JP6302836B2 - 単一分子を処理するための装置 - Google Patents

単一分子を処理するための装置 Download PDF

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Publication number
JP6302836B2
JP6302836B2 JP2014532529A JP2014532529A JP6302836B2 JP 6302836 B2 JP6302836 B2 JP 6302836B2 JP 2014532529 A JP2014532529 A JP 2014532529A JP 2014532529 A JP2014532529 A JP 2014532529A JP 6302836 B2 JP6302836 B2 JP 6302836B2
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slit
layer
aperture
bottom layer
molecule
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JP2014529082A5 (enExample
JP2014529082A (ja
Inventor
デル ザーグ ピーター ジャン バン
デル ザーグ ピーター ジャン バン
レインダー クーホルン
レインダー クーホルン
デルフト ファルコ コーネリウス マリヌス ヤコブス マリア バン
デルフト ファルコ コーネリウス マリヌス ヤコブス マリア バン
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Koninklijke Philips NV
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Koninklijke Philips NV
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Nanotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2014532529A 2011-09-28 2012-09-25 単一分子を処理するための装置 Expired - Fee Related JP6302836B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161540014P 2011-09-28 2011-09-28
US61/540,014 2011-09-28
EP11191966.8 2011-12-05
EP11191966A EP2574923A1 (en) 2011-09-28 2011-12-05 Apparatus for the processing of single molecules
PCT/IB2012/055091 WO2013046116A1 (en) 2011-09-28 2012-09-25 Apparatus for the processing of single molecules

Publications (3)

Publication Number Publication Date
JP2014529082A JP2014529082A (ja) 2014-10-30
JP2014529082A5 JP2014529082A5 (enExample) 2015-11-12
JP6302836B2 true JP6302836B2 (ja) 2018-03-28

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JP2014532529A Expired - Fee Related JP6302836B2 (ja) 2011-09-28 2012-09-25 単一分子を処理するための装置

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US (1) US10281453B2 (enExample)
EP (2) EP2574923A1 (enExample)
JP (1) JP6302836B2 (enExample)
CN (1) CN103890580B (enExample)
WO (1) WO2013046116A1 (enExample)

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* Cited by examiner, † Cited by third party
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US9475709B2 (en) 2010-08-25 2016-10-25 Lockheed Martin Corporation Perforated graphene deionization or desalination
EP2574923A1 (en) 2011-09-28 2013-04-03 Koninklijke Philips Electronics N.V. Apparatus for the processing of single molecules
US10376845B2 (en) 2016-04-14 2019-08-13 Lockheed Martin Corporation Membranes with tunable selectivity
US9744617B2 (en) 2014-01-31 2017-08-29 Lockheed Martin Corporation Methods for perforating multi-layer graphene through ion bombardment
US10203295B2 (en) 2016-04-14 2019-02-12 Lockheed Martin Corporation Methods for in situ monitoring and control of defect formation or healing
US9834809B2 (en) 2014-02-28 2017-12-05 Lockheed Martin Corporation Syringe for obtaining nano-sized materials for selective assays and related methods of use
US10213746B2 (en) 2016-04-14 2019-02-26 Lockheed Martin Corporation Selective interfacial mitigation of graphene defects
US10653824B2 (en) 2012-05-25 2020-05-19 Lockheed Martin Corporation Two-dimensional materials and uses thereof
US10418143B2 (en) 2015-08-05 2019-09-17 Lockheed Martin Corporation Perforatable sheets of graphene-based material
KR20140028602A (ko) * 2012-08-29 2014-03-10 삼성전자주식회사 그래핀을 포함하는 나노 센서 및 이의 제조 방법
WO2014164621A1 (en) 2013-03-12 2014-10-09 Lockheed Martin Corporation Method for forming filter with uniform aperture size
WO2014177408A1 (en) 2013-05-01 2014-11-06 Koninklijke Philips N.V. Method of manufacturing a partially freestanding two-dimensional crystal film and device comprising such a film
US9572918B2 (en) 2013-06-21 2017-02-21 Lockheed Martin Corporation Graphene-based filter for isolating a substance from blood
SG11201606287VA (en) 2014-01-31 2016-08-30 Lockheed Corp Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer
SG11201606289RA (en) 2014-01-31 2016-08-30 Lockheed Corp Perforating two-dimensional materials using broad ion field
WO2015138771A1 (en) 2014-03-12 2015-09-17 Lockheed Martin Corporation Separation membranes formed from perforated graphene
US9869658B2 (en) 2014-07-22 2018-01-16 International Business Machines Corporation Electronic label free detection of DNA complexes using nanogap
WO2016036888A1 (en) 2014-09-02 2016-03-10 Lockheed Martin Corporation Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same
JP2018530499A (ja) 2015-08-06 2018-10-18 ロッキード・マーチン・コーポレーション グラフェンのナノ粒子変性及び穿孔
US20210165314A1 (en) 2015-12-22 2021-06-03 Koninklijke Philips N.V. Method of creating a nano-sized recess
US20170191912A1 (en) 2016-01-06 2017-07-06 International Business Machines Corporation Semiconductor manufactured nano-structures for microbe or virus trapping or destruction
WO2017180134A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
WO2017180137A1 (en) * 2016-04-14 2017-10-19 Lockheed Martin Corporation Method for treating graphene sheets for large-scale transfer using free-float method
KR20190018410A (ko) 2016-04-14 2019-02-22 록히드 마틴 코포레이션 흐름 통로들을 갖는 2차원 막 구조들
CN107058082A (zh) * 2017-04-22 2017-08-18 天津智巧数据科技有限公司 一种基于近场光学技术的单分子dna无损检测芯片

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JPH08315760A (ja) 1995-05-23 1996-11-29 Hitachi Ltd ビーム成形絞りとその作成方法およびこれを用いた荷電粒子ビーム露光装置
JP3051099B2 (ja) 1997-05-14 2000-06-12 株式会社東芝 マーク基板，マーク基板の製造方法，電子ビーム描画装置及び電子ビーム描画装置の光学系の調整方法
JP2002522780A (ja) 1998-08-13 2002-07-23 ユー．エス．ゲノミクス ポリマーの光学的な特性決定
US7582490B2 (en) * 1999-06-22 2009-09-01 President And Fellows Of Harvard College Controlled fabrication of gaps in electrically conducting structures
JP4719906B2 (ja) * 2000-04-24 2011-07-06 ライフ テクノロジーズ コーポレーション 超高速の核酸配列決定のための電界効果トランジスタ装置
US6503409B1 (en) * 2000-05-25 2003-01-07 Sandia Corporation Lithographic fabrication of nanoapertures
JP2006526777A (ja) * 2003-02-28 2006-11-24 ブラウン ユニバーシティー ナノ細孔、その使用方法、その作成方法、及びそれを使用して生体分子を特徴付ける方法
EP1877762B1 (en) * 2005-04-06 2011-10-19 President and Fellows of Harvard College Molecular characterization with carbon nanotube control
US20060228721A1 (en) * 2005-04-12 2006-10-12 Leamon John H Methods for determining sequence variants using ultra-deep sequencing
EP3540436B1 (en) 2007-09-12 2023-11-01 President And Fellows Of Harvard College High-resolution molecular sensor
EP2205522B1 (en) 2007-10-02 2019-03-13 President and Fellows of Harvard College Carbon nanotube synthesis for nanopore devices
US8968540B2 (en) * 2008-10-06 2015-03-03 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Trans-base tunnel reader for sequencing
US8486630B2 (en) 2008-11-07 2013-07-16 Industrial Technology Research Institute Methods for accurate sequence data and modified base position determination
KR101127579B1 (ko) 2009-08-28 2012-03-23 삼성모바일디스플레이주식회사 헤테로아릴아민 화합물 및 이를 이용한 유기 발광 소자
BR112012005888B1 (pt) * 2009-09-18 2019-10-22 President And Fellows Of Harvard College sensores de nanoporo de grafeno e método para avaliar uma molécula de polímero
CN101694474B (zh) * 2009-10-22 2012-10-10 浙江大学 一种纳米孔电学传感器
EP2574923A1 (en) 2011-09-28 2013-04-03 Koninklijke Philips Electronics N.V. Apparatus for the processing of single molecules

Also Published As

Publication number Publication date
EP2748603B1 (en) 2021-01-27
EP2748603A1 (en) 2014-07-02
US20140349892A1 (en) 2014-11-27
US10281453B2 (en) 2019-05-07
CN103890580A (zh) 2014-06-25
WO2013046116A1 (en) 2013-04-04
CN103890580B (zh) 2017-06-27
JP2014529082A (ja) 2014-10-30
EP2574923A1 (en) 2013-04-03

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