KR20030088329A - Diabetes treatment substance extraction - Google Patents

Abstract

PURPOSE: Provided is an extraction of therapeutic material for diabetes, thereby ameliorating physical constitution and blood circulation and giving health tonic effect. CONSTITUTION: An extraction of therapeutic material for diabetes is characterized by the steps of: dipping 40-50% of Aralia Continentalis kitagawa, Trichosanthis radix, red ginseng, Rehmannia glutinosa, Asian celandine, corn's hair which are dried and pulverized, respectively, in 50-60% of purified water regulated pH 6.0-6.5 by addition of citric acid or organic acid; sterilizing them a 90 deg.C, and followed by drying or concentrating their filtrate regulated to pH 6-8 by addition of a potassium hydroxide solution under reduced pressure; and additionally adding additives, such as Angelica gigas NAKAI., Schizandra spp., Astragalus membranaceus (Fisch.) Bunge, and the like and ameliorants, such as vitamin C, B, E, nicotinic acid(niacin), citric acid, benzoic acid, and the like.

Description

Extraction of Diabetes Therapeutics {omitted}

The present invention relates to a manufacturing method using bran, cheonhwabun, red ginseng, rhubarb, jihwang, jimo, horseradish whiskers, myocardial muscles that have a doubled mortality rate than high blood pressure and normal people due to blood circulation disorder, chronic fatigue and complications caused by diabetes. The incidence of diabetes is extremely high in the process of the development and rapid change of modern culture, such as infarction and the incidence of cataracts five times higher than the general population and osteoporosis two to three times higher than the general population. Accordingly, according to the present invention, general pharmaceuticals and vitamin C which have been proved to be stabilized that can be added to the bran, cheonhwabun, red ginseng, rhubarb, jihwang, jimo, and corn stub without departing from the purpose of preventing and treating diabetes of the present invention. , Citric acid, nicotinic acid, sodium benzoate and the like, and the purpose of incorporating these active ingredients in the form of tablets or capsules for the purpose of preventing and treating diabetes.

1) Aralia contientalis is a perennial herbaceous plant, known as a "perennial herbaceous plant," and is a representative old plant, or a wild plant, with a very distinctive fragrance and its freshness and freshness in spring. Unlike other herbs, it can be eaten raw or boiled.

There are 7 types of ground larvae, including decayed donkey, virulent ulcer, larvae vulgaris, unicapsicum fulcrum, guan-dok activ, soft-hair venom, and mother-ear.

In particular, spring shoots are purple, hairy, scented, and slightly astringent. After the green flower blooms in the flower season of July to September, the fruit turns black from dark red to ripen. These grounds have a lot of potassium and play an important role in blood pressure control. The root contains asparagine, starch and glucose.

It is already excellent alkaline food in Dongbobo-gam-tang medicinal herbs. It has good temper and taste. It is old in all red wind and white rice gout, old wind and stimulation of flesh, tingling and consoling pain. It is proven to be harmless to value and the human body.

2) Cheonhwabun (heaven) is a perennial herbaceous herb that is distributed in the southern and central regions of Korea, and widely distributed in the wild mountains of China and Mongolia. It is also called a general herb. As the roots become thicker and starches can be collected from these roots, these starches are called cheonhwa, and they are effective against sweat bands, eczema and swelling, and can be used to treat coughs and asthma by drinking seeds. Secondary metabolic As a physiologically active substance that is effective in pathways, it is well represented in Tokyo.

3) Red ginseng is red ginseng that has been dried by steaming ginseng. After hot air drying, the red ginseng is selected for drying up to 12.5 ~ 13.5% by using solar heat or other methods. It also protects and softens the skin with anti-inflammatory, anti-tumor, and protective effects against radiation.

The main components of red ginseng, such as ginseng, contain glycosides, ginseng fragrances (Panacen), nitrogen-containing components, flavonoids, vitamin B, enzymes, organic acids, amino acids, polyacetylene compounds, etc. .

4) Cotis chinensis is an evergreen perennial herb of the Buttercup family, distributed in Korea, Japan, and China, and grows mainly in shaded eczema. The stem descending vertically is thick and extends laterally, with many beard roots and usually about 10 ~ 27cm long. The stem was dark yellow in color, and the word was used to refer to the name Hunan. In oriental medicine, roots are harvested and dried around November, and are prescribed for the treatment of gastritis, enteritis, abdominal pain, vomiting, dysentery, mental anxiety, sore throat, bleeding, and burns.

(references)

Jeju Agricultural Promotion Administration, 1988, Test and Research Report

5) Rehmannia glutinosa is native to China, and the flowers are reddish purple with strong red light in June to July. This is an edible plant that usually uses roots. Is called 黃).

It is one of the most widely used herbal medicines such as antipyretic, geothermal, strong heart, blood and nourishing tonic. It contains mandit, sugar, karten, cytosterol and vitamin A.

(references)

Yuk Chang-Soo, 1989 Illustration of Korean medicinal plants

Yoo Soo Yeol, 1988 The Realities of Growing Medicinal Crops

6) Anemarrhena asphodeloides uses root stems of the genus and its origin is China, and is distributed evenly in Hwanghae Province in Korea. Leaves grow slowly from the root, and are divided into exogenous, normal and endogenous leaves from the outer part of the leaf. The top leaf is the largest in the middle part, and the shape of the leaf is lanceolate lanceolate, and the tip is very sharp. The leaves are also solid and the outer parts are shiny and shiny.

These roots and stems contain timomosaponin, chimonin, prococathechi acid, pantothenicacid, antipyretic, cardiac, diuretic, diuretic, antibacterial, expectorant If it works, it is also used as an antipyretic.

(references)

Lee Seung-taek 1990 Medicinal crop cultivation technology (Jimo, latest gardening P24 ~ 27)

7) Wasabi beard.

Also known as Oval. White beards, which are usually grown as a high-land cultivar and are enveloped with silk seeds and covered with silk, have a sweet taste, are mild and soft in fiber, and their main ingredients are fatty oils, fumigated oils, water-soluble substances, and resins. In addition, it contains biotic acid, malic acid, etc., and is particularly used as food in mountainous areas.

Distilled water, methanol, ethanol or mixed solvents from ground bran, cheonhwa flour, red ginseng, rhubarb, and jimo etc. can be extruded, chilled condensed or centrifuged. Here are some examples to increase the extraction efficiency of.

Example 1.

Each of these ingredients is separated and chopped or ground to add 40-50% by weight in a suitable container so that the active ingredients of these materials can be easily eluted. 50 to 60% of water adjusted to ˜6.5 and left at 20 to 25 ° C. for 2 to 3 days to wet. Then, the resultant is heated again to 70 to 80 ° C. for 40 to 50 minutes or instant sterilization and disinfection at a temperature of 90 ° C. or higher. After drying them by blowing them in a dryer at 30 to 40 ° C., the active ingredients are easily eluted from the water, and then crushed again and purified by extrusion or centrifugation or cooling condensation with purified water or ethanol. How to extract.

Example 2.

20-30% by weight of each of these ingredients in a container, 70-80% by weight for 0.5 normal ammonia, left for 8-9 hours at 40-45 ℃, extracted by putting in a press or centrifuge, etc. Filtration with

After stirring butyl alcohol and ethyl acetate in a filtrate (2: 1) in a mixing ratio, the container solvent layer is repeated under reduced pressure and concentrated under reduced pressure until the solvent layer is clear.

The filtered residue was completely dissolved in 99.5% of ethanol, and diluted sodium hydroxide solution adjusted to PH 6-7.0 was added to remove water, followed by filtration and purification.

Example 3.

Each of these materials was put into a container by using a blower or a low-temperature hot air in a shade, and 15 to 20% by weight of pulverized powder was added to the container, and 80 to 85% by weight of saturated potassium hydroxide solution was added. The mixture was left for 9 hours, extracted by an extrusion method, and filtered. Secondly, after stirring with saturated NaCl solution (8: 1), neutralizing with dilute hydrochloric acid aqueous solution, and adjusting the pH to 4 to% to filter the precipitate. This extract can be obtained again with high concentration and high concentration, and the extract is thus rested and concentrated under reduced pressure to be extracted or spray-dried to be effective for preventing and treating diabetes in powder or granule form.

Example 4.

In the method of Examples 1, 2, and 3 of the present invention, these bran, cheonhwabun, red ginseng, rhubarb. Each of the extracts, such as yohwang, gimo, and horseradish whiskers, is mixed in six equal parts to extract the common additives, ie, drugs whose safety has been proven, within the scope of the present invention without departing from the inherent purpose of preventing and treating diabetes. Formulation of liquid ingredients that can be concentrated under reduced pressure by adding improvers such as sodium benzoate.

Extract fraction (extract) 43.18%

Astragalus 2.95%

2.10% powder

Macmundong 8.25%

Hawk 2.51%

Salvia 2.47%

Baek axis 2.40%

2.50% raw

Incho 2.45%

2.50% golden

Baekbokyeong 2.85%

Cornus 2.00%

Neck skin 2.62%

Angelica 2.90%

Schisandra 2.82%

Baikushin 2.50%

Licorice 2.75%

2.52% of dew

Chaser 2.35%

Vitamin E 2.00%

Vitamin B 0.05%

Benzoic Acid 0.001%

A breakthrough product that can be directly used, granulated, tableted or encapsulated by extracting these effective extract ingredients for the prevention and treatment of diabetes prepared by the method of Example 4 from the extracts extracted by the methods of Examples 1 to 3, etc. to be.

(Clinical Trial)

In Example 4, the blood glucose level was increased to 200-350 per blood (mg / dl) to increase or decrease the pancreatic function, renal function, and kidney function. The results of the first administration of the drug for 7 days with tidal tides for patients with complications such as sexual dysfunction and osteoporosis were tested for blood sugar levels for the first time in 30 days and then for 45 days for the second time for 30 days, as shown in Table 1. 2. 3. Shown.

Reference: Normal value per blood 69 ~ 110 (mg / dl)

* A group pancreatic depression

Deterioration of group B kidney function

Group C sexual life disorder

Group D osteoporosis

As can be seen from the clinical test table 1, the blood glucose level was found to be remarkably lowered, and after the first examination, the drug of the present invention was decided.

Reference: Normal blood glucose level 69-110 (mg / dl)-

* A group pancreatic depression

Deterioration of group B kidney function

Group C sexual life disorder

Group D osteoporosis

As can be seen in the second clinical trial 2 table, the blood fructose level was normal among 6 of 13 subjects, and the other 7 showed a good response.

Reference: Normal value per blood 69 ~ 110 (mg / dl)

* A group pancreatic depression

Deterioration of group B kidney function

Group C sexual life disorder

Group D osteoporosis

As can be seen in Table 3, the blood glucose levels of all 13 clinical subjects in groups A, B, C, and D, which caused complications due to diabetes, were shown to be normal. The ingredients are excellent for the treatment of diabetes.

Claims (1)

Crunch, cheonhwabun, red ginseng, turmeric, gimos, rhubarb, and corn whiskers were dried and pulverized, respectively, and 40 to 50% by weight of citric acid or organic acid was added to the acid value, i.e., 50 to 60% of purified water adjusted to pH 6.0 to 6.5. After wetting, sterilization at a temperature of 90 ° C. or higher and then drying, or the filtrate adjusted to PH 6 to 8 with an alkali solution such as potassium hydroxide aqueous solution can be added in Example 4 as long as the present invention is not impaired by impairing the present invention. The present invention aims to extract substances effective for human physiological activity for the purpose of preventing or treating diabetes by adding vitamin E, C, B, nicotinic acid, citric acid, benzoic acid, etc. as additives and improving agents such as Angelica, Schisandra chinensis and Astragalus.