CN102363017B

CN102363017B - Chinese medicinal composition having effects of clearing away heat and toxic materials, promoting blood circulation by removing blood stasis, removing dampness through diuresis and reducing phlegm and preparation method thereof

Info

Publication number: CN102363017B
Application number: CN2011103303430A
Authority: CN
Inventors: 黄小华; 付彬; 石丽; 张�浩
Original assignee: BEILIN PHARMACEUTICAL Co Ltd XI'AN
Current assignee: BEILIN PHARMACEUTICAL Co Ltd XI'AN
Priority date: 2011-10-26
Filing date: 2011-10-26
Publication date: 2013-04-03
Anticipated expiration: 2031-10-26
Also published as: CN102363017A

Abstract

The invention relates to a Chinese medicinal composition having effects of clearing away heat and toxic materials, promoting blood circulation by removing blood stasis, removing dampness through diuresis and reducing phlegm and a preparation method thereof. The Chinese medicinal composition is prepared from sixteen traditional Chinese medicines, including puffball, vinegar-treated curcuma zedoary, honeysuckle flower, water-boiled peach kernel, figwort, vinegar-treated common burreed rhizome, safflower, red-rooted salvia root, isatis root, dwarf lilyturf root, thunberg fritillary bulb, oriental waterplantain rhizome, cicada shell, fried chicken gizzard membrane, indian trum etflower seed and dandelion, has the effects of clearing away heat and toxic materials, promoting blood circulation by removing blood stasis, removing dampness through diuresis and reducing phlegm, and is mainly used for treating hoarseness, injection of vocal cord and swelling caused by accumulation of toxic heat and qi depression to blood stasis, chronic laryngitis, vocal nodule and polyp of vocal cord. The clinical pharmacodynamic study effect of the Chinese medicinal composition is enhanced remarkably, and the Chinese medicinal composition does not have any toxic or side effect.

Description

A kind of Chinese medicine composition that reduces phlegm for heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dampness removing and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition that reduces phlegm for heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dampness removing and preparation method thereof, belong to the pharmaceutical technology field.

Technical background

Along with the sustainable development of China's industry, environmental pollution is more and more serious, and the people who thereupon suffers from throat disease is more and more, has seriously influenced daily life, has brought great misery to people.The medicine for the treatment of clinically throat disease at present is few, especially treats the medicine of the pure Chinese medicines such as chronic laryngitis, vocal nodule, polyp of vocal cord still less.The prior art patent retrieval: 1, the Chinese patent communique disclosed name and has been called " Jinsangsanjie preparation and preparation method thereof " on August 29th, 2007, and publication number is the patent application of CN 101024060A.2, on November 10th, 2004 Chinese patent gazette disclose the name be called " a kind of Chinese medicine for the treatment of throat chronic hoarseness symptom and preparation method thereof ", publication number is the patent application of CN 1544077A.3, on January 24th, 2007 Chinese patent gazette disclose the name be called " a kind of preparation technique of traditional Chinese medicine for the treatment of vocal nodule, polyp of vocal cord symptom and uses thereof ", publication number is the patent application of CN 1899569A.4, on June 14th, 2006 Chinese patent gazette disclose the name be called " a kind of Jinsang sanjie fast dispersion solid preparation for treating throat and preparation method thereof ", publication number is the patent application of CN 1785406A.Above four patents all exist technique thicker, the undesirable defective of curative effect in the process of practical application.In the time in recent years, we are by excavating the abundant natural resources of Chinese medicinal materials of motherland, in conjunction with a large amount of traditional Chinese medical science prescription theory and Study on clinical pharmacodynamics, use the modern pharmaceutical technology this Product Process is made significant improvement, grope by a large amount of experiments, the unexpected discovery changes former technique to stir-baked RHIIZOMA CURCUMAE with vinegar into, Semen Oroxyli is extracted volatile oil, to Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) carries out alcohol extraction, Radix Salviae Miltiorrhizae is carried out alcohol extraction, the Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) is pulverized, Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis water extraction, with the preparation that this technique is made, clinical pharmacodynamics test effect significantly improves, without any side effects, active constituent content is high, and preparation stabilization is evident in efficacy.We routinely technique made: pill, tablet, granule, capsule, soft capsule and drop pill.

Summary of the invention

The purpose of this invention is to provide a kind of technique advanced, active constituent content is high, and better stability of preparation, curative effect are used for heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, the dampness removing Chinese medicine composition and preparation method thereof that reduces phlegm more significantly.This preparation is mainly used in Re Du Yun knot, the hoarseness of caused by energy stagnation and blood stasis, vocal congestion, swelling; Chronic laryngitis, vocal nodule, polyp of vocal cord are seen above-mentioned patient.Its clinical pharmacodynamics test effect significantly improves, and without any side effects.

Prior art: 1, the Chinese patent communique disclosed name and has been called " Jinsangsanjie preparation and preparation method thereof " on August 29th, 2007, and publication number is the patent application of CN 101024060A.2, on November 10th, 2004 Chinese patent gazette disclose the name be called " a kind of Chinese medicine for the treatment of throat chronic hoarseness symptom and preparation method thereof ", publication number is the patent application of CN 1544077A.3, on January 24th, 2007 Chinese patent gazette disclose the name be called " a kind of preparation technique of traditional Chinese medicine for the treatment of vocal nodule, polyp of vocal cord symptom and uses thereof ", publication number is the patent application of CN 1899569A.4, on June 14th, 2006 Chinese patent gazette disclose the name be called " a kind of Jinsang sanjie fast dispersion solid preparation for treating throat and preparation method thereof ", publication number is the patent application of CN 1785406A.The applicant in recent years time back warp development test, finds all to exist technique thicker the undesirable defective of curative effect in the process of practical application to above prior art.

The defective that exists for overcoming prior art, the applicant is by excavating the abundant natural resources of Chinese medicinal materials of motherland, in conjunction with a large amount of traditional Chinese medical science prescription theory and Study on clinical pharmacodynamics, use the modern pharmaceutical technology this Product Process is made significant improvement, grope by a large amount of experiments, the unexpected discovery changes former technique to stir-baked RHIIZOMA CURCUMAE with vinegar into, Semen Oroxyli is extracted volatile oil, to Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) carries out alcohol extraction, Radix Salviae Miltiorrhizae is carried out alcohol extraction, the Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) is pulverized, Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis water extraction, with the preparation that this technique is made, clinical pharmacodynamics test effect significantly improves, without any side effects, active constituent content is high, and preparation stabilization is evident in efficacy.We routinely technique made: pill, tablet, granule, capsule, soft capsule and drop pill have better met needs of medical treatment.

The present invention consists of like this: it mainly is by " 25 parts of Lasiosphaera Seu Calvatia, 50 parts of stir-baked RHIIZOMA CURCUMAE with vinegar, 125 parts of Flos Loniceraes, 50 parts in Dan Semen Persicae, 125 parts of Radix Scrophulariaes, 50 parts of stir-baked RHIZOMA SPARGANII with vinegar, 50 parts on Flos Carthami, 75 parts of Radix Salviae Miltiorrhizaes, 125 parts of Radix Isatidis, 100 parts of Radix Ophiopogonis, 75 parts of Bulbus Fritillariae Thunbergiis, 75 parts of Rhizoma Alismatis, 75 parts of Periostracum Cicadaes, 50 parts of Endothelium Corneum Gigeriae Galli (parched)s, 75 parts of Semen Oroxylis, 125 parts of Herba Taraxacis." traditional Chinese medicinal material raw materials of the weight portion pill, tablet, granule, capsule, soft capsule and the drop pill that are prepared from; Specific as follows:

1, the preparation of Chinese medicine composition of the present invention:

Prescription consists of:

Preparation method is: above ten Six-elements, and Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add water (8～12) and doubly measure reflux, extract, volatile oil 2 times, and each (1～3) hour collects volatile oil for subsequent use, merges filtrate twice, and is for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) be with (6～10) amount (20%～60%) alcohol reflux 2 times doubly, and each (0.5～2) hour merges filtrate twice, and decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is with (5～8) amount (75%～85%) alcohol reflux 2 times doubly, and each (1～3) hour merges filtrate twice, and decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time doubly amount of water (8～12), decoct (1～3) hour, add for the second time doubly amount of water (6～10), decoct (1～3) hour, merge filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, decompression (0.07Mpa～-0.08Mpa, 70-80 ℃) be concentrated into the clear paste that relative density is 1.06～1.20 (60～80 ℃), cross the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder and each dosage form proper auxiliary materials mixing, spray into volatile oil by each dosage form common process, make pill, tablet, granule, capsule, soft capsule or drop pill.

2, the preparation of Chinese medicine composition of the present invention is preferably as follows:

Prescription consists of:

Preparation method is: above ten Six-elements, and Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, decompression (0.08Mpa, 70 ℃) be concentrated into the clear paste that relative density is 1.08-1.12 (70 ℃), cross the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder and each dosage form proper auxiliary materials mixing, spray into volatile oil by each dosage form common process, make pill, tablet, granule, capsule, soft capsule or drop pill.

3, the preparation of Chinese medicine composition pill of the present invention:

Prescription consists of:

Preparation method is: above ten Six-elements, and Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, decompression (0.08Mpa, 70 ℃) is concentrated into the clear paste that relative density is 1.08-1.12 (70 ℃), crosses the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder mixing spray into volatile oil, add refined honey, make water-honeyed pill or big honeyed pills, namely get pill.

4, the preparation of Chinese medicine composition tablet of the present invention:

Prescription consists of:

Preparation method is: above ten Six-elements, and Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, and merged filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, decompression (0.08Mpa, 70 ℃) is concentrated into the clear paste that relative density is 1.08-1.12 (70 ℃), crosses the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder and appropriate amount of starch mixing are granulated drying, granulate, add an amount of magnesium stearate, mixing sprays into volatile oil, tabletting namely gets tablet.

5, the preparation of Chinese medicinal composition granules of the present invention:

Prescription consists of:

Preparation method is: above ten Six-elements, and Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, decompression (0.08Mpa, 70 ℃) be concentrated into the clear paste that relative density is 1.08-1.12 (70 ℃), cross the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder and an amount of dextrin mixing, granulate, drying, granulate sprays into volatile oil, pack namely gets granule.

6, the preparation of Chinese medicinal composition capsules agent of the present invention:

Prescription consists of:

Preparation method is: above ten Six-elements, and Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, decompression (0.08Mpa, 70 ℃) be concentrated into the clear paste that relative density is 1.08-1.12 (70 ℃), cross the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder and appropriate amount of starch mixing, granulate, drying, granulate sprays into volatile oil, encapsulated, namely get capsule.

7, the preparation of Chinese medicine composition soft capsule of the present invention:

Prescription consists of:

Preparation method is: above ten Six-elements, and Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, and decompression (0.08Mpa, 70 ℃) is concentrated into the clear paste that relative density is 1.08-1.12 (70 ℃), cross the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder mixing get mixed powder, spray into volatile oil, mixing adds PEG400, and is even through colloidal grinding; In gelatin: glycerol: water is 1: 0.3: 1 ratio glue, adopts the encapsulating machine pelleting, namely gets soft capsule.

8, the preparation of Chinese medicine composition pill agent of the present invention:

Prescription consists of:

Preparation method is: above ten Six-elements, and Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, decompression (0.08Mpa, 70 ℃) is concentrated into the clear paste that relative density is 1.08-1.12 (70 ℃), crosses the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder mixing spray into volatile oil, mixing, sieve, add in the Macrogol 4000 of melting, stir, add in the pill dripping machine, dripping becomes ball, namely gets drop pill.

The present invention program is through inventor's repetition test repeatedly, updates to adjust and sums up out, and the clinical pharmacodynamics test effect of said medicine significantly strengthens, and technique is advanced, and active constituent content is high, and better stability of preparation is evident in efficacy.

Pharmacodynamic test of active extract is as follows:

One, the preparation of Experimental agents:

1, raw material:

The a group is pill group of the present invention: the method according to description embodiment 1 of the present invention makes.

B group is: be the pill that the method for description embodiment three of the patent application of CN 101024060A makes according to publication number;

Concrete method for making is as follows:

Get Lasiosphaera Seu Calvatia 50g, Rhizoma Curcumae (vinegar stir-fry) 100g, Flos Lonicerae 250g, Semen Persicae (Dan) 100g, Radix Scrophulariae 250g, rhizoma sparganic (vinegar stir-fry) 100g, Flos Carthami 100g, Radix Salviae Miltiorrhizae 150g, Radix Isatidis 250g, Radix Ophiopogonis 200g, Bulbus Fritillariae Thunbergii 150g, Rhizoma Alismatis 150g, Endothelium Corneum Gigeriae Galli (stir-fry) 100g, Periostracum Cicadae 150g, Semen Oroxyli 150g, Herba Taraxaci 250g, for subsequent use;

In A, the above medicine, get Bulbus Fritillariae Thunbergii 50g, Endothelium Corneum Gigeriae Galli 33g, be ground into fine powder, sieve, mixing, for subsequent use; The fine particle size is 200～300 purpose superfine powder;

B, Rhizoma Curcumae (vinegar stir-fry) 50g, Semen Persicae (Dan) 50g, Flos Carthami 50g extract volatile oil, collect volatile oil, and be for subsequent use;

C, Herba Taraxaci 125g, Flos Lonicerae 125g add hydro-thermal with the residue Flos Carthami and soak secondary, each 3 hours, filter merging filtrate;

The surplus of D, Radix Salviae Miltiorrhizae 75g, Lasiosphaera Seu Calvatia 25g and all the other flavour of a drug and above-mentioned flavour of a drug decocts with water 3 times, and each 3 hours, merge medicinal liquid, filter;

E, Radix Salviae Miltiorrhizae, Lasiosphaera Seu Calvatia surplus add 70% alcohol heating reflux secondary, and each 3 hours, filter, merging filtrate, Recycled ethanol merges with above-mentioned medicinal liquid; Medicinal liquid is concentrated into the thick paste that relative density is 1.28～1.32 (85 ℃); With the fine powder mixing, spray into volatile oil, add refined honey, make the pill of sphere or class sphere, polishing, drying gets concentrated pill.

C group is: be the tablet that the method for description embodiment 2 of the patent application of CN 1544077A makes according to publication number.

Concrete method for making is as follows:

Above ten Six-elements, extracting honeysuckle, Bulbus Fritillariae Thunbergii, Flos Carthami 1/2 amount are ground into fine powder, sieve, mixing, the Lasiosphaera Seu Calvatia sieve is got the 10g fine powder, the surplus of all the other 12 flavors and above-mentioned four Chinese medicine decocts with water secondary, each 2 hours, collecting decoction filtered, filtrate be concentrated into when temperature is 85 ℃ relative density be 1.28～1.32 thick paste and above-mentioned fine powder and 80g starch, magnesium stearate 3g, it is being pressed into 1000, film coating, and get final product.

D group is: be the capsule that the method for description embodiment 2 of the patent application of CN 1899569A makes according to publication number.

Concrete method for making is as follows:

Prescription: Lasiosphaera Seu Calvatia 25g, Rhizoma Curcumae (vinegar stir-fry) 50g, Flos Lonicerae 125g, Semen Persicae 50g, Radix Scrophulariae 125g, rhizoma sparganic (vinegar stir-fry) 50g, Flos Carthami 50g, Radix Salviae Miltiorrhizae 75g, Radix Isatidis 125g, Radix Ophiopogonis 100g, Bulbus Fritillariae Thunbergii 75g, Rhizoma Alismatis 75g, Periostracum Cicadae 75g, Endothelium Corneum Gigeriae Galli (stir-fry) 50g, Semen Oroxyli 75g, Herba Taraxaci 125g;

Get 50% Flos Lonicerae, Bulbus Fritillariae Thunbergii, Flos Carthami of recipe quantity, the Lasiosphaera Seu Calvatia of recipe quantity 2% is ground into fine powder, sieve, and mixing, for subsequent use; Surplus after the pulverizing of Rhizoma Curcumae, Semen Persicae, Radix Scrophulariae, rhizoma sparganic, Radix Salviae Miltiorrhizae, Radix Isatidis, Radix Ophiopogonis, Rhizoma Alismatis, Endothelium Corneum Gigeriae Galli, Periostracum Cicadae, Semen Oroxyli, Herba Taraxaci and Flos Lonicerae, Bulbus Fritillariae Thunbergii, Flos Carthami, Lasiosphaera Seu Calvatia four Chinese medicine is added 10 times, 8 times decoctings boil secondary, each 2 hours, collecting decoction, filter, filtrate is concentrated into the thick paste that relative density is 1.28～1.32 (60 ℃), adding 95% ethanol makes and contains alcohol amount and reach 60%, stir, left standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to relative density is the clear paste of 1.38～1.40 (60 ℃); The fine powder and the appropriate amount of auxiliary materials mixing that add preparation, drying is pulverized, and makes fine particle, incapsulates, and get final product.

E group is: be the tablet that the method for description embodiment 2 of the patent application of CN 1785406A makes according to publication number.

Concrete method for making is as follows:

25 parts of Lasiosphaera Seu Calvatia, 50 parts of Rhizoma Curcumae (vinegar stir-fry), 125 parts of Flos Loniceraes, 50 parts in Semen Persicae (peeling), 125 parts of Radix Scrophulariaes, 50 parts of rhizoma sparganic (vinegar stir-fry), 50 parts on Flos Carthami, 75 parts of Radix Salviae Miltiorrhizaes, 125 parts of Radix Isatidis, 100 parts of Radix Ophiopogonis, 75 parts of Bulbus Fritillariae Thunbergiis, 75 parts of Rhizoma Alismatis, 50 parts of Endothelium Corneum Gigeriae Galli (stir-fry), 75 parts of Periostracum Cicadaes, 75 parts of Semen Oroxylis, 125 parts of Herba Taraxacis, above ten Six-elements decoct extraction 2 hours with 8 times of amounts of water, filter, add again 6 times of amounts of water, decoct and extracted 2 hours, filter; Merge filtrate twice, be condensed into relative density and be 1.30～1.35 (60 ℃) thick paste, drying is ground into fine powder, sieves, micronizing is crossed 400 orders; Per 100 parts of powder and adjuvant mix homogeneously are pressed full length film after granulating, and be get final product.

Two: process of the test and result of the test

Experiment purpose: by to the antiinflammatory of pill a group of the present invention and b, c, d, e group, ease pain, reduce phlegm, improve the pharmacological experiment studies such as microcirculation, blood circulation promoting and blood stasis dispelling, pill a group of the present invention and b, c, d, e group are compared, observe the power of its pharmacological action.

Test method: the impact of pill a group of the present invention and b, c, d, e group xylol induced mice auricle edema; On Carrageenan causes the impact of mice foot swelling; On the swollen impact of rat granuloma; The impact of Dichlorodiphenyl Acetate induced mice writhing response;

Impact on mice hot plate induced pain; Impact on the phenol red excretion amount of mice trachea; Impact on the rat phlegm-dispelling functions;

On the microcirculatory impact of Mice Auricle; Impact on stasis syndrome rat model hemorheological property.

Experimental result: pill a group of the present invention and b, c, d, e group can obviously suppress dimethylbenzene induced mice auricle edema; It is inhibited that on Carrageenan causes the swelling of mice foot; Suppress the rat granulation tissue hyperplasia that cotton balls causes, reduce the weight of granulation tissue; Dichlorodiphenyl Acetate induced mice writhing has obvious inhibitory action; Can prolong the pain threshold of hot plate induced pain mice; Can obviously increase the phenol red excretion amount of mice trachea; Significantly increase the phlegm-dispelling functions of rat; The blood capillary opening amount is increased, and arteriole, thin vein external caliber obviously increase; The high shear rate of stasis syndrome rat model whole blood and low shear rate viscosity, plasma viscosity are obviously increased, and the blood Fibrinogen increases, and platelet adhesion rate raises.

Conclusion: pill a of the present invention group than the antiinflammatory of b, c, d, e group, to ease pain, reduce phlegm, improve the pharmacological actions such as microcirculation, blood circulation promoting and blood stasis dispelling strong, therefore, to have the effect that heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dampness removing reduce phlegm than b, c, d, e group strong for pill a of the present invention group.

One, the impact of xylol induced mice auricle edema

Experiment material

1, animal: Kunming mouse, male and female have concurrently, body weight 18～22g.

2, medicine: pill a group of the present invention and b, c, d, e organize pill, and every gram is equivalent to raw medicinal herbs 1 gram.Medicine configures with distilled water before experiment, gastric infusion.

Experimental technique

60 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random, 10 every group.The matched group gavage is with the normal saline of volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 8.4g crude drug/kg respectively.Successive administration 7d, every day 1 time, behind the last administration 2h, drip on the left ear of mice surface and to be coated with dimethylbenzene 0.05ml and to cause inflammation, cause scorching 15min after, and two basal parts of the ear cut about two ears, two ears are together overlapping, card punch with diameter 7mm is beaten circular piece, claims two auricle weight about it, and with the swelling degree of left and right sides auricle weight difference value representation mice ear inflammation.Experimental result: see Table 1

Table 1 is on the impact of swelling due to the Mice Auricle dimethylbenzene

Compare * * P＜0.01 with matched group; Organize than Δ P＜0.05 with pill a of the present invention.

The result shows: the control group mice auris dextra is obviously red and swollen, and thickness increases, and auricle swelling degree is large.A of the present invention and b, c, d, e group can obviously suppress the swelling of dimethylbenzene induced mice auricle, the utmost point significant difference of having compared with matched group (P＜0.01); Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.As seen, pill a group of the present invention is stronger than the antiinflammatory action of b, c, d, e group.

Two, on Carrageenan causes the impact of mice foot swelling

Experiment material

Experimental technique

60 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random, 10 every group.The matched group gavage is with the normal saline of volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 8.4g crude drug/kg respectively.Successive administration 7d, every day 1 time, before the last administration 2h will every the sufficient sole of the foot of the left back foot of mice with 1% carrageenin 0.03mL.Animal is put to death in the 1h dislocation of cervical vertebra behind the medicine, cuts metapedes from ankle joint 0.5mm place and weighs respectively, take the difference of two heavy sensation in the foot amounts as swelling.Experimental result: see Table 2

Table 2 on Carrageenan causes the impact of mice foot swelling

The result shows: pill a group of the present invention and b, c, d, e group can obviously suppress the swelling that carrageenin causes the mice foot, have compared utmost point significant difference (P＜0.01) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d.As seen, pill a group of the present invention is stronger than the antiinflammatory action of b, c, d, e group.

Three, on the swollen impact of rat granuloma

Experiment material

1, animal: the SD rat, male and female have concurrently, body weight 200～250g.

Experimental technique

60 of SD rats, male and female half and half, body weight 200～250g is divided into 6 groups at random, 10 every group.During test, the rat chesk hair is wiped out in the ether light anaesthesia, and iodine disinfection cuts skin of chest, fills in respectively each one of the aseptic cotton balls of 50mg to two forelimb oxters from otch, skin suture, and intramuscular injection is blue or green, the chain enzyme infection.Postoperative 1h gastric infusion, the matched group gavage is with the normal saline of volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 5.6g crude drug/kg respectively.Successive administration 7d puts to death rat in the dislocation of 8d cervical vertebra every day 1 time, peels off the cotton balls granulation tissue, dry 12h in 60 ℃ of baking ovens, and electronic balance precise weighing (1/1000g) deducts the raw cotton ball weight, calculates granulation weight.Experimental result: see Table 3

Table 3 is on the swollen impact of rat granuloma

The result shows: the rat granulation tissue hyperplasia that pill a group of the present invention and b, c, d, e group cause cotton balls has very strong inhibitory action, reduces the weight of granulation tissue, has compared utmost point significant difference (P＜0.01) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.As seen, pill a group of the present invention is stronger than the antiinflammatory action of b, c, d, e group.

Four, the impact of Dichlorodiphenyl Acetate induced mice writhing response

Experiment material

Experimental technique

60 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random, 10 every group.The matched group gavage is with the normal saline of volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 8.4g crude drug/kg respectively.Successive administration 7d, every day 1 time, behind the last administration 1h, the equal lumbar injection 0.6% acetic acid 0.2ml/ of every Mus, mouse writhing number of times in the record 15min, and calculate each and organize analgesia percentage rate.Experimental result: see Table 4

The impact of table 4 Dichlorodiphenyl Acetate induced mice writhing response

Compare * P＜0.05 with matched group, * * P＜0.01; Organize than Δ P＜0.05 with pill a of the present invention.

The result shows: pill a group of the present invention and b, c, d, e group Dichlorodiphenyl Acetate induced mice writhing have obvious inhibitory action.Pill a group of the present invention has been compared utmost point significant difference (P＜0.01) with matched group; B, c, d, e group have been compared significant difference (P＜0.05) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.As seen, pill a group of the present invention is stronger than the analgesic activity of b, c, d, e group.

Five, on the impact of mice hot plate induced pain

Experiment material

1, animal: Kunming mouse, female, body weight 18～22g.

Experimental technique

The electric hot plate instrument is transferred to (55 ± 0.5) ℃, be that the Kunming kind female mice of 18～22g screens to body weight, the record mice is dropped into hot plate to occurring licking the time of metapedes as the pain threshold of this mice, 60 of the female mice of screening pain threshold in 30s, be divided at random 6 groups, 10 every group.The matched group gavage is with the normal saline of volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 8.4g crude drug/kg respectively.Successive administration 7d behind the last administration 1h, is placed on mice in the electric hot plate instrument every day 1 time, and the time that metapedes occurs licking after the record administration, pain threshold was as difference before the pain threshold after the medication deducted medication.Experimental result: see Table 5

Table 5 is on the impact of mice hot plate induced pain

The result shows: pill a group of the present invention and b, c, d, e group all can prolong the pain threshold of hot plate induced pain mice.Pill a group of the present invention has been compared utmost point significant difference (P＜0.01) with matched group; B, c, d, e group have been compared significant difference (P＜0.05) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.As seen, pill a group of the present invention is stronger than the analgesic activity of b, c, d, e group.

Six, on the impact of the phenol red excretion amount of mice trachea

Experiment material

Experimental technique

60 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random, 10 every group.The matched group gavage is with the normal saline of volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 8.4g crude drug/kg respectively.Successive administration 7d, every day 1 time, behind the last administration 0.5h, lumbar injection 5% phenol red normal saline 0.1ml/10g body weight is put to death animal behind the 0.5h, peel off the trachea surrounding tissue, cut one section trachea down to the trachea bifurcation from thyroid cartilage, put in the test tube that the people fills the 2ml normal saline, add again the NaOH of 0.1ml 5%, survey the OD value with 722 type spectrophotometers (wavelength 540nm).Experimental result: see Table 6

Table 6 is on the impact of the phenol red excretion amount of mice trachea

The result shows: pill a group of the present invention and b, c, d, e group can make the phenol red excretion amount of mice trachea obviously increase, and pill a group of the present invention has been compared utmost point significant difference (P＜0.01) with matched group; B, c, d, e group have been compared significant difference (P＜0.05) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.As seen, pill a group of the present invention is stronger than the resolve phlegm effect of b, c, d, e group.

Seven, on the impact of rat phlegm-dispelling functions

Experiment material

Experimental technique

60 of SD rats, male and female half and half, body weight 200～250g is divided into 6 groups at random, 10 every group.The matched group gavage is with the normal saline of volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 5.6g crude drug/kg respectively.Successive administration 7d, every day 1 time, after 50min anaesthetizes rat after the last administration with urethane (1g/kg), face upward the position fixing, separate trachea, hit exactly the capillary glass tube (length is 10cm) that inserts known weight between two cartilages at the cricoid cartilage lower edge, make juice along capillary rise, respectively organize the secretions of rat trachea when collecting 1h, weigh at electronic balance, and calculate the secretions amount of every 1kg body weight.

Experimental result: see Table 7

Table 7 is on the impact of rat phlegm-dispelling functions

With compare * P＜0.05 with matched group, * * P＜0.01; Organize than Δ P＜0.05 with pill a of the present invention.

The result shows: pill a group of the present invention and b, c, d, e group significantly increase the phlegm-dispelling functions of rat, and pill a group of the present invention has been compared utmost point significant difference (P＜0.01) with matched group; B, c, d, e group have been compared significant difference (P＜0.05) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.As seen, pill a group of the present invention is stronger than the resolve phlegm effect of b, c, d, e group.

Eight, on the microcirculatory impact of Mice Auricle

Experiment material

Experimental technique

60 of Kunming mouses, male and female half and half, body weight 18～22g is divided into 6 groups at random, 10 every group.The matched group gavage is with the normal saline of volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 8.4g crude drug/kg respectively.Successive administration 7d, every day 1 time.Reach successive administration before the administration after 7 days, behind the last administration 30min, each organize mice with 20% urethane 0.07ml/10g intraperitoneal injection of anesthesia after, mouse web portion is lain against downwards on the optical microscope object stage, make Mice Auricle open and flat, and drip a little liquid paraffin on its surface, regulate light-source brightness, under transillumination, observe and the open quantity of record Mice Auricle microcirculation blood capillary before and after medication (being the number of hits on blood capillary and border in the 1mm zone) with 16 times of eyepieces and 4 times of object lens.With 16 times of eyepieces and 10 times of object lens, observe and record the external caliber of Mice Auricle arteriole, thin vein before and after administration.Experimental result: see Table 8

Table 8 is on the microcirculatory impact of Mice Auricle

The result shows: pill a group of the present invention and b, c, d, e group all make the blood capillary opening amount increase, and arteriole, thin vein external caliber obviously increase, and have compared utmost point significant difference (P＜0.01) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.As seen, pill a group of the present invention is stronger than the microcirculatory effect of improvement of b, c, d, e group.

Nine, on the impact of stasis syndrome rat model hemorheological property

Experiment material

Experimental technique

70 of SD rats, male and female half and half, body weight 200～250g is divided into 7 groups at random, 10 every group.Matched group and model group gavage are with the normal saline of volume; Pill a group of the present invention and b, c, d, e group be gastric infusion 5.6g crude drug/kg respectively.Successive administration 7d, every day 1 time, dosage 10ml/kg.Except the blank group, other 5 groups in 7d subcutaneous injection epinephrine 0.08ml/100g, and totally 2 times, interval 4h.Between 2 Injection of Adrenalines, rat is immersed 5min in 0 ℃ of frozen water.Then fasting, carotid artery blood sampling under the etherization after 12 hours, anticoagulant heparin is used for measuring the high (200s that cuts of whole blood ^-1) and the low viscosity (40s that cuts ^-1), erythrocyte sedimentation rate; Measure the blood fibrinogen content with thermal precipitator method; Taking heparin anticoagulation centrifugal separation plasma is measured plasma viscosity in addition; Get again the sodium citrate anticoagulation, be used for measuring platelet adhesion rate.

Experimental result: see Table 9,10

Table 9 is on the impact of stasis syndrome rat model hemorheological property

Compare * * P＜0.01 with model group; Organize than Δ P＜0.05 with pill a of the present invention.

Table 10 is on the impact of stasis syndrome rat model hemorheological property

Compare * * P＜0.01 with model group; Organize than Δ P＜0.05 with pill a of the present invention

The result shows: pill a group of the present invention and b, c, d, e group all can make the high shear rate of stasis syndrome rat model whole blood and low shear rate viscosity, plasma viscosity obviously increase, the blood Fibrinogen increases, platelet adhesion rate raises, and has compared utmost point significant difference (P＜0.01) with matched group; Pill a group of the present invention is organized the significant difference (P＜0.05) of having compared with b, c, d, e.As seen, pill a group of the present invention is stronger than the effect of the blood circulation promoting and blood stasis dispelling of b, c, d, e group.

Experiment conclusion: pill a of the present invention group than the antiinflammatory of b, c, d, e group, to ease pain, reduce phlegm, improve the pharmacological actions such as microcirculation, blood circulation promoting and blood stasis dispelling strong, therefore, to have the effect that heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dampness removing reduce phlegm than b, c, d, e group strong for pill a of the present invention group.

Toxicological experiment:

Acute toxicity testing is the result show: with pill a group Cmax of the present invention, maximum volume gastric infusion, successive administration is 3 times in 24h, every minor tick 4h, and accumulation medicine total amount reaches 65g crude drug/kg, is equivalent to 189.6 times of the clinical plan consumption of people.After the administration in the 7d, mice is movable, feed, drain all normal, well-grown, the hair color light, its average body weight average increases with the prolongation of test period.Dissect every mice perusal heart, liver, spleen, lung, kidney, brain, thymus, stomach, intestinal etc. after 8d puts to death and all do not find color and paramophia, fail to measure LD50.Show that pill a group of the present invention is without acute toxic reaction.

Long term toxicity test is the result show: pill a component of the present invention is that basic, normal, high dosage is respectively 7,14,28g crude drug/kg/d, be equivalent to 20.4,40.8,81.7 times of clinical dosage, gastric infusion is after 12 weeks, pill a group of the present invention all affects without obvious general status, hematological indices, the blood parameters of animal, and system's dissection, organ coefficient and histopathological examination be no abnormal pathological change also.2 weeks of drug withdrawal also have no obvious change.Pill a group of the present invention is not found overt toxicity reaction and delayed toxicity reaction in long term toxicity test.As seen, pill a group non-toxic reaction of the present invention, long-term prescription is safe and reliable.

The specific embodiment

1, the preparation of Chinese medicine composition pill of the present invention:

Prescription:

Preparation method:

Above ten Six-elements, Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, decompression (0.08Mpa, 70 ℃) is concentrated into the clear paste that relative density is 1.08-1.12 (70 ℃), crosses the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder mixing spray into volatile oil, add refined honey, make water-honeyed pill or big honeyed pills, namely get pill.

2, the preparation of Chinese medicine composition tablet of the present invention:

Prescription:

Preparation method is:

Above ten Six-elements, Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, and merged filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, decompression (0.08Mpa, 70 ℃) is concentrated into the clear paste that relative density is 1.08-1.12 (70 ℃), crosses the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder and appropriate amount of starch mixing are granulated drying, granulate, add an amount of magnesium stearate, mixing sprays into volatile oil, tabletting namely gets tablet.

3, the preparation of Chinese medicinal composition granules of the present invention:

Prescription:

Preparation method is:

Above ten Six-elements, Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, decompression (0.08Mpa, 70 ℃) be concentrated into the clear paste that relative density is 1.08-1.12 (70 ℃), cross the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder and an amount of dextrin mixing, granulate, drying, granulate sprays into volatile oil, pack namely gets granule.

4, the preparation of Chinese medicinal composition capsules agent of the present invention:

Prescription:

Preparation method is:

Above ten Six-elements, Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, decompression (0.08Mpa, 70 ℃) be concentrated into the clear paste that relative density is 1.08-1.12 (70 ℃), cross the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder and appropriate amount of starch mixing, granulate, drying, granulate sprays into volatile oil, encapsulated, namely get capsule.

5, the preparation of Chinese medicine composition soft capsule of the present invention:

Prescription:

Preparation method is:

Above ten Six-elements, Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, and decompression (0.08Mpa, 70 ℃) is concentrated into the clear paste that relative density is 1.08-1.12 (70 ℃), cross the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder mixing get mixed powder, spray into volatile oil, mixing adds PEG400, and is even through colloidal grinding; In gelatin: glycerol: water is 1: 0.3: 1 ratio glue, adopts the encapsulating machine pelleting, namely gets soft capsule.

6, the preparation of Chinese medicine composition pill agent of the present invention:

Prescription:

Preparation method is:

Above ten Six-elements, Dan Semen Persicae, Bulbus Fritillariae Thunbergii (half amount), Flos Carthami (half amount) are ground into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Flos Carthami (half amount), Lasiosphaera Seu Calvatia, Flos Lonicerae, Bulbus Fritillariae Thunbergii (half amount), Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, being evaporated to relative density is the clear paste of 1.08～1.10 (70 ℃), with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, decompression (0.08Mpa, 70 ℃) is concentrated into the clear paste that relative density is 1.08-1.12 (70 ℃), crosses the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder mixing spray into volatile oil, mixing, sieve, add in the Macrogol 4000 of melting, stir, add in the pill dripping machine, dripping becomes ball, namely gets drop pill.

Claims

1. preparation method that is used for the Chinese medicine composition that heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dampness removing reduce phlegm is characterized in that the prescription of described Chinese medicine composition consists of:

125 parts of 50 portions of Radix Scrophulariaes of 125 parts of Dan Semen Persicaes of 50 portions of Flos Loniceraes of 25 parts of stir-baked RHIIZOMA CURCUMAE with vinegar of Lasiosphaera Seu Calvatia

100 parts of 75 parts of Radix Isatidis of 50 parts of Radix Salviae Miltiorrhizaes of 50 parts of Flos Carthamis of stir-baked RHIZOMA SPARGANII with vinegar 125 parts of Radix Ophiopogonis

75 parts of 50 portions of Semen Oroxylis of 75 parts of Endothelium Corneum Gigeriae Galli (parched)s of 75 portions of Periostracum Cicadaes of 75 portions of Rhizoma Alismatis of Bulbus Fritillariae Thunbergii

125 parts of Herba Taraxacis;

Preparation method is: above ten Six-elements, and the Bulbus Fritillariae Thunbergii of Dan Semen Persicae, half consumption, the Flos Carthami powder of half consumption are broken into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 8～12 times of amounts of water reflux, extract, volatile oil 2 times, and each 1～3 hour, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) be with the alcohol reflux of 6～10 times of amounts 20%～60% 2 times, and each 0.5～2 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is with 5～8 times of amount alcohol reflux of 75%～85% 2 times, and each 1～3 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; The Flos Carthami of half consumption, Lasiosphaera Seu Calvatia, Flos Lonicerae, the Bulbus Fritillariae Thunbergii of half consumption, Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 8～12 times of amounts of water, decocted 1～3 hour, add for the second time 6～10 times of amounts of water, decocted 1～3 hour, merge filtrate twice, relative density is 1.08～1.10 clear paste when being evaporated to temperature and being 70 ℃, with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, during concentrating under reduced pressure control vacuum be-0.07Mpa～-0.08Mpa, temperature is 70-80 ℃, relative density is 1.06～1.20 clear paste when being concentrated into temperature and being 60～80 ℃, cross the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder and each dosage form proper auxiliary materials mixing, spray into volatile oil by each dosage form common process, make pill, tablet, granule, capsule or drop pill.

2. the preparation method of described Chinese medicine composition according to claim 1 is characterized in that the prescription of described Chinese medicine composition consists of:

125 parts of Herba Taraxacis;

Preparation method is: above ten Six-elements, and the Bulbus Fritillariae Thunbergii of Dan Semen Persicae, half consumption, the Flos Carthami powder of half consumption are broken into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; The Flos Carthami of half consumption, Lasiosphaera Seu Calvatia, Flos Lonicerae, the Bulbus Fritillariae Thunbergii of half consumption, Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, relative density is 1.08～1.10 clear paste when being evaporated to temperature and being 70 ℃, with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, control vacuum is-0.08Mpa during concentrating under reduced pressure, temperature is 70 ℃, relative density is 1.08～1.12 clear paste when being concentrated into temperature and being 70 ℃, cross the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder and each dosage form proper auxiliary materials mixing, spray into volatile oil by each dosage form common process, make pill, tablet, granule, capsule or drop pill.

3. the preparation method of described Chinese medicine composition according to claim 2 is characterized in that the prescription of described Chinese medicine composition consists of:

125 parts of Herba Taraxacis;

Preparation method is: above ten Six-elements, and the Bulbus Fritillariae Thunbergii of Dan Semen Persicae, half consumption, the Flos Carthami powder of half consumption are broken into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; The Flos Carthami of half consumption, Lasiosphaera Seu Calvatia, Flos Lonicerae, the Bulbus Fritillariae Thunbergii of half consumption, Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, relative density is 1.08～1.10 clear paste when being evaporated to temperature and being 70 ℃, with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, control vacuum is-0.08Mpa during concentrating under reduced pressure, temperature is 70 ℃, and relative density is 1.08～1.12 clear paste when being concentrated into temperature and being 70 ℃, crosses the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder mixing spray into volatile oil, add refined honey, make water-honeyed pill or big honeyed pills, namely get pill.

4. the preparation method of described Chinese medicine composition according to claim 2 is characterized in that the prescription of described Chinese medicine composition consists of:

125 parts of Herba Taraxacis;

Preparation method is: above ten Six-elements, and the Bulbus Fritillariae Thunbergii of Dan Semen Persicae, half consumption, the Flos Carthami powder of half consumption are broken into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; The Flos Carthami of half consumption, Lasiosphaera Seu Calvatia, Flos Lonicerae, the Bulbus Fritillariae Thunbergii of half consumption, Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, relative density is 1.08～1.10 clear paste when being evaporated to temperature and being 70 ℃, with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, control vacuum is-0.08Mpa during concentrating under reduced pressure, temperature is 70 ℃, and relative density is 1.08～1.12 clear paste when being concentrated into temperature and being 70 ℃, crosses the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder and appropriate amount of starch mixing are granulated drying, granulate, add an amount of magnesium stearate, mixing sprays into volatile oil, tabletting namely gets tablet.

5. the preparation method of described Chinese medicine composition according to claim 2 is characterized in that the prescription of described Chinese medicine composition consists of:

125 parts of Herba Taraxacis;

Preparation method is: above ten Six-elements, and the Bulbus Fritillariae Thunbergii of Dan Semen Persicae, half consumption, the Flos Carthami powder of half consumption are broken into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; The Flos Carthami of half consumption, Lasiosphaera Seu Calvatia, Flos Lonicerae, the Bulbus Fritillariae Thunbergii of half consumption, Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, relative density is 1.08～1.10 clear paste when being evaporated to temperature and being 70 ℃, with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, and control vacuum is-0.08Mpa during concentrating under reduced pressure, temperature is 70 ℃, relative density is 1.08～1.12 clear paste when being concentrated into temperature and being 70 ℃, cross the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder and an amount of dextrin mixing, granulate, drying, granulate sprays into volatile oil, pack namely gets granule.

6. the preparation method of described Chinese medicine composition according to claim 2 is characterized in that the prescription of described Chinese medicine composition consists of:

125 parts of Herba Taraxacis;

Preparation method is: above ten Six-elements, and the Bulbus Fritillariae Thunbergii of Dan Semen Persicae, half consumption, the Flos Carthami powder of half consumption are broken into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; The Flos Carthami of half consumption, Lasiosphaera Seu Calvatia, Flos Lonicerae, the Bulbus Fritillariae Thunbergii of half consumption, Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, relative density is 1.08～1.10 clear paste when being evaporated to temperature and being 70 ℃, with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, and control vacuum is-0.08Mpa during concentrating under reduced pressure, temperature is 70 ℃, relative density is 1.08～1.12 clear paste when being concentrated into temperature and being 70 ℃, cross the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder and appropriate amount of starch mixing, granulate, drying, granulate sprays into volatile oil, encapsulated, namely get capsule.

7. the preparation method of described Chinese medicine composition according to claim 2 is characterized in that the prescription of described Chinese medicine composition consists of:

125 parts of Herba Taraxacis;

Preparation method is: above ten Six-elements, and the Bulbus Fritillariae Thunbergii of Dan Semen Persicae, half consumption, the Flos Carthami powder of half consumption are broken into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; The Flos Carthami of half consumption, Lasiosphaera Seu Calvatia, Flos Lonicerae, the Bulbus Fritillariae Thunbergii of half consumption, Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, relative density is 1.08～1.10 clear paste when being evaporated to temperature and being 70 ℃, with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, and control vacuum is-0.08Mpa during concentrating under reduced pressure, temperature is 70 ℃, and relative density is 1.08～1.12 clear paste when being concentrated into temperature and being 70 ℃, cross the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder mixing get mixed powder, spray into volatile oil, mixing adds PEG400, and is even through colloidal grinding; In gelatin: glycerol: water is 1: 0.3: 1 ratio glue, adopts the encapsulating machine pelleting, namely gets soft capsule.

8. the preparation method of described Chinese medicine composition according to claim 2 is characterized in that the prescription of described Chinese medicine composition consists of:

125 parts of Herba Taraxacis;

Preparation method is: above ten Six-elements, and the Bulbus Fritillariae Thunbergii of Dan Semen Persicae, half consumption, the Flos Carthami powder of half consumption are broken into fine powder, and be for subsequent use; Stir-baked RHIIZOMA CURCUMAE with vinegar, Semen Oroxyli add 10 times of amounts of water reflux, extract, volatile oil 2 times, and each 2 hours, collect volatile oil for subsequent use, merge filtrate twice, for subsequent use; Periostracum Cicadae, Endothelium Corneum Gigeriae Galli (parched) are measured 30% alcohol reflux 2 times with 8 times, and each 1 hour, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; Radix Salviae Miltiorrhizae is measured 80% alcohol reflux 2 times with 6 times, and each 1.5 hours, merge filtrate twice, decompression recycling ethanol gets extracting solution, and is for subsequent use; The Flos Carthami of half consumption, Lasiosphaera Seu Calvatia, Flos Lonicerae, the Bulbus Fritillariae Thunbergii of half consumption, Herba Taraxaci, Radix Isatidis, stir-baked RHIZOMA SPARGANII with vinegar, Radix Scrophulariae, Rhizoma Alismatis, Radix Ophiopogonis, totally 10 flavors decocted with water 2 times, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1.5 hours, merge filtrate twice, relative density is 1.08～1.10 clear paste when being evaporated to temperature and being 70 ℃, with the filtrate behind the said extracted volatile oil, the alcohol extract of Periostracum Cicadae and Endothelium Corneum Gigeriae Galli (parched), the alcohol extract of Radix Salviae Miltiorrhizae merges, control vacuum is-0.08Mpa during concentrating under reduced pressure, temperature is 70 ℃, and relative density is 1.08～1.12 clear paste when being concentrated into temperature and being 70 ℃, crosses the above filter screen of 60 orders, carry out spray drying, gained spraying dry powder and above-mentioned fine powder mixing spray into volatile oil, mixing, sieve, add in the Macrogol 4000 of melting, stir, add in the pill dripping machine, dripping becomes ball, namely gets drop pill.