CN103920033A - Traditional Chinese medicinal composition for treating calculi - Google Patents
Traditional Chinese medicinal composition for treating calculi Download PDFInfo
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- CN103920033A CN103920033A CN201410141616.0A CN201410141616A CN103920033A CN 103920033 A CN103920033 A CN 103920033A CN 201410141616 A CN201410141616 A CN 201410141616A CN 103920033 A CN103920033 A CN 103920033A
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Abstract
The invention relates to a traditional Chinese medicinal composition for treating calculi. The traditional Chinese medicinal composition is prepared from lygodium japonicum, lysimachia christinae hance, plantain seeds, chingma abutilon seeds, radix cudramiae, pyrrosia lingua, rehmannia, talcum, endothelium corneum gigeriae galli, liquorice, root of bidentate achyranthes, astragalus membranaceus, honeysuckle, lalang grass rhizome and codonopsis pilosula. In addition, the invention further relates to an optimized preparation method of the traditional Chinese medicinal composition, and the like.
Description
Technical field
The invention belongs to traditional medicine field, particularly, the present invention relates to be used for the treatment of the Chinese medicine composition of calculus, it is prepared from by Spora Lygodii, Herba Lysimachiae, Semen Plantaginis, Semen Abutili, Radix Cudraniae, Folium Pyrrosiae, Radix Rehmanniae, Talcum, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae, Radix Achyranthis Bidentatae, the Radix Astragali, Flos Lonicerae, Rhizoma Imperatae and Radix Codonopsis.In addition, the invention still further relates to the preparation method etc. of the optimization of this Chinese medicine composition.
Background technology
Due to dietary habit, China is calculus prone areas.Except utilizing operating lamp means to process calculus, utilize China's Chinese medicine material to treat calculus, also have report more, reported the very large Chinese medicine of many formula differences.
For example, Chinese patent discloses a kind of Chinese medicine of promoting urination and dissolving and discharging calculus for No. 200910145011, and crude drug formula is wherein: Semen Juglandis, Radix Astragali, Radix Clematidis, Herba Lysimachiae, Semen Abutili, Endothelium Corneum Gigeriae Galli, Semen Plantaginis, Rhizoma Alismatis, Talcum, Retinervus Luffae Fructus, Olibanum, Myrrha, Spora Lygodii, Rhizoma Dioscoreae, Natrii Sulfas, ferrous sulfate, Borax, Folium Pyrrosiae, Herba Dianthi and succinum.This is the formula of Semen Juglandis as monarch drug or principal agent of take.
And for example, Chinese patent discloses a kind of Chinese medicine for the treatment of urinary calculus No. 201010224038, crude drug formula is wherein: Sal Nitri, Endothelium Corneum Gigeriae Galli, Alumen, Fructus Gardeniae, Spora Lygodii, Herba Lysimachiae, Semen Abutili, Folium Pyrrosiae, Herba Artemisiae Scopariae, succinum, Endoconcha Sepiae, Squama Manis, Semen Vaccariae, Herba Hedyotidis Diffusae, Olibanum, Myrrha, the Radix Paeoniae Alba, Rhizoma Imperatae, Radix Clematidis, Rhizoma Corydalis, Radix Curcumae, Talcum, Herba Dianthi, Radix Cyathulae, Rhizoma Polygoni Cuspidati, the Radix Astragali, Herba Taraxaci, Gryllotalpa, Semen Plantaginis, Herba Polygoni Avicularis, Asteriscus Pseudosciaenae, Rhizoma Sparganii, Rhizoma Curcumae, Spina Gleditsiae, Pericarpium Citri Reticulatae, Herba Ephedrae, Rhizoma Alismatis, Exocarpium Benincasae, Radix Notoginseng, Polyporus, Lignum Aquilariae Resinatum, Caulis Akebiae, Radix Et Rhizoma Rhei and Radix Rubiae.In this formula, used state guarantee animal, it is large that industry is promoted difficulty.
The inventor is according to handed down from the older generations of the family and long-term research, rely on long-term practice but not the guidance of Chinese medical theory, summed up new Chinese medicine formula, its difference of thinking with existing prescription is large (as there is no obvious monarch drug or principal agent, and do not use the crude drug that is difficult to industrialization), crude drug kind and proportioning difference are larger, but still can treat efficiently calculus, especially instant effect.In addition, except conventional preparation method, the inventor also finds to be usually used in to treat the existing property of medicine that is conducive to treat calculus of Spora Lygodii in the Chinese medicine of calculus, also there is the property of medicine that is unfavorable for treating calculus, so through long-felt, also work out new preparation method, brought into play to a greater extent its favourable property of medicine, thereby obtained better drug effect.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of new Chinese medicine composition, and it is used for the treatment of calculus.In addition, the present invention also provides the Preparation Method of optimization of this Chinese medicine composition and application etc.
Particularly, in first aspect, the invention provides the Chinese medicine composition for the treatment of calculus, it is characterized in that, it is prepared from by Spora Lygodii, Herba Lysimachiae, Semen Plantaginis, Semen Abutili, Radix Cudraniae, Folium Pyrrosiae, Radix Rehmanniae, Talcum, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae, Radix Achyranthis Bidentatae, the Radix Astragali, Flos Lonicerae, Rhizoma Imperatae and Radix Codonopsis.
In this article, as the indication without contrary, above crude drug (medical material) all comes from existing known plant, can on China's medical material market, buy.For example, Spora Lygodii (Lygodium japonicum) has another name called left-hand rotation rattan ash, Spora Lygodii; Radix Cudraniae (Cudrania cochinchinensis) have another name called the broken stone of three-bristle cudrania root, river, cotton root; Folium Pyrrosiae (Folium Pyrrosiae) has another name called stone skin, Folium Pyrrosiae; Radix Rehmanniae (Rehmannia glutinosa) has another name called the fresh Radix Rehmanniae, Radix Rehmanniae, Radix Rehmanniae, Radix Rehmanniae; Endothelium Corneum Gigeriae Galli (Gallus gallus domesticus Brisson) has another name called Clausena lansium (Lour.) Skeels, chicken doze skin, chicken yellow skin, chicken sub-prime, Endothelium corneum in chicken Leg shin, chicken doze; Radix Achyranthis Bidentatae (Achyranthes bidentata) has another name called cattle paint, Radix Achyranthis Bidentatae, Radix Achyranthis Bidentatae; The Radix Astragali (Radix Astragali) has another name called Radix Astragali, Radix Astragali, Radix Astragali, Radix Astragali, Radix Astragali; Flos Lonicerae (Flos Lonicerae) has another name called Flos Lonicerae, Flos Lonicerae, little egret flower, JINHUA; Rhizoma Imperatae (Rhizoma Imperatae) has another name called Rhizoma Imperatae, Cymbidium ensifolium (L.) Sw. root, eats root, villous themeda, Radix seu herba Heteropogonis Contorti, Du holds concurrently.
Preferably, in the Chinese medicine composition of first aspect present invention, the parts by weight of each taste crude drug are as follows:
25～35 parts of Spora Lygodii; 25～35 parts of Herba Lysimachiaes; 17～23 parts of Semen Plantaginiss; 17～23 parts of Semen Abutilis; 15～21 parts of Radix Cudraniaes; 15～21 parts of Folium Pyrrosiaes; 15～21 parts of Radix Rehmanniae; 21～29 parts, Talcum; 13～17 parts of Endothelium Corneum Gigeriae Galli; 5～7 parts, Radix Glycyrrhizae; 17～23 parts of Radix Achyranthis Bidentataes; 17～23 parts of the Radixs Astragali; 10～14 parts of Flos Loniceraes; 15～21 parts of Rhizoma Imperataes; 17～23 parts of Radix Codonopsis.
More preferably in the Chinese medicine composition of first aspect present invention, the parts by weight of each taste crude drug are as follows:
30 parts of Spora Lygodii; 30 parts of Herba Lysimachiaes; 20 parts of Semen Plantaginiss; 20 parts of Semen Abutilis; 18 parts of Radix Cudraniaes; 18 parts of Folium Pyrrosiaes; 18 parts of Radix Rehmanniae; 25 parts, Talcum; 15 parts of Endothelium Corneum Gigeriae Galli; 6 parts, Radix Glycyrrhizae; 20 parts of Radix Achyranthis Bidentataes; 20 parts of the Radixs Astragali; 12 parts of Flos Loniceraes; 18 parts of Rhizoma Imperataes; 20 parts of Radix Codonopsis.
The Chinese medicine composition of first aspect present invention can be mixed with suitable dosage form with providing with pharmaceutically acceptable carrier, as, oral liquid, granule, electuary, pharmaceutically acceptable carrier, as water, the parts by weight of preferred water are 800～1200 parts, more preferably 1000 parts.Preferably the Chinese medicine composition of first aspect present invention is oral liquid.
Oral liquid can, by formation soluble in water after above-mentioned crude drug preparation, still more preferably directly form oral liquid in preparation process.For example, the Chinese medicine composition of first aspect present invention is prepared by each taste crude drug decocted with water.
The time decocting can be identical, and above-mentioned like this crude drug can be put together and be decocted simultaneously.Yet the inventor studies discovery, the existing property of medicine that is conducive to treat calculus of Spora Lygodii, also has the property of medicine that is unfavorable for treating calculus, and long-time decoction is unfavorable to final drug effect on the contrary.So, preferably in the Chinese medicine composition of first aspect present invention, Spora Lygodii decocts 3～10 minutes (more preferably 5 minutes), and all the other crude drugs (Herba Lysimachiae, Semen Plantaginis, Semen Abutili, Radix Cudraniae, Folium Pyrrosiae, Radix Rehmanniae, Talcum, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae, Radix Achyranthis Bidentatae, the Radix Astragali, Flos Lonicerae, Rhizoma Imperatae and Radix Codonopsis) are decocted to 45～90 minutes (more preferably 60 minutes).First decoct all the other crude drugs, by the time also remain after the time of the required decoction of Spora Lygodii, then drop into Spora Lygodii decoction, substantially do not increase the difficulty of preparation.
In second aspect, the invention provides the preparation method of the Chinese medicine composition of first aspect present invention.
Preferably the preparation method of second aspect present invention comprises Spora Lygodii, Herba Lysimachiae, Semen Plantaginis, Semen Abutili, Radix Cudraniae, Folium Pyrrosiae, Radix Rehmanniae, Talcum, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae, Radix Achyranthis Bidentatae, the Radix Astragali, Flos Lonicerae, Rhizoma Imperatae and Radix Codonopsis is decocted with water.Decoction can adopt conventional decoction method, as kept fluidized state with little fire.In order to prevent that decocting for a long time moisture content loses, and can decoct in hermetic container.
More preferably in the preparation method of second aspect present invention, Spora Lygodii is decocted with water to 3～10 minutes (more preferably 5 minutes), and Herba Lysimachiae, Semen Plantaginis, Semen Abutili, Radix Cudraniae, Folium Pyrrosiae, Radix Rehmanniae, Talcum, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae, Radix Achyranthis Bidentatae, the Radix Astragali, Flos Lonicerae, Rhizoma Imperatae and Radix Codonopsis are decocted to 45～90 minutes (more preferably 60 minutes).
Also in the preparation method of preferred second aspect present invention, the parts by weight of water are 800～1200 parts, more preferably 1000 parts.
In the third aspect, the application of the Chinese medicine composition that the invention provides first aspect present invention in the medicine for the preparation of prevention or treatment calculus, preferably calculus is lithangiuria.
Beneficial effect of the present invention is: the new pharmaceutical composition that can select for patient is provided; This pharmaceutical composition can be treated calculus, instant effect efficiently; Optimize preparation method, be conducive to bring into play to a greater extent the property of medicine of the favourable aspect of medical material, thereby obtained better drug effect.
For the ease of understanding, below will to the present invention, be described in detail by specific embodiment.It needs to be noted, instantiation is only in order to illustrate, does not form limitation of the scope of the invention.Obviously those of ordinary skill in the art can make various corrections and change to the present invention within the scope of the invention according to explanation herein, and these corrections and change are also included in scope of the present invention.
The specific embodiment
Below will invention be described by specific embodiment herein.As do not specialize part, can implement according to the familiar national drug standards of those skilled in the art and relevant laws and regulations, regulation.In addition, the raw material using in embodiment and reagent unless otherwise stated, all can be bought by medical material market.
The preparation method 1 of embodiment 1 Chinese medicine
Get 20 grams of 30 grams of Spora Lygodii, 30 grams of Herba Lysimachiaes, 20 grams of Semen Plantaginiss, 20 grams of Semen Abutilis, 18 grams of Radix Cudraniaes, 18 grams of Folium Pyrrosiaes, 18 grams of Radix Rehmanniae, 25 grams, Talcum, 15 grams of Endothelium Corneum Gigeriae Galli, 6 grams, Radix Glycyrrhizae, 20 grams of Radix Achyranthis Bidentataes, 20 grams of the Radixs Astragali, 12 grams of Flos Loniceraes, 18 grams of Rhizoma Imperataes and Radix Codonopsis, after mixing, be ground into the medicated powder that particle diameter is no more than 2mm, add water 1L boils 1 hour in airtight decoction pot, after naturally cooling to room temperature (25 ℃), filter, retain filtrate, the i.e. Chinese medicine oral liquid of a course for the treatment of, be divided into three parts, respectively sterile filling.
The preparation method 2 of embodiment 2 Chinese medicines
Get 30 grams of Spora Lygodii, bind up with gauze, standby; Get 20 grams of 30 grams of Herba Lysimachiaes, 20 grams of Semen Plantaginiss, 20 grams of Semen Abutilis, 18 grams of Radix Cudraniaes, 18 grams of Folium Pyrrosiaes, 18 grams of Radix Rehmanniae, 25 grams, Talcum, 15 grams of Endothelium Corneum Gigeriae Galli, 6 grams, Radix Glycyrrhizae, 20 grams of Radix Achyranthis Bidentataes, 20 grams of the Radixs Astragali, 12 grams of Flos Loniceraes, 18 grams of Rhizoma Imperataes and Radix Codonopsis, after mixing, be ground into the medicated powder that particle diameter is no more than 2mm, add water 1L boils 55 minutes in airtight decoction pot, then drop in decoction pot, continue to boil 5 minutes, after naturally cooling to room temperature (25 ℃), filter, retain filtrate, the i.e. Chinese medicine oral liquid of a course for the treatment of, be divided into three parts, respectively sterile filling.
The efficacy test of embodiment 3 Chinese medicines of the present invention
The in the situation that of informed consent, clinical diagnosis is suffered to 179 routine adult patients of lithangiuria, and (diameter of maximum calculus is 3mm～19mm, wherein 102 examples are for patients with recurrent) random packet treats, the oral Chinese medicine oral liquid of preparing according to the method for embodiment 1 (122 example) and embodiment 2 (57 example) respectively, every day is portion for (medicine) being taken before meal, within continuous three days, is a course for the treatment of (patient that the diameter of calculus is greater than 10mm carries out a course for the treatment of every a Zhou Houzai).After having treated, in one week, by visiting with phone, understand patient's further consultation result, the recovery from illness of counting to the disappearance of calculus image; To calculus image do not disappear but dwindle or reduce more than 60% count effective; All the other meters are not invalid.Result is as shown in table 1, pharmaceutical formulation of the present invention can be once can produce curative effect within two courses for the treatment of, especially the preparation method of optimizing by embodiment 2, wherein total effective rate nearly improves 20%, illustrates that the difference of preparation method also has a great impact the performance of the medicine property of medicine.
The therapeutic effect of table 1 Chinese medicine of the present invention
| Group | Recovery from illness case load | Recovery from illness ratio | Effective case load | Effective ratio | Total effective rate |
| Embodiment 1 | 27 | 22.1％ | 63 | 51.6％ | 73.8％ |
| Embodiment 2 | 18 | 31.6％ | 34 | 59.6％ | 91.2％ |
Claims (10)
1. the Chinese medicine composition for the treatment of calculus, is characterized in that, it is prepared from by Spora Lygodii, Herba Lysimachiae, Semen Plantaginis, Semen Abutili, Radix Cudraniae, Folium Pyrrosiae, Radix Rehmanniae, Talcum, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae, Radix Achyranthis Bidentatae, the Radix Astragali, Flos Lonicerae, Rhizoma Imperatae and Radix Codonopsis.
2. Chinese medicine composition claimed in claim 1, is characterized in that, wherein the parts by weight of each taste crude drug are as follows:
25～35 parts of Spora Lygodii; 25～35 parts of Herba Lysimachiaes; 17～23 parts of Semen Plantaginiss; 17～23 parts of Semen Abutilis; 15～21 parts of Radix Cudraniaes; 15～21 parts of Folium Pyrrosiaes; 15～21 parts of Radix Rehmanniae; 21～29 parts, Talcum; 13～17 parts of Endothelium Corneum Gigeriae Galli; 5～7 parts, Radix Glycyrrhizae; 17～23 parts of Radix Achyranthis Bidentataes; 17～23 parts of the Radixs Astragali; 10～14 parts of Flos Loniceraes; 15～21 parts of Rhizoma Imperataes; 17～23 parts of Radix Codonopsis.
3. Chinese medicine composition claimed in claim 2, is characterized in that, wherein the parts by weight of each taste crude drug are as follows:
30 parts of Spora Lygodii; 30 parts of Herba Lysimachiaes; 20 parts of Semen Plantaginiss; 20 parts of Semen Abutilis; 18 parts of Radix Cudraniaes; 18 parts of Folium Pyrrosiaes; 18 parts of Radix Rehmanniae; 25 parts, Talcum; 15 parts of Endothelium Corneum Gigeriae Galli; 6 parts, Radix Glycyrrhizae; 20 parts of Radix Achyranthis Bidentataes; 20 parts of the Radixs Astragali; 12 parts of Flos Loniceraes; 18 parts of Rhizoma Imperataes; 20 parts of Radix Codonopsis.
4. arbitrary described Chinese medicine composition of claim 1～3, is characterized in that, it is oral liquid.
5. the arbitrary described Chinese medicine composition of claim 1～3, is characterized in that, it is prepared by each taste crude drug is decocted with water.
6. Chinese medicine composition claimed in claim 5, is characterized in that, wherein Spora Lygodii is decocted 3～10 minutes, and all the other crude drugs are decocted 45～90 minutes.
7. the preparation method of the arbitrary described Chinese medicine composition of claim 1～6, it is characterized in that, it comprises, Spora Lygodii, Herba Lysimachiae, Semen Plantaginis, Semen Abutili, Radix Cudraniae, Folium Pyrrosiae, Radix Rehmanniae, Talcum, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae, Radix Achyranthis Bidentatae, the Radix Astragali, Flos Lonicerae, Rhizoma Imperatae and Radix Codonopsis are decocted with water.
8. preparation method claimed in claim 7, it is characterized in that, wherein Spora Lygodii is decocted with water to 3～10 minutes, and Herba Lysimachiae, Semen Plantaginis, Semen Abutili, Radix Cudraniae, Folium Pyrrosiae, Radix Rehmanniae, Talcum, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae, Radix Achyranthis Bidentatae, the Radix Astragali, Flos Lonicerae, Rhizoma Imperatae and Radix Codonopsis are decocted 45～90 minutes.
9. preparation method claimed in claim 7, is characterized in that, wherein the parts by weight of water are 800～1200 parts, is preferably 1000 parts.
10. the application of arbitrary described Chinese medicine composition of claim 1～6 in the medicine for the preparation of prevention or treatment calculus.
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| CN201410141616.0A CN103920033B (en) | 2014-04-10 | 2014-04-10 | For treating the Chinese medicine composition of calculus |
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| CN201410141616.0A CN103920033B (en) | 2014-04-10 | 2014-04-10 | For treating the Chinese medicine composition of calculus |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435341A (en) * | 2014-09-23 | 2015-03-25 | 陈伟 | Traditional Chinese medicine formula for treating calculus |
| CN104940441A (en) * | 2015-07-15 | 2015-09-30 | 龚灿锋 | Traditional Chinese medicine for treating lithangiuria |
| CN105708935A (en) * | 2015-01-07 | 2016-06-29 | 泸州岷宏科技有限公司 | Urinary calculus decomposing pills and preparation method thereof |
| CN105901734A (en) * | 2016-05-13 | 2016-08-31 | 何家英 | Solid drink capable of promoting diuresis and treating stranguria and preparation method thereof |
| CN106236902A (en) * | 2016-08-23 | 2016-12-21 | 吴斌 | A kind of medicine for treating urinary system calculus |
| CN110583875A (en) * | 2019-10-21 | 2019-12-20 | 郑州百瑞动物药业有限公司 | Traditional Chinese medicine feed additive for preventing and treating sheep urolithiasis and preparation method and application thereof |
| CN110772565A (en) * | 2018-07-13 | 2020-02-11 | 广西医科大学附属肿瘤医院 | Traditional Chinese medicine composition for treating urinary calculus and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1357342A (en) * | 2000-12-07 | 2002-07-10 | 王跃辉 | Nephrolithiasis treating medicine |
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2014
- 2014-04-10 CN CN201410141616.0A patent/CN103920033B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1357342A (en) * | 2000-12-07 | 2002-07-10 | 王跃辉 | Nephrolithiasis treating medicine |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435341A (en) * | 2014-09-23 | 2015-03-25 | 陈伟 | Traditional Chinese medicine formula for treating calculus |
| CN105708935A (en) * | 2015-01-07 | 2016-06-29 | 泸州岷宏科技有限公司 | Urinary calculus decomposing pills and preparation method thereof |
| CN104940441A (en) * | 2015-07-15 | 2015-09-30 | 龚灿锋 | Traditional Chinese medicine for treating lithangiuria |
| CN105901734A (en) * | 2016-05-13 | 2016-08-31 | 何家英 | Solid drink capable of promoting diuresis and treating stranguria and preparation method thereof |
| CN106236902A (en) * | 2016-08-23 | 2016-12-21 | 吴斌 | A kind of medicine for treating urinary system calculus |
| CN110772565A (en) * | 2018-07-13 | 2020-02-11 | 广西医科大学附属肿瘤医院 | Traditional Chinese medicine composition for treating urinary calculus and preparation method thereof |
| CN110583875A (en) * | 2019-10-21 | 2019-12-20 | 郑州百瑞动物药业有限公司 | Traditional Chinese medicine feed additive for preventing and treating sheep urolithiasis and preparation method and application thereof |
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|---|---|
| CN103920033B (en) | 2016-09-07 |
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