CN103890580B - 用于处理单分子的设备 - Google Patents

用于处理单分子的设备 Download PDF

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Publication number
CN103890580B
CN103890580B CN201280047984.8A CN201280047984A CN103890580B CN 103890580 B CN103890580 B CN 103890580B CN 201280047984 A CN201280047984 A CN 201280047984A CN 103890580 B CN103890580 B CN 103890580B
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layer
elongated slit
top layer
slit
nucleic acid
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Chinese (zh)
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CN103890580A (zh
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P·J·范德扎格
R·库霍恩
F·C·M·J·M·范德尔夫特
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Koninklijke Philips NV
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Koninklijke Philips Electronics NV
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Nanotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201280047984.8A 2011-09-28 2012-09-25 用于处理单分子的设备 Active CN103890580B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161540014P 2011-09-28 2011-09-28
US61/540,014 2011-09-28
EP11191966.8 2011-12-05
EP11191966A EP2574923A1 (en) 2011-09-28 2011-12-05 Apparatus for the processing of single molecules
PCT/IB2012/055091 WO2013046116A1 (en) 2011-09-28 2012-09-25 Apparatus for the processing of single molecules

Publications (2)

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CN103890580A CN103890580A (zh) 2014-06-25
CN103890580B true CN103890580B (zh) 2017-06-27

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CN201280047984.8A Active CN103890580B (zh) 2011-09-28 2012-09-25 用于处理单分子的设备

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US (1) US10281453B2 (enExample)
EP (2) EP2574923A1 (enExample)
JP (1) JP6302836B2 (enExample)
CN (1) CN103890580B (enExample)
WO (1) WO2013046116A1 (enExample)

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EP2574923A1 (en) 2011-09-28 2013-04-03 Koninklijke Philips Electronics N.V. Apparatus for the processing of single molecules
US10017852B2 (en) * 2016-04-14 2018-07-10 Lockheed Martin Corporation Method for treating graphene sheets for large-scale transfer using free-float method
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US10980919B2 (en) 2016-04-14 2021-04-20 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
US10653824B2 (en) 2012-05-25 2020-05-19 Lockheed Martin Corporation Two-dimensional materials and uses thereof
US9744617B2 (en) 2014-01-31 2017-08-29 Lockheed Martin Corporation Methods for perforating multi-layer graphene through ion bombardment
US10376845B2 (en) 2016-04-14 2019-08-13 Lockheed Martin Corporation Membranes with tunable selectivity
KR20140028602A (ko) * 2012-08-29 2014-03-10 삼성전자주식회사 그래핀을 포함하는 나노 센서 및 이의 제조 방법
US9592475B2 (en) 2013-03-12 2017-03-14 Lockheed Martin Corporation Method for forming perforated graphene with uniform aperture size
WO2014177408A1 (en) 2013-05-01 2014-11-06 Koninklijke Philips N.V. Method of manufacturing a partially freestanding two-dimensional crystal film and device comprising such a film
US9572918B2 (en) 2013-06-21 2017-02-21 Lockheed Martin Corporation Graphene-based filter for isolating a substance from blood
KR20160142820A (ko) 2014-01-31 2016-12-13 록히드 마틴 코포레이션 브로드 이온 필드를 사용한 2차원 물질 천공
AU2015210875A1 (en) 2014-01-31 2016-09-15 Lockheed Martin Corporation Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer
CN106232205A (zh) 2014-03-12 2016-12-14 洛克希德马丁公司 由有孔石墨烯形成的分离膜
US9869658B2 (en) 2014-07-22 2018-01-16 International Business Machines Corporation Electronic label free detection of DNA complexes using nanogap
CN107073408A (zh) 2014-09-02 2017-08-18 洛克希德马丁公司 基于二维膜材料的血液透析膜和血液过滤膜及其应用方法
CA2994549A1 (en) 2015-08-05 2017-02-09 Lockheed Martin Corporation Perforatable sheets of graphene-based material
CA2994664A1 (en) 2015-08-06 2017-02-09 Lockheed Martin Corporation Nanoparticle modification and perforation of graphene
WO2017108591A1 (en) 2015-12-22 2017-06-29 Koninklijke Philips N.V. Method of creating a nano-sized recess
US20170191912A1 (en) 2016-01-06 2017-07-06 International Business Machines Corporation Semiconductor manufactured nano-structures for microbe or virus trapping or destruction
EP3442697A4 (en) 2016-04-14 2020-03-18 Lockheed Martin Corporation SELECTIVE INTERFACE REDUCTION OF GRAPH DEFECTS
JP2019519756A (ja) 2016-04-14 2019-07-11 ロッキード・マーチン・コーポレーション 欠陥形成または欠陥修復をその場で監視して制御する方法
KR20190018410A (ko) 2016-04-14 2019-02-22 록히드 마틴 코포레이션 흐름 통로들을 갖는 2차원 막 구조들
CN107058082A (zh) * 2017-04-22 2017-08-18 天津智巧数据科技有限公司 一种基于近场光学技术的单分子dna无损检测芯片

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CN101171345A (zh) * 2005-04-12 2008-04-30 454生命科学公司 用ultra-deep测序法测定序列变体的方法
US7468271B2 (en) * 2005-04-06 2008-12-23 President And Fellows Of Harvard College Molecular characterization with carbon nanotube control
US7582490B2 (en) * 1999-06-22 2009-09-01 President And Fellows Of Harvard College Controlled fabrication of gaps in electrically conducting structures
WO2011046706A1 (en) * 2009-09-18 2011-04-21 President And Fellows Of Harvard College Bare single-layer graphene membrane having a nanopore enabling high-sensitivity molecular detection and analysis
WO2011047582A1 (zh) * 2009-10-22 2011-04-28 浙江大学 一种纳米孔电学传感器
CN102076871A (zh) * 2008-11-07 2011-05-25 财团法人工业技术研究院 精确序列信息及修饰碱基位置确定的方法

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Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
US7582490B2 (en) * 1999-06-22 2009-09-01 President And Fellows Of Harvard College Controlled fabrication of gaps in electrically conducting structures
US7468271B2 (en) * 2005-04-06 2008-12-23 President And Fellows Of Harvard College Molecular characterization with carbon nanotube control
CN101171345A (zh) * 2005-04-12 2008-04-30 454生命科学公司 用ultra-deep测序法测定序列变体的方法
CN102076871A (zh) * 2008-11-07 2011-05-25 财团法人工业技术研究院 精确序列信息及修饰碱基位置确定的方法
WO2011046706A1 (en) * 2009-09-18 2011-04-21 President And Fellows Of Harvard College Bare single-layer graphene membrane having a nanopore enabling high-sensitivity molecular detection and analysis
WO2011047582A1 (zh) * 2009-10-22 2011-04-28 浙江大学 一种纳米孔电学传感器

Also Published As

Publication number Publication date
JP2014529082A (ja) 2014-10-30
EP2748603A1 (en) 2014-07-02
JP6302836B2 (ja) 2018-03-28
EP2748603B1 (en) 2021-01-27
EP2574923A1 (en) 2013-04-03
US20140349892A1 (en) 2014-11-27
US10281453B2 (en) 2019-05-07
WO2013046116A1 (en) 2013-04-04
CN103890580A (zh) 2014-06-25

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