 2015-01-21 | 2015-05-06 | 河南科技大学 | Method for preparing American ginseng solid instant tea |
| CN106177515A (en) * | 2016-08-08 | 2016-12-07 | 湖南盟合投资管理有限公司 | The preparation method of Rhizoma Gastrodiae breaking cellular wall decoction pieces |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104056074A (en) * | 2013-03-20 | 2014-09-24 | 中山市中智药业集团有限公司 | Wall-broken tall gastrodia tuber preparation |
| CN104585399A (en) * | 2015-01-21 | 2015-05-06 | 河南科技大学 | Method for preparing American ginseng solid instant tea |
| CN106177515A (en) * | 2016-08-08 | 2016-12-07 | 湖南盟合投资管理有限公司 | The preparation method of Rhizoma Gastrodiae breaking cellular wall decoction pieces |
Non-Patent Citations (1)
| Title |
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| 天麻粉末粒度分布和有效成分溶出曲线研究;赵唯君等;《亚太传统医药》;20170531;第13卷(第09期);19-23 * |
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