CN103889930B - 用于制备68Ga络合物的工艺 - Google Patents
用于制备68Ga络合物的工艺 Download PDFInfo
- Publication number
- CN103889930B CN103889930B CN201280039304.8A CN201280039304A CN103889930B CN 103889930 B CN103889930 B CN 103889930B CN 201280039304 A CN201280039304 A CN 201280039304A CN 103889930 B CN103889930 B CN 103889930B
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- CN
- China
- Prior art keywords
- vial
- formate
- chelator
- reaction
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000180A ITFI20110180A1 (it) | 2011-08-12 | 2011-08-12 | Processo per la preparazione di complessi di 68ga. |
| ITFI2011A000180 | 2011-08-12 | ||
| PCT/EP2012/065659 WO2013024013A2 (en) | 2011-08-12 | 2012-08-10 | Process for the preparation of complexes of 68ga. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103889930A CN103889930A (zh) | 2014-06-25 |
| CN103889930B true CN103889930B (zh) | 2017-03-29 |
Family
ID=44898621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280039304.8A Active CN103889930B (zh) | 2011-08-12 | 2012-08-10 | 用于制备68Ga络合物的工艺 |
Country Status (19)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11027030B2 (en) | 2014-08-29 | 2021-06-08 | Anmi S.A. | Kit for radiolabelling |
| BE1021191B1 (fr) * | 2014-08-29 | 2015-10-27 | Anmi S.A. | Kit pour radiomarquage. |
| WO2016120365A1 (en) * | 2015-01-30 | 2016-08-04 | Advanced Accelerator Applications S.A. | Process for the purification of ga-68 from eluate deriving from 68ge/ 68ga generators and chromatographic columns for use in said process |
| IL237525A (en) | 2015-03-03 | 2017-05-29 | Shalom Eli | Method for labeling a prostate-specific membrane antigen with a radioactive isotope |
| GB201504064D0 (en) * | 2015-03-10 | 2015-04-22 | Accretion Biotechnology Ltd | Method and kits for preparing radionuclide complexes |
| IL297323A (en) * | 2020-04-29 | 2022-12-01 | Novartis Ag | Methods for radiological labeling of psma-binding ligands and their kits |
| RU2760273C1 (ru) * | 2020-11-02 | 2021-11-23 | Федеральное государственное бюджетное учреждение науки Ордена Трудового Красного Знамени Институт химии силикатов им. И.В. Гребенщикова Российской академии наук (ИХС РАН) | Способ получения комплексов на основе изотопа галлий-68 |
| CN117500772A (zh) | 2021-05-31 | 2024-02-02 | 泰利克斯制药(创新)私人有限公司 | 改进的前列腺特异性膜抗原靶向放射性药物及其用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010092114A1 (en) * | 2009-02-13 | 2010-08-19 | Guerbet | Use of buffers for radionuclide complexation |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6056939A (en) * | 1998-08-28 | 2000-05-02 | Desreux; Jean F. | Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals |
| WO2003048207A2 (en) * | 2001-11-28 | 2003-06-12 | Immunomedics, Inc. | Anti-dota antibody |
| GB0308408D0 (en) * | 2003-04-11 | 2003-05-21 | Amersham Plc | Microwave activation |
| JP5139678B2 (ja) * | 2003-07-24 | 2013-02-06 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | 安定な放射性医薬品組成物およびその製法 |
| CN1874792A (zh) | 2003-09-03 | 2006-12-06 | 布里斯托尔-迈尔斯.斯奎布制药公司 | 包含基质金属蛋白酶底物的化合物及其使用方法 |
| DE102004057225B4 (de) * | 2004-11-26 | 2006-10-12 | Johannes-Gutenberg-Universität Mainz | Verfahren und Vorrichtung zur Isolierung eines chemisch und radiochemisch gereinigten 68Ga-Radionuklids und zum Markieren eines Markierungsvorläufers mit dem 68Ga-Radionuklid |
| EP2056886A2 (en) * | 2006-08-28 | 2009-05-13 | GE Healthcare Limited | 68ga-labeled peptide-based radiopharmaceuticals |
| US20120121509A1 (en) * | 2009-06-05 | 2012-05-17 | The General Hospital Corporation | Vital fluorochrome conjugates and methods of use |
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2011
- 2011-08-12 IT IT000180A patent/ITFI20110180A1/it unknown
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2012
- 2012-08-10 CA CA3045484A patent/CA3045484C/en active Active
- 2012-08-10 AU AU2012297008A patent/AU2012297008B2/en active Active
- 2012-08-10 US US14/237,728 patent/US9375498B2/en active Active
- 2012-08-10 BR BR122020011908-0A patent/BR122020011908B1/pt active IP Right Grant
- 2012-08-10 DK DK12756391.4T patent/DK2742017T3/da active
- 2012-08-10 ES ES15174234T patent/ES2835581T3/es active Active
- 2012-08-10 EP EP15174234.3A patent/EP2955168B1/en active Active
- 2012-08-10 CA CA2844145A patent/CA2844145C/en active Active
- 2012-08-10 MX MX2014001691A patent/MX370081B/es active IP Right Grant
- 2012-08-10 PL PL12756391T patent/PL2742017T3/pl unknown
- 2012-08-10 JP JP2014524396A patent/JP6161610B2/ja active Active
- 2012-08-10 BR BR112014003336-6A patent/BR112014003336B1/pt active IP Right Grant
- 2012-08-10 CN CN201280039304.8A patent/CN103889930B/zh active Active
- 2012-08-10 WO PCT/EP2012/065659 patent/WO2013024013A2/en not_active Ceased
- 2012-08-10 IN IN1897CHN2014 patent/IN2014CN01897A/en unknown
- 2012-08-10 RU RU2014109381/04A patent/RU2605090C2/ru active
- 2012-08-10 EP EP12756391.4A patent/EP2742017B1/en active Active
- 2012-08-10 ES ES12756391.4T patent/ES2560231T3/es active Active
- 2012-08-10 EP EP20177270.4A patent/EP3718991A1/en active Pending
- 2012-08-10 PT PT127563914T patent/PT2742017E/pt unknown
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2014
- 2014-02-10 IL IL230904A patent/IL230904B/en active IP Right Grant
- 2014-03-10 CO CO14050755A patent/CO7020857A2/es unknown
- 2014-03-11 ZA ZA2014/01789A patent/ZA201401789B/en unknown
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2016
- 2016-05-24 US US15/163,484 patent/US9907868B2/en active Active
- 2016-05-25 IL IL245849A patent/IL245849B/en active IP Right Grant
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2020
- 2020-06-23 RU RU2020120802A patent/RU2020120802A/ru unknown
- 2020-07-12 IL IL275979A patent/IL275979B2/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010092114A1 (en) * | 2009-02-13 | 2010-08-19 | Guerbet | Use of buffers for radionuclide complexation |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20170215 Address after: geneva Applicant after: Advanced catalyst applications International Ltd Address before: The French Saint Genis Pouilly Applicant before: Advanced Accelerator Applic S. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |