CN103893498A - Extract for reducing blood sugar, raw material composition, preparation method and applications of extract - Google Patents
Extract for reducing blood sugar, raw material composition, preparation method and applications of extract Download PDFInfo
- Publication number
- CN103893498A CN103893498A CN201210577015.5A CN201210577015A CN103893498A CN 103893498 A CN103893498 A CN 103893498A CN 201210577015 A CN201210577015 A CN 201210577015A CN 103893498 A CN103893498 A CN 103893498A
- Authority
- CN
- China
- Prior art keywords
- extract
- blood sugar
- preparation
- sugar lowering
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses an extract for reducing blood sugar, a raw material composition, a preparation method and applications of the extract. The raw material composition is composed of the following components in percentage by weight: 3 to 80% of ginseng, 3 to 80% of red sage root, 3 to 80% of mulberry bark, 3 to 80% of prepared fleece flower root, 3 to 80% of anemarrhena, and 3 to 80% of wolfberry. The preparation method of the extract comprises the following steps: soaking the raw material composition in a solvent for a while, extracting, decocting, condensing so as to obtain extract, and finally drying the extract so as to obtain the extract for reducing blood sugar. The extract for reducing blood sugar does not have any side or toxic effect, and has better blood sugar reducing effect than that of conventional food and drugs for reducing blood sugar.
Description
Technical field
The present invention relates to the field of Chinese medicines, relate in particular to a kind of blood sugar lowering extract and feedstock composition and preparation method thereof, purposes.
Background technology
Type ii diabetes (diabetes) is take thirsty polydipsia, the easy famine of rapid digestion of food as Clinical symptoms, at present the medicine for the treatment of diabetes is three major types: 1. Western medicine: take insulin and second filial generation sulfonylureas as representative, advantage is that control symptom is rapid, effect is remarkable, but side effect is obvious, not only can damage hepatic and renal function, but also can cause leukocyte, granulocyte and hematoblastic minimizing, and can cause patient's medicine secondary failure; 2. combination of Chinese and Western medicine medicine, " in a diabetes pill " producing as Guangzhou No.1 Chinese Pharmacy Factory, main component is the Radix Astragali, Radix Rehmanniae, Radix Trichosanthis and Western medicine glyburide, this medical instrument has nourishing YIN for benefiting the kidney, the feature that supplementing QI for promoting the production of body fluid and curative effect are fast, but in every ball, still contain the Western medicine glyburide of 0.25mg, therefore also have certain toxic and side effects; 3. pure Chinese medicine, as Zuogui Yin, LIUWEI DIHUANG WAN, ginseng glycopeptide injection (tonifying QI to produce body fluid quenches the thirst), three capsule for eliminating (YIN nourishing and the production of body fluid promoting more, benefiting QI for activating blood circulation), Kelening capsule (QI invigorating, yin nourishing, promotes the production of body fluid), QIZHI JIANGTANG JIAONANG (supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling), JINQI JIANGTANG PIAN (heat clearing away QI invigorating), SHENQI JIANGTANG sheet (supplementing QI and nourishing YIN, grow spleen the kidney invigorating) etc., said medicine is addressed the lung that pathological changes internal organs are blamed, stomach, kidney; The pathogenesis of touching upon is called it " deficiency of YIN is scorching ", and the treatment of touching upon specially overweights replenishing YIN and removing heat.The present invention, according to Traditional Chinese medical theory, in conjunction with clinical practice, proves that medicine has obvious curative effects to reducing blood glucose.
Summary of the invention
Technical problem solved by the invention is, in order to overcome the defect that existing blood sugar lowering extract toxicity is large, hypoglycemic effect is bad, to provide a kind of blood sugar lowering extract and feedstock composition and preparation method thereof, purposes.Blood sugar lowering extract of the present invention has no side effect, and has better effect than existing hypoglycemic food, medicine.
The present invention solves the problems of the technologies described above by the following technical programs:
The invention provides a kind of blood sugar lowering extract feedstock composition, it comprises the following component with percentage by weight: Radix Ginseng 3-80%, Radix Salviae Miltiorrhizae 3-80%, Cortex Mori 3-80%, Radix Polygoni Multiflori Preparata 3-80%, Rhizoma Anemarrhenae 3-80%, Fructus Lycii 3-80%.
Wherein, described blood sugar lowering extract feedstock composition preferably comprises the following component with percentage by weight: Radix Ginseng 5-50%, Radix Salviae Miltiorrhizae 5-50%, Cortex Mori 3-50%, Radix Polygoni Multiflori Preparata 3-50%, Rhizoma Anemarrhenae 3-50%, Fructus Lycii 3-50%.
Wherein, described blood sugar lowering extract feedstock composition more preferably comprises the following component with percentage by weight: Radix Ginseng 50%, Radix Salviae Miltiorrhizae 20%, Cortex Mori 10%, Radix Polygoni Multiflori Preparata 10%, the Rhizoma Anemarrhenae 5%, Fructus Lycii 5%.
Each component of blood sugar lowering extract feedstock composition of the present invention can independently exist, and does not mutually react.
The present invention also provides a kind of preparation method of blood sugar lowering extract, and it comprises the steps: the component of above-mentioned raw materials compositions to soak in solvent, extracts, and decocts, and is concentrated into extractum, dry.
Wherein, the consumption of described solvent be preferably described feedstock composition gross weight 6-10 doubly.
Wherein, described preferred solvents ground is one or more in water, ethanol, petroleum ether and ethyl acetate.
Wherein, the time of described immersion is preferably 1 ~ 2 hour.
Wherein, described extraction can be the extracting method of this area routine, is preferably one or more in percolation extraction, reflux, extract, and supercritical extraction.The number of times of described extraction is preferably 2 ~ 3 times.
Wherein, the time of described decoction is preferably 0.5 ~ 2.5 hour.
Wherein, the temperature of described decoction is preferably 50 ~ 90 ℃.
Wherein, the relative density of described extractum is preferably 1.0 ~ 1.4.
Wherein, the described dry conventional drying means using in this area that can be, preferably one or more for spraying is dry, in vacuum drying, fluid bed drying and lyophilization.
In the present invention, the preparation method of described blood sugar lowering extract can also further comprise following post-processing step: pulverize, sieve.
Wherein, described sieving was preferably 80 ~ 100 mesh sieves.
The present invention also provides the blood sugar lowering being made by above-mentioned preparation method extract.
In the present invention, the above-mentioned blood sugar lowering extract making can be used as active component to prepare the medicine of different dosage form.While preparing different dosage form, needed various conventional adjuvants comprise disintegrating agent, lubricant, binding agent, correctives etc., or are prepared into capsule, tablet and granule with conventional method of Chinese medicinal.
The present invention also provides the application of above-mentioned blood sugar lowering extract in the medicine for the preparation for the treatment of type ii diabetes.
Meeting on the basis of this area general knowledge, above-mentioned each optimum condition, can combination in any, obtains the preferred embodiments of the invention.
Agents useful for same of the present invention and raw material be commercially available obtaining all.
Positive progressive effect of the present invention is: blood sugar lowering extract of the present invention has no side effect, and has better effect than existing hypoglycemic food, medicine.
The specific embodiment
Mode below by embodiment further illustrates the present invention, but does not therefore limit the present invention among described scope of embodiments.The experimental technique of unreceipted actual conditions in the following example, according to conventional method and condition, or selects according to catalogue.
Embodiment 1
The preparation of blood sugar lowering extract
Get the Radix Ginseng of 50% weight, the Radix Salviae Miltiorrhizae of 20% weight, the Cortex Mori of 10% weight, the Radix Polygoni Multiflori Preparata of 10% weight, the Rhizoma Anemarrhenae of 5% weight, the Fructus Lycii of 5% weight, add the water of 10 times of above-mentioned raw materials gross weights, the time of soaking is 1 hour, extract 2 times, the sufficient time of each decoction is 2 hours, is concentrated into density 1.2g/cm
3the extractum of (60 ℃), vacuum drying obtains dry extract, pulverizes 80 mesh sieves, makes blood sugar lowering extract.
Embodiment 2
Biological assessment
In following biological experiment, the treatment of the hyperglycemia mice of the blood sugar lowering extract making in embodiment 1 on alloxan modeling and the impact on the resistance to sugar amount of intact animal are mainly investigated.
(1) blood sugar reducing function to the sugared mice of height
Male Kunming strain mice is selected in experiment, and after fasting 5-8h, tail vein injection alloxan 80mg/kg, selects blood glucose value 11.0mmol/L above for qualified hyperglycemia model after 72h, and by high, normal, basic 3 dosage groups and the positive and the negative control group of establishing, every group of 12-16 only.Every day, gastric infusion, took 7 days continuously, and Monitoring Blood Glucose, the results are shown in Table 1.
The blood sugar reducing function of the hyperglycemia mice of table 1 blood sugar lowering extract to alloxan modeling
Result shows: the high dose group of positive control drug and blood sugar lowering extract can demonstrate good blood sugar reducing function, shows that blood sugar lowering extract of the present invention has good blood sugar reducing function.
(2) impact on the resistance to sugar amount of intact animal
Experiment select SD rat, 6 every group, in advance every day gavage blood sugar lowering extract, after 12 days, animal fasting was measured fasting blood sugar after 8 hours, took and was subject to after reagent 1 hour, lumbar injection 1.11mmol/L Glucose Liquid, dosage is 2g/kg, injection rear 0,30,60, after 120 minutes, tail vein goes to learn and surveys blood glucose value, the results are shown in Table 2.
The impact of table 2 blood sugar lowering extract on the resistance to sugar amount of normal rat
Result shows: in blood sugar lowering extract, and the secretion of high dose group energy effective stimulus insulin in the time of glucose load, curative effect and glyburide are close, illustrate that this blood sugar lowering extract has higher exploitation at treatment type ii diabetes and is worth.
Claims (10)
1. a blood sugar lowering extract feedstock composition, is characterized in that, it comprises the following component with percentage by weight: Radix Ginseng 3-80%, Radix Salviae Miltiorrhizae 3-80%, Cortex Mori 3-80%, Radix Polygoni Multiflori Preparata 3-80%, Rhizoma Anemarrhenae 3-80%, Fructus Lycii 3-80%.
2. blood sugar lowering extract feedstock composition as claimed in claim 1, is characterized in that, it comprises the following component with percentage by weight: Radix Ginseng 5-50%, Radix Salviae Miltiorrhizae 5-50%, Cortex Mori 3-50%, Radix Polygoni Multiflori Preparata 3-50%, Rhizoma Anemarrhenae 3-50%, Fructus Lycii 3-50%.
3. blood sugar lowering extract feedstock composition as claimed in claim 2, is characterized in that, it comprises the following component with percentage by weight: Radix Ginseng 50%, Radix Salviae Miltiorrhizae 20%, Cortex Mori 10%, Radix Polygoni Multiflori Preparata 10%, the Rhizoma Anemarrhenae 5%, Fructus Lycii 5%.
4. a preparation method for blood sugar lowering extract, is characterized in that, it comprises the steps: the component of the feedstock composition as described in any one in claim 1 ~ 3 to soak in solvent, extracts, and decocts, and is concentrated into extractum, dry.
5. preparation method as claimed in claim 4, is characterized in that, the consumption of described solvent be described feedstock composition gross weight 6-10 doubly, described solvent is one or more in water, ethanol, petroleum ether and ethyl acetate.
6. preparation method as claimed in claim 4, is characterized in that, the time of described immersion is 1 ~ 2 hour, described is extracted as one or more in percolation extraction, reflux, extract, and supercritical extraction; The number of times of described extraction is 2 ~ 3 times.
7. preparation method as claimed in claim 4, is characterized in that, the time of described decoction is 0.5 ~ 2.5 hour, and the temperature of described decoction is 50 ~ 90 ℃, and the relative density of described extractum is 1.0 ~ 1.4.
8. preparation method as claimed in claim 4, is characterized in that, described being dried is dry for spraying, one or more in vacuum drying, fluid bed drying and lyophilization, and described sieves as crossing 80 ~ 100 mesh sieves.
9. the blood sugar lowering extract being made by the preparation method as described in any one in claim 4 ~ 8.
10. the application of blood sugar lowering extract as claimed in claim 9 in the medicine for the preparation for the treatment of type ii diabetes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210577015.5A CN103893498B (en) | 2012-12-26 | 2012-12-26 | A kind of blood sugar lowering extract and feedstock composition and preparation method thereof, purposes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210577015.5A CN103893498B (en) | 2012-12-26 | 2012-12-26 | A kind of blood sugar lowering extract and feedstock composition and preparation method thereof, purposes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103893498A true CN103893498A (en) | 2014-07-02 |
| CN103893498B CN103893498B (en) | 2016-08-03 |
Family
ID=50985282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210577015.5A Expired - Fee Related CN103893498B (en) | 2012-12-26 | 2012-12-26 | A kind of blood sugar lowering extract and feedstock composition and preparation method thereof, purposes |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103893498B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030088329A (en) * | 2002-05-11 | 2003-11-19 | 박준희 | Diabetes treatment substance extraction |
| CN101869663A (en) * | 2010-07-09 | 2010-10-27 | 喇孝瑾 | Chinese medicinal preparation for treating diabetes and preparation method thereof |
-
2012
- 2012-12-26 CN CN201210577015.5A patent/CN103893498B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030088329A (en) * | 2002-05-11 | 2003-11-19 | 박준희 | Diabetes treatment substance extraction |
| CN101869663A (en) * | 2010-07-09 | 2010-10-27 | 喇孝瑾 | Chinese medicinal preparation for treating diabetes and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 侯天印 等: "《糖尿病偏验方与食疗》", 30 September 2011, 金盾出版社 * |
| 高宏杰 等: "中医药治疗糖尿病肾病研究进展", 《辽宁中医药大学学报》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103893498B (en) | 2016-08-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103055016B (en) | Freeze-dried fresh rehmannia for treating acne | |
| CN104984124A (en) | Traditional Chinese medicine for treating chronic renal failure | |
| CN101406598B (en) | Chinese medicine composite for treating diabetes and preparation method thereof | |
| CN102327340B (en) | Chinese medicine granular preparation for poultry and preparation method thereof | |
| CN104107348A (en) | Chinese herbal medicine for blood sugar reducing, and administration method thereof | |
| CN103705860B (en) | A kind of Chinese medicine composition for the treatment of infant jaundice and preparation method thereof | |
| CN102726589A (en) | Chewing gum specially for diabetic patients and preparation method thereof | |
| CN101167951A (en) | Traditional Chinese medicinal composition for treating diabetes and its preparation method | |
| CN103417694A (en) | Traditional Chinese medicine used for treating diabetes | |
| CN102363017B (en) | Chinese medicinal composition having effects of clearing away heat and toxic materials, promoting blood circulation by removing blood stasis, removing dampness through diuresis and reducing phlegm and preparation method thereof | |
| CN103566227B (en) | A kind of Chinese medicine composition preventing and treating type 2 diabetes mellitus and preparation method thereof | |
| CN113826882A (en) | Dietary nutrition supplement for preventing and treating diabetes and preparation process thereof | |
| CN103893498B (en) | A kind of blood sugar lowering extract and feedstock composition and preparation method thereof, purposes | |
| CN101987188B (en) | Biological Chinese patent drug for preventing and treating hyperlipoidemia | |
| CN105327181A (en) | Medicine composition for treating diabetes | |
| CN105796915A (en) | Composition for treating diabetes and preparation method thereof | |
| CN102120000B (en) | Composition of effective parts of traditional Chinese medicine preparation for resisting Coxsackie virus B and preparation method thereof | |
| CN101411822B (en) | Kidney-tonifying Chinese medicinal formulation for treating diabetes and preparation method thereof | |
| CN105148240A (en) | Medicinal preparation used for treating chronic cardiac failure | |
| CN104958474A (en) | Traditional Chinese medicine for treating damp heat stagnation type pancreatic cancer and preparation method thereof | |
| CN104524359B (en) | A kind of Chinese medicine composition, its preparation method and application | |
| CN105597011A (en) | Method for preparing traditional Chinese medicine composition for treating acute or chronic rhinitis | |
| CN103041320A (en) | Traditional Chinese medicine composition for treating cervical spondylosis and preparation method thereof | |
| CN102755580B (en) | Method for preparing chewable tablets of drug for treating unstable angina pectoris | |
| CN102526470B (en) | Medicinal composition for treating primary hypertension |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160803 Termination date: 20211226 |